PMC:7293470 / 4871-5222 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T147","span":{"begin":140,"end":146},"obj":"GO:0045087"},{"id":"T148","span":{"begin":151,"end":159},"obj":"GO:0002250"},{"id":"T149","span":{"begin":160,"end":166},"obj":"GO:0002250;UBERON:0002405"},{"id":"T150","span":{"begin":167,"end":176},"obj":"GO:0002250"},{"id":"T151","span":{"begin":205,"end":215},"obj":"SP_7"},{"id":"T152","span":{"begin":262,"end":267},"obj":"PR:000001173"},{"id":"T153","span":{"begin":269,"end":277},"obj":"CL:0000233;GO:0030168"},{"id":"T154","span":{"begin":278,"end":288},"obj":"GO:0030168"},{"id":"T155","span":{"begin":290,"end":295},"obj":"PR:000001136"},{"id":"T156","span":{"begin":297,"end":301},"obj":"PR:000001379"},{"id":"T157","span":{"begin":303,"end":307},"obj":"PR:000001393"},{"id":"T158","span":{"begin":309,"end":314},"obj":"PR:000000134"},{"id":"T159","span":{"begin":316,"end":320},"obj":"PR:000001199"},{"id":"T160","span":{"begin":335,"end":339},"obj":"PR:000002122"},{"id":"T161","span":{"begin":345,"end":350},"obj":"PR:000001257"},{"id":"T66311","span":{"begin":140,"end":146},"obj":"GO:0045087"},{"id":"T89429","span":{"begin":151,"end":159},"obj":"GO:0002250"},{"id":"T83884","span":{"begin":160,"end":166},"obj":"GO:0002250;UBERON:0002405"},{"id":"T58055","span":{"begin":167,"end":176},"obj":"GO:0002250"},{"id":"T11954","span":{"begin":205,"end":215},"obj":"SP_7"},{"id":"T41665","span":{"begin":262,"end":267},"obj":"PR:000001173"},{"id":"T18310","span":{"begin":269,"end":277},"obj":"CL:0000233;GO:0030168"},{"id":"T71710","span":{"begin":278,"end":288},"obj":"GO:0030168"},{"id":"T92918","span":{"begin":290,"end":295},"obj":"PR:000001136"},{"id":"T94394","span":{"begin":297,"end":301},"obj":"PR:000001379"},{"id":"T78460","span":{"begin":303,"end":307},"obj":"PR:000001393"},{"id":"T88059","span":{"begin":309,"end":314},"obj":"PR:000000134"},{"id":"T99547","span":{"begin":316,"end":320},"obj":"PR:000001199"},{"id":"T8821","span":{"begin":335,"end":339},"obj":"PR:000002122"},{"id":"T8352","span":{"begin":345,"end":350},"obj":"PR:000001257"}],"text":"These and other studies ([9], [10], [11] \u0026 unpublished data) revealed down-regulation of multiple proinflammatory components driven by both innate and adaptive immune responses that also contribute to the SARS-CoV-2 cytokine storm, including complement receptor C5aR1, platelet activation, IL-1β, IL-2, IL-6, TNF-α, CCR2 (receptor for CCL2) and CXCR2."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T60","span":{"begin":216,"end":224},"obj":"Body_part"},{"id":"T61","span":{"begin":269,"end":277},"obj":"Body_part"},{"id":"T62","span":{"begin":290,"end":294},"obj":"Body_part"},{"id":"T63","span":{"begin":297,"end":301},"obj":"Body_part"}],"attributes":[{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma84051"}],"text":"These and other studies ([9], [10], [11] \u0026 unpublished data) revealed down-regulation of multiple proinflammatory components driven by both innate and adaptive immune responses that also contribute to the SARS-CoV-2 cytokine storm, including complement receptor C5aR1, platelet activation, IL-1β, IL-2, IL-6, TNF-α, CCR2 (receptor for CCL2) and CXCR2."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T32","span":{"begin":205,"end":213},"obj":"Disease"},{"id":"T33","span":{"begin":205,"end":209},"obj":"Disease"}],"attributes":[{"id":"A32","pred":"mondo_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A33","pred":"mondo_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"These and other studies ([9], [10], [11] \u0026 unpublished data) revealed down-regulation of multiple proinflammatory components driven by both innate and adaptive immune responses that also contribute to the SARS-CoV-2 cytokine storm, including complement receptor C5aR1, platelet activation, IL-1β, IL-2, IL-6, TNF-α, CCR2 (receptor for CCL2) and CXCR2."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T77","span":{"begin":37,"end":39},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T78","span":{"begin":278,"end":288},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T79","span":{"begin":297,"end":301},"obj":"http://purl.obolibrary.org/obo/PR_000001379"}],"text":"These and other studies ([9], [10], [11] \u0026 unpublished data) revealed down-regulation of multiple proinflammatory components driven by both innate and adaptive immune responses that also contribute to the SARS-CoV-2 cytokine storm, including complement receptor C5aR1, platelet activation, IL-1β, IL-2, IL-6, TNF-α, CCR2 (receptor for CCL2) and CXCR2."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T80","span":{"begin":290,"end":292},"obj":"Chemical"},{"id":"T82","span":{"begin":297,"end":299},"obj":"Chemical"},{"id":"T84","span":{"begin":303,"end":305},"obj":"Chemical"}],"attributes":[{"id":"A80","pred":"chebi_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A81","pred":"chebi_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A82","pred":"chebi_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A83","pred":"chebi_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A84","pred":"chebi_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A85","pred":"chebi_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"These and other studies ([9], [10], [11] \u0026 unpublished data) revealed down-regulation of multiple proinflammatory components driven by both innate and adaptive immune responses that also contribute to the SARS-CoV-2 cytokine storm, including complement receptor C5aR1, platelet activation, IL-1β, IL-2, IL-6, TNF-α, CCR2 (receptor for CCL2) and CXCR2."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T12","span":{"begin":216,"end":230},"obj":"Phenotype"}],"attributes":[{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"These and other studies ([9], [10], [11] \u0026 unpublished data) revealed down-regulation of multiple proinflammatory components driven by both innate and adaptive immune responses that also contribute to the SARS-CoV-2 cytokine storm, including complement receptor C5aR1, platelet activation, IL-1β, IL-2, IL-6, TNF-α, CCR2 (receptor for CCL2) and CXCR2."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T15","span":{"begin":75,"end":85},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T16","span":{"begin":151,"end":176},"obj":"http://purl.obolibrary.org/obo/GO_0002250"},{"id":"T17","span":{"begin":269,"end":288},"obj":"http://purl.obolibrary.org/obo/GO_0030168"}],"text":"These and other studies ([9], [10], [11] \u0026 unpublished data) revealed down-regulation of multiple proinflammatory components driven by both innate and adaptive immune responses that also contribute to the SARS-CoV-2 cytokine storm, including complement receptor C5aR1, platelet activation, IL-1β, IL-2, IL-6, TNF-α, CCR2 (receptor for CCL2) and CXCR2."}

{"project":"LitCovid-sentences","denotations":[{"id":"T23","span":{"begin":0,"end":351},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"These and other studies ([9], [10], [11] \u0026 unpublished data) revealed down-regulation of multiple proinflammatory components driven by both innate and adaptive immune responses that also contribute to the SARS-CoV-2 cytokine storm, including complement receptor C5aR1, platelet activation, IL-1β, IL-2, IL-6, TNF-α, CCR2 (receptor for CCL2) and CXCR2."}

{"project":"LitCovid-PubTator","denotations":[{"id":"198","span":{"begin":262,"end":267},"obj":"Gene"},{"id":"199","span":{"begin":290,"end":295},"obj":"Gene"},{"id":"200","span":{"begin":297,"end":301},"obj":"Gene"},{"id":"201","span":{"begin":303,"end":307},"obj":"Gene"},{"id":"202","span":{"begin":309,"end":314},"obj":"Gene"},{"id":"203","span":{"begin":316,"end":320},"obj":"Gene"},{"id":"204","span":{"begin":335,"end":339},"obj":"Gene"},{"id":"205","span":{"begin":345,"end":350},"obj":"Gene"},{"id":"210","span":{"begin":205,"end":215},"obj":"Species"}],"attributes":[{"id":"A198","pred":"tao:has_database_id","subj":"198","obj":"Gene:728"},{"id":"A199","pred":"tao:has_database_id","subj":"199","obj":"Gene:3552"},{"id":"A200","pred":"tao:has_database_id","subj":"200","obj":"Gene:3558"},{"id":"A201","pred":"tao:has_database_id","subj":"201","obj":"Gene:3569"},{"id":"A202","pred":"tao:has_database_id","subj":"202","obj":"Gene:7124"},{"id":"A203","pred":"tao:has_database_id","subj":"203","obj":"Gene:729230"},{"id":"A204","pred":"tao:has_database_id","subj":"204","obj":"Gene:6347"},{"id":"A205","pred":"tao:has_database_id","subj":"205","obj":"Gene:3579"},{"id":"A210","pred":"tao:has_database_id","subj":"210","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"These and other studies ([9], [10], [11] \u0026 unpublished data) revealed down-regulation of multiple proinflammatory components driven by both innate and adaptive immune responses that also contribute to the SARS-CoV-2 cytokine storm, including complement receptor C5aR1, platelet activation, IL-1β, IL-2, IL-6, TNF-α, CCR2 (receptor for CCL2) and CXCR2."}