PMC:7293470 / 3409-6113
Annnotations
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T115 | 51-55 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T116 | 129-133 | PR:000001822 | denotes | CD74 |
| T117 | 206-209 | PR:000029150 | denotes | HLA |
| T118 | 215-221 | SO:0000417 | denotes | domain |
| T119 | 292-296 | PR:000001822 | denotes | CD74 |
| T120 | 332-338 | CL:0000218;UBERON:0000345 | denotes | myelin |
| T121 | 339-360 | CL:0000128 | denotes | oligodendroglial cell |
| T122 | 361-373 | PR:000037069;CHEBI:17089;BV_11;CHEBI:17089 | denotes | glycoprotein |
| T123 | 380-383 | PR:000010514 | denotes | MOG |
| T124 | 440-452 | GO:0042613 | denotes | MHC Class II |
| T125 | 453-454 | PR:P0CY06 | denotes | α |
| T126 | 459-468 | CHEBI:59132;CHEBI:59132 | denotes | antigenic |
| T127 | 511-517 | GO:0006266 | denotes | ligate |
| T128 | 527-533 | CL:0000084 | denotes | T cell |
| T129 | 589-596 | GO:0032991 | denotes | complex |
| T130 | 718-721 | GO:0042611 | denotes | MHC |
| T131 | 726-735 | CHEBI:59132;CHEBI:59132 | denotes | antigenic |
| T132 | 777-780 | GO:0042611 | denotes | MHC |
| T133 | 792-799 | CHEBI:59132;CHEBI:59132 | denotes | antigen |
| T134 | 809-816 | CL:0000084 | denotes | T cells |
| T135 | 822-833 | GO:0006412 | denotes | translation |
| T136 | 849-854 | SP_6;NCBITaxon:9606 | denotes | human |
| T137 | 930-933 | GO:0042611 | denotes | MHC |
| T138 | 1037-1042 | SP_6;NCBITaxon:9606 | denotes | human |
| T139 | 1048-1054 | SO:0000417 | denotes | domain |
| T140 | 1089-1095 | SO:0000417 | denotes | domain |
| T141 | 1097-1103 | MOP:0000779 | denotes | linked |
| T142 | 1226-1232 | UBERON:0000479 | denotes | tissue |
| T143 | 1281-1284 | PR:000010514 | denotes | MOG |
| T144 | 1359-1365 | NCBITaxon:33208 | denotes | animal |
| T145 | 1404-1419 | CHEBI:6809;CHEBI:6809 | denotes | methamphetamine |
| T146 | 1444-1449 | UBERON:0000955 | denotes | brain |
| T147 | 1602-1608 | GO:0045087 | denotes | innate |
| T148 | 1613-1621 | GO:0002250 | denotes | adaptive |
| T149 | 1622-1628 | GO:0002250;UBERON:0002405 | denotes | immune |
| T150 | 1629-1638 | GO:0002250 | denotes | responses |
| T151 | 1667-1677 | SP_7 | denotes | SARS-CoV-2 |
| T152 | 1724-1729 | PR:000001173 | denotes | C5aR1 |
| T153 | 1731-1739 | CL:0000233;GO:0030168 | denotes | platelet |
| T154 | 1740-1750 | GO:0030168 | denotes | activation |
| T155 | 1752-1757 | PR:000001136 | denotes | IL-1β |
| T156 | 1759-1763 | PR:000001379 | denotes | IL-2 |
| T157 | 1765-1769 | PR:000001393 | denotes | IL-6 |
| T158 | 1771-1776 | PR:000000134 | denotes | TNF-α |
| T159 | 1778-1782 | PR:000001199 | denotes | CCR2 |
| T160 | 1797-1801 | PR:000002122 | denotes | CCL2 |
| T161 | 1807-1812 | PR:000001257 | denotes | CXCR2 |
| T162 | 1882-1891 | CL:0002629 | denotes | activated |
| T163 | 1892-1899 | CL:0002248;UBERON:0002048 | denotes | pleural |
| T164 | 1900-1906 | CL:0000084 | denotes | T cell |
| T165 | 1938-1947 | CHEBI:30501;CHEBI:30501 | denotes | beryllium |
| T166 | 1956-1960 | UBERON:0002048 | denotes | lung |
| T167 | 2073-2081 | SP_7 | denotes | COVID-19 |
| T168 | 2182-2192 | SP_7 | denotes | SARS-CoV-2 |
| T169 | 2217-2221 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T170 | 2239-2242 | PR:000029150 | denotes | HLA |
| T171 | 2248-2254 | SO:0000417 | denotes | domain |
| T172 | 2255-2272 | MOP:0000779 | denotes | covalently linked |
| T173 | 2276-2281 | SP_6;NCBITaxon:9606 | denotes | human |
| T174 | 2282-2288 | UBERON:0000345 | denotes | myelin |
| T175 | 2289-2310 | CL:0000128 | denotes | oligodendroglial cell |
| T176 | 2311-2323 | CHEBI:17089;CHEBI:17089;PR:000037069;BV_11 | denotes | glycoprotein |
| T177 | 2325-2328 | PR:000010514 | denotes | MOG |
| T178 | 2405-2411 | CL:0000084 | denotes | T cell |
| T179 | 2430-2433 | GO:0042611 | denotes | MHC |
| T180 | 2453-2457 | PR:000001822 | denotes | CD74 |
| T181 | 2511-2519 | SO:0000853 | denotes | homologs |
| T182 | 2529-2533 | PR:P11914 | denotes | MIF2 |
| T183 | 2634-2640 | SO:0000417 | denotes | domain |
| T51111 | 51-55 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T81051 | 129-133 | PR:000001822 | denotes | CD74 |
| T22349 | 206-209 | PR:000029150 | denotes | HLA |
| T63661 | 215-221 | SO:0000417 | denotes | domain |
| T30295 | 292-296 | PR:000001822 | denotes | CD74 |
| T18138 | 332-338 | CL:0000218;UBERON:0000345 | denotes | myelin |
| T44160 | 339-360 | CL:0000128 | denotes | oligodendroglial cell |
| T56256 | 361-373 | PR:000037069;CHEBI:17089;BV_11;CHEBI:17089 | denotes | glycoprotein |
| T52727 | 380-383 | PR:000010514 | denotes | MOG |
| T81970 | 440-452 | GO:0042613 | denotes | MHC Class II |
| T83534 | 453-454 | PR:P0CY06 | denotes | α |
| T67777 | 459-468 | CHEBI:59132;CHEBI:59132 | denotes | antigenic |
| T72943 | 511-517 | GO:0006266 | denotes | ligate |
| T16068 | 527-533 | CL:0000084 | denotes | T cell |
| T82716 | 589-596 | GO:0032991 | denotes | complex |
| T28841 | 718-721 | GO:0042611 | denotes | MHC |
| T93931 | 726-735 | CHEBI:59132;CHEBI:59132 | denotes | antigenic |
| T69769 | 777-780 | GO:0042611 | denotes | MHC |
| T81989 | 792-799 | CHEBI:59132;CHEBI:59132 | denotes | antigen |
| T41673 | 809-816 | CL:0000084 | denotes | T cells |
| T85672 | 822-833 | GO:0006412 | denotes | translation |
| T81660 | 849-854 | SP_6;NCBITaxon:9606 | denotes | human |
| T64396 | 930-933 | GO:0042611 | denotes | MHC |
| T74610 | 1037-1042 | SP_6;NCBITaxon:9606 | denotes | human |
| T78710 | 1048-1054 | SO:0000417 | denotes | domain |
| T50125 | 1089-1095 | SO:0000417 | denotes | domain |
| T69070 | 1097-1103 | MOP:0000779 | denotes | linked |
| T53267 | 1226-1232 | UBERON:0000479 | denotes | tissue |
| T15961 | 1281-1284 | PR:000010514 | denotes | MOG |
| T98332 | 1359-1365 | NCBITaxon:33208 | denotes | animal |
| T91272 | 1404-1419 | CHEBI:6809;CHEBI:6809 | denotes | methamphetamine |
| T78478 | 1444-1449 | UBERON:0000955 | denotes | brain |
| T66311 | 1602-1608 | GO:0045087 | denotes | innate |
| T89429 | 1613-1621 | GO:0002250 | denotes | adaptive |
| T83884 | 1622-1628 | GO:0002250;UBERON:0002405 | denotes | immune |
| T58055 | 1629-1638 | GO:0002250 | denotes | responses |
| T11954 | 1667-1677 | SP_7 | denotes | SARS-CoV-2 |
| T41665 | 1724-1729 | PR:000001173 | denotes | C5aR1 |
| T18310 | 1731-1739 | CL:0000233;GO:0030168 | denotes | platelet |
| T71710 | 1740-1750 | GO:0030168 | denotes | activation |
| T92918 | 1752-1757 | PR:000001136 | denotes | IL-1β |
| T94394 | 1759-1763 | PR:000001379 | denotes | IL-2 |
| T78460 | 1765-1769 | PR:000001393 | denotes | IL-6 |
| T88059 | 1771-1776 | PR:000000134 | denotes | TNF-α |
| T99547 | 1778-1782 | PR:000001199 | denotes | CCR2 |
| T8821 | 1797-1801 | PR:000002122 | denotes | CCL2 |
| T8352 | 1807-1812 | PR:000001257 | denotes | CXCR2 |
| T50176 | 1882-1891 | CL:0002629 | denotes | activated |
| T96883 | 1892-1899 | CL:0002248;UBERON:0002048 | denotes | pleural |
| T20532 | 1900-1906 | CL:0000084 | denotes | T cell |
| T96822 | 1938-1947 | CHEBI:30501;CHEBI:30501 | denotes | beryllium |
| T17438 | 1956-1960 | UBERON:0002048 | denotes | lung |
| T18732 | 2073-2081 | SP_7 | denotes | COVID-19 |
| T35466 | 2182-2192 | SP_7 | denotes | SARS-CoV-2 |
| T93107 | 2217-2221 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T51669 | 2239-2242 | PR:000029150 | denotes | HLA |
| T21336 | 2248-2254 | SO:0000417 | denotes | domain |
| T8587 | 2255-2272 | MOP:0000779 | denotes | covalently linked |
| T89061 | 2276-2281 | SP_6;NCBITaxon:9606 | denotes | human |
| T84719 | 2282-2288 | UBERON:0000345 | denotes | myelin |
| T35539 | 2289-2310 | CL:0000128 | denotes | oligodendroglial cell |
| T48954 | 2311-2323 | CHEBI:17089;CHEBI:17089;PR:000037069;BV_11 | denotes | glycoprotein |
| T10720 | 2325-2328 | PR:000010514 | denotes | MOG |
| T14874 | 2405-2411 | CL:0000084 | denotes | T cell |
| T62496 | 2430-2433 | GO:0042611 | denotes | MHC |
| T5107 | 2453-2457 | PR:000001822 | denotes | CD74 |
| T21593 | 2511-2519 | SO:0000853 | denotes | homologs |
| T530 | 2529-2533 | PR:P11914 | denotes | MIF2 |
| T28730 | 2634-2640 | SO:0000417 | denotes | domain |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T45 | 206-209 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
| T46 | 235-245 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T47 | 332-338 | Body_part | denotes | myelin | http://purl.org/sig/ont/fma/fma62977 |
| T48 | 339-360 | Body_part | denotes | oligodendroglial cell | http://purl.org/sig/ont/fma/fma54540 |
| T49 | 356-360 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T50 | 361-373 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T51 | 440-443 | Body_part | denotes | MHC | http://purl.org/sig/ont/fma/fma84079 |
| T52 | 529-533 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T53 | 718-721 | Body_part | denotes | MHC | http://purl.org/sig/ont/fma/fma84079 |
| T54 | 777-780 | Body_part | denotes | MHC | http://purl.org/sig/ont/fma/fma84079 |
| T55 | 811-816 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T56 | 930-933 | Body_part | denotes | MHC | http://purl.org/sig/ont/fma/fma84079 |
| T57 | 1080-1083 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
| T58 | 1226-1232 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T59 | 1444-1449 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T60 | 1678-1686 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T61 | 1731-1739 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T62 | 1752-1756 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T63 | 1759-1763 | Body_part | denotes | IL-2 | http://purl.org/sig/ont/fma/fma84051 |
| T64 | 1847-1850 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
| T65 | 1902-1906 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T66 | 1956-1960 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T67 | 2155-2163 | Body_part | denotes | Cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T68 | 2239-2242 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
| T69 | 2282-2288 | Body_part | denotes | myelin | http://purl.org/sig/ont/fma/fma62977 |
| T70 | 2289-2310 | Body_part | denotes | oligodendroglial cell | http://purl.org/sig/ont/fma/fma54540 |
| T71 | 2306-2310 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T72 | 2311-2323 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T73 | 2407-2411 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T74 | 2430-2433 | Body_part | denotes | MHC | http://purl.org/sig/ont/fma/fma84079 |
| T75 | 2589-2597 | Body_part | denotes | Cytokine | http://purl.org/sig/ont/fma/fma84050 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T14 | 332-338 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
| T15 | 1129-1138 | Body_part | denotes | extension | http://purl.obolibrary.org/obo/UBERON_2000106 |
| T16 | 1226-1232 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T17 | 1444-1449 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T18 | 1956-1960 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T19 | 2282-2288 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
| T20 | 2694-2703 | Body_part | denotes | extension | http://purl.obolibrary.org/obo/UBERON_2000106 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T26 | 1320-1337 | Disease | denotes | neuroinflammation | http://purl.obolibrary.org/obo/MONDO_0004466 |
| T27 | 1376-1394 | Disease | denotes | multiple sclerosis | http://purl.obolibrary.org/obo/MONDO_0005301 |
| T28 | 1396-1402 | Disease | denotes | stroke | http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057 |
| T30 | 1444-1456 | Disease | denotes | brain injury | http://purl.obolibrary.org/obo/MONDO_0043510 |
| T31 | 1450-1456 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T32 | 1667-1675 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T33 | 1667-1671 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T34 | 1956-1968 | Disease | denotes | lung fibroma | http://purl.obolibrary.org/obo/MONDO_0021531 |
| T35 | 1961-1968 | Disease | denotes | fibroma | http://purl.obolibrary.org/obo/MONDO_0005167 |
| T36 | 2073-2081 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T37 | 2096-2100 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T38 | 2182-2190 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T39 | 2182-2186 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T58 | 18-19 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T59 | 323-330 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
| T60 | 356-360 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T61 | 384-386 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T62 | 390-397 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
| T63 | 469-476 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
| T64 | 527-533 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T65 | 736-743 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
| T66 | 809-816 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T67 | 849-854 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T68 | 862-863 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T69 | 1037-1042 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T70 | 1115-1117 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T71 | 1121-1128 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
| T72 | 1253-1256 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T73 | 1285-1287 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T74 | 1359-1365 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
| T75 | 1444-1449 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T76 | 1444-1449 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T77 | 1499-1501 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T78 | 1740-1750 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T79 | 1759-1763 | http://purl.obolibrary.org/obo/PR_000001379 | denotes | IL-2 |
| T80 | 1837-1838 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T81 | 1882-1891 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T82 | 1900-1906 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T83 | 1956-1960 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T84 | 1956-1960 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T85 | 2009-2017 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T86 | 2058-2059 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T87 | 2114-2124 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T88 | 2202-2203 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T89 | 2276-2281 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T90 | 2306-2310 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T91 | 2330-2332 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T92 | 2336-2343 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
| T93 | 2405-2411 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T94 | 2680-2682 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T95 | 2686-2693 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T61 | 51-55 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T62 | 210-212 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T63 | 235-245 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T64 | 235-240 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T65 | 241-245 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T66 | 323-330 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T67 | 361-373 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T68 | 390-397 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T69 | 450-452 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T70 | 469-476 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T71 | 621-628 | Chemical | denotes | ligands | http://purl.obolibrary.org/obo/CHEBI_52214 |
| T72 | 653-661 | Chemical | denotes | agonists | http://purl.obolibrary.org/obo/CHEBI_48705 |
| T73 | 736-743 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T74 | 792-799 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T75 | 1043-1045 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T76 | 1084-1086 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T77 | 1121-1128 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T78 | 1276-1278 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T79 | 1404-1419 | Chemical | denotes | methamphetamine | http://purl.obolibrary.org/obo/CHEBI_6809 |
| T80 | 1752-1754 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T82 | 1759-1761 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T84 | 1765-1767 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T86 | 1851-1853 | Chemical | denotes | DP | http://purl.obolibrary.org/obo/CHEBI_137245 |
| T87 | 1938-1947 | Chemical | denotes | beryllium | http://purl.obolibrary.org/obo/CHEBI_30501|http://purl.obolibrary.org/obo/CHEBI_33783 |
| T89 | 2217-2221 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T90 | 2243-2245 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T91 | 2311-2323 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T92 | 2336-2343 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T93 | 2625-2627 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T94 | 2686-2693 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T11 | 1396-1402 | Phenotype | denotes | stroke | http://purl.obolibrary.org/obo/HP_0001297 |
| T12 | 1678-1692 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T13 | 1956-1968 | Phenotype | denotes | lung fibroma | http://purl.obolibrary.org/obo/HP_0010616 |
| T14 | 2155-2169 | Phenotype | denotes | Cytokine Storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T15 | 2589-2603 | Phenotype | denotes | Cytokine Storm | http://purl.obolibrary.org/obo/HP_0033041 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14 | 822-833 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | translation |
| T15 | 1537-1547 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T16 | 1613-1638 | http://purl.obolibrary.org/obo/GO_0002250 | denotes | adaptive immune responses |
| T17 | 1731-1750 | http://purl.obolibrary.org/obo/GO_0030168 | denotes | platelet activation |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T1 | 380-386 | GlycoEpitope | denotes | MOG-35 | http://www.glycoepitope.jp/epitopes/AN0706 |
| T2 | 1111-1117 | GlycoEpitope | denotes | MOG-35 | http://www.glycoepitope.jp/epitopes/AN0706 |
| T3 | 1281-1287 | GlycoEpitope | denotes | MOG-35 | http://www.glycoepitope.jp/epitopes/AN0706 |
| T4 | 2676-2682 | GlycoEpitope | denotes | MOG-35 | http://www.glycoepitope.jp/epitopes/AN0706 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T17 | 0-180 | Sentence | denotes | We are developing a second generation bifunctional drug called DRhQ that can simultaneously bind to and inhibit both the TCR and CD74 through distinct regions of the construct [6]. |
| T18 | 181-409 | Sentence | denotes | DRhQ is comprised of the HLA-DRα1 domain with an L50Q amino acid substitution (to enhance binding affinity for CD74) linked to an autoantigen peptide (myelin oligodendroglial cell glycoprotein, i.e. MOG-35-55 peptide) (Fig. 1 ). |
| T19 | 410-637 | Sentence | denotes | DRhQ was derived from soluble MHC Class II α1-β1-antigenic peptide constructs originally designed to ligate specific T cell receptors as the distal components of the trimolecular complex (called Recombinant TCR ligands – RTLs). |
| T20 | 638-957 | Sentence | denotes | As partial TCR agonists these constructs, containing various disease-associated MHC and antigenic peptide components, could indeed inhibit MHC-restricted antigen specific T cells, but translation of RTL1000 for human use in a Phase 1 clinical trial (showing safety and tolerability) required MHC-matched recipients [7]. |
| T21 | 958-1247 | Sentence | denotes | Thus, the simpler DRhQ construct was designed, retaining just the conserved-in-human DRα1 domain (without the polymorphic HLA-DRβ1 domain) linked to the MOG-35-55 peptide extension, with the added benefit that it can be administered to all recipients without need for tissue type matching. |
| T22 | 1248-1461 | Sentence | denotes | This has enabled use of the DRα1-MOG-35-55 construct to reverse ongoing neuroinflammation and disease signs in animal models of multiple sclerosis, stroke, methamphetamine disorders and traumatic brain injury [8]. |
| T23 | 1462-1813 | Sentence | denotes | These and other studies ([9], [10], [11] & unpublished data) revealed down-regulation of multiple proinflammatory components driven by both innate and adaptive immune responses that also contribute to the SARS-CoV-2 cytokine storm, including complement receptor C5aR1, platelet activation, IL-1β, IL-2, IL-6, TNF-α, CCR2 (receptor for CCL2) and CXCR2. |
| T24 | 1814-2101 | Sentence | denotes | Of further importance, a partial HLA-DP RTL construct could inhibit activated pleural T cell infiltrates from patients with beryllium-induced lung fibroma [12], suggesting more-directly-relevant activity that could be potentially beneficial as a treatment of COVID-19 patients with ARDS. |
| T25 | 2102-2193 | Sentence | denotes | Fig. 1 Dual activities of DRhQ that could block the “Cytokine Storm” induced by SARS-CoV-2. |
| T26 | 2194-2344 | Sentence | denotes | DRhQ is a bifunctional drug comprised of the HLA-DRα1 domain covalently linked to human myelin oligodendroglial cell glycoprotein (MOG)-35-55 peptide. |
| T27 | 2345-2604 | Sentence | denotes | Due to its unique design, DRhQ can bind to and inhibit both T cell receptors and the MHC “invariant” chain, CD74, that serves as the receptor for the proinflammatory homologs, MIF and MIF2, resulting in blockade of multiple contributors to the Cytokine Storm. |
| T28 | 2605-2616 | Sentence | denotes | DRhQ image: |
| T29 | 2617-2704 | Sentence | denotes | Green = DRα1L50Q domain; Dark green line = linker; Black = MOG-35-55 peptide extension. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id | tao:has_standard_notation |
|---|---|---|---|---|---|---|
| 153 | 2282-2323 | Gene | denotes | myelin oligodendroglial cell glycoprotein | Gene:4340 | |
| 154 | 2325-2328 | Gene | denotes | MOG | Gene:4340 | |
| 155 | 2430-2433 | Gene | denotes | MHC | Gene:3107 | |
| 156 | 2521-2524 | Gene | denotes | MIF | Gene:4282 | |
| 157 | 2529-2533 | Gene | denotes | MIF2 | Gene:1060 | |
| 158 | 2676-2679 | Gene | denotes | MOG | Gene:4340 | |
| 159 | 2182-2192 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
| 160 | 2276-2281 | Species | denotes | human | Tax:9606 | |
| 161 | 2194-2198 | Chemical | denotes | DRhQ | ||
| 194 | 332-373 | Gene | denotes | myelin oligodendroglial cell glycoprotein | Gene:4340 | |
| 195 | 380-383 | Gene | denotes | MOG | Gene:4340 | |
| 196 | 718-721 | Gene | denotes | MHC | Gene:3107 | |
| 197 | 930-933 | Gene | denotes | MHC | Gene:3107 | |
| 198 | 1724-1729 | Gene | denotes | C5aR1 | Gene:728 | |
| 199 | 1752-1757 | Gene | denotes | IL-1β | Gene:3552 | |
| 200 | 1759-1763 | Gene | denotes | IL-2 | Gene:3558 | |
| 201 | 1765-1769 | Gene | denotes | IL-6 | Gene:3569 | |
| 202 | 1771-1776 | Gene | denotes | TNF-α | Gene:7124 | |
| 203 | 1778-1782 | Gene | denotes | CCR2 | Gene:729230 | |
| 204 | 1797-1801 | Gene | denotes | CCL2 | Gene:6347 | |
| 205 | 1807-1812 | Gene | denotes | CXCR2 | Gene:3579 | |
| 206 | 1281-1284 | Gene | denotes | MOG | Gene:4340 | |
| 207 | 1111-1114 | Gene | denotes | MOG | Gene:4340 | |
| 208 | 849-854 | Species | denotes | human | Tax:9606 | |
| 209 | 1037-1042 | Species | denotes | human | Tax:9606 | |
| 210 | 1667-1677 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
| 211 | 1924-1932 | Species | denotes | patients | Tax:9606 | |
| 212 | 2082-2090 | Species | denotes | patients | Tax:9606 | |
| 213 | 777-780 | Gene | denotes | MHC | Gene:3107 | |
| 214 | 63-67 | Chemical | denotes | DRhQ | ||
| 215 | 1404-1419 | Chemical | denotes | methamphetamine | MESH:D008694 | |
| 216 | 1938-1947 | Chemical | denotes | beryllium | MESH:D001608 | |
| 217 | 1320-1337 | Disease | denotes | neuroinflammation | MESH:D020078 | |
| 218 | 1376-1394 | Disease | denotes | multiple sclerosis | MESH:D009103 | |
| 219 | 1396-1402 | Disease | denotes | stroke | MESH:D020521 | |
| 220 | 1434-1456 | Disease | denotes | traumatic brain injury | MESH:D000070642 | |
| 221 | 1892-1901 | Disease | denotes | pleural T | MESH:D010995 | |
| 222 | 1956-1968 | Disease | denotes | lung fibroma | MESH:D008171 | |
| 223 | 2073-2081 | Disease | denotes | COVID-19 | MESH:C000657245 | |
| 224 | 2096-2100 | Disease | denotes | ARDS | MESH:D012128 | |
| 225 | 230-234 | Mutation | denotes | L50Q | p.L50Q |