PMC:7293470 / 1868-3408
Annnotations
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T69 | 42-57 | CHEBI:24261;CHEBI:24261 | denotes | glucocorticoids |
| T70 | 80-88 | SP_7 | denotes | COVID-19 |
| T71 | 118-122 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T72 | 222-237 | CHEBI:52217;CHEBI:52217 | denotes | pharmacological |
| T73 | 238-243 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
| T74 | 309-318 | UBERON:0002048 | denotes | pulmonary |
| T75 | 386-392 | UBERON:0001005 | denotes | airway |
| T76 | 393-406 | UBERON:0001135 | denotes | smooth muscle |
| T77 | 424-434 | CHEBI:7034;CHEBI:7034 | denotes | muscarinic |
| T78 | 435-455 | CHEBI:48561;CHEBI:48561 | denotes | receptor antagonists |
| T79 | 500-504 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T80 | 552-560 | CL:0000233;GO:0030168;CHEBI:44811;CHEBI:44811 | denotes | platelet |
| T81 | 560-571 | GO:0030168;CHEBI:44811;CHEBI:44811 | denotes | -activating |
| T82 | 572-578 | CHEBI:44811;CHEBI:44811 | denotes | factor |
| T83 | 583-592 | CHEBI:18295;CHEBI:18295 | denotes | histamine |
| T84 | 598-607 | CL:0000097 | denotes | mast cell |
| T85 | 644-666 | CHEBI:35472;CHEBI:35472 | denotes | anti-inflammatory drug |
| T86 | 698-709 | CHEBI:26995;CHEBI:26995 | denotes | thromboxane |
| T87 | 733-744 | CHEBI:49159;CHEBI:49159 | denotes | leukotriene |
| T88 | 771-779 | CHEBI:36357;CHEBI:36357 | denotes | molecule |
| T89 | 796-804 | GO:0042571 | denotes | antibody |
| T90 | 838-842 | PR:000001391 | denotes | IL-4 |
| T91 | 847-852 | PR:000001370 | denotes | IL-13 |
| T92 | 867-871 | PR:000001391 | denotes | IL-4 |
| T93 | 890-895 | UBERON:0001977 | denotes | serum |
| T94 | 920-926 | UBERON:0001005 | denotes | airway |
| T95 | 948-952 | UBERON:0002048 | denotes | lung |
| T96 | 973-977 | SO:0000704;GO:0010467 | denotes | gene |
| T97 | 978-988 | GO:0010467 | denotes | expression |
| T98 | 993-998 | UBERON:0001977 | denotes | serum |
| T99 | 1022-1026 | NCBITaxon:10088 | denotes | mice |
| T100 | 1036-1040 | UBERON:0001638 | denotes | vein |
| T101 | 1142-1150 | SP_7 | denotes | COVID-19 |
| T102 | 1186-1191 | GO:0016265 | denotes | death |
| T103 | 1257-1262 | PR:000001136 | denotes | IL-1β |
| T104 | 1264-1269 | PR:000000134 | denotes | TNF-α |
| T105 | 1271-1275 | PR:000001393 | denotes | IL-6 |
| T106 | 1280-1284 | PR:000001379 | denotes | IL-2 |
| T107 | 1314-1324 | CL:0000235;PR:000010413;GO:0042116 | denotes | macrophage |
| T108 | 1325-1334 | PR:000010413;GO:0042116 | denotes | migration |
| T109 | 1346-1352 | PR:000010413 | denotes | factor |
| T110 | 1367-1374 | SO:0000853 | denotes | homolog |
| T111 | 1375-1379 | PR:P11914 | denotes | MIF2 |
| T112 | 1388-1392 | PR:000001822 | denotes | CD74 |
| T113 | 1409-1414 | PR:000001257 | denotes | CXCR2 |
| T114 | 1443-1453 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T25830 | 1271-1275 | PR:000001393 | denotes | IL-6 |
| T60848 | 42-57 | CHEBI:24261;CHEBI:24261 | denotes | glucocorticoids |
| T95231 | 80-88 | SP_7 | denotes | COVID-19 |
| T65747 | 118-122 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T49829 | 222-237 | CHEBI:52217;CHEBI:52217 | denotes | pharmacological |
| T6948 | 238-243 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
| T52070 | 309-318 | UBERON:0002048 | denotes | pulmonary |
| T37965 | 386-392 | UBERON:0001005 | denotes | airway |
| T82075 | 393-406 | UBERON:0001135 | denotes | smooth muscle |
| T68520 | 424-434 | CHEBI:7034;CHEBI:7034 | denotes | muscarinic |
| T83831 | 435-455 | CHEBI:48561;CHEBI:48561 | denotes | receptor antagonists |
| T70978 | 500-504 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T2252 | 552-560 | CL:0000233;GO:0030168;CHEBI:44811;CHEBI:44811 | denotes | platelet |
| T56269 | 560-571 | GO:0030168;CHEBI:44811;CHEBI:44811 | denotes | -activating |
| T88762 | 572-578 | CHEBI:44811;CHEBI:44811 | denotes | factor |
| T44552 | 583-592 | CHEBI:18295;CHEBI:18295 | denotes | histamine |
| T96679 | 598-607 | CL:0000097 | denotes | mast cell |
| T70624 | 644-666 | CHEBI:35472;CHEBI:35472 | denotes | anti-inflammatory drug |
| T40591 | 698-709 | CHEBI:26995;CHEBI:26995 | denotes | thromboxane |
| T26436 | 733-744 | CHEBI:49159;CHEBI:49159 | denotes | leukotriene |
| T36736 | 771-779 | CHEBI:36357;CHEBI:36357 | denotes | molecule |
| T93139 | 796-804 | GO:0042571 | denotes | antibody |
| T20922 | 838-842 | PR:000001391 | denotes | IL-4 |
| T14132 | 847-852 | PR:000001370 | denotes | IL-13 |
| T866 | 867-871 | PR:000001391 | denotes | IL-4 |
| T67645 | 890-895 | UBERON:0001977 | denotes | serum |
| T49861 | 920-926 | UBERON:0001005 | denotes | airway |
| T290 | 948-952 | UBERON:0002048 | denotes | lung |
| T6036 | 973-977 | SO:0000704;GO:0010467 | denotes | gene |
| T62989 | 978-988 | GO:0010467 | denotes | expression |
| T5551 | 993-998 | UBERON:0001977 | denotes | serum |
| T64215 | 1022-1026 | NCBITaxon:10088 | denotes | mice |
| T47575 | 1036-1040 | UBERON:0001638 | denotes | vein |
| T51817 | 1142-1150 | SP_7 | denotes | COVID-19 |
| T1627 | 1186-1191 | GO:0016265 | denotes | death |
| T71744 | 1257-1262 | PR:000001136 | denotes | IL-1β |
| T72874 | 1264-1269 | PR:000000134 | denotes | TNF-α |
| T50374 | 1280-1284 | PR:000001379 | denotes | IL-2 |
| T81675 | 1314-1324 | CL:0000235;PR:000010413;GO:0042116 | denotes | macrophage |
| T30336 | 1325-1334 | PR:000010413;GO:0042116 | denotes | migration |
| T28390 | 1346-1352 | PR:000010413 | denotes | factor |
| T86655 | 1367-1374 | SO:0000853 | denotes | homolog |
| T67518 | 1375-1379 | PR:P11914 | denotes | MIF2 |
| T13748 | 1388-1392 | PR:000001822 | denotes | CD74 |
| T20136 | 1409-1414 | PR:000001257 | denotes | CXCR2 |
| T16871 | 1443-1453 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T28 | 400-406 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T29 | 552-560 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T30 | 583-592 | Body_part | denotes | histamine | http://purl.org/sig/ont/fma/fma61806 |
| T31 | 598-607 | Body_part | denotes | mast cell | http://purl.org/sig/ont/fma/fma66784 |
| T32 | 603-607 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T33 | 796-804 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T34 | 890-895 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T35 | 896-899 | Body_part | denotes | IgE | http://purl.org/sig/ont/fma/fma62875 |
| T36 | 948-952 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T37 | 973-977 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T38 | 993-998 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T39 | 1036-1040 | Body_part | denotes | vein | http://purl.org/sig/ont/fma/fma50723 |
| T40 | 1124-1132 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T41 | 1257-1261 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T42 | 1280-1284 | Body_part | denotes | IL-2 | http://purl.org/sig/ont/fma/fma84051 |
| T43 | 1314-1324 | Body_part | denotes | macrophage | http://purl.org/sig/ont/fma/fma63261 |
| T44 | 1457-1465 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T10 | 890-895 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T11 | 948-952 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T12 | 993-998 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T13 | 1036-1040 | Body_part | denotes | vein | http://purl.obolibrary.org/obo/UBERON_0001638 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T18 | 80-88 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T19 | 275-281 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
| T20 | 289-326 | Disease | denotes | chronic obstructive pulmonary disease | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T21 | 309-326 | Disease | denotes | pulmonary disease | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T22 | 328-332 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T23 | 953-965 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T24 | 1142-1150 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T25 | 1165-1169 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T41 | 386-392 | http://purl.obolibrary.org/obo/UBERON_0001005 | denotes | airway |
| T42 | 400-406 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T43 | 400-406 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T44 | 400-406 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T45 | 400-406 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T46 | 561-571 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
| T47 | 603-607 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T48 | 636-637 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T49 | 781-782 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T50 | 920-926 | http://purl.obolibrary.org/obo/UBERON_0001005 | denotes | airway |
| T51 | 948-952 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T52 | 948-952 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T53 | 973-977 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T54 | 1036-1040 | http://purl.obolibrary.org/obo/UBERON_0001638 | denotes | vein |
| T55 | 1036-1040 | http://www.ebi.ac.uk/efo/EFO_0000816 | denotes | vein |
| T56 | 1280-1284 | http://purl.obolibrary.org/obo/PR_000001379 | denotes | IL-2 |
| T57 | 1531-1539 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T23 | 42-57 | Chemical | denotes | glucocorticoids | http://purl.obolibrary.org/obo/CHEBI_24261 |
| T24 | 118-122 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T25 | 238-243 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T26 | 368-376 | Chemical | denotes | agonists | http://purl.obolibrary.org/obo/CHEBI_48705 |
| T27 | 444-455 | Chemical | denotes | antagonists | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T28 | 465-467 | Chemical | denotes | M3 | http://purl.obolibrary.org/obo/CHEBI_51083|http://purl.obolibrary.org/obo/CHEBI_53453 |
| T30 | 500-504 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T31 | 552-578 | Chemical | denotes | platelet-activating factor | http://purl.obolibrary.org/obo/CHEBI_36707|http://purl.obolibrary.org/obo/CHEBI_44811|http://purl.obolibrary.org/obo/CHEBI_52450 |
| T34 | 583-592 | Chemical | denotes | histamine | http://purl.obolibrary.org/obo/CHEBI_18295|http://purl.obolibrary.org/obo/CHEBI_58432 |
| T36 | 644-666 | Chemical | denotes | anti-inflammatory drug | http://purl.obolibrary.org/obo/CHEBI_35472 |
| T37 | 662-666 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T38 | 679-689 | Chemical | denotes | antagonist | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T39 | 698-709 | Chemical | denotes | thromboxane | http://purl.obolibrary.org/obo/CHEBI_26995 |
| T40 | 723-732 | Chemical | denotes | cysteinyl | http://purl.obolibrary.org/obo/CHEBI_23511|http://purl.obolibrary.org/obo/CHEBI_32460 |
| T42 | 733-756 | Chemical | denotes | leukotriene antagonists | http://purl.obolibrary.org/obo/CHEBI_49159 |
| T43 | 733-744 | Chemical | denotes | leukotriene | http://purl.obolibrary.org/obo/CHEBI_25029 |
| T44 | 745-756 | Chemical | denotes | antagonists | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T45 | 771-779 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T46 | 838-840 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T48 | 847-849 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T50 | 867-869 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T52 | 904-906 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T54 | 1257-1259 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T56 | 1271-1273 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T58 | 1280-1282 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T60 | 1443-1453 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T5 | 275-281 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
| T6 | 289-326 | Phenotype | denotes | chronic obstructive pulmonary disease | http://purl.obolibrary.org/obo/HP_0006510 |
| T7 | 328-332 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
| T8 | 920-946 | Phenotype | denotes | airway hyperresponsiveness | http://purl.obolibrary.org/obo/HP_0032933 |
| T9 | 1124-1138 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T10 | 1457-1471 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T9 | 552-571 | http://purl.obolibrary.org/obo/GO_0030168 | denotes | platelet-activating |
| T10 | 608-617 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T11 | 953-965 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T12 | 973-988 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
| T13 | 1314-1334 | http://purl.obolibrary.org/obo/GO_1905517 | denotes | macrophage migration |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T10 | 0-183 | Sentence | denotes | In addition to current approaches such as glucocorticoids for treating advanced COVID-19 patients, there may be other drug combinations that could be helpful, some being bifunctional. |
| T11 | 184-478 | Sentence | denotes | As relevant examples reviewed in [5], pharmacological drugs for treatment of patients with asthma and/or chronic obstructive pulmonary disease (COPD) were developed to include both β2-agonists to relax airway smooth muscle constriction and muscarinic receptor antagonists to block M3 receptors. |
| T12 | 479-635 | Sentence | denotes | Another bifunctional drug was formulated to antagonize the receptors for platelet-activating factor and histamine, and mast cell secretion-blocking effects. |
| T13 | 636-780 | Sentence | denotes | A third anti-inflammatory drug combined an antagonist for the thromboxane receptor and cysteinyl-leukotriene antagonists into the same molecule. |
| T14 | 781-1027 | Sentence | denotes | A bifunctional antibody construct was also developed for IL-4 and IL-13 to reduce the IL-4-dependent rise in serum IgE and IL-13-dependent airway hyperresponsiveness, lung inflammation, mucin gene expression and serum chitinase responses in mice. |
| T15 | 1028-1192 | Sentence | denotes | In this vein, bifunctional immunotherapeutic approaches could be developed for treatment of the cytokine storm in COVID-19 patients with ARDS at high risk of death. |
| T16 | 1193-1540 | Sentence | denotes | Proven and developing therapies that downregulate receptors for IL-1β, TNF-α, IL-6 and IL-2 as well as those which block macrophage migration inhibitory factor (MIF) and its homolog MIF2 through CD74 and potentially CXCR2&4 for MIF are all potential inhibitors of cytokine storm effects and could be combined or designed for bifunctional activity. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 115 | 365-367 | Gene | denotes | β2 | Gene:170589 |
| 116 | 838-842 | Gene | denotes | IL-4 | Gene:16189 |
| 117 | 847-852 | Gene | denotes | IL-13 | Gene:16163 |
| 118 | 867-871 | Gene | denotes | IL-4 | Gene:16189 |
| 119 | 904-909 | Gene | denotes | IL-13 | Gene:16163 |
| 120 | 1257-1262 | Gene | denotes | IL-1β | Gene:3552 |
| 121 | 1264-1269 | Gene | denotes | TNF-α | Gene:7124 |
| 122 | 1271-1275 | Gene | denotes | IL-6 | Gene:3569 |
| 123 | 1280-1284 | Gene | denotes | IL-2 | Gene:3558 |
| 124 | 1314-1352 | Gene | denotes | macrophage migration inhibitory factor | Gene:4282 |
| 125 | 1354-1357 | Gene | denotes | MIF | Gene:4282 |
| 126 | 1375-1379 | Gene | denotes | MIF2 | Gene:1060 |
| 127 | 1409-1416 | Gene | denotes | CXCR2&4 | Gene:3579 |
| 128 | 1421-1424 | Gene | denotes | MIF | Gene:4282 |
| 129 | 89-97 | Species | denotes | patients | Tax:9606 |
| 130 | 261-269 | Species | denotes | patients | Tax:9606 |
| 131 | 1022-1026 | Species | denotes | mice | Tax:10090 |
| 132 | 1151-1159 | Species | denotes | patients | Tax:9606 |
| 133 | 583-592 | Chemical | denotes | histamine | MESH:D006632 |
| 134 | 723-744 | Chemical | denotes | cysteinyl-leukotriene | MESH:C112381 |
| 135 | 80-88 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 136 | 275-281 | Disease | denotes | asthma | MESH:D001249 |
| 137 | 289-326 | Disease | denotes | chronic obstructive pulmonary disease | MESH:D029424 |
| 138 | 328-332 | Disease | denotes | COPD | MESH:D029424 |
| 139 | 920-946 | Disease | denotes | airway hyperresponsiveness | MESH:D000402 |
| 140 | 948-965 | Disease | denotes | lung inflammation | MESH:D011014 |
| 141 | 1142-1150 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 142 | 1165-1169 | Disease | denotes | ARDS | MESH:D012128 |
| 143 | 1186-1191 | Disease | denotes | death | MESH:D003643 |