PMC:7291971 / 984-1418 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T17","span":{"begin":4,"end":14},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T18","span":{"begin":99,"end":108},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T19","span":{"begin":159,"end":171},"obj":"NCBITaxon:31032"},{"id":"T20","span":{"begin":175,"end":183},"obj":"SP_10"},{"id":"T21","span":{"begin":265,"end":273},"obj":"SP_10"},{"id":"T22","span":{"begin":349,"end":354},"obj":"PR:000000125"},{"id":"T23","span":{"begin":355,"end":364},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T40194","span":{"begin":4,"end":14},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T7397","span":{"begin":99,"end":108},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T53306","span":{"begin":159,"end":171},"obj":"NCBITaxon:31032"},{"id":"T48802","span":{"begin":175,"end":183},"obj":"SP_10"},{"id":"T86425","span":{"begin":265,"end":273},"obj":"SP_10"},{"id":"T66103","span":{"begin":349,"end":354},"obj":"PR:000000125"},{"id":"T45404","span":{"begin":355,"end":364},"obj":"CHEBI:35222;CHEBI:35222"}],"text":"oth adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. The most active nsp14 inhibitor identified is as potent as but particularly more specific than the br"}

{"project":"LitCovid-PubTator","denotations":[{"id":"11","span":{"begin":4,"end":14},"obj":"Chemical"},{"id":"12","span":{"begin":36,"end":44},"obj":"Chemical"}],"attributes":[{"id":"A11","pred":"tao:has_database_id","subj":"11","obj":"MESH:D000241"},{"id":"A12","pred":"tao:has_database_id","subj":"12","obj":"MESH:D009584"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"oth adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. The most active nsp14 inhibitor identified is as potent as but particularly more specific than the br"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T4","span":{"begin":175,"end":183},"obj":"Disease"},{"id":"T5","span":{"begin":265,"end":273},"obj":"Disease"}],"attributes":[{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"oth adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. The most active nsp14 inhibitor identified is as potent as but particularly more specific than the br"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T6","span":{"begin":121,"end":127},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T7","span":{"begin":342,"end":348},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"oth adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. The most active nsp14 inhibitor identified is as potent as but particularly more specific than the br"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T11","span":{"begin":4,"end":14},"obj":"Chemical"},{"id":"T12","span":{"begin":36,"end":44},"obj":"Chemical"},{"id":"T13","span":{"begin":355,"end":364},"obj":"Chemical"}],"attributes":[{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_22260"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_25555"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"oth adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. The most active nsp14 inhibitor identified is as potent as but particularly more specific than the br"}

{"project":"LitCovid-sentences","denotations":[{"id":"T9","span":{"begin":65,"end":332},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"oth adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. The most active nsp14 inhibitor identified is as potent as but particularly more specific than the br"}