PMC:7291971 / 910-1365
Annnotations
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T17 | 78-88 | CHEBI:22260;CHEBI:22260 | denotes | adenosines |
| T18 | 173-182 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
| T19 | 233-245 | NCBITaxon:31032 | denotes | flaviviruses |
| T20 | 249-257 | SP_10 | denotes | SARS-CoV |
| T21 | 339-347 | SP_10 | denotes | SARS-CoV |
| T22 | 423-428 | PR:000000125 | denotes | nsp14 |
| T23 | 429-438 | CHEBI:35222;CHEBI:35222 | denotes | inhibitor |
| T40194 | 78-88 | CHEBI:22260;CHEBI:22260 | denotes | adenosines |
| T7397 | 173-182 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
| T53306 | 233-245 | NCBITaxon:31032 | denotes | flaviviruses |
| T48802 | 249-257 | SP_10 | denotes | SARS-CoV |
| T86425 | 339-347 | SP_10 | denotes | SARS-CoV |
| T66103 | 423-428 | PR:000000125 | denotes | nsp14 |
| T45404 | 429-438 | CHEBI:35222;CHEBI:35222 | denotes | inhibitor |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T7 | 46-53 | Body_part | denotes | adenine | http://purl.org/sig/ont/fma/fma82774 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 10 | 46-67 | Chemical | denotes | adenine dinucleosides | |
| 11 | 78-88 | Chemical | denotes | adenosines | MESH:D000241 |
| 12 | 110-118 | Chemical | denotes | nitrogen | MESH:D009584 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T4 | 249-257 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T5 | 339-347 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T6 | 195-201 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T7 | 416-422 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T10 | 46-53 | Chemical | denotes | adenine | http://purl.obolibrary.org/obo/CHEBI_16708 |
| T11 | 78-88 | Chemical | denotes | adenosines | http://purl.obolibrary.org/obo/CHEBI_22260 |
| T12 | 110-118 | Chemical | denotes | nitrogen | http://purl.obolibrary.org/obo/CHEBI_25555 |
| T13 | 429-438 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 30-39 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T8 | 4-138 | Sentence | denotes | This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers. |
| T9 | 139-406 | Sentence | denotes | Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. |