PMC:7291971 / 8731-9097 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T170","span":{"begin":15,"end":28},"obj":"SO:0000409"},{"id":"T171","span":{"begin":41,"end":46},"obj":"PR:000000125"},{"id":"T172","span":{"begin":87,"end":95},"obj":"SP_10"},{"id":"T173","span":{"begin":100,"end":110},"obj":"SP_7"},{"id":"T174","span":{"begin":125,"end":133},"obj":"SO:0000857"},{"id":"T175","span":{"begin":246,"end":254},"obj":"SP_10"},{"id":"T176","span":{"begin":305,"end":315},"obj":"SP_7"}],"text":"As SAM and RNA binding sites of N7-MTase nsp14 are almost completely conserved between SARS-CoV and SARS-CoV-2 (95% sequence homology, Supporting Info Fig. S1) [18], we can forecast that the candidate ligands that are efficient in inhibiting the SARS-CoV functions will be efficient in doing the same for SARS-CoV-2, this emphasizes the interest of the present work."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T45","span":{"begin":11,"end":14},"obj":"Body_part"}],"attributes":[{"id":"A45","pred":"fma_id","subj":"T45","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":"As SAM and RNA binding sites of N7-MTase nsp14 are almost completely conserved between SARS-CoV and SARS-CoV-2 (95% sequence homology, Supporting Info Fig. S1) [18], we can forecast that the candidate ligands that are efficient in inhibiting the SARS-CoV functions will be efficient in doing the same for SARS-CoV-2, this emphasizes the interest of the present work."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T28","span":{"begin":87,"end":95},"obj":"Disease"},{"id":"T29","span":{"begin":100,"end":108},"obj":"Disease"},{"id":"T30","span":{"begin":246,"end":254},"obj":"Disease"},{"id":"T31","span":{"begin":305,"end":313},"obj":"Disease"}],"attributes":[{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A29","pred":"mondo_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A30","pred":"mondo_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A31","pred":"mondo_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"As SAM and RNA binding sites of N7-MTase nsp14 are almost completely conserved between SARS-CoV and SARS-CoV-2 (95% sequence homology, Supporting Info Fig. S1) [18], we can forecast that the candidate ligands that are efficient in inhibiting the SARS-CoV functions will be efficient in doing the same for SARS-CoV-2, this emphasizes the interest of the present work."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T65","span":{"begin":156,"end":158},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T66","span":{"begin":161,"end":163},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"}],"text":"As SAM and RNA binding sites of N7-MTase nsp14 are almost completely conserved between SARS-CoV and SARS-CoV-2 (95% sequence homology, Supporting Info Fig. S1) [18], we can forecast that the candidate ligands that are efficient in inhibiting the SARS-CoV functions will be efficient in doing the same for SARS-CoV-2, this emphasizes the interest of the present work."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T101","span":{"begin":3,"end":6},"obj":"Chemical"},{"id":"T103","span":{"begin":201,"end":208},"obj":"Chemical"}],"attributes":[{"id":"A101","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_15414"},{"id":"A102","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_67040"},{"id":"A103","pred":"chebi_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"}],"text":"As SAM and RNA binding sites of N7-MTase nsp14 are almost completely conserved between SARS-CoV and SARS-CoV-2 (95% sequence homology, Supporting Info Fig. S1) [18], we can forecast that the candidate ligands that are efficient in inhibiting the SARS-CoV functions will be efficient in doing the same for SARS-CoV-2, this emphasizes the interest of the present work."}

{"project":"LitCovid-sentences","denotations":[{"id":"T59","span":{"begin":0,"end":366},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"As SAM and RNA binding sites of N7-MTase nsp14 are almost completely conserved between SARS-CoV and SARS-CoV-2 (95% sequence homology, Supporting Info Fig. S1) [18], we can forecast that the candidate ligands that are efficient in inhibiting the SARS-CoV functions will be efficient in doing the same for SARS-CoV-2, this emphasizes the interest of the present work."}