PMC:7291971 / 83920-85021 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T1681","span":{"begin":83,"end":95},"obj":"CHEBI:38472;CHEBI:38472"},{"id":"T1682","span":{"begin":819,"end":822},"obj":"CHEBI:36927;CHEBI:36927"},{"id":"T44819","span":{"begin":83,"end":95},"obj":"CHEBI:38472;CHEBI:38472"},{"id":"T53973","span":{"begin":819,"end":822},"obj":"CHEBI:36927;CHEBI:36927"}],"text":"Using method C with 36 (172 mg, 0.18 mmol, 1.00 eq) and a 0–40% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 16 (45 mg, 37%) was obtained as a white powder with 98% purity determined by HPLC analysis at 260 nm. 1H NMR (600 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.25 (s, 1H), 8.13 (s, 1H), 8.11 (s, 1H), 7.34 (br. s, 2H), 7.25 (br. s, 2H), 7.23–7.17 (m, 2H), 7.17–7.11 (m, 2H), 6.00 (d, J = 6.2 Hz, 1H), 5.84 (d, J = 5.0 Hz, 1H), 5.45–5.39 (m, 2H), 5.27 (d, J = 4.8 Hz, 1H), 5.12 (d, J = 5.4 Hz, 1H), 4.58 (q, J = 5.5 Hz, 1H), 4.48 (dd, J = 6.2 Hz, J = 4.8 Hz, 1H), 4.30 (td, J = 4.6 Hz, J = 2.9 Hz, 1H), 4.04 (q, J = 5.1 Hz, 1H), 4.02–3.96 (m, 2H), 3.70–3.63 (m, 2H), 3.60–3.48 (m, 4H), 2.80 (dd, J = 14.0 Hz, J = 4.5 Hz, 1H), 2.67 (dd, J = 13.9 Hz, J = 7.0 Hz, 1H), 2.61 (q, J = 6.1 Hz, 2H). 13C NMR (150 MHz, DMSO‑d 6) δ 156.2, 156.0, 152.6, 152.5, 149.3, 149.0, 139.8, 139.7, 138.2, 131.1, 130.4, 127.8, 119.3, 119.16, 87.67, 86.3, 86.1, 82.4, 81.2, 72.4, 71.8, 69.0, 67.5, 61.5, 57.5, 55.8, 52.9. HRMS (ESI+): m/z calcd for C29H35N11O7Cl [M+H]+: 684.2404, Found 684.2398."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1587","span":{"begin":83,"end":95},"obj":"Chemical"},{"id":"1588","span":{"begin":99,"end":104},"obj":"Chemical"},{"id":"1589","span":{"begin":244,"end":246},"obj":"Chemical"},{"id":"1590","span":{"begin":261,"end":269},"obj":"Chemical"},{"id":"1591","span":{"begin":282,"end":284},"obj":"Chemical"},{"id":"1592","span":{"begin":296,"end":298},"obj":"Chemical"},{"id":"1593","span":{"begin":310,"end":312},"obj":"Chemical"},{"id":"1594","span":{"begin":324,"end":326},"obj":"Chemical"},{"id":"1595","span":{"begin":342,"end":344},"obj":"Chemical"},{"id":"1596","span":{"begin":819,"end":822},"obj":"Chemical"},{"id":"1597","span":{"begin":837,"end":843},"obj":"Chemical"},{"id":"1598","span":{"begin":1054,"end":1067},"obj":"Chemical"},{"id":"1599","span":{"begin":1027,"end":1031},"obj":"Disease"}],"attributes":[{"id":"A1587","pred":"tao:has_database_id","subj":"1587","obj":"MESH:C032159"},{"id":"A1595","pred":"tao:has_database_id","subj":"1595","obj":"MESH:D003903"},{"id":"A1596","pred":"tao:has_database_id","subj":"1596","obj":"MESH:C000615229"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Using method C with 36 (172 mg, 0.18 mmol, 1.00 eq) and a 0–40% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 16 (45 mg, 37%) was obtained as a white powder with 98% purity determined by HPLC analysis at 260 nm. 1H NMR (600 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.25 (s, 1H), 8.13 (s, 1H), 8.11 (s, 1H), 7.34 (br. s, 2H), 7.25 (br. s, 2H), 7.23–7.17 (m, 2H), 7.17–7.11 (m, 2H), 6.00 (d, J = 6.2 Hz, 1H), 5.84 (d, J = 5.0 Hz, 1H), 5.45–5.39 (m, 2H), 5.27 (d, J = 4.8 Hz, 1H), 5.12 (d, J = 5.4 Hz, 1H), 4.58 (q, J = 5.5 Hz, 1H), 4.48 (dd, J = 6.2 Hz, J = 4.8 Hz, 1H), 4.30 (td, J = 4.6 Hz, J = 2.9 Hz, 1H), 4.04 (q, J = 5.1 Hz, 1H), 4.02–3.96 (m, 2H), 3.70–3.63 (m, 2H), 3.60–3.48 (m, 4H), 2.80 (dd, J = 14.0 Hz, J = 4.5 Hz, 1H), 2.67 (dd, J = 13.9 Hz, J = 7.0 Hz, 1H), 2.61 (q, J = 6.1 Hz, 2H). 13C NMR (150 MHz, DMSO‑d 6) δ 156.2, 156.0, 152.6, 152.5, 149.3, 149.0, 139.8, 139.7, 138.2, 131.1, 130.4, 127.8, 119.3, 119.16, 87.67, 86.3, 86.1, 82.4, 81.2, 72.4, 71.8, 69.0, 67.5, 61.5, 57.5, 55.8, 52.9. HRMS (ESI+): m/z calcd for C29H35N11O7Cl [M+H]+: 684.2404, Found 684.2398."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T437","span":{"begin":20,"end":22},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T438","span":{"begin":56,"end":57},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T439","span":{"begin":146,"end":148},"obj":"http://purl.obolibrary.org/obo/CLO_0053799"},{"id":"T440","span":{"begin":174,"end":175},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T441","span":{"begin":1069,"end":1072},"obj":"http://purl.obolibrary.org/obo/CLO_0007706"}],"text":"Using method C with 36 (172 mg, 0.18 mmol, 1.00 eq) and a 0–40% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 16 (45 mg, 37%) was obtained as a white powder with 98% purity determined by HPLC analysis at 260 nm. 1H NMR (600 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.25 (s, 1H), 8.13 (s, 1H), 8.11 (s, 1H), 7.34 (br. s, 2H), 7.25 (br. s, 2H), 7.23–7.17 (m, 2H), 7.17–7.11 (m, 2H), 6.00 (d, J = 6.2 Hz, 1H), 5.84 (d, J = 5.0 Hz, 1H), 5.45–5.39 (m, 2H), 5.27 (d, J = 4.8 Hz, 1H), 5.12 (d, J = 5.4 Hz, 1H), 4.58 (q, J = 5.5 Hz, 1H), 4.48 (dd, J = 6.2 Hz, J = 4.8 Hz, 1H), 4.30 (td, J = 4.6 Hz, J = 2.9 Hz, 1H), 4.04 (q, J = 5.1 Hz, 1H), 4.02–3.96 (m, 2H), 3.70–3.63 (m, 2H), 3.60–3.48 (m, 4H), 2.80 (dd, J = 14.0 Hz, J = 4.5 Hz, 1H), 2.67 (dd, J = 13.9 Hz, J = 7.0 Hz, 1H), 2.61 (q, J = 6.1 Hz, 2H). 13C NMR (150 MHz, DMSO‑d 6) δ 156.2, 156.0, 152.6, 152.5, 149.3, 149.0, 139.8, 139.7, 138.2, 131.1, 130.4, 127.8, 119.3, 119.16, 87.67, 86.3, 86.1, 82.4, 81.2, 72.4, 71.8, 69.0, 67.5, 61.5, 57.5, 55.8, 52.9. HRMS (ESI+): m/z calcd for C29H35N11O7Cl [M+H]+: 684.2404, Found 684.2398."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T66816","span":{"begin":83,"end":95},"obj":"Chemical"},{"id":"T72613","span":{"begin":105,"end":111},"obj":"Chemical"},{"id":"T80950","span":{"begin":244,"end":246},"obj":"Chemical"},{"id":"T931","span":{"begin":261,"end":265},"obj":"Chemical"},{"id":"T50590","span":{"begin":282,"end":284},"obj":"Chemical"},{"id":"T933","span":{"begin":296,"end":298},"obj":"Chemical"},{"id":"T70854","span":{"begin":310,"end":312},"obj":"Chemical"},{"id":"T90888","span":{"begin":324,"end":326},"obj":"Chemical"},{"id":"T90836","span":{"begin":424,"end":426},"obj":"Chemical"},{"id":"T44310","span":{"begin":450,"end":452},"obj":"Chemical"},{"id":"T48190","span":{"begin":495,"end":497},"obj":"Chemical"},{"id":"T98950","span":{"begin":521,"end":523},"obj":"Chemical"},{"id":"T940","span":{"begin":547,"end":549},"obj":"Chemical"},{"id":"T84390","span":{"begin":586,"end":588},"obj":"Chemical"},{"id":"T37547","span":{"begin":625,"end":627},"obj":"Chemical"},{"id":"T943","span":{"begin":651,"end":653},"obj":"Chemical"},{"id":"T944","span":{"begin":748,"end":750},"obj":"Chemical"},{"id":"T945","span":{"begin":788,"end":790},"obj":"Chemical"},{"id":"T946","span":{"begin":837,"end":841},"obj":"Chemical"}],"attributes":[{"id":"A57037","pred":"chebi_id","subj":"T66816","obj":"http://purl.obolibrary.org/obo/CHEBI_38472"},{"id":"A91965","pred":"chebi_id","subj":"T72613","obj":"http://purl.obolibrary.org/obo/CHEBI_35225"},{"id":"A20593","pred":"chebi_id","subj":"T80950","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A66379","pred":"chebi_id","subj":"T931","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"},{"id":"A22486","pred":"chebi_id","subj":"T50590","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A18489","pred":"chebi_id","subj":"T933","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A7262","pred":"chebi_id","subj":"T70854","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A78843","pred":"chebi_id","subj":"T90888","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A11589","pred":"chebi_id","subj":"T90836","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A22835","pred":"chebi_id","subj":"T44310","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A46676","pred":"chebi_id","subj":"T48190","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A53552","pred":"chebi_id","subj":"T98950","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A71988","pred":"chebi_id","subj":"T940","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A47312","pred":"chebi_id","subj":"T84390","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A94907","pred":"chebi_id","subj":"T37547","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A943","pred":"chebi_id","subj":"T943","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A944","pred":"chebi_id","subj":"T944","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A945","pred":"chebi_id","subj":"T945","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A946","pred":"chebi_id","subj":"T946","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"}],"text":"Using method C with 36 (172 mg, 0.18 mmol, 1.00 eq) and a 0–40% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 16 (45 mg, 37%) was obtained as a white powder with 98% purity determined by HPLC analysis at 260 nm. 1H NMR (600 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.25 (s, 1H), 8.13 (s, 1H), 8.11 (s, 1H), 7.34 (br. s, 2H), 7.25 (br. s, 2H), 7.23–7.17 (m, 2H), 7.17–7.11 (m, 2H), 6.00 (d, J = 6.2 Hz, 1H), 5.84 (d, J = 5.0 Hz, 1H), 5.45–5.39 (m, 2H), 5.27 (d, J = 4.8 Hz, 1H), 5.12 (d, J = 5.4 Hz, 1H), 4.58 (q, J = 5.5 Hz, 1H), 4.48 (dd, J = 6.2 Hz, J = 4.8 Hz, 1H), 4.30 (td, J = 4.6 Hz, J = 2.9 Hz, 1H), 4.04 (q, J = 5.1 Hz, 1H), 4.02–3.96 (m, 2H), 3.70–3.63 (m, 2H), 3.60–3.48 (m, 4H), 2.80 (dd, J = 14.0 Hz, J = 4.5 Hz, 1H), 2.67 (dd, J = 13.9 Hz, J = 7.0 Hz, 1H), 2.61 (q, J = 6.1 Hz, 2H). 13C NMR (150 MHz, DMSO‑d 6) δ 156.2, 156.0, 152.6, 152.5, 149.3, 149.0, 139.8, 139.7, 138.2, 131.1, 130.4, 127.8, 119.3, 119.16, 87.67, 86.3, 86.1, 82.4, 81.2, 72.4, 71.8, 69.0, 67.5, 61.5, 57.5, 55.8, 52.9. HRMS (ESI+): m/z calcd for C29H35N11O7Cl [M+H]+: 684.2404, Found 684.2398."}

{"project":"LitCovid-sentences","denotations":[{"id":"T553","span":{"begin":0,"end":243},"obj":"Sentence"},{"id":"T554","span":{"begin":244,"end":818},"obj":"Sentence"},{"id":"T555","span":{"begin":819,"end":1026},"obj":"Sentence"},{"id":"T556","span":{"begin":1027,"end":1075},"obj":"Sentence"},{"id":"T557","span":{"begin":1076,"end":1101},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Using method C with 36 (172 mg, 0.18 mmol, 1.00 eq) and a 0–40% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 16 (45 mg, 37%) was obtained as a white powder with 98% purity determined by HPLC analysis at 260 nm. 1H NMR (600 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.25 (s, 1H), 8.13 (s, 1H), 8.11 (s, 1H), 7.34 (br. s, 2H), 7.25 (br. s, 2H), 7.23–7.17 (m, 2H), 7.17–7.11 (m, 2H), 6.00 (d, J = 6.2 Hz, 1H), 5.84 (d, J = 5.0 Hz, 1H), 5.45–5.39 (m, 2H), 5.27 (d, J = 4.8 Hz, 1H), 5.12 (d, J = 5.4 Hz, 1H), 4.58 (q, J = 5.5 Hz, 1H), 4.48 (dd, J = 6.2 Hz, J = 4.8 Hz, 1H), 4.30 (td, J = 4.6 Hz, J = 2.9 Hz, 1H), 4.04 (q, J = 5.1 Hz, 1H), 4.02–3.96 (m, 2H), 3.70–3.63 (m, 2H), 3.60–3.48 (m, 4H), 2.80 (dd, J = 14.0 Hz, J = 4.5 Hz, 1H), 2.67 (dd, J = 13.9 Hz, J = 7.0 Hz, 1H), 2.61 (q, J = 6.1 Hz, 2H). 13C NMR (150 MHz, DMSO‑d 6) δ 156.2, 156.0, 152.6, 152.5, 149.3, 149.0, 139.8, 139.7, 138.2, 131.1, 130.4, 127.8, 119.3, 119.16, 87.67, 86.3, 86.1, 82.4, 81.2, 72.4, 71.8, 69.0, 67.5, 61.5, 57.5, 55.8, 52.9. HRMS (ESI+): m/z calcd for C29H35N11O7Cl [M+H]+: 684.2404, Found 684.2398."}