PMC:7291971 / 761-1020 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T14","span":{"begin":32,"end":42},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T15","span":{"begin":108,"end":111},"obj":"GO:0008541"},{"id":"T16","span":{"begin":134,"end":139},"obj":"NCBITaxon:10239"},{"id":"T17","span":{"begin":227,"end":237},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T50627","span":{"begin":32,"end":42},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T65425","span":{"begin":108,"end":111},"obj":"GO:0008541"},{"id":"T87174","span":{"begin":134,"end":139},"obj":"NCBITaxon:10239"},{"id":"T40194","span":{"begin":227,"end":237},"obj":"CHEBI:22260;CHEBI:22260"}],"text":"herapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various "}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T6","span":{"begin":112,"end":115},"obj":"Body_part"},{"id":"T7","span":{"begin":195,"end":202},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma82774"}],"text":"herapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various "}

{"project":"LitCovid-PubTator","denotations":[{"id":"10","span":{"begin":195,"end":216},"obj":"Chemical"},{"id":"11","span":{"begin":227,"end":237},"obj":"Chemical"}],"attributes":[{"id":"A11","pred":"tao:has_database_id","subj":"11","obj":"MESH:D000241"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"herapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various "}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T9","span":{"begin":32,"end":42},"obj":"Chemical"},{"id":"T10","span":{"begin":195,"end":202},"obj":"Chemical"},{"id":"T11","span":{"begin":227,"end":237},"obj":"Chemical"}],"attributes":[{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_16708"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_22260"}],"text":"herapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various "}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":89,"end":100},"obj":"http://purl.obolibrary.org/obo/GO_0032259"},{"id":"T3","span":{"begin":179,"end":188},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"herapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various "}

{"project":"LitCovid-sentences","denotations":[{"id":"T7","span":{"begin":8,"end":152},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"herapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various "}