PMC:7291971 / 672-1134 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7291971","sourcedb":"PMC","sourceid":"7291971","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7291971","text":"′O-methyltransferases (MTases) are now admitted as potential targets for antiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of","tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T14","span":{"begin":121,"end":131},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T15","span":{"begin":197,"end":200},"obj":"GO:0008541"},{"id":"T16","span":{"begin":223,"end":228},"obj":"NCBITaxon:10239"},{"id":"T17","span":{"begin":316,"end":326},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T18","span":{"begin":411,"end":420},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T50627","span":{"begin":121,"end":131},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T65425","span":{"begin":197,"end":200},"obj":"GO:0008541"},{"id":"T87174","span":{"begin":223,"end":228},"obj":"NCBITaxon:10239"},{"id":"T40194","span":{"begin":316,"end":326},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T7397","span":{"begin":411,"end":420},"obj":"CHEBI:36357;CHEBI:36357"}],"attributes":[{"subj":"T14","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T17","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T18","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T50627","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65425","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T87174","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T40194","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T7397","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T6","span":{"begin":201,"end":204},"obj":"Body_part"},{"id":"T7","span":{"begin":284,"end":291},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma82774"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"10","span":{"begin":284,"end":305},"obj":"Chemical"},{"id":"11","span":{"begin":316,"end":326},"obj":"Chemical"},{"id":"12","span":{"begin":348,"end":356},"obj":"Chemical"}],"attributes":[{"id":"A11","pred":"tao:has_database_id","subj":"11","obj":"MESH:D000241"},{"id":"A12","pred":"tao:has_database_id","subj":"12","obj":"MESH:D009584"},{"subj":"10","pred":"source","obj":"LitCovid-PubTator"},{"subj":"11","pred":"source","obj":"LitCovid-PubTator"},{"subj":"12","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T6","span":{"begin":433,"end":439},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T8","span":{"begin":73,"end":82},"obj":"Chemical"},{"id":"T9","span":{"begin":121,"end":131},"obj":"Chemical"},{"id":"T10","span":{"begin":284,"end":291},"obj":"Chemical"},{"id":"T11","span":{"begin":316,"end":326},"obj":"Chemical"},{"id":"T12","span":{"begin":348,"end":356},"obj":"Chemical"}],"attributes":[{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_16708"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_22260"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_25555"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":178,"end":189},"obj":"http://purl.obolibrary.org/obo/GO_0032259"},{"id":"T3","span":{"begin":268,"end":277},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T7","span":{"begin":97,"end":241},"obj":"Sentence"},{"id":"T8","span":{"begin":242,"end":376},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#93beec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#d8ec93"},{"id":"LitCovid-PubTator","color":"#e693ec"},{"id":"LitCovid-PD-CLO","color":"#93eccc"},{"id":"LitCovid-PD-CHEBI","color":"#ecb293"},{"id":"LitCovid-PD-GO-BP","color":"#9893ec"},{"id":"LitCovid-sentences","color":"#a8ec93"}]}]}}