PMC:7291971 / 659-922 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T14","span":{"begin":134,"end":144},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T15","span":{"begin":210,"end":213},"obj":"GO:0008541"},{"id":"T16","span":{"begin":236,"end":241},"obj":"NCBITaxon:10239"},{"id":"T50627","span":{"begin":134,"end":144},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T65425","span":{"begin":210,"end":213},"obj":"GO:0008541"},{"id":"T87174","span":{"begin":236,"end":241},"obj":"NCBITaxon:10239"}],"text":" RNA N7- or 2′O-methyltransferases (MTases) are now admitted as potential targets for antiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This wor"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T5","span":{"begin":1,"end":4},"obj":"Body_part"},{"id":"T6","span":{"begin":214,"end":217},"obj":"Body_part"}],"attributes":[{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":" RNA N7- or 2′O-methyltransferases (MTases) are now admitted as potential targets for antiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This wor"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T8","span":{"begin":86,"end":95},"obj":"Chemical"},{"id":"T9","span":{"begin":134,"end":144},"obj":"Chemical"}],"attributes":[{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":" RNA N7- or 2′O-methyltransferases (MTases) are now admitted as potential targets for antiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This wor"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":191,"end":202},"obj":"http://purl.obolibrary.org/obo/GO_0032259"}],"text":" RNA N7- or 2′O-methyltransferases (MTases) are now admitted as potential targets for antiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This wor"}

{"project":"LitCovid-sentences","denotations":[{"id":"T7","span":{"begin":110,"end":254},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" RNA N7- or 2′O-methyltransferases (MTases) are now admitted as potential targets for antiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This wor"}