PMC:7291971 / 5993-7814 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7291971","sourcedb":"PMC","sourceid":"7291971","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7291971","text":"With the aim of enhancing specificity of MTase inhibitors, we developed an approach of bisubstrate inhibitors that display a suitable linker between two adenosines that mimic the transition state of the methyl transfer reaction at 2′-O position of the RNA cap structure [12]. One adenosine is supposed to target the SAM binding site and another adenosine would target the RNA binding site (Fig. 1 ). Recently, we described the synthesis of a first series of bisubstrate adenine dinucleosides with various sulfur-containing linkers [14]. Unexpectedly, such compounds tested at 50 μM or 200 μM concentration failed to inhibit several RNA 2′O-MTases of SARS-CoV, Zika, West Nile, Dengue and Pox viruses such as vaccinia virus. Their potential of inhibition toward N7-MTases of SARS-CoV and vaccinia virus was also explored and none of the S-linked dinucleosides was active against these N7-MTases. From these data, in the present work we replaced the sulfur atom (S) by a nitrogen atom (N) in the linker between both adenosines. This modification presents the advantage of increasing the chemical stability of the linker and offers a possible variability of compounds due to the N-substitution by any chain susceptible to interact with additional protein residues (Scheme 1). It is noteworthy that bisubstrate dinucleosides with N-containing linkers have already been reported in transition state analogs of DNA methylation [15] and of RNA methylation at N6 position of adenosine [16,17]. However, till our work, none viral 2′O-MTase or N7-MTase have been targeted by bisubstrate adenine dinucleosides. This observation led us to explore the impact of N-linkers on the antiviral activity of bisubstrate SAM analogs.\nFig. 1 Rationale for designing a library of bisubstrate compounds for targeting RNA 2′-O-methyltransferases.","divisions":[{"label":"label","span":{"begin":1713,"end":1719}}],"tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T117","span":{"begin":47,"end":57},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T118","span":{"begin":87,"end":98},"obj":"CHEBI:17544;CHEBI:17544"},{"id":"T119","span":{"begin":99,"end":109},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T120","span":{"begin":153,"end":163},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T121","span":{"begin":256,"end":259},"obj":"GO:0008541"},{"id":"T122","span":{"begin":280,"end":289},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T123","span":{"begin":320,"end":332},"obj":"SO:0000409"},{"id":"T124","span":{"begin":345,"end":354},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T125","span":{"begin":376,"end":388},"obj":"SO:0000409"},{"id":"T126","span":{"begin":470,"end":477},"obj":"CHEBI:28748;CHEBI:28748"},{"id":"T127","span":{"begin":478,"end":491},"obj":"CHEBI:23447;CHEBI:23447"},{"id":"T128","span":{"begin":556,"end":565},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T129","span":{"begin":650,"end":658},"obj":"SP_10"},{"id":"T130","span":{"begin":677,"end":683},"obj":"NCBITaxon:10376"},{"id":"T131","span":{"begin":688,"end":691},"obj":"NCBITaxon:6040"},{"id":"T132","span":{"begin":692,"end":699},"obj":"NCBITaxon:10239"},{"id":"T133","span":{"begin":708,"end":716},"obj":"NCBITaxon:7742"},{"id":"T134","span":{"begin":717,"end":722},"obj":"NCBITaxon:10239"},{"id":"T135","span":{"begin":774,"end":782},"obj":"SP_10"},{"id":"T136","span":{"begin":787,"end":795},"obj":"NCBITaxon:10442"},{"id":"T137","span":{"begin":796,"end":801},"obj":"NCBITaxon:10239"},{"id":"T138","span":{"begin":845,"end":858},"obj":"CHEBI:23447;CHEBI:23447"},{"id":"T139","span":{"begin":955,"end":959},"obj":"CHEBI:33250;CHEBI:33250"},{"id":"T140","span":{"begin":978,"end":982},"obj":"CHEBI:33250;CHEBI:33250"},{"id":"T141","span":{"begin":1155,"end":1164},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T142","span":{"begin":1405,"end":1420},"obj":"GO:0006306"},{"id":"T143","span":{"begin":1433,"end":1448},"obj":"GO:0001510"},{"id":"T144","span":{"begin":1467,"end":1476},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T145","span":{"begin":1515,"end":1520},"obj":"NCBITaxon:10239"},{"id":"T146","span":{"begin":1577,"end":1584},"obj":"CHEBI:28748;CHEBI:28748"},{"id":"T147","span":{"begin":1585,"end":1598},"obj":"CHEBI:23447;CHEBI:23447"},{"id":"T148","span":{"begin":1688,"end":1699},"obj":"CHEBI:17544;CHEBI:17544"},{"id":"T149","span":{"begin":1769,"end":1778},"obj":"CHEBI:36357;CHEBI:36357"}],"attributes":[{"subj":"T117","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T118","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T119","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T120","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T121","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T122","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T123","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T124","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T125","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T126","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T127","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T128","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T129","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T130","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T131","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T132","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T133","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T134","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T135","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T136","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T137","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T138","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T139","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T140","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T141","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T142","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T143","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T144","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T145","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T146","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T147","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T148","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T149","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T33","span":{"begin":252,"end":255},"obj":"Body_part"},{"id":"T34","span":{"begin":372,"end":375},"obj":"Body_part"},{"id":"T35","span":{"begin":470,"end":477},"obj":"Body_part"},{"id":"T36","span":{"begin":632,"end":635},"obj":"Body_part"},{"id":"T37","span":{"begin":1244,"end":1251},"obj":"Body_part"},{"id":"T38","span":{"begin":1405,"end":1408},"obj":"Body_part"},{"id":"T39","span":{"begin":1433,"end":1436},"obj":"Body_part"},{"id":"T40","span":{"begin":1577,"end":1584},"obj":"Body_part"},{"id":"T41","span":{"begin":1793,"end":1796},"obj":"Body_part"}],"attributes":[{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma82774"},{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A38","pred":"fma_id","subj":"T38","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A39","pred":"fma_id","subj":"T39","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A40","pred":"fma_id","subj":"T40","obj":"http://purl.org/sig/ont/fma/fma82774"},{"id":"A41","pred":"fma_id","subj":"T41","obj":"http://purl.org/sig/ont/fma/fma67095"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"80","span":{"begin":153,"end":163},"obj":"Chemical"},{"id":"81","span":{"begin":280,"end":289},"obj":"Chemical"},{"id":"82","span":{"begin":345,"end":354},"obj":"Chemical"},{"id":"83","span":{"begin":458,"end":491},"obj":"Chemical"},{"id":"84","span":{"begin":505,"end":511},"obj":"Chemical"},{"id":"85","span":{"begin":836,"end":858},"obj":"Chemical"},{"id":"86","span":{"begin":948,"end":954},"obj":"Chemical"},{"id":"87","span":{"begin":969,"end":977},"obj":"Chemical"},{"id":"88","span":{"begin":1014,"end":1024},"obj":"Chemical"},{"id":"89","span":{"begin":1295,"end":1320},"obj":"Chemical"},{"id":"90","span":{"begin":1326,"end":1327},"obj":"Chemical"},{"id":"91","span":{"begin":1467,"end":1476},"obj":"Chemical"},{"id":"92","span":{"begin":1565,"end":1598},"obj":"Chemical"},{"id":"93","span":{"begin":1688,"end":1703},"obj":"Chemical"}],"attributes":[{"id":"A80","pred":"tao:has_database_id","subj":"80","obj":"MESH:D000241"},{"id":"A81","pred":"tao:has_database_id","subj":"81","obj":"MESH:D000241"},{"id":"A82","pred":"tao:has_database_id","subj":"82","obj":"MESH:D000241"},{"id":"A84","pred":"tao:has_database_id","subj":"84","obj":"MESH:D013455"},{"id":"A86","pred":"tao:has_database_id","subj":"86","obj":"MESH:D013455"},{"id":"A87","pred":"tao:has_database_id","subj":"87","obj":"MESH:D009584"},{"id":"A88","pred":"tao:has_database_id","subj":"88","obj":"MESH:D000241"},{"id":"A90","pred":"tao:has_database_id","subj":"90","obj":"MESH:D009584"},{"id":"A91","pred":"tao:has_database_id","subj":"91","obj":"MESH:D000241"},{"subj":"80","pred":"source","obj":"LitCovid-PubTator"},{"subj":"81","pred":"source","obj":"LitCovid-PubTator"},{"subj":"82","pred":"source","obj":"LitCovid-PubTator"},{"subj":"83","pred":"source","obj":"LitCovid-PubTator"},{"subj":"84","pred":"source","obj":"LitCovid-PubTator"},{"subj":"85","pred":"source","obj":"LitCovid-PubTator"},{"subj":"86","pred":"source","obj":"LitCovid-PubTator"},{"subj":"87","pred":"source","obj":"LitCovid-PubTator"},{"subj":"88","pred":"source","obj":"LitCovid-PubTator"},{"subj":"89","pred":"source","obj":"LitCovid-PubTator"},{"subj":"90","pred":"source","obj":"LitCovid-PubTator"},{"subj":"91","pred":"source","obj":"LitCovid-PubTator"},{"subj":"92","pred":"source","obj":"LitCovid-PubTator"},{"subj":"93","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T19","span":{"begin":650,"end":658},"obj":"Disease"},{"id":"T20","span":{"begin":660,"end":664},"obj":"Disease"},{"id":"T21","span":{"begin":677,"end":683},"obj":"Disease"},{"id":"T22","span":{"begin":708,"end":716},"obj":"Disease"},{"id":"T23","span":{"begin":774,"end":782},"obj":"Disease"},{"id":"T24","span":{"begin":787,"end":795},"obj":"Disease"}],"attributes":[{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0018661"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/MONDO_0005502"},{"id":"A22","pred":"mondo_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/MONDO_0002595"},{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A24","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0002595"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T44","span":{"begin":9,"end":12},"obj":"http://purl.obolibrary.org/obo/PR_000001343"},{"id":"T45","span":{"begin":123,"end":124},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T46","span":{"begin":440,"end":441},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T47","span":{"begin":566,"end":572},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T48","span":{"begin":692,"end":699},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T49","span":{"begin":717,"end":722},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T50","span":{"begin":796,"end":801},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T51","span":{"begin":863,"end":869},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T52","span":{"begin":967,"end":968},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T53","span":{"begin":1129,"end":1130},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T54","span":{"begin":1244,"end":1260},"obj":"http://purl.obolibrary.org/obo/CHEBI_33708"},{"id":"T55","span":{"begin":1676,"end":1684},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T56","span":{"begin":1744,"end":1745},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T44","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T69","span":{"begin":47,"end":57},"obj":"Chemical"},{"id":"T70","span":{"begin":99,"end":109},"obj":"Chemical"},{"id":"T71","span":{"begin":153,"end":163},"obj":"Chemical"},{"id":"T72","span":{"begin":203,"end":209},"obj":"Chemical"},{"id":"T74","span":{"begin":280,"end":289},"obj":"Chemical"},{"id":"T75","span":{"begin":316,"end":319},"obj":"Chemical"},{"id":"T77","span":{"begin":345,"end":354},"obj":"Chemical"},{"id":"T78","span":{"begin":470,"end":477},"obj":"Chemical"},{"id":"T79","span":{"begin":505,"end":511},"obj":"Chemical"},{"id":"T80","span":{"begin":948,"end":959},"obj":"Chemical"},{"id":"T81","span":{"begin":955,"end":959},"obj":"Chemical"},{"id":"T82","span":{"begin":969,"end":982},"obj":"Chemical"},{"id":"T84","span":{"begin":978,"end":982},"obj":"Chemical"},{"id":"T85","span":{"begin":1014,"end":1024},"obj":"Chemical"},{"id":"T86","span":{"begin":1244,"end":1251},"obj":"Chemical"},{"id":"T87","span":{"begin":1405,"end":1408},"obj":"Chemical"},{"id":"T88","span":{"begin":1467,"end":1476},"obj":"Chemical"},{"id":"T89","span":{"begin":1577,"end":1584},"obj":"Chemical"},{"id":"T90","span":{"begin":1666,"end":1675},"obj":"Chemical"},{"id":"T91","span":{"begin":1700,"end":1703},"obj":"Chemical"}],"attributes":[{"id":"A69","pred":"chebi_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A70","pred":"chebi_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A71","pred":"chebi_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/CHEBI_22260"},{"id":"A72","pred":"chebi_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A73","pred":"chebi_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A74","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_16335"},{"id":"A75","pred":"chebi_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/CHEBI_15414"},{"id":"A76","pred":"chebi_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/CHEBI_67040"},{"id":"A77","pred":"chebi_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/CHEBI_16335"},{"id":"A78","pred":"chebi_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/CHEBI_16708"},{"id":"A79","pred":"chebi_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/CHEBI_26833"},{"id":"A80","pred":"chebi_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/CHEBI_26833"},{"id":"A81","pred":"chebi_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/CHEBI_33250"},{"id":"A82","pred":"chebi_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/CHEBI_25555"},{"id":"A83","pred":"chebi_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/CHEBI_29351"},{"id":"A84","pred":"chebi_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/CHEBI_33250"},{"id":"A85","pred":"chebi_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/CHEBI_22260"},{"id":"A86","pred":"chebi_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A87","pred":"chebi_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A88","pred":"chebi_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/CHEBI_16335"},{"id":"A89","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_16708"},{"id":"A90","pred":"chebi_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A91","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_15414"},{"id":"A92","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_67040"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T84","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T18","span":{"begin":427,"end":436},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T19","span":{"begin":1405,"end":1420},"obj":"http://purl.obolibrary.org/obo/GO_0006306"},{"id":"T20","span":{"begin":1409,"end":1420},"obj":"http://purl.obolibrary.org/obo/GO_0032259"},{"id":"T21","span":{"begin":1433,"end":1448},"obj":"http://purl.obolibrary.org/obo/GO_0001510"},{"id":"T22","span":{"begin":1437,"end":1448},"obj":"http://purl.obolibrary.org/obo/GO_0032259"}],"attributes":[{"subj":"T18","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"2_test","denotations":[{"id":"32563813-26540123-29105573","span":{"begin":271,"end":273},"obj":"26540123"}],"attributes":[{"subj":"32563813-26540123-29105573","pred":"source","obj":"2_test"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T42","span":{"begin":0,"end":275},"obj":"Sentence"},{"id":"T43","span":{"begin":276,"end":399},"obj":"Sentence"},{"id":"T44","span":{"begin":400,"end":536},"obj":"Sentence"},{"id":"T45","span":{"begin":537,"end":723},"obj":"Sentence"},{"id":"T46","span":{"begin":724,"end":894},"obj":"Sentence"},{"id":"T47","span":{"begin":895,"end":1025},"obj":"Sentence"},{"id":"T48","span":{"begin":1026,"end":1272},"obj":"Sentence"},{"id":"T49","span":{"begin":1273,"end":1485},"obj":"Sentence"},{"id":"T50","span":{"begin":1486,"end":1599},"obj":"Sentence"},{"id":"T51","span":{"begin":1600,"end":1712},"obj":"Sentence"},{"id":"T52","span":{"begin":1713,"end":1821},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T42","pred":"source","obj":"LitCovid-sentences"},{"subj":"T43","pred":"source","obj":"LitCovid-sentences"},{"subj":"T44","pred":"source","obj":"LitCovid-sentences"},{"subj":"T45","pred":"source","obj":"LitCovid-sentences"},{"subj":"T46","pred":"source","obj":"LitCovid-sentences"},{"subj":"T47","pred":"source","obj":"LitCovid-sentences"},{"subj":"T48","pred":"source","obj":"LitCovid-sentences"},{"subj":"T49","pred":"source","obj":"LitCovid-sentences"},{"subj":"T50","pred":"source","obj":"LitCovid-sentences"},{"subj":"T51","pred":"source","obj":"LitCovid-sentences"},{"subj":"T52","pred":"source","obj":"LitCovid-sentences"}]},{"project":"MyTest","denotations":[{"id":"32563813-26540123-29105573","span":{"begin":271,"end":273},"obj":"26540123"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32563813-26540123-29105573","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#ecc193","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#a693ec"},{"id":"LitCovid-PubTator","color":"#99ec93"},{"id":"LitCovid-PD-MONDO","color":"#ec93b3"},{"id":"LitCovid-PD-CLO","color":"#93cdec"},{"id":"LitCovid-PD-CHEBI","color":"#e7ec93"},{"id":"LitCovid-PD-GO-BP","color":"#d793ec"},{"id":"2_test","color":"#93ecbd"},{"id":"LitCovid-sentences","color":"#eca393"},{"id":"MyTest","color":"#939dec"}]}]}}