PMC:7291971 / 5993-6268 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T117","span":{"begin":47,"end":57},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T118","span":{"begin":87,"end":98},"obj":"CHEBI:17544;CHEBI:17544"},{"id":"T119","span":{"begin":99,"end":109},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T120","span":{"begin":153,"end":163},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T121","span":{"begin":256,"end":259},"obj":"GO:0008541"}],"text":"With the aim of enhancing specificity of MTase inhibitors, we developed an approach of bisubstrate inhibitors that display a suitable linker between two adenosines that mimic the transition state of the methyl transfer reaction at 2′-O position of the RNA cap structure [12]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T33","span":{"begin":252,"end":255},"obj":"Body_part"}],"attributes":[{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":"With the aim of enhancing specificity of MTase inhibitors, we developed an approach of bisubstrate inhibitors that display a suitable linker between two adenosines that mimic the transition state of the methyl transfer reaction at 2′-O position of the RNA cap structure [12]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"80","span":{"begin":153,"end":163},"obj":"Chemical"}],"attributes":[{"id":"A80","pred":"tao:has_database_id","subj":"80","obj":"MESH:D000241"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"With the aim of enhancing specificity of MTase inhibitors, we developed an approach of bisubstrate inhibitors that display a suitable linker between two adenosines that mimic the transition state of the methyl transfer reaction at 2′-O position of the RNA cap structure [12]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T44","span":{"begin":9,"end":12},"obj":"http://purl.obolibrary.org/obo/PR_000001343"},{"id":"T45","span":{"begin":123,"end":124},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"With the aim of enhancing specificity of MTase inhibitors, we developed an approach of bisubstrate inhibitors that display a suitable linker between two adenosines that mimic the transition state of the methyl transfer reaction at 2′-O position of the RNA cap structure [12]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T69","span":{"begin":47,"end":57},"obj":"Chemical"},{"id":"T70","span":{"begin":99,"end":109},"obj":"Chemical"},{"id":"T71","span":{"begin":153,"end":163},"obj":"Chemical"},{"id":"T72","span":{"begin":203,"end":209},"obj":"Chemical"}],"attributes":[{"id":"A69","pred":"chebi_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A70","pred":"chebi_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A71","pred":"chebi_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/CHEBI_22260"},{"id":"A72","pred":"chebi_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A73","pred":"chebi_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"}],"text":"With the aim of enhancing specificity of MTase inhibitors, we developed an approach of bisubstrate inhibitors that display a suitable linker between two adenosines that mimic the transition state of the methyl transfer reaction at 2′-O position of the RNA cap structure [12]."}

{"project":"2_test","denotations":[{"id":"32563813-26540123-29105573","span":{"begin":271,"end":273},"obj":"26540123"}],"text":"With the aim of enhancing specificity of MTase inhibitors, we developed an approach of bisubstrate inhibitors that display a suitable linker between two adenosines that mimic the transition state of the methyl transfer reaction at 2′-O position of the RNA cap structure [12]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T42","span":{"begin":0,"end":275},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"With the aim of enhancing specificity of MTase inhibitors, we developed an approach of bisubstrate inhibitors that display a suitable linker between two adenosines that mimic the transition state of the methyl transfer reaction at 2′-O position of the RNA cap structure [12]."}

{"project":"MyTest","denotations":[{"id":"32563813-26540123-29105573","span":{"begin":271,"end":273},"obj":"26540123"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"With the aim of enhancing specificity of MTase inhibitors, we developed an approach of bisubstrate inhibitors that display a suitable linker between two adenosines that mimic the transition state of the methyl transfer reaction at 2′-O position of the RNA cap structure [12]."}