PMC:7291971 / 57088-57536 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T1146","span":{"begin":150,"end":165},"obj":"CHEBI:50488;CHEBI:50488"},{"id":"T1147","span":{"begin":168,"end":170},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T1148","span":{"begin":171,"end":177},"obj":"CHEBI:16625;CHEBI:16625"},{"id":"T1149","span":{"begin":210,"end":214},"obj":"CHEBI:30756;CHEBI:30756"},{"id":"T1150","span":{"begin":215,"end":217},"obj":"CHEBI:17500;CHEBI:17500"},{"id":"T1151","span":{"begin":217,"end":218},"obj":"CHEBI:34018;CHEBI:34018"},{"id":"T1152","span":{"begin":218,"end":225},"obj":"CHEBI:43176;CHEBI:43176"},{"id":"T1153","span":{"begin":225,"end":229},"obj":"CHEBI:17500;CHEBI:17500"},{"id":"T1154","span":{"begin":229,"end":242},"obj":"CHEBI:24712;CHEBI:24712"},{"id":"T1155","span":{"begin":243,"end":249},"obj":"CHEBI:26911;CHEBI:26911"},{"id":"T1156","span":{"begin":249,"end":255},"obj":"CHEBI:15533;CHEBI:15533"},{"id":"T1157","span":{"begin":255,"end":258},"obj":"CHEBI:29354;CHEBI:29354"},{"id":"T1158","span":{"begin":259,"end":264},"obj":"CHEBI:37807;CHEBI:37807"},{"id":"T1159","span":{"begin":265,"end":270},"obj":"CHEBI:46882;CHEBI:46882"},{"id":"T1160","span":{"begin":271,"end":284},"obj":"CHEBI:30772;CHEBI:30772"},{"id":"T1161","span":{"begin":365,"end":370},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T1162","span":{"begin":408,"end":416},"obj":"CHEBI:46787;CHEBI:46787"},{"id":"T67979","span":{"begin":150,"end":165},"obj":"CHEBI:50488;CHEBI:50488"},{"id":"T32544","span":{"begin":168,"end":170},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T12991","span":{"begin":171,"end":177},"obj":"CHEBI:16625;CHEBI:16625"},{"id":"T86322","span":{"begin":210,"end":214},"obj":"CHEBI:30756;CHEBI:30756"},{"id":"T2693","span":{"begin":215,"end":217},"obj":"CHEBI:17500;CHEBI:17500"},{"id":"T25161","span":{"begin":217,"end":218},"obj":"CHEBI:34018;CHEBI:34018"},{"id":"T69413","span":{"begin":218,"end":225},"obj":"CHEBI:43176;CHEBI:43176"},{"id":"T26102","span":{"begin":225,"end":229},"obj":"CHEBI:17500;CHEBI:17500"},{"id":"T20939","span":{"begin":229,"end":242},"obj":"CHEBI:24712;CHEBI:24712"},{"id":"T70312","span":{"begin":243,"end":249},"obj":"CHEBI:26911;CHEBI:26911"},{"id":"T56764","span":{"begin":249,"end":255},"obj":"CHEBI:15533;CHEBI:15533"},{"id":"T75470","span":{"begin":255,"end":258},"obj":"CHEBI:29354;CHEBI:29354"},{"id":"T3995","span":{"begin":259,"end":264},"obj":"CHEBI:37807;CHEBI:37807"},{"id":"T67962","span":{"begin":265,"end":270},"obj":"CHEBI:46882;CHEBI:46882"},{"id":"T85476","span":{"begin":271,"end":284},"obj":"CHEBI:30772;CHEBI:30772"},{"id":"T88015","span":{"begin":365,"end":370},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T32144","span":{"begin":408,"end":416},"obj":"CHEBI:46787;CHEBI:46787"}],"text":" 53.4, 51.2, 30.9, 21.8. HRMS (ESI+): m/z calcd for C27H38N11O9 [M+H]+: 660.2854, Found 660.2855.\n\n4.1.20 4-({[(2R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(2-[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]oxy}ethyl)amino)butanoic acid (8)\nCompound 25 (140 mg, 0.15 mmol, 1.00 eq) was treated with TFA (1.37 mL) and water (0.34 mL). After stirring for 5.5 h, solvents were removed under vacuum. The "}

{"project":"LitCovid-PubTator","denotations":[{"id":"974","span":{"begin":52,"end":63},"obj":"Chemical"},{"id":"975","span":{"begin":25,"end":29},"obj":"Disease"},{"id":"991","span":{"begin":347,"end":350},"obj":"Chemical"},{"id":"992","span":{"begin":365,"end":370},"obj":"Chemical"}],"attributes":[{"id":"A991","pred":"tao:has_database_id","subj":"991","obj":"MESH:D014269"},{"id":"A992","pred":"tao:has_database_id","subj":"992","obj":"MESH:D014867"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":" 53.4, 51.2, 30.9, 21.8. HRMS (ESI+): m/z calcd for C27H38N11O9 [M+H]+: 660.2854, Found 660.2855.\n\n4.1.20 4-({[(2R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(2-[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]oxy}ethyl)amino)butanoic acid (8)\nCompound 25 (140 mg, 0.15 mmol, 1.00 eq) was treated with TFA (1.37 mL) and water (0.34 mL). After stirring for 5.5 h, solvents were removed under vacuum. The "}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T344","span":{"begin":65,"end":68},"obj":"http://purl.obolibrary.org/obo/CLO_0007706"}],"text":" 53.4, 51.2, 30.9, 21.8. HRMS (ESI+): m/z calcd for C27H38N11O9 [M+H]+: 660.2854, Found 660.2855.\n\n4.1.20 4-({[(2R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(2-[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]oxy}ethyl)amino)butanoic acid (8)\nCompound 25 (140 mg, 0.15 mmol, 1.00 eq) was treated with TFA (1.37 mL) and water (0.34 mL). After stirring for 5.5 h, solvents were removed under vacuum. The "}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T52186","span":{"begin":123,"end":144},"obj":"Chemical"},{"id":"T71124","span":{"begin":125,"end":130},"obj":"Chemical"},{"id":"T91179","span":{"begin":171,"end":177},"obj":"Chemical"},{"id":"T191","span":{"begin":193,"end":214},"obj":"Chemical"},{"id":"T25223","span":{"begin":195,"end":200},"obj":"Chemical"},{"id":"T4835","span":{"begin":218,"end":225},"obj":"Chemical"},{"id":"T67895","span":{"begin":229,"end":242},"obj":"Chemical"},{"id":"T64132","span":{"begin":255,"end":258},"obj":"Chemical"},{"id":"T8624","span":{"begin":259,"end":264},"obj":"Chemical"},{"id":"T3060","span":{"begin":265,"end":270},"obj":"Chemical"},{"id":"T19597","span":{"begin":271,"end":284},"obj":"Chemical"},{"id":"T17443","span":{"begin":280,"end":284},"obj":"Chemical"},{"id":"T55499","span":{"begin":347,"end":350},"obj":"Chemical"},{"id":"T92108","span":{"begin":365,"end":370},"obj":"Chemical"},{"id":"T27273","span":{"begin":408,"end":416},"obj":"Chemical"}],"attributes":[{"id":"A91133","pred":"chebi_id","subj":"T52186","obj":"http://purl.obolibrary.org/obo/CHEBI_30756"},{"id":"A1490","pred":"chebi_id","subj":"T71124","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A12450","pred":"chebi_id","subj":"T91179","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A80948","pred":"chebi_id","subj":"T91179","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A39674","pred":"chebi_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/CHEBI_30756"},{"id":"A82875","pred":"chebi_id","subj":"T25223","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A76448","pred":"chebi_id","subj":"T4835","obj":"http://purl.obolibrary.org/obo/CHEBI_43176"},{"id":"A94937","pred":"chebi_id","subj":"T67895","obj":"http://purl.obolibrary.org/obo/CHEBI_24712"},{"id":"A74502","pred":"chebi_id","subj":"T64132","obj":"http://purl.obolibrary.org/obo/CHEBI_29354"},{"id":"A53013","pred":"chebi_id","subj":"T8624","obj":"http://purl.obolibrary.org/obo/CHEBI_37807"},{"id":"A25309","pred":"chebi_id","subj":"T8624","obj":"http://purl.obolibrary.org/obo/CHEBI_62801"},{"id":"A26351","pred":"chebi_id","subj":"T3060","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A84610","pred":"chebi_id","subj":"T19597","obj":"http://purl.obolibrary.org/obo/CHEBI_30772"},{"id":"A36341","pred":"chebi_id","subj":"T17443","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A70168","pred":"chebi_id","subj":"T55499","obj":"http://purl.obolibrary.org/obo/CHEBI_45892"},{"id":"A87067","pred":"chebi_id","subj":"T92108","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A32876","pred":"chebi_id","subj":"T27273","obj":"http://purl.obolibrary.org/obo/CHEBI_46787"}],"text":" 53.4, 51.2, 30.9, 21.8. HRMS (ESI+): m/z calcd for C27H38N11O9 [M+H]+: 660.2854, Found 660.2855.\n\n4.1.20 4-({[(2R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(2-[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]oxy}ethyl)amino)butanoic acid (8)\nCompound 25 (140 mg, 0.15 mmol, 1.00 eq) was treated with TFA (1.37 mL) and water (0.34 mL). After stirring for 5.5 h, solvents were removed under vacuum. The "}

{"project":"LitCovid-sentences","denotations":[{"id":"T395","span":{"begin":25,"end":71},"obj":"Sentence"},{"id":"T396","span":{"begin":72,"end":97},"obj":"Sentence"},{"id":"T397","span":{"begin":99,"end":288},"obj":"Sentence"},{"id":"T398","span":{"begin":289,"end":381},"obj":"Sentence"},{"id":"T399","span":{"begin":382,"end":443},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" 53.4, 51.2, 30.9, 21.8. HRMS (ESI+): m/z calcd for C27H38N11O9 [M+H]+: 660.2854, Found 660.2855.\n\n4.1.20 4-({[(2R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(2-[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]oxy}ethyl)amino)butanoic acid (8)\nCompound 25 (140 mg, 0.15 mmol, 1.00 eq) was treated with TFA (1.37 mL) and water (0.34 mL). After stirring for 5.5 h, solvents were removed under vacuum. The "}