PMC:7291971 / 54862-55921 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T1123","span":{"begin":86,"end":98},"obj":"CHEBI:38472;CHEBI:38472"},{"id":"T1124","span":{"begin":791,"end":794},"obj":"CHEBI:36927;CHEBI:36927"},{"id":"T33829","span":{"begin":86,"end":98},"obj":"CHEBI:38472;CHEBI:38472"},{"id":"T10815","span":{"begin":791,"end":794},"obj":"CHEBI:36927;CHEBI:36927"}],"text":"Following method C with 24 (40 mg, 0.42 μmol, 1.00 eq) and a 0–50% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 6 (8 mg, 28%) was obtained as a white powder with 99% purity determined by HPLC analysis at 260 nm. 1H NMR (500 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.32 (s, 1H), 8.14 (s, 1H), 8.13 (s, 1H), 7.33 (br. s, 2H), 7.25 (br. s, 2H), 5.97 (d, J = 6.3 Hz, 1H), 5.85 (d, J = 5.2 Hz, 1H), 5.49–5.39 (m, 3H), 5.14 (d, J = 5.3 Hz, 1H), 4.62 (q, J = 5.4 Hz, 1H), 4.52 (dd, J = 6.5, 4.7 Hz, 1H), 4.29 (dd, J = 4.8, 2.8 Hz, 1H), 4.06 (q, J = 4.9 Hz, 1H), 4.00–3.92 (m, 2H), 3.68–3.46 (m, 4H), 2.79 (dd, J = 14.0, 4.6 Hz, 1H), 2.70–2.51 (m, 3H), 2.41–2.30 (m, 2H), 1.22 (q, J = 7.4, 2H), 1.07 (tdd, J = 13.4 Hz, J = 10.5 Hz, J = 6.3 Hz, 2H), 0.73 (t, J = 7.3 Hz, 2H). 13C NMR (125 MHz, DMSO‑d 6) δ 156.1, 156.0, 152.5, 152.4, 149.3, 149.0, 139.8, 139.8, 119.3, 119.2, 87.6, 86.3, 86.2, 82.4, 81.2, 72.5, 71.9, 69.2, 68.0, 62.0, 56.2, 54.0, 53.7, 28.3, 19.8, 13.8. HRMS (ESI+): m/z calcd for C26H38N11O7 [M+H]+: 616.2956, Found 616.2955."}

{"project":"LitCovid-PubTator","denotations":[{"id":"937","span":{"begin":86,"end":98},"obj":"Chemical"},{"id":"938","span":{"begin":102,"end":107},"obj":"Chemical"},{"id":"939","span":{"begin":245,"end":247},"obj":"Chemical"},{"id":"940","span":{"begin":262,"end":270},"obj":"Chemical"},{"id":"941","span":{"begin":283,"end":285},"obj":"Chemical"},{"id":"942","span":{"begin":297,"end":299},"obj":"Chemical"},{"id":"943","span":{"begin":311,"end":313},"obj":"Chemical"},{"id":"944","span":{"begin":325,"end":327},"obj":"Chemical"},{"id":"945","span":{"begin":343,"end":345},"obj":"Chemical"},{"id":"946","span":{"begin":791,"end":794},"obj":"Chemical"},{"id":"947","span":{"begin":809,"end":817},"obj":"Chemical"},{"id":"948","span":{"begin":1014,"end":1025},"obj":"Chemical"},{"id":"949","span":{"begin":987,"end":991},"obj":"Disease"}],"attributes":[{"id":"A937","pred":"tao:has_database_id","subj":"937","obj":"MESH:C032159"},{"id":"A945","pred":"tao:has_database_id","subj":"945","obj":"MESH:D003903"},{"id":"A946","pred":"tao:has_database_id","subj":"946","obj":"MESH:C000615229"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Following method C with 24 (40 mg, 0.42 μmol, 1.00 eq) and a 0–50% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 6 (8 mg, 28%) was obtained as a white powder with 99% purity determined by HPLC analysis at 260 nm. 1H NMR (500 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.32 (s, 1H), 8.14 (s, 1H), 8.13 (s, 1H), 7.33 (br. s, 2H), 7.25 (br. s, 2H), 5.97 (d, J = 6.3 Hz, 1H), 5.85 (d, J = 5.2 Hz, 1H), 5.49–5.39 (m, 3H), 5.14 (d, J = 5.3 Hz, 1H), 4.62 (q, J = 5.4 Hz, 1H), 4.52 (dd, J = 6.5, 4.7 Hz, 1H), 4.29 (dd, J = 4.8, 2.8 Hz, 1H), 4.06 (q, J = 4.9 Hz, 1H), 4.00–3.92 (m, 2H), 3.68–3.46 (m, 4H), 2.79 (dd, J = 14.0, 4.6 Hz, 1H), 2.70–2.51 (m, 3H), 2.41–2.30 (m, 2H), 1.22 (q, J = 7.4, 2H), 1.07 (tdd, J = 13.4 Hz, J = 10.5 Hz, J = 6.3 Hz, 2H), 0.73 (t, J = 7.3 Hz, 2H). 13C NMR (125 MHz, DMSO‑d 6) δ 156.1, 156.0, 152.5, 152.4, 149.3, 149.0, 139.8, 139.8, 119.3, 119.2, 87.6, 86.3, 86.2, 82.4, 81.2, 72.5, 71.9, 69.2, 68.0, 62.0, 56.2, 54.0, 53.7, 28.3, 19.8, 13.8. HRMS (ESI+): m/z calcd for C26H38N11O7 [M+H]+: 616.2956, Found 616.2955."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T338","span":{"begin":59,"end":60},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T339","span":{"begin":175,"end":176},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T340","span":{"begin":1027,"end":1030},"obj":"http://purl.obolibrary.org/obo/CLO_0007706"}],"text":"Following method C with 24 (40 mg, 0.42 μmol, 1.00 eq) and a 0–50% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 6 (8 mg, 28%) was obtained as a white powder with 99% purity determined by HPLC analysis at 260 nm. 1H NMR (500 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.32 (s, 1H), 8.14 (s, 1H), 8.13 (s, 1H), 7.33 (br. s, 2H), 7.25 (br. s, 2H), 5.97 (d, J = 6.3 Hz, 1H), 5.85 (d, J = 5.2 Hz, 1H), 5.49–5.39 (m, 3H), 5.14 (d, J = 5.3 Hz, 1H), 4.62 (q, J = 5.4 Hz, 1H), 4.52 (dd, J = 6.5, 4.7 Hz, 1H), 4.29 (dd, J = 4.8, 2.8 Hz, 1H), 4.06 (q, J = 4.9 Hz, 1H), 4.00–3.92 (m, 2H), 3.68–3.46 (m, 4H), 2.79 (dd, J = 14.0, 4.6 Hz, 1H), 2.70–2.51 (m, 3H), 2.41–2.30 (m, 2H), 1.22 (q, J = 7.4, 2H), 1.07 (tdd, J = 13.4 Hz, J = 10.5 Hz, J = 6.3 Hz, 2H), 0.73 (t, J = 7.3 Hz, 2H). 13C NMR (125 MHz, DMSO‑d 6) δ 156.1, 156.0, 152.5, 152.4, 149.3, 149.0, 139.8, 139.8, 119.3, 119.2, 87.6, 86.3, 86.2, 82.4, 81.2, 72.5, 71.9, 69.2, 68.0, 62.0, 56.2, 54.0, 53.7, 28.3, 19.8, 13.8. HRMS (ESI+): m/z calcd for C26H38N11O7 [M+H]+: 616.2956, Found 616.2955."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T91685","span":{"begin":86,"end":98},"obj":"Chemical"},{"id":"T55170","span":{"begin":108,"end":114},"obj":"Chemical"},{"id":"T49282","span":{"begin":245,"end":247},"obj":"Chemical"},{"id":"T84039","span":{"begin":262,"end":266},"obj":"Chemical"},{"id":"T94512","span":{"begin":283,"end":285},"obj":"Chemical"},{"id":"T37040","span":{"begin":297,"end":299},"obj":"Chemical"},{"id":"T28951","span":{"begin":311,"end":313},"obj":"Chemical"},{"id":"T27788","span":{"begin":325,"end":327},"obj":"Chemical"},{"id":"T92805","span":{"begin":387,"end":389},"obj":"Chemical"},{"id":"T146","span":{"begin":413,"end":415},"obj":"Chemical"},{"id":"T26862","span":{"begin":458,"end":460},"obj":"Chemical"},{"id":"T40060","span":{"begin":484,"end":486},"obj":"Chemical"},{"id":"T89685","span":{"begin":516,"end":518},"obj":"Chemical"},{"id":"T52261","span":{"begin":548,"end":550},"obj":"Chemical"},{"id":"T151","span":{"begin":574,"end":576},"obj":"Chemical"},{"id":"T60336","span":{"begin":645,"end":647},"obj":"Chemical"},{"id":"T95747","span":{"begin":809,"end":813},"obj":"Chemical"}],"attributes":[{"id":"A18978","pred":"chebi_id","subj":"T91685","obj":"http://purl.obolibrary.org/obo/CHEBI_38472"},{"id":"A85283","pred":"chebi_id","subj":"T55170","obj":"http://purl.obolibrary.org/obo/CHEBI_35225"},{"id":"A6468","pred":"chebi_id","subj":"T49282","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A20917","pred":"chebi_id","subj":"T84039","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"},{"id":"A31327","pred":"chebi_id","subj":"T94512","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A57058","pred":"chebi_id","subj":"T37040","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A13992","pred":"chebi_id","subj":"T28951","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A95338","pred":"chebi_id","subj":"T27788","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A70196","pred":"chebi_id","subj":"T92805","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A59830","pred":"chebi_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A5822","pred":"chebi_id","subj":"T26862","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A83435","pred":"chebi_id","subj":"T40060","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A72141","pred":"chebi_id","subj":"T89685","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A27469","pred":"chebi_id","subj":"T52261","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A46920","pred":"chebi_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A61030","pred":"chebi_id","subj":"T60336","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A11844","pred":"chebi_id","subj":"T95747","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"}],"text":"Following method C with 24 (40 mg, 0.42 μmol, 1.00 eq) and a 0–50% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 6 (8 mg, 28%) was obtained as a white powder with 99% purity determined by HPLC analysis at 260 nm. 1H NMR (500 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.32 (s, 1H), 8.14 (s, 1H), 8.13 (s, 1H), 7.33 (br. s, 2H), 7.25 (br. s, 2H), 5.97 (d, J = 6.3 Hz, 1H), 5.85 (d, J = 5.2 Hz, 1H), 5.49–5.39 (m, 3H), 5.14 (d, J = 5.3 Hz, 1H), 4.62 (q, J = 5.4 Hz, 1H), 4.52 (dd, J = 6.5, 4.7 Hz, 1H), 4.29 (dd, J = 4.8, 2.8 Hz, 1H), 4.06 (q, J = 4.9 Hz, 1H), 4.00–3.92 (m, 2H), 3.68–3.46 (m, 4H), 2.79 (dd, J = 14.0, 4.6 Hz, 1H), 2.70–2.51 (m, 3H), 2.41–2.30 (m, 2H), 1.22 (q, J = 7.4, 2H), 1.07 (tdd, J = 13.4 Hz, J = 10.5 Hz, J = 6.3 Hz, 2H), 0.73 (t, J = 7.3 Hz, 2H). 13C NMR (125 MHz, DMSO‑d 6) δ 156.1, 156.0, 152.5, 152.4, 149.3, 149.0, 139.8, 139.8, 119.3, 119.2, 87.6, 86.3, 86.2, 82.4, 81.2, 72.5, 71.9, 69.2, 68.0, 62.0, 56.2, 54.0, 53.7, 28.3, 19.8, 13.8. HRMS (ESI+): m/z calcd for C26H38N11O7 [M+H]+: 616.2956, Found 616.2955."}

{"project":"LitCovid-sentences","denotations":[{"id":"T386","span":{"begin":0,"end":244},"obj":"Sentence"},{"id":"T387","span":{"begin":245,"end":790},"obj":"Sentence"},{"id":"T388","span":{"begin":791,"end":986},"obj":"Sentence"},{"id":"T389","span":{"begin":987,"end":1033},"obj":"Sentence"},{"id":"T390","span":{"begin":1034,"end":1059},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Following method C with 24 (40 mg, 0.42 μmol, 1.00 eq) and a 0–50% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 6 (8 mg, 28%) was obtained as a white powder with 99% purity determined by HPLC analysis at 260 nm. 1H NMR (500 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.32 (s, 1H), 8.14 (s, 1H), 8.13 (s, 1H), 7.33 (br. s, 2H), 7.25 (br. s, 2H), 5.97 (d, J = 6.3 Hz, 1H), 5.85 (d, J = 5.2 Hz, 1H), 5.49–5.39 (m, 3H), 5.14 (d, J = 5.3 Hz, 1H), 4.62 (q, J = 5.4 Hz, 1H), 4.52 (dd, J = 6.5, 4.7 Hz, 1H), 4.29 (dd, J = 4.8, 2.8 Hz, 1H), 4.06 (q, J = 4.9 Hz, 1H), 4.00–3.92 (m, 2H), 3.68–3.46 (m, 4H), 2.79 (dd, J = 14.0, 4.6 Hz, 1H), 2.70–2.51 (m, 3H), 2.41–2.30 (m, 2H), 1.22 (q, J = 7.4, 2H), 1.07 (tdd, J = 13.4 Hz, J = 10.5 Hz, J = 6.3 Hz, 2H), 0.73 (t, J = 7.3 Hz, 2H). 13C NMR (125 MHz, DMSO‑d 6) δ 156.1, 156.0, 152.5, 152.4, 149.3, 149.0, 139.8, 139.8, 119.3, 119.2, 87.6, 86.3, 86.2, 82.4, 81.2, 72.5, 71.9, 69.2, 68.0, 62.0, 56.2, 54.0, 53.7, 28.3, 19.8, 13.8. HRMS (ESI+): m/z calcd for C26H38N11O7 [M+H]+: 616.2956, Found 616.2955."}