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PMC:7291971 / 49320-50670 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T998 46-48 CHEBI:30756;CHEBI:30756 denotes 9H
T999 49-59 CHEBI:30756;CHEBI:30756 denotes purin-9-yl
T1000 60-84 CHEBI:53233;CHEBI:53233 denotes -2,2-dimethyl-tetrahydro
T1001 85-87 CHEBI:53233;CHEBI:53233 denotes 2H
T1002 103-111 CHEBI:53233;CHEBI:53233 denotes 3]dioxol
T1003 112-113 CHEBI:53233;CHEBI:53233 denotes 4
T1004 113-116 CHEBI:28714;CHEBI:28714 denotes -yl
T1005 117-123 CHEBI:29309;CHEBI:29309 denotes methyl
T1006 125-130 CHEBI:34594;CHEBI:34594 denotes butyl
T1007 131-136 CHEBI:46882;CHEBI:46882 denotes amino
T1008 137-143 CHEBI:42241;CHEBI:42241 denotes ethoxy
T1009 145-146 CHEBI:53233;CHEBI:53233 denotes 4
T1010 154-172 CHEBI:28714;CHEBI:28714 denotes butyldimethylsilyl
T1011 173-176 CHEBI:29354;CHEBI:29354 denotes oxy
T1012 207-210 CHEBI:29354;CHEBI:29354 denotes oxy
T1013 211-217 CHEBI:29309;CHEBI:29309 denotes methyl
T1014 218-224 CHEBI:26911;CHEBI:26911 denotes oxolan
T1015 224-225 CHEBI:15533;CHEBI:15533 denotes -
T1016 225-230 CHEBI:53233;CHEBI:53233 denotes 2-yl]
T1017 231-233 CHEBI:53233;CHEBI:53233 denotes 9H
T1018 234-239 CHEBI:35589;CHEBI:35589 denotes purin
T1019 242-247 CHEBI:32952;CHEBI:32952 denotes amine
T1020 310-323 CHEBI:20067;CHEBI:20067 denotes 1-bromobutane
T1021 381-385 CHEBI:32145;CHEBI:32145 denotes MeOH
T1022 414-419 CHEBI:30808;CHEBI:30808 denotes CDCl3
T1023 1014-1017 CHEBI:36927;CHEBI:36927 denotes 13C
T32363 46-48 CHEBI:30756;CHEBI:30756 denotes 9H
T13211 49-59 CHEBI:30756;CHEBI:30756 denotes purin-9-yl
T96959 60-84 CHEBI:53233;CHEBI:53233 denotes -2,2-dimethyl-tetrahydro
T81968 85-87 CHEBI:53233;CHEBI:53233 denotes 2H
T62563 103-111 CHEBI:53233;CHEBI:53233 denotes 3]dioxol
T71718 112-113 CHEBI:53233;CHEBI:53233 denotes 4
T20039 113-116 CHEBI:28714;CHEBI:28714 denotes -yl
T58470 117-123 CHEBI:29309;CHEBI:29309 denotes methyl
T88741 125-130 CHEBI:34594;CHEBI:34594 denotes butyl
T90855 131-136 CHEBI:46882;CHEBI:46882 denotes amino
T4988 137-143 CHEBI:42241;CHEBI:42241 denotes ethoxy
T98861 145-146 CHEBI:53233;CHEBI:53233 denotes 4
T30207 154-172 CHEBI:28714;CHEBI:28714 denotes butyldimethylsilyl
T63301 173-176 CHEBI:29354;CHEBI:29354 denotes oxy
T91694 207-210 CHEBI:29354;CHEBI:29354 denotes oxy
T32425 211-217 CHEBI:29309;CHEBI:29309 denotes methyl
T53106 218-224 CHEBI:26911;CHEBI:26911 denotes oxolan
T98099 224-225 CHEBI:15533;CHEBI:15533 denotes -
T44173 225-230 CHEBI:53233;CHEBI:53233 denotes 2-yl]
T15637 231-233 CHEBI:53233;CHEBI:53233 denotes 9H
T88656 234-239 CHEBI:35589;CHEBI:35589 denotes purin
T83607 242-247 CHEBI:32952;CHEBI:32952 denotes amine
T96207 310-323 CHEBI:20067;CHEBI:20067 denotes 1-bromobutane
T31939 381-385 CHEBI:32145;CHEBI:32145 denotes MeOH
T15973 414-419 CHEBI:30808;CHEBI:30808 denotes CDCl3
T79430 1014-1017 CHEBI:36927;CHEBI:36927 denotes 13C

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
864 310-323 Chemical denotes 1-bromobutane MESH:C047757
865 381-385 Chemical denotes MeOH
866 386-389 Chemical denotes DCM
867 397-399 Chemical denotes 1H
868 414-419 Chemical denotes CDCl3
869 432-434 Chemical denotes 2H MESH:D003903
870 446-448 Chemical denotes 1H
871 460-462 Chemical denotes 1H
872 486-488 Chemical denotes 1H
873 512-514 Chemical denotes 1H
874 1301-1315 Chemical denotes C46H72N11O7Si2
875 1274-1278 Disease denotes HRMS

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T329 357-358 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T330 1317-1320 http://purl.obolibrary.org/obo/CLO_0007706 denotes M+H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T928 38-59 Chemical denotes 6-amino-9H-purin-9-yl http://purl.obolibrary.org/obo/CHEBI_30756
T929 40-45 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T930 65-73 Chemical denotes dimethyl http://purl.obolibrary.org/obo/CHEBI_33601|http://purl.obolibrary.org/obo/CHEBI_42266
T932 117-123 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T934 125-130 Chemical denotes butyl http://purl.obolibrary.org/obo/CHEBI_41264
T935 131-136 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T936 137-143 Chemical denotes ethoxy http://purl.obolibrary.org/obo/CHEBI_42241
T937 173-176 Chemical denotes oxy http://purl.obolibrary.org/obo/CHEBI_29354
T938 207-210 Chemical denotes oxy http://purl.obolibrary.org/obo/CHEBI_29354
T939 211-217 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T941 231-247 Chemical denotes 9H-purin-6-amine http://purl.obolibrary.org/obo/CHEBI_16708
T942 242-247 Chemical denotes amine http://purl.obolibrary.org/obo/CHEBI_32952
T24253 372-374 Chemical denotes Rf http://purl.obolibrary.org/obo/CHEBI_33346
T16296 381-385 Chemical denotes MeOH http://purl.obolibrary.org/obo/CHEBI_17790
T3 386-389 Chemical denotes DCM http://purl.obolibrary.org/obo/CHEBI_15767
T98279 397-399 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T14128 414-419 Chemical denotes CDCl3 http://purl.obolibrary.org/obo/CHEBI_85365
T7839 446-448 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T62523 460-462 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T51533 486-488 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T47370 512-514 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T35194 569-571 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T23227 608-610 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T97352 634-636 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T68865 692-694 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T34711 732-734 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T82490 772-774 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T26759 850-852 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T72541 1032-1037 Chemical denotes CDCl3 http://purl.obolibrary.org/obo/CHEBI_85365

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T19 386-389 Phenotype denotes DCM http://purl.obolibrary.org/obo/HP_0001644

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T358 0-252 Sentence denotes 4.1.14 9-[(2R,5R)-3-[2-({[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}(butyl)amino)ethoxy]-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-2-yl]-9H-purin-6-amine (23)
T359 253-371 Sentence denotes Following method D with 20 (80 mg, 97 μmol, 1.00 eq) and 1-bromobutane, 23 (40 mg, 47%) was obtained as a white solid.
T360 372-396 Sentence denotes Rf 0.48 (MeOH/DCM 5:95).
T361 397-1013 Sentence denotes 1H NMR (600 MHz, CDCl3) δ 8.33 (s, 2H), 8.16 (s, 1H), 7.92 (s, 1H), 6.11 (d, J = 3.8 Hz, 1H), 6.03 (d, J = 2.3 Hz, 1H), 5.77 (br. s, 4H), 5.47 (dd, J = 6.4 Hz, J = 2.2 Hz, 1H), 4.91 (dd, J = 6.4 Hz, J = 3.2 Hz, 1H), 4.51 (t, J = 5.1 Hz, 1H), 4.37–4.24 (m, 2H), 4.09 (dt, J = 5.9 Hz, J = 3.0 Hz, 1H), 3.99 (dd, J = 11.5 Hz, J = 3.7 Hz, 1H), 3.76 (dd, J = 11.5 Hz, J = 2.8 Hz, 1H), 3.70–3.61 (m, 2H), 2.77–2.68 (m, 3H), 2.63 (dd, J = 13.5 Hz, J = 7.0 Hz, 1H), 2.46–2.37 (m, 2H), 1.59 (s, 3H), 1.38 (s, 3H), 1.31–1.22 (m, 2H), 1.22–1.12 (m, 2H), 0.92 (s, 9H), 0.91 (s, 9H), 0.82 (t, J = 7.3 Hz, 3H), 0.10–0.08 (m, 12H).
T362 1014-1273 Sentence denotes 13C NMR (150 MHz, CDCl3) δ 155.6, 155.5, 153.2, 153.1, 149.8, 149.4, 140.2, 139.7, 120.5, 120.3, 114.4, 91.2, 87.2, 85.8, 84.9, 84.0, 83.4, 82.4, 69.9, 69.3, 62.0, 56.7, 55.1, 53.9, 29.2, 27.2, 26.1, 25.9, 25.5, 20.5, 18.6, 18.2, 14.1, −4.4, −4.6, −5.2, −5.2.
T363 1274-1323 Sentence denotes HRMS (ESI+): m/z calcd for C46H72N11O7Si2 [M+H]+:
T364 1324-1340 Sentence denotes 884.4998, found:
T365 1341-1350 Sentence denotes 884.5002.