PMC:7291971 / 49189-49406 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T995","span":{"begin":33,"end":39},"obj":"CHEBI:30563;CHEBI:30563"},{"id":"T996","span":{"begin":66,"end":70},"obj":"CHEBI:32145;CHEBI:32145"},{"id":"T997","span":{"begin":99,"end":107},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T998","span":{"begin":177,"end":179},"obj":"CHEBI:30756;CHEBI:30756"},{"id":"T999","span":{"begin":180,"end":190},"obj":"CHEBI:30756;CHEBI:30756"},{"id":"T1000","span":{"begin":191,"end":215},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T31885","span":{"begin":33,"end":39},"obj":"CHEBI:30563;CHEBI:30563"},{"id":"T20744","span":{"begin":66,"end":70},"obj":"CHEBI:32145;CHEBI:32145"},{"id":"T50504","span":{"begin":99,"end":107},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T32363","span":{"begin":177,"end":179},"obj":"CHEBI:30756;CHEBI:30756"},{"id":"T13211","span":{"begin":180,"end":190},"obj":"CHEBI:30756;CHEBI:30756"},{"id":"T96959","span":{"begin":191,"end":215},"obj":"CHEBI:53233;CHEBI:53233"}],"text":" by flash column chromatography (silica gel, linear gradient 0–4% MeOH in DCM) to give the desired compound as a colorless solid.\n\n4.1.14 9-[(2R,5R)-3-[2-({[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2"}

{"project":"LitCovid-PubTator","denotations":[{"id":"849","span":{"begin":33,"end":43},"obj":"Chemical"},{"id":"850","span":{"begin":66,"end":70},"obj":"Chemical"},{"id":"851","span":{"begin":74,"end":77},"obj":"Chemical"}],"attributes":[{"id":"A849","pred":"tao:has_database_id","subj":"849","obj":"MESH:D058428"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":" by flash column chromatography (silica gel, linear gradient 0–4% MeOH in DCM) to give the desired compound as a colorless solid.\n\n4.1.14 9-[(2R,5R)-3-[2-({[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T328","span":{"begin":111,"end":112},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":" by flash column chromatography (silica gel, linear gradient 0–4% MeOH in DCM) to give the desired compound as a colorless solid.\n\n4.1.14 9-[(2R,5R)-3-[2-({[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T925","span":{"begin":33,"end":39},"obj":"Chemical"},{"id":"T926","span":{"begin":66,"end":70},"obj":"Chemical"},{"id":"T927","span":{"begin":74,"end":77},"obj":"Chemical"},{"id":"T928","span":{"begin":169,"end":190},"obj":"Chemical"},{"id":"T929","span":{"begin":171,"end":176},"obj":"Chemical"},{"id":"T930","span":{"begin":196,"end":204},"obj":"Chemical"}],"attributes":[{"id":"A925","pred":"chebi_id","subj":"T925","obj":"http://purl.obolibrary.org/obo/CHEBI_30563"},{"id":"A926","pred":"chebi_id","subj":"T926","obj":"http://purl.obolibrary.org/obo/CHEBI_17790"},{"id":"A927","pred":"chebi_id","subj":"T927","obj":"http://purl.obolibrary.org/obo/CHEBI_15767"},{"id":"A928","pred":"chebi_id","subj":"T928","obj":"http://purl.obolibrary.org/obo/CHEBI_30756"},{"id":"A929","pred":"chebi_id","subj":"T929","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A930","pred":"chebi_id","subj":"T930","obj":"http://purl.obolibrary.org/obo/CHEBI_33601"},{"id":"A931","pred":"chebi_id","subj":"T930","obj":"http://purl.obolibrary.org/obo/CHEBI_42266"}],"text":" by flash column chromatography (silica gel, linear gradient 0–4% MeOH in DCM) to give the desired compound as a colorless solid.\n\n4.1.14 9-[(2R,5R)-3-[2-({[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T18","span":{"begin":74,"end":77},"obj":"Phenotype"}],"attributes":[{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0001644"}],"text":" by flash column chromatography (silica gel, linear gradient 0–4% MeOH in DCM) to give the desired compound as a colorless solid.\n\n4.1.14 9-[(2R,5R)-3-[2-({[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2"}