PMC:7291971 / 446-894 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T12","span":{"begin":49,"end":59},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T13","span":{"begin":184,"end":191},"obj":"NCBITaxon:10239"},{"id":"T14","span":{"begin":347,"end":357},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T15","span":{"begin":423,"end":426},"obj":"GO:0008541"},{"id":"T93340","span":{"begin":49,"end":59},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T49466","span":{"begin":184,"end":191},"obj":"NCBITaxon:10239"},{"id":"T50627","span":{"begin":347,"end":357},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T65425","span":{"begin":423,"end":426},"obj":"GO:0008541"}],"text":". The discovery of potent and specific antiviral inhibitors and/or vaccines to fight these massive outbreaks is an urgent research priority. Enzymes involved in the capping pathway of viruses and more specifically RNA N7- or 2′O-methyltransferases (MTases) are now admitted as potential targets for antiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T5","span":{"begin":214,"end":217},"obj":"Body_part"},{"id":"T6","span":{"begin":427,"end":430},"obj":"Body_part"}],"attributes":[{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":". The discovery of potent and specific antiviral inhibitors and/or vaccines to fight these massive outbreaks is an urgent research priority. Enzymes involved in the capping pathway of viruses and more specifically RNA N7- or 2′O-methyltransferases (MTases) are now admitted as potential targets for antiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T5","span":{"begin":184,"end":191},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":". The discovery of potent and specific antiviral inhibitors and/or vaccines to fight these massive outbreaks is an urgent research priority. Enzymes involved in the capping pathway of viruses and more specifically RNA N7- or 2′O-methyltransferases (MTases) are now admitted as potential targets for antiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T6","span":{"begin":39,"end":48},"obj":"Chemical"},{"id":"T7","span":{"begin":49,"end":59},"obj":"Chemical"},{"id":"T8","span":{"begin":299,"end":308},"obj":"Chemical"},{"id":"T9","span":{"begin":347,"end":357},"obj":"Chemical"}],"attributes":[{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":". The discovery of potent and specific antiviral inhibitors and/or vaccines to fight these massive outbreaks is an urgent research priority. Enzymes involved in the capping pathway of viruses and more specifically RNA N7- or 2′O-methyltransferases (MTases) are now admitted as potential targets for antiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":404,"end":415},"obj":"http://purl.obolibrary.org/obo/GO_0032259"}],"text":". The discovery of potent and specific antiviral inhibitors and/or vaccines to fight these massive outbreaks is an urgent research priority. Enzymes involved in the capping pathway of viruses and more specifically RNA N7- or 2′O-methyltransferases (MTases) are now admitted as potential targets for antiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block"}

{"project":"LitCovid-sentences","denotations":[{"id":"T5","span":{"begin":2,"end":140},"obj":"Sentence"},{"id":"T6","span":{"begin":141,"end":322},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":". The discovery of potent and specific antiviral inhibitors and/or vaccines to fight these massive outbreaks is an urgent research priority. Enzymes involved in the capping pathway of viruses and more specifically RNA N7- or 2′O-methyltransferases (MTases) are now admitted as potential targets for antiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block"}