PMC:7291971 / 41292-42169 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T864","span":{"begin":87,"end":99},"obj":"CHEBI:38472;CHEBI:38472"},{"id":"T865","span":{"begin":631,"end":634},"obj":"CHEBI:36927;CHEBI:36927"},{"id":"T80338","span":{"begin":87,"end":99},"obj":"CHEBI:38472;CHEBI:38472"},{"id":"T77870","span":{"begin":631,"end":634},"obj":"CHEBI:36927;CHEBI:36927"}],"text":"Following method C with 20 (117 mg, 0.14 mmol, 1.00 eq) and a 0–25% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 1 (60 mg, 76%) was obtained as a white powder with 99% purity determined by HPLC analysis at 260 nm. 1H NMR (600 MHz, DMSO‑d 6) δ 8.38 (s, 1H), 8.34 (s, 1H), 8.15 (s, 1H), 8.14 (s, 1H), 7.36 (br.s, 2H), 7.29 (br. s, 2H), 5.97 (d, J = 6.4 Hz, 1H), 5.85 (d, J = 5.9 Hz, 1H), 5.58–4.98 (m, 4H), 4.70–4.63 (m, 1H), 4.52 (dd, J = 6.4 Hz, J = 4.7 Hz, 1H), 4.33 (dd, J = 4.7 Hz, J = 2.6 Hz, 1H), 4.12 (dd, J = 5.2 Hz, J = 3.8 Hz, 1H), 4.02–3.93 (m, 2H), 3.70–3.48 (m, 4H), 2.86–2.58 (m, 4H). 13C NMR (150 MHz, DMSO‑d 6) δ 156.2, 156.1, 152.6, 152.5, 149.4, 149.0, 140.1, 139.9, 119.4, 119.3, 87.6, 86.3 (2C), 83.7, 81.5, 72.8, 71.5, 69.5, 69.1, 61.7, 51.2, 49.0. HRMS (ESI+): m/z calcd for C22H30N11O7 [M+H]+: 560.23242, found: 560.23188."}

{"project":"LitCovid-PubTator","denotations":[{"id":"727","span":{"begin":87,"end":99},"obj":"Chemical"},{"id":"728","span":{"begin":103,"end":108},"obj":"Chemical"},{"id":"729","span":{"begin":247,"end":249},"obj":"Chemical"},{"id":"730","span":{"begin":264,"end":272},"obj":"Chemical"},{"id":"731","span":{"begin":285,"end":287},"obj":"Chemical"},{"id":"732","span":{"begin":299,"end":301},"obj":"Chemical"},{"id":"733","span":{"begin":313,"end":315},"obj":"Chemical"},{"id":"734","span":{"begin":327,"end":329},"obj":"Chemical"},{"id":"735","span":{"begin":344,"end":346},"obj":"Chemical"},{"id":"736","span":{"begin":631,"end":634},"obj":"Chemical"},{"id":"737","span":{"begin":649,"end":655},"obj":"Chemical"},{"id":"738","span":{"begin":829,"end":840},"obj":"Chemical"},{"id":"739","span":{"begin":802,"end":806},"obj":"Disease"}],"attributes":[{"id":"A727","pred":"tao:has_database_id","subj":"727","obj":"MESH:C032159"},{"id":"A735","pred":"tao:has_database_id","subj":"735","obj":"MESH:D003903"},{"id":"A736","pred":"tao:has_database_id","subj":"736","obj":"MESH:C000615229"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Following method C with 20 (117 mg, 0.14 mmol, 1.00 eq) and a 0–25% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 1 (60 mg, 76%) was obtained as a white powder with 99% purity determined by HPLC analysis at 260 nm. 1H NMR (600 MHz, DMSO‑d 6) δ 8.38 (s, 1H), 8.34 (s, 1H), 8.15 (s, 1H), 8.14 (s, 1H), 7.36 (br.s, 2H), 7.29 (br. s, 2H), 5.97 (d, J = 6.4 Hz, 1H), 5.85 (d, J = 5.9 Hz, 1H), 5.58–4.98 (m, 4H), 4.70–4.63 (m, 1H), 4.52 (dd, J = 6.4 Hz, J = 4.7 Hz, 1H), 4.33 (dd, J = 4.7 Hz, J = 2.6 Hz, 1H), 4.12 (dd, J = 5.2 Hz, J = 3.8 Hz, 1H), 4.02–3.93 (m, 2H), 3.70–3.48 (m, 4H), 2.86–2.58 (m, 4H). 13C NMR (150 MHz, DMSO‑d 6) δ 156.2, 156.1, 152.6, 152.5, 149.4, 149.0, 140.1, 139.9, 119.4, 119.3, 87.6, 86.3 (2C), 83.7, 81.5, 72.8, 71.5, 69.5, 69.1, 61.7, 51.2, 49.0. HRMS (ESI+): m/z calcd for C22H30N11O7 [M+H]+: 560.23242, found: 560.23188."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T297","span":{"begin":60,"end":61},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T298","span":{"begin":177,"end":178},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T299","span":{"begin":842,"end":845},"obj":"http://purl.obolibrary.org/obo/CLO_0007706"}],"text":"Following method C with 20 (117 mg, 0.14 mmol, 1.00 eq) and a 0–25% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 1 (60 mg, 76%) was obtained as a white powder with 99% purity determined by HPLC analysis at 260 nm. 1H NMR (600 MHz, DMSO‑d 6) δ 8.38 (s, 1H), 8.34 (s, 1H), 8.15 (s, 1H), 8.14 (s, 1H), 7.36 (br.s, 2H), 7.29 (br. s, 2H), 5.97 (d, J = 6.4 Hz, 1H), 5.85 (d, J = 5.9 Hz, 1H), 5.58–4.98 (m, 4H), 4.70–4.63 (m, 1H), 4.52 (dd, J = 6.4 Hz, J = 4.7 Hz, 1H), 4.33 (dd, J = 4.7 Hz, J = 2.6 Hz, 1H), 4.12 (dd, J = 5.2 Hz, J = 3.8 Hz, 1H), 4.02–3.93 (m, 2H), 3.70–3.48 (m, 4H), 2.86–2.58 (m, 4H). 13C NMR (150 MHz, DMSO‑d 6) δ 156.2, 156.1, 152.6, 152.5, 149.4, 149.0, 140.1, 139.9, 119.4, 119.3, 87.6, 86.3 (2C), 83.7, 81.5, 72.8, 71.5, 69.5, 69.1, 61.7, 51.2, 49.0. HRMS (ESI+): m/z calcd for C22H30N11O7 [M+H]+: 560.23242, found: 560.23188."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T730","span":{"begin":87,"end":99},"obj":"Chemical"},{"id":"T731","span":{"begin":109,"end":115},"obj":"Chemical"},{"id":"T732","span":{"begin":247,"end":249},"obj":"Chemical"},{"id":"T733","span":{"begin":264,"end":268},"obj":"Chemical"},{"id":"T734","span":{"begin":285,"end":287},"obj":"Chemical"},{"id":"T735","span":{"begin":299,"end":301},"obj":"Chemical"},{"id":"T736","span":{"begin":313,"end":315},"obj":"Chemical"},{"id":"T737","span":{"begin":327,"end":329},"obj":"Chemical"},{"id":"T738","span":{"begin":388,"end":390},"obj":"Chemical"},{"id":"T739","span":{"begin":414,"end":416},"obj":"Chemical"},{"id":"T740","span":{"begin":452,"end":454},"obj":"Chemical"},{"id":"T741","span":{"begin":491,"end":493},"obj":"Chemical"},{"id":"T742","span":{"begin":530,"end":532},"obj":"Chemical"},{"id":"T743","span":{"begin":569,"end":571},"obj":"Chemical"},{"id":"T744","span":{"begin":649,"end":653},"obj":"Chemical"}],"attributes":[{"id":"A730","pred":"chebi_id","subj":"T730","obj":"http://purl.obolibrary.org/obo/CHEBI_38472"},{"id":"A731","pred":"chebi_id","subj":"T731","obj":"http://purl.obolibrary.org/obo/CHEBI_35225"},{"id":"A732","pred":"chebi_id","subj":"T732","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A733","pred":"chebi_id","subj":"T733","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"},{"id":"A734","pred":"chebi_id","subj":"T734","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A735","pred":"chebi_id","subj":"T735","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A736","pred":"chebi_id","subj":"T736","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A737","pred":"chebi_id","subj":"T737","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A738","pred":"chebi_id","subj":"T738","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A739","pred":"chebi_id","subj":"T739","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A740","pred":"chebi_id","subj":"T740","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A741","pred":"chebi_id","subj":"T741","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A742","pred":"chebi_id","subj":"T742","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A743","pred":"chebi_id","subj":"T743","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A744","pred":"chebi_id","subj":"T744","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"}],"text":"Following method C with 20 (117 mg, 0.14 mmol, 1.00 eq) and a 0–25% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 1 (60 mg, 76%) was obtained as a white powder with 99% purity determined by HPLC analysis at 260 nm. 1H NMR (600 MHz, DMSO‑d 6) δ 8.38 (s, 1H), 8.34 (s, 1H), 8.15 (s, 1H), 8.14 (s, 1H), 7.36 (br.s, 2H), 7.29 (br. s, 2H), 5.97 (d, J = 6.4 Hz, 1H), 5.85 (d, J = 5.9 Hz, 1H), 5.58–4.98 (m, 4H), 4.70–4.63 (m, 1H), 4.52 (dd, J = 6.4 Hz, J = 4.7 Hz, 1H), 4.33 (dd, J = 4.7 Hz, J = 2.6 Hz, 1H), 4.12 (dd, J = 5.2 Hz, J = 3.8 Hz, 1H), 4.02–3.93 (m, 2H), 3.70–3.48 (m, 4H), 2.86–2.58 (m, 4H). 13C NMR (150 MHz, DMSO‑d 6) δ 156.2, 156.1, 152.6, 152.5, 149.4, 149.0, 140.1, 139.9, 119.4, 119.3, 87.6, 86.3 (2C), 83.7, 81.5, 72.8, 71.5, 69.5, 69.1, 61.7, 51.2, 49.0. HRMS (ESI+): m/z calcd for C22H30N11O7 [M+H]+: 560.23242, found: 560.23188."}

{"project":"LitCovid-sentences","denotations":[{"id":"T305","span":{"begin":0,"end":246},"obj":"Sentence"},{"id":"T306","span":{"begin":247,"end":630},"obj":"Sentence"},{"id":"T307","span":{"begin":631,"end":801},"obj":"Sentence"},{"id":"T308","span":{"begin":802,"end":848},"obj":"Sentence"},{"id":"T309","span":{"begin":849,"end":866},"obj":"Sentence"},{"id":"T310","span":{"begin":867,"end":877},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Following method C with 20 (117 mg, 0.14 mmol, 1.00 eq) and a 0–25% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 1 (60 mg, 76%) was obtained as a white powder with 99% purity determined by HPLC analysis at 260 nm. 1H NMR (600 MHz, DMSO‑d 6) δ 8.38 (s, 1H), 8.34 (s, 1H), 8.15 (s, 1H), 8.14 (s, 1H), 7.36 (br.s, 2H), 7.29 (br. s, 2H), 5.97 (d, J = 6.4 Hz, 1H), 5.85 (d, J = 5.9 Hz, 1H), 5.58–4.98 (m, 4H), 4.70–4.63 (m, 1H), 4.52 (dd, J = 6.4 Hz, J = 4.7 Hz, 1H), 4.33 (dd, J = 4.7 Hz, J = 2.6 Hz, 1H), 4.12 (dd, J = 5.2 Hz, J = 3.8 Hz, 1H), 4.02–3.93 (m, 2H), 3.70–3.48 (m, 4H), 2.86–2.58 (m, 4H). 13C NMR (150 MHz, DMSO‑d 6) δ 156.2, 156.1, 152.6, 152.5, 149.4, 149.0, 140.1, 139.9, 119.4, 119.3, 87.6, 86.3 (2C), 83.7, 81.5, 72.8, 71.5, 69.5, 69.1, 61.7, 51.2, 49.0. HRMS (ESI+): m/z calcd for C22H30N11O7 [M+H]+: 560.23242, found: 560.23188."}