PMC:7291971 / 38788-39329 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T796","span":{"begin":53,"end":55},"obj":"CHEBI:30756;CHEBI:30756"},{"id":"T797","span":{"begin":56,"end":66},"obj":"CHEBI:30756;CHEBI:30756"},{"id":"T798","span":{"begin":67,"end":91},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T799","span":{"begin":92,"end":94},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T800","span":{"begin":110,"end":112},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T801","span":{"begin":112,"end":118},"obj":"CHEBI:82321;CHEBI:82321"},{"id":"T802","span":{"begin":118,"end":124},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T803","span":{"begin":124,"end":130},"obj":"CHEBI:29309;CHEBI:29309"},{"id":"T804","span":{"begin":130,"end":131},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T805","span":{"begin":131,"end":136},"obj":"CHEBI:46882;CHEBI:46882"},{"id":"T806","span":{"begin":137,"end":143},"obj":"CHEBI:42241;CHEBI:42241"},{"id":"T807","span":{"begin":145,"end":173},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T808","span":{"begin":173,"end":176},"obj":"CHEBI:29354;CHEBI:29354"},{"id":"T809","span":{"begin":178,"end":179},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T810","span":{"begin":187,"end":188},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T811","span":{"begin":188,"end":206},"obj":"CHEBI:28714;CHEBI:28714"},{"id":"T812","span":{"begin":207,"end":210},"obj":"CHEBI:29354;CHEBI:29354"},{"id":"T813","span":{"begin":211,"end":217},"obj":"CHEBI:29309;CHEBI:29309"},{"id":"T814","span":{"begin":218,"end":224},"obj":"CHEBI:26911;CHEBI:26911"},{"id":"T815","span":{"begin":224,"end":225},"obj":"CHEBI:15533;CHEBI:15533"},{"id":"T816","span":{"begin":225,"end":230},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T817","span":{"begin":231,"end":233},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T818","span":{"begin":233,"end":239},"obj":"CHEBI:35589;CHEBI:35589"},{"id":"T819","span":{"begin":240,"end":241},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T820","span":{"begin":242,"end":247},"obj":"CHEBI:32952;CHEBI:32952"},{"id":"T821","span":{"begin":258,"end":266},"obj":"CHEBI:75958;CHEBI:75958"},{"id":"T822","span":{"begin":337,"end":342},"obj":"CHEBI:32031;CHEBI:32031"},{"id":"T823","span":{"begin":375,"end":385},"obj":"CHEBI:48498;CHEBI:48498"},{"id":"T824","span":{"begin":484,"end":491},"obj":"CHEBI:60004;CHEBI:60004"},{"id":"T37264","span":{"begin":53,"end":55},"obj":"CHEBI:30756;CHEBI:30756"},{"id":"T61516","span":{"begin":56,"end":66},"obj":"CHEBI:30756;CHEBI:30756"},{"id":"T43297","span":{"begin":67,"end":91},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T26849","span":{"begin":92,"end":94},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T6291","span":{"begin":110,"end":112},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T10899","span":{"begin":112,"end":118},"obj":"CHEBI:82321;CHEBI:82321"},{"id":"T30917","span":{"begin":118,"end":124},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T29054","span":{"begin":124,"end":130},"obj":"CHEBI:29309;CHEBI:29309"},{"id":"T91631","span":{"begin":130,"end":131},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T71293","span":{"begin":131,"end":136},"obj":"CHEBI:46882;CHEBI:46882"},{"id":"T48278","span":{"begin":137,"end":143},"obj":"CHEBI:42241;CHEBI:42241"},{"id":"T81026","span":{"begin":145,"end":173},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T93948","span":{"begin":173,"end":176},"obj":"CHEBI:29354;CHEBI:29354"},{"id":"T43751","span":{"begin":178,"end":179},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T98761","span":{"begin":187,"end":188},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T36094","span":{"begin":188,"end":206},"obj":"CHEBI:28714;CHEBI:28714"},{"id":"T18228","span":{"begin":207,"end":210},"obj":"CHEBI:29354;CHEBI:29354"},{"id":"T76224","span":{"begin":211,"end":217},"obj":"CHEBI:29309;CHEBI:29309"},{"id":"T41246","span":{"begin":218,"end":224},"obj":"CHEBI:26911;CHEBI:26911"},{"id":"T37085","span":{"begin":224,"end":225},"obj":"CHEBI:15533;CHEBI:15533"},{"id":"T61179","span":{"begin":225,"end":230},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T12065","span":{"begin":231,"end":233},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T53177","span":{"begin":233,"end":239},"obj":"CHEBI:35589;CHEBI:35589"},{"id":"T82206","span":{"begin":240,"end":241},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T57054","span":{"begin":242,"end":247},"obj":"CHEBI:32952;CHEBI:32952"},{"id":"T10400","span":{"begin":258,"end":266},"obj":"CHEBI:75958;CHEBI:75958"},{"id":"T2918","span":{"begin":337,"end":342},"obj":"CHEBI:32031;CHEBI:32031"},{"id":"T54095","span":{"begin":375,"end":385},"obj":"CHEBI:48498;CHEBI:48498"},{"id":"T6657","span":{"begin":484,"end":491},"obj":"CHEBI:60004;CHEBI:60004"}],"text":".4155.\n\n4.1.6 9-[(2R,5R)-3-[2-({[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}amino)ethoxy]-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-2-yl]-9H-purin-6-amine (20)\nTo a solution of 19 (210 mg, 0.20 mmol, 1.00 eq) in anhydrous DMF (10 mL) was added K2CO3 (85 mg, 0.61 mmol, 3.00 eq) and thiophenol (11 μL, 1.14 mmol, 5.70 eq). After stirring for 2 h at room temperature under argon, the reaction mixture was diluted with DCM (20 mL) and washed with 1 M "}

{"project":"LitCovid-PubTator","denotations":[{"id":"676","span":{"begin":315,"end":318},"obj":"Chemical"},{"id":"677","span":{"begin":337,"end":342},"obj":"Chemical"},{"id":"678","span":{"begin":375,"end":385},"obj":"Chemical"},{"id":"679","span":{"begin":464,"end":469},"obj":"Chemical"},{"id":"680","span":{"begin":509,"end":512},"obj":"Chemical"}],"attributes":[{"id":"A677","pred":"tao:has_database_id","subj":"677","obj":"MESH:C037593"},{"id":"A678","pred":"tao:has_database_id","subj":"678","obj":"MESH:C042983"},{"id":"A679","pred":"tao:has_database_id","subj":"679","obj":"MESH:D001128"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":".4155.\n\n4.1.6 9-[(2R,5R)-3-[2-({[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}amino)ethoxy]-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-2-yl]-9H-purin-6-amine (20)\nTo a solution of 19 (210 mg, 0.20 mmol, 1.00 eq) in anhydrous DMF (10 mL) was added K2CO3 (85 mg, 0.61 mmol, 3.00 eq) and thiophenol (11 μL, 1.14 mmol, 5.70 eq). After stirring for 2 h at room temperature under argon, the reaction mixture was diluted with DCM (20 mL) and washed with 1 M "}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T286","span":{"begin":256,"end":257},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T287","span":{"begin":387,"end":389},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"}],"text":".4155.\n\n4.1.6 9-[(2R,5R)-3-[2-({[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}amino)ethoxy]-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-2-yl]-9H-purin-6-amine (20)\nTo a solution of 19 (210 mg, 0.20 mmol, 1.00 eq) in anhydrous DMF (10 mL) was added K2CO3 (85 mg, 0.61 mmol, 3.00 eq) and thiophenol (11 μL, 1.14 mmol, 5.70 eq). After stirring for 2 h at room temperature under argon, the reaction mixture was diluted with DCM (20 mL) and washed with 1 M "}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T659","span":{"begin":45,"end":66},"obj":"Chemical"},{"id":"T660","span":{"begin":47,"end":52},"obj":"Chemical"},{"id":"T661","span":{"begin":72,"end":80},"obj":"Chemical"},{"id":"T663","span":{"begin":124,"end":130},"obj":"Chemical"},{"id":"T665","span":{"begin":131,"end":136},"obj":"Chemical"},{"id":"T666","span":{"begin":137,"end":143},"obj":"Chemical"},{"id":"T667","span":{"begin":173,"end":176},"obj":"Chemical"},{"id":"T668","span":{"begin":207,"end":210},"obj":"Chemical"},{"id":"T669","span":{"begin":211,"end":217},"obj":"Chemical"},{"id":"T671","span":{"begin":231,"end":247},"obj":"Chemical"},{"id":"T672","span":{"begin":242,"end":247},"obj":"Chemical"},{"id":"T673","span":{"begin":258,"end":266},"obj":"Chemical"},{"id":"T674","span":{"begin":315,"end":318},"obj":"Chemical"},{"id":"T675","span":{"begin":337,"end":342},"obj":"Chemical"},{"id":"T676","span":{"begin":375,"end":385},"obj":"Chemical"},{"id":"T677","span":{"begin":464,"end":469},"obj":"Chemical"},{"id":"T678","span":{"begin":484,"end":491},"obj":"Chemical"},{"id":"T679","span":{"begin":509,"end":512},"obj":"Chemical"}],"attributes":[{"id":"A659","pred":"chebi_id","subj":"T659","obj":"http://purl.obolibrary.org/obo/CHEBI_30756"},{"id":"A660","pred":"chebi_id","subj":"T660","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A661","pred":"chebi_id","subj":"T661","obj":"http://purl.obolibrary.org/obo/CHEBI_33601"},{"id":"A662","pred":"chebi_id","subj":"T661","obj":"http://purl.obolibrary.org/obo/CHEBI_42266"},{"id":"A663","pred":"chebi_id","subj":"T663","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A664","pred":"chebi_id","subj":"T663","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A665","pred":"chebi_id","subj":"T665","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A666","pred":"chebi_id","subj":"T666","obj":"http://purl.obolibrary.org/obo/CHEBI_42241"},{"id":"A667","pred":"chebi_id","subj":"T667","obj":"http://purl.obolibrary.org/obo/CHEBI_29354"},{"id":"A668","pred":"chebi_id","subj":"T668","obj":"http://purl.obolibrary.org/obo/CHEBI_29354"},{"id":"A669","pred":"chebi_id","subj":"T669","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A670","pred":"chebi_id","subj":"T669","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A671","pred":"chebi_id","subj":"T671","obj":"http://purl.obolibrary.org/obo/CHEBI_16708"},{"id":"A672","pred":"chebi_id","subj":"T672","obj":"http://purl.obolibrary.org/obo/CHEBI_32952"},{"id":"A673","pred":"chebi_id","subj":"T673","obj":"http://purl.obolibrary.org/obo/CHEBI_75958"},{"id":"A674","pred":"chebi_id","subj":"T674","obj":"http://purl.obolibrary.org/obo/CHEBI_17741"},{"id":"A675","pred":"chebi_id","subj":"T675","obj":"http://purl.obolibrary.org/obo/CHEBI_131526"},{"id":"A676","pred":"chebi_id","subj":"T676","obj":"http://purl.obolibrary.org/obo/CHEBI_48498"},{"id":"A677","pred":"chebi_id","subj":"T677","obj":"http://purl.obolibrary.org/obo/CHEBI_49475"},{"id":"A678","pred":"chebi_id","subj":"T678","obj":"http://purl.obolibrary.org/obo/CHEBI_60004"},{"id":"A679","pred":"chebi_id","subj":"T679","obj":"http://purl.obolibrary.org/obo/CHEBI_15767"}],"text":".4155.\n\n4.1.6 9-[(2R,5R)-3-[2-({[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}amino)ethoxy]-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-2-yl]-9H-purin-6-amine (20)\nTo a solution of 19 (210 mg, 0.20 mmol, 1.00 eq) in anhydrous DMF (10 mL) was added K2CO3 (85 mg, 0.61 mmol, 3.00 eq) and thiophenol (11 μL, 1.14 mmol, 5.70 eq). After stirring for 2 h at room temperature under argon, the reaction mixture was diluted with DCM (20 mL) and washed with 1 M "}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T7","span":{"begin":509,"end":512},"obj":"Phenotype"}],"attributes":[{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0001644"}],"text":".4155.\n\n4.1.6 9-[(2R,5R)-3-[2-({[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}amino)ethoxy]-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-2-yl]-9H-purin-6-amine (20)\nTo a solution of 19 (210 mg, 0.20 mmol, 1.00 eq) in anhydrous DMF (10 mL) was added K2CO3 (85 mg, 0.61 mmol, 3.00 eq) and thiophenol (11 μL, 1.14 mmol, 5.70 eq). After stirring for 2 h at room temperature under argon, the reaction mixture was diluted with DCM (20 mL) and washed with 1 M "}

{"project":"LitCovid-sentences","denotations":[{"id":"T287","span":{"begin":8,"end":252},"obj":"Sentence"},{"id":"T288","span":{"begin":253,"end":414},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":".4155.\n\n4.1.6 9-[(2R,5R)-3-[2-({[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}amino)ethoxy]-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-2-yl]-9H-purin-6-amine (20)\nTo a solution of 19 (210 mg, 0.20 mmol, 1.00 eq) in anhydrous DMF (10 mL) was added K2CO3 (85 mg, 0.61 mmol, 3.00 eq) and thiophenol (11 μL, 1.14 mmol, 5.70 eq). After stirring for 2 h at room temperature under argon, the reaction mixture was diluted with DCM (20 mL) and washed with 1 M "}