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PMC:7291971 / 3525-5992 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T64 35-42 NCBITaxon:10239 denotes viruses
T65 112-118 SO:0001026 denotes genome
T66 124-127 GO:0008541 denotes cap
T67 152-162 NCBITaxon:2759 denotes eukaryotic
T68 163-172 CHEBI:33280;CHEBI:33280 denotes messenger
T69 288-298 GO:0006413 denotes initiation
T70 299-301 GO:0006270 denotes of
T71 350-353 GO:0008541 denotes cap
T72 404-419 GO:0045087 denotes cellular innate
T73 420-428 GO:0045087;UBERON:0002405 denotes immunity
T74 445-452 NCBITaxon:10239 denotes viruses
T75 461-473 NCBITaxon:31032 denotes flaviviruses
T76 478-491 NCBITaxon:11118 denotes coronaviruses
T77 539-549 NCBITaxon:2759;CL:0000255 denotes eukaryotic
T78 550-555 CL:0000255 denotes cells
T79 563-570 NCBITaxon:10239 denotes viruses
T80 689-692 GO:0008541 denotes cap
T81 736-739 GO:0008541 denotes cap
T82 1079-1084 PR:000002289 denotes cap-1
T83 1145-1150 NCBITaxon:10239 denotes viral
T84 1155-1158 GO:0008541 denotes cap
T85 1182-1187 NCBITaxon:10239 denotes viral
T86 1247-1252 NCBITaxon:10239 denotes viral
T87 1274-1279 NCBITaxon:10239 denotes virus
T88 1314-1320 UBERON:0002405;GO:0006955 denotes immune
T89 1321-1329 GO:0006955 denotes response
T90 1373-1378 NCBITaxon:10239 denotes viral
T91 1477-1482 NCBITaxon:10239 denotes viral
T92 1489-1499 CHEBI:35222;CHEBI:35222 denotes inhibitors
T93 1658-1659 CHEBI:53233;CHEBI:53233 denotes 5
T94 1659-1660 CHEBI:24195;CHEBI:24195 denotes ′
T95 1660-1661 CHEBI:53233;CHEBI:53233 denotes -
T96 1661-1680 CHEBI:16625;CHEBI:16625 denotes methylthioadenosine
T97 1690-1700 CHEBI:24195;CHEBI:24195 denotes S-adenosyl
T98 1701-1713 CHEBI:17230;CHEBI:17230 denotes homocysteine
T99 1736-1741 NCBITaxon:10239 denotes viral
T100 1923-1928 SP_6;NCBITaxon:9606 denotes human
T101 1942-1947 NCBITaxon:10239 denotes viral
T102 2035-2045 CHEBI:35222;CHEBI:35222 denotes inhibitors
T103 2050-2055 NCBITaxon:10239 denotes viral
T104 2252-2255 GO:0008541 denotes cap
T105 2309-2314 PR:000002289 denotes Cap-1
T106 2341-2350 CHEBI:36357;CHEBI:36357 denotes compounds
T107 2366-2370 GO:0006272 denotes ′-O-
T108 2419-2428 CHEBI:22260;CHEBI:22260 denotes adenosine
T109 2448-2457 CHEBI:22260;CHEBI:22260 denotes adenosine

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T12 31-34 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T13 112-118 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T14 163-176 Body_part denotes messenger RNA http://purl.org/sig/ont/fma/fma67122
T15 173-176 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T16 254-257 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T17 306-309 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T18 327-335 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T19 501-504 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T20 550-555 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T21 624-627 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T22 685-688 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T23 818-825 Body_part denotes guanine http://purl.org/sig/ont/fma/fma82775
T24 883-893 Body_part denotes methionine http://purl.org/sig/ont/fma/fma82759
T25 1052-1062 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T26 1066-1069 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T27 1151-1154 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T28 1253-1261 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T29 1948-1951 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T30 2296-2300 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T31 2315-2318 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T32 2413-2417 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
46 2419-2428 Chemical denotes adenosine MESH:D000241
47 2448-2457 Chemical denotes adenosine MESH:D000241
57 818-825 Chemical denotes guanine MESH:D006147
58 872-893 Chemical denotes S-adenosyl methionine MESH:D012436
59 895-898 Chemical denotes SAM MESH:D012436
60 1020-1026 Chemical denotes ribose MESH:D012266
61 1646-1656 Chemical denotes sinefungin MESH:C006235
62 1658-1680 Chemical denotes 5′-methylthioadenosine MESH:C008500
63 1682-1685 Chemical denotes MTA MESH:C008500
64 1690-1713 Chemical denotes S-adenosyl homocysteine MESH:D012435
65 1182-1197 Disease denotes viral infection MESH:D001102

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T17 1182-1197 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T18 1188-1197 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T19 35-42 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T20 122-123 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 152-162 http://purl.obolibrary.org/obo/NCBITaxon_2759 denotes eukaryotic
T22 357-358 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 445-452 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T24 539-549 http://purl.obolibrary.org/obo/NCBITaxon_2759 denotes eukaryotic
T25 550-555 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T26 563-570 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T27 579-580 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 601-611 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T29 622-623 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30 647-648 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 769-770 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32 829-830 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 912-913 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 942-943 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 984-987 http://purl.obolibrary.org/obo/CLO_0001562 denotes a 2
T36 984-987 http://purl.obolibrary.org/obo/CLO_0001563 denotes a 2
T37 1274-1279 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T38 1754-1755 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T39 1783-1784 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 1923-1931 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human or
T41 1971-1972 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T42 1993-2005 http://purl.obolibrary.org/obo/OBI_0000245 denotes organization
T43 2075-2076 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T32 163-176 Chemical denotes messenger RNA http://purl.obolibrary.org/obo/CHEBI_33699
T33 327-335 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T34 818-825 Chemical denotes guanine http://purl.obolibrary.org/obo/CHEBI_16235
T35 859-865 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T37 866-871 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T38 872-893 Chemical denotes S-adenosyl methionine http://purl.obolibrary.org/obo/CHEBI_15414
T39 874-882 Chemical denotes adenosyl http://purl.obolibrary.org/obo/CHEBI_33505
T40 883-893 Chemical denotes methionine http://purl.obolibrary.org/obo/CHEBI_16811|http://purl.obolibrary.org/obo/CHEBI_64558
T42 895-898 Chemical denotes SAM http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040
T44 1020-1026 Chemical denotes ribose http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013
T46 1052-1062 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T47 1253-1261 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T48 1446-1455 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T49 1489-1499 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T50 1536-1539 Chemical denotes SAM http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040
T52 1626-1629 Chemical denotes SAM http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040
T54 1646-1656 Chemical denotes sinefungin http://purl.obolibrary.org/obo/CHEBI_45453
T55 1682-1685 Chemical denotes MTA http://purl.obolibrary.org/obo/CHEBI_17509
T56 1692-1713 Chemical denotes adenosyl homocysteine http://purl.obolibrary.org/obo/CHEBI_16680
T57 1692-1700 Chemical denotes adenosyl http://purl.obolibrary.org/obo/CHEBI_33505
T58 1701-1713 Chemical denotes homocysteine http://purl.obolibrary.org/obo/CHEBI_17230
T59 1715-1718 Chemical denotes SAH http://purl.obolibrary.org/obo/CHEBI_16680
T60 1897-1900 Chemical denotes SAM http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040
T62 2035-2045 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T63 2107-2116 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T64 2269-2279 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T65 2419-2428 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T66 2443-2446 Chemical denotes SAM http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040
T68 2448-2457 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T5 310-321 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T6 413-428 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T7 501-512 http://purl.obolibrary.org/obo/GO_0036260 denotes RNA capping
T8 501-512 http://purl.obolibrary.org/obo/GO_0009452 denotes RNA capping
T9 777-788 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T10 952-963 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T11 1126-1137 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T12 1182-1197 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T13 1234-1243 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T14 1295-1329 http://purl.obolibrary.org/obo/GO_0050778 denotes stimulation of the immune response
T15 1314-1329 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T16 2233-2244 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T17 2370-2381 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation

2_test

Id Subject Object Predicate Lexical cue
32563813-28527860-29105567 722-723 28527860 denotes 8
32563813-27009949-29105568 1331-1332 27009949 denotes 9
32563813-24530452-29105569 1465-1467 24530452 denotes 10
32563813-28676301-29105570 1468-1470 28676301 denotes 11
32563813-26540123-29105571 1812-1814 26540123 denotes 12
32563813-23617634-29105572 2007-2009 23617634 denotes 13

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T28 0-177 Sentence denotes Most of single positive strand RNA viruses have evolved strategies in order to decorate the 5′ end of their own genome by a cap structure mimicking the eukaryotic messenger RNA.
T29 178-336 Sentence denotes This structure plays several key biological functions such as protection of RNA from 5′-exoribonucleoases and initiation of the RNA translation into proteins.
T30 337-439 Sentence denotes Moreover the cap is a marker of ‘self’ preventing detection by the cellular innate immunity mechanism.
T31 440-556 Sentence denotes Thus viruses such as flaviviruses and coronaviruses code for RNA capping pathway mimicking that of eukaryotic cells.
T32 557-725 Sentence denotes These viruses produce a subset of enzymatic activities including a RNA 5′-triphosphatase, a guanilyltransferase (GTase) and two RNA cap methyltransferases (MTases) [8].
T33 726-1108 Sentence denotes After the cap (GpppN) is set by the GTase, a first methylation occurs at N7 position of the guanine by a N7-MTase in the presence of methyl donor S-adenosyl methionine (SAM) yielding to a cap-0 (7mGpppN) followed by a further methylation that is achieved by a 2′-O-MTase at 2′- position of the ribose of the first transcribed nucleotide in RNA yielding cap-1 (7mGpppNm) (Scheme 1 ).
T34 1109-1334 Sentence denotes The N7- and 2′-O-methylation of the viral RNA cap are key events for the viral infection as their inhibition might limit the synthesis of viral proteins and support virus elimination by stimulation of the immune response [9].
T35 1335-1472 Sentence denotes Therefore it is now admitted that the viral MTases are considered as attractive targets for the development of antiviral therapy [10,11].
T36 1473-1618 Sentence denotes Few viral MTase inhibitors have been developed so far, however SAM-mimetics acting as competitors against the MTase co-substrate merit attention.
T37 1619-1816 Sentence denotes Indeed SAM analogs such as sinefungin, 5′-methylthioadenosine (MTA) or S-adenosyl homocysteine (SAH) inhibit most of viral MTases with a potent efficiency but with a total lack of specificity [12].
T38 1817-2011 Sentence denotes This is certainly due to the high conservation of the shape and location of the SAM binding pocket in the human or different viral RNA MTases which share a common Rossman fold organization [13].
T39 2012-2186 Sentence denotes The rarity of specific inhibitors for viral MTases constitutes a stimulating challenge for new antiviral therapy but also for functional studies of these fascinating enzymes.
T40 2187-2319 Sentence denotes Scheme 1 Schematic representation of the 2′-O-methylation of the cap structure at nucleoside N1 at 5′-end of mRNA to form Cap-1 RNA.
T41 2320-2467 Sentence denotes General structure of compounds mimicking the 2′-O-methylation transition state between N1 of mRNA (adenosine in green) and SAM (adenosine in blue).

MyTest

Id Subject Object Predicate Lexical cue
32563813-28527860-29105567 722-723 28527860 denotes 8
32563813-27009949-29105568 1331-1332 27009949 denotes 9
32563813-24530452-29105569 1465-1467 24530452 denotes 10
32563813-28676301-29105570 1468-1470 28676301 denotes 11
32563813-26540123-29105571 1812-1814 26540123 denotes 12
32563813-23617634-29105572 2007-2009 23617634 denotes 13