PMC:7291971 / 33313-33611 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T704","span":{"begin":68,"end":70},"obj":"CHEBI:86228;CHEBI:86228"},{"id":"T705","span":{"begin":70,"end":76},"obj":"CHEBI:47853;CHEBI:47853"},{"id":"T706","span":{"begin":76,"end":102},"obj":"CHEBI:86228;CHEBI:86228"},{"id":"T707","span":{"begin":139,"end":149},"obj":"CHEBI:28748;CHEBI:28748"},{"id":"T708","span":{"begin":179,"end":187},"obj":"SP_10"},{"id":"T61222","span":{"begin":68,"end":70},"obj":"CHEBI:86228;CHEBI:86228"},{"id":"T60782","span":{"begin":70,"end":76},"obj":"CHEBI:47853;CHEBI:47853"},{"id":"T84456","span":{"begin":76,"end":102},"obj":"CHEBI:86228;CHEBI:86228"},{"id":"T6725","span":{"begin":139,"end":149},"obj":"CHEBI:28748;CHEBI:28748"},{"id":"T96719","span":{"begin":179,"end":187},"obj":"SP_10"}],"text":"Nevertheless, our work did identify one dinucleoside (13) bearing a 4-chloro-3-nitrobenzenesulfonamide moiety in the N-linker between both adenosines, that blocks the activity of SARS-CoV nsp14 at the submicromolar concentration in the same range than sinefungin but with a significant specificity."}

{"project":"LitCovid-PubTator","denotations":[{"id":"548","span":{"begin":40,"end":52},"obj":"Chemical"},{"id":"549","span":{"begin":68,"end":102},"obj":"Chemical"},{"id":"550","span":{"begin":139,"end":149},"obj":"Chemical"},{"id":"551","span":{"begin":252,"end":262},"obj":"Chemical"}],"attributes":[{"id":"A550","pred":"tao:has_database_id","subj":"550","obj":"MESH:D000241"},{"id":"A551","pred":"tao:has_database_id","subj":"551","obj":"MESH:C006235"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Nevertheless, our work did identify one dinucleoside (13) bearing a 4-chloro-3-nitrobenzenesulfonamide moiety in the N-linker between both adenosines, that blocks the activity of SARS-CoV nsp14 at the submicromolar concentration in the same range than sinefungin but with a significant specificity."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T92","span":{"begin":179,"end":187},"obj":"Disease"}],"attributes":[{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Nevertheless, our work did identify one dinucleoside (13) bearing a 4-chloro-3-nitrobenzenesulfonamide moiety in the N-linker between both adenosines, that blocks the activity of SARS-CoV nsp14 at the submicromolar concentration in the same range than sinefungin but with a significant specificity."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T250","span":{"begin":66,"end":67},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T251","span":{"begin":167,"end":175},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T252","span":{"begin":272,"end":273},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Nevertheless, our work did identify one dinucleoside (13) bearing a 4-chloro-3-nitrobenzenesulfonamide moiety in the N-linker between both adenosines, that blocks the activity of SARS-CoV nsp14 at the submicromolar concentration in the same range than sinefungin but with a significant specificity."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T557","span":{"begin":70,"end":76},"obj":"Chemical"},{"id":"T558","span":{"begin":139,"end":149},"obj":"Chemical"},{"id":"T559","span":{"begin":252,"end":262},"obj":"Chemical"}],"attributes":[{"id":"A557","pred":"chebi_id","subj":"T557","obj":"http://purl.obolibrary.org/obo/CHEBI_47853"},{"id":"A558","pred":"chebi_id","subj":"T558","obj":"http://purl.obolibrary.org/obo/CHEBI_22260"},{"id":"A559","pred":"chebi_id","subj":"T559","obj":"http://purl.obolibrary.org/obo/CHEBI_45453"}],"text":"Nevertheless, our work did identify one dinucleoside (13) bearing a 4-chloro-3-nitrobenzenesulfonamide moiety in the N-linker between both adenosines, that blocks the activity of SARS-CoV nsp14 at the submicromolar concentration in the same range than sinefungin but with a significant specificity."}

{"project":"LitCovid-sentences","denotations":[{"id":"T239","span":{"begin":0,"end":298},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Nevertheless, our work did identify one dinucleoside (13) bearing a 4-chloro-3-nitrobenzenesulfonamide moiety in the N-linker between both adenosines, that blocks the activity of SARS-CoV nsp14 at the submicromolar concentration in the same range than sinefungin but with a significant specificity."}