PMC:7291971 / 31721-32284 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T671","span":{"begin":53,"end":61},"obj":"SP_10"},{"id":"T672","span":{"begin":126,"end":149},"obj":"CHEBI:53325;CHEBI:53325"},{"id":"T673","span":{"begin":197,"end":206},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T674","span":{"begin":214,"end":227},"obj":"CHEBI:23447;CHEBI:23447"},{"id":"T675","span":{"begin":243,"end":251},"obj":"CHEBI:16240;CHEBI:16240"},{"id":"T679","span":{"begin":53,"end":61},"obj":"SP_10"},{"id":"T680","span":{"begin":126,"end":149},"obj":"CHEBI:53325;CHEBI:53325"},{"id":"T681","span":{"begin":197,"end":206},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T682","span":{"begin":214,"end":227},"obj":"CHEBI:23447;CHEBI:23447"},{"id":"T683","span":{"begin":243,"end":251},"obj":"CHEBI:16240;CHEBI:16240"}],"text":"Fig. 4 Modeling results in the SAM binding pocket of SARS-CoV nsp14 (PDB ID: 5C8T, resolution 3.2 Å). (A) Contribution of the nitrobenzenesulfonamide core of 13. (B) Contribution of the 2′O linked adenosine of all dinucleosides, including 13. Hydrogen bonds (yellow), halogen bond (green) and π-π stacking interaction (cyan) are represented. (Atoms not involved in protein-ligand interaction are not represented for clarity purpose). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T94","span":{"begin":365,"end":372},"obj":"Body_part"}],"attributes":[{"id":"A94","pred":"fma_id","subj":"T94","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Fig. 4 Modeling results in the SAM binding pocket of SARS-CoV nsp14 (PDB ID: 5C8T, resolution 3.2 Å). (A) Contribution of the nitrobenzenesulfonamide core of 13. (B) Contribution of the 2′O linked adenosine of all dinucleosides, including 13. Hydrogen bonds (yellow), halogen bond (green) and π-π stacking interaction (cyan) are represented. (Atoms not involved in protein-ligand interaction are not represented for clarity purpose). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)"}

{"project":"LitCovid-PubTator","denotations":[{"id":"468","span":{"begin":126,"end":149},"obj":"Chemical"},{"id":"469","span":{"begin":197,"end":206},"obj":"Chemical"},{"id":"470","span":{"begin":214,"end":227},"obj":"Chemical"},{"id":"471","span":{"begin":243,"end":251},"obj":"Chemical"}],"attributes":[{"id":"A469","pred":"tao:has_database_id","subj":"469","obj":"MESH:D000241"},{"id":"A471","pred":"tao:has_database_id","subj":"471","obj":"MESH:D006859"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Fig. 4 Modeling results in the SAM binding pocket of SARS-CoV nsp14 (PDB ID: 5C8T, resolution 3.2 Å). (A) Contribution of the nitrobenzenesulfonamide core of 13. (B) Contribution of the 2′O linked adenosine of all dinucleosides, including 13. Hydrogen bonds (yellow), halogen bond (green) and π-π stacking interaction (cyan) are represented. (Atoms not involved in protein-ligand interaction are not represented for clarity purpose). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T90","span":{"begin":53,"end":61},"obj":"Disease"}],"attributes":[{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Fig. 4 Modeling results in the SAM binding pocket of SARS-CoV nsp14 (PDB ID: 5C8T, resolution 3.2 Å). (A) Contribution of the nitrobenzenesulfonamide core of 13. (B) Contribution of the 2′O linked adenosine of all dinucleosides, including 13. Hydrogen bonds (yellow), halogen bond (green) and π-π stacking interaction (cyan) are represented. (Atoms not involved in protein-ligand interaction are not represented for clarity purpose). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T245","span":{"begin":98,"end":104},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T246","span":{"begin":163,"end":164},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"text":"Fig. 4 Modeling results in the SAM binding pocket of SARS-CoV nsp14 (PDB ID: 5C8T, resolution 3.2 Å). (A) Contribution of the nitrobenzenesulfonamide core of 13. (B) Contribution of the 2′O linked adenosine of all dinucleosides, including 13. Hydrogen bonds (yellow), halogen bond (green) and π-π stacking interaction (cyan) are represented. (Atoms not involved in protein-ligand interaction are not represented for clarity purpose). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T532","span":{"begin":31,"end":34},"obj":"Chemical"},{"id":"T534","span":{"begin":73,"end":75},"obj":"Chemical"},{"id":"T535","span":{"begin":197,"end":206},"obj":"Chemical"},{"id":"T536","span":{"begin":243,"end":251},"obj":"Chemical"},{"id":"T537","span":{"begin":268,"end":275},"obj":"Chemical"},{"id":"T538","span":{"begin":365,"end":372},"obj":"Chemical"},{"id":"T539","span":{"begin":373,"end":379},"obj":"Chemical"}],"attributes":[{"id":"A532","pred":"chebi_id","subj":"T532","obj":"http://purl.obolibrary.org/obo/CHEBI_15414"},{"id":"A533","pred":"chebi_id","subj":"T532","obj":"http://purl.obolibrary.org/obo/CHEBI_67040"},{"id":"A534","pred":"chebi_id","subj":"T534","obj":"http://purl.obolibrary.org/obo/CHEBI_141439"},{"id":"A535","pred":"chebi_id","subj":"T535","obj":"http://purl.obolibrary.org/obo/CHEBI_16335"},{"id":"A536","pred":"chebi_id","subj":"T536","obj":"http://purl.obolibrary.org/obo/CHEBI_18276"},{"id":"A537","pred":"chebi_id","subj":"T537","obj":"http://purl.obolibrary.org/obo/CHEBI_24473"},{"id":"A538","pred":"chebi_id","subj":"T538","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A539","pred":"chebi_id","subj":"T539","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"}],"text":"Fig. 4 Modeling results in the SAM binding pocket of SARS-CoV nsp14 (PDB ID: 5C8T, resolution 3.2 Å). (A) Contribution of the nitrobenzenesulfonamide core of 13. (B) Contribution of the 2′O linked adenosine of all dinucleosides, including 13. Hydrogen bonds (yellow), halogen bond (green) and π-π stacking interaction (cyan) are represented. (Atoms not involved in protein-ligand interaction are not represented for clarity purpose). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)"}

{"project":"LitCovid-sentences","denotations":[{"id":"T229","span":{"begin":0,"end":76},"obj":"Sentence"},{"id":"T230","span":{"begin":77,"end":242},"obj":"Sentence"},{"id":"T231","span":{"begin":243,"end":563},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Fig. 4 Modeling results in the SAM binding pocket of SARS-CoV nsp14 (PDB ID: 5C8T, resolution 3.2 Å). (A) Contribution of the nitrobenzenesulfonamide core of 13. (B) Contribution of the 2′O linked adenosine of all dinucleosides, including 13. Hydrogen bonds (yellow), halogen bond (green) and π-π stacking interaction (cyan) are represented. (Atoms not involved in protein-ligand interaction are not represented for clarity purpose). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)"}