PMC:7291971 / 30715-31296 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7291971","sourcedb":"PMC","sourceid":"7291971","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7291971","text":"he sulfone. Finally, the common element of all dinucleosides is an adenosine linked to a N-adenosine by the 2′O position. Its contribution is well defined by the formation of intermolecular hydrogen bonds between the adenosine and Gly333 (3′OH), Ile338 (5′OH), Lys336 (N7) and His424 (N1) residues (Fig. 4). All the major interactions maintain 13 in a suitable orientation in the binding site in place of the natural substrate GpppA-RNA. The docking model of 13 is consistent with our inhibition experimental data and high thermal stability of SARS-CoV nsp14 in the presence of the","tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T661","span":{"begin":3,"end":10},"obj":"CHEBI:33543;CHEBI:33543"},{"id":"T662","span":{"begin":67,"end":76},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T663","span":{"begin":217,"end":226},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T664","span":{"begin":380,"end":392},"obj":"SO:0000409"},{"id":"T665","span":{"begin":544,"end":552},"obj":"SP_10"},{"id":"T666","span":{"begin":553,"end":558},"obj":"PR:000000125"},{"id":"T63105","span":{"begin":81,"end":89},"obj":"SP_10"},{"id":"T65347","span":{"begin":154,"end":177},"obj":"CHEBI:53325;CHEBI:53325"},{"id":"T36376","span":{"begin":225,"end":234},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T55564","span":{"begin":242,"end":254},"obj":"CHEBI:23447;CHEBI:23447"},{"id":"T92854","span":{"begin":270,"end":278},"obj":"CHEBI:16240;CHEBI:16240"}],"attributes":[{"subj":"T661","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T662","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T663","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T664","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T665","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T666","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T63105","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65347","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T36376","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T55564","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T92854","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T92","span":{"begin":433,"end":436},"obj":"Body_part"}],"attributes":[{"id":"A92","pred":"fma_id","subj":"T92","obj":"http://purl.org/sig/ont/fma/fma67095"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"531","span":{"begin":3,"end":10},"obj":"Chemical"},{"id":"532","span":{"begin":67,"end":76},"obj":"Chemical"},{"id":"533","span":{"begin":91,"end":100},"obj":"Chemical"},{"id":"534","span":{"begin":217,"end":226},"obj":"Chemical"}],"attributes":[{"id":"A531","pred":"tao:has_database_id","subj":"531","obj":"MESH:D013450"},{"id":"A532","pred":"tao:has_database_id","subj":"532","obj":"MESH:D000241"},{"id":"A533","pred":"tao:has_database_id","subj":"533","obj":"MESH:D000241"},{"id":"A534","pred":"tao:has_database_id","subj":"534","obj":"MESH:D000241"},{"subj":"531","pred":"source","obj":"LitCovid-PubTator"},{"subj":"532","pred":"source","obj":"LitCovid-PubTator"},{"subj":"533","pred":"source","obj":"LitCovid-PubTator"},{"subj":"534","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T88","span":{"begin":544,"end":552},"obj":"Disease"}],"attributes":[{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T241","span":{"begin":87,"end":88},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T242","span":{"begin":350,"end":351},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T241","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T242","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T520","span":{"begin":3,"end":10},"obj":"Chemical"},{"id":"T521","span":{"begin":67,"end":76},"obj":"Chemical"},{"id":"T522","span":{"begin":91,"end":100},"obj":"Chemical"},{"id":"T523","span":{"begin":190,"end":198},"obj":"Chemical"},{"id":"T524","span":{"begin":217,"end":226},"obj":"Chemical"}],"attributes":[{"id":"A520","pred":"chebi_id","subj":"T520","obj":"http://purl.obolibrary.org/obo/CHEBI_35850"},{"id":"A521","pred":"chebi_id","subj":"T521","obj":"http://purl.obolibrary.org/obo/CHEBI_16335"},{"id":"A522","pred":"chebi_id","subj":"T522","obj":"http://purl.obolibrary.org/obo/CHEBI_16335"},{"id":"A523","pred":"chebi_id","subj":"T523","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A524","pred":"chebi_id","subj":"T524","obj":"http://purl.obolibrary.org/obo/CHEBI_16335"},{"subj":"T520","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T521","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T522","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T523","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T524","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T42","span":{"begin":162,"end":171},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"attributes":[{"subj":"T42","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T221","span":{"begin":12,"end":121},"obj":"Sentence"},{"id":"T222","span":{"begin":122,"end":307},"obj":"Sentence"},{"id":"T223","span":{"begin":308,"end":437},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T221","pred":"source","obj":"LitCovid-sentences"},{"subj":"T222","pred":"source","obj":"LitCovid-sentences"},{"subj":"T223","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#a493ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#9cec93"},{"id":"LitCovid-PubTator","color":"#ec93b6"},{"id":"LitCovid-PD-MONDO","color":"#93d0ec"},{"id":"LitCovid-PD-CLO","color":"#eaec93"},{"id":"LitCovid-PD-CHEBI","color":"#d493ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ecba"},{"id":"LitCovid-sentences","color":"#eca093"}]}]}}