PMC:7291971 / 28114-32284
Annnotations
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T621 | 43-48 | PR:000000125 | denotes | nsp14 |
| T622 | 67-80 | CHEBI:23447;CHEBI:23447 | denotes | dinucleosides |
| T623 | 137-146 | CHEBI:35222;CHEBI:35222 | denotes | inhibitor |
| T624 | 200-208 | SP_10 | denotes | SARS-CoV |
| T625 | 209-214 | PR:000000125 | denotes | nsp14 |
| T626 | 215-220 | PR:000000125 | denotes | nsp10 |
| T627 | 221-228 | GO:0032991 | denotes | complex |
| T628 | 271-279 | SP_10 | denotes | SARS-CoV |
| T629 | 280-285 | PR:000000125 | denotes | nsp14 |
| T630 | 363-369 | SO:0000417 | denotes | domain |
| T631 | 466-472 | SO:0000417 | denotes | domain |
| T632 | 504-510 | SO:0000417 | denotes | domain |
| T633 | 726-734 | SP_10 | denotes | SARS-CoV |
| T634 | 829-838 | CHEBI:37886;CHEBI:37886 | denotes | adenosine |
| T635 | 854-863 | CHEBI:28748;CHEBI:28748 | denotes | adenosine |
| T636 | 960-983 | CHEBI:53325;CHEBI:53325 | denotes | nitrobenzenesulfonamide |
| T637 | 1008-1016 | SP_10 | denotes | SARS-CoV |
| T638 | 1034-1046 | SO:0000409 | denotes | binding site |
| T639 | 1163-1174 | CHEBI:50325;CHEBI:50325 | denotes | side chains |
| T640 | 1234-1237 | GO:0008541 | denotes | cap |
| T641 | 1257-1260 | GO:0008541 | denotes | cap |
| T642 | 1261-1273 | SO:0000409 | denotes | binding site |
| T643 | 1460-1483 | CHEBI:53325;CHEBI:53325 | denotes | nitrobenzenesulfonamide |
| T644 | 1603-1620 | CHEBI:8102;CHEBI:8102 | denotes | phenylsulfonamide |
| T645 | 1657-1669 | SO:0000409 | denotes | binding site |
| T646 | 1742-1748 | CHEBI:30396;CHEBI:30396 | denotes | phenyl |
| T647 | 1760-1769 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
| T648 | 1779-1788 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
| T649 | 1981-2004 | CHEBI:53325;CHEBI:53325 | denotes | nitrobenzenesulfonamide |
| T650 | 2021-2029 | CHEBI:33910;CHEBI:33910 | denotes | chlorine |
| T651 | 2030-2034 | CHEBI:33250;CHEBI:33250 | denotes | atom |
| T652 | 2043-2050 | CHEBI:24473;CHEBI:24473 | denotes | halogen |
| T653 | 2051-2055 | CHEBI:29826;CHEBI:29826 | denotes | bond |
| T654 | 2161-2172 | CHEBI:29785;CHEBI:29785 | denotes | nitro group |
| T655 | 2224-2239 | CHEBI:32958;CHEBI:32958 | denotes | phosphate group |
| T656 | 2272-2275 | GO:0008541 | denotes | cap |
| T657 | 2322-2329 | CHEBI:33543;CHEBI:33543 | denotes | sulfone |
| T658 | 2330-2335 | CHEBI:24433;CHEBI:24433 | denotes | group |
| T659 | 2537-2546 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
| T660 | 2573-2588 | CHEBI:50728;CHEBI:50728 | denotes | methylene group |
| T661 | 2604-2611 | CHEBI:33543;CHEBI:33543 | denotes | sulfone |
| T662 | 2668-2677 | CHEBI:22260;CHEBI:22260 | denotes | adenosine |
| T663 | 2818-2827 | CHEBI:22260;CHEBI:22260 | denotes | adenosine |
| T664 | 2981-2993 | SO:0000409 | denotes | binding site |
| T665 | 3145-3153 | SP_10 | denotes | SARS-CoV |
| T666 | 3154-3159 | PR:000000125 | denotes | nsp14 |
| T667 | 3185-3194 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
| T668 | 3249-3257 | SP_10 | denotes | SARS-CoV |
| T669 | 3343-3351 | CHEBI:16240;CHEBI:16240 | denotes | Hydrogen |
| T670 | 3356-3363 | CHEBI:30563;CHEBI:30563 | denotes | halogen |
| T671 | 3660-3668 | SP_10 | denotes | SARS-CoV |
| T672 | 3733-3756 | CHEBI:53325;CHEBI:53325 | denotes | nitrobenzenesulfonamide |
| T673 | 3804-3813 | CHEBI:22260;CHEBI:22260 | denotes | adenosine |
| T674 | 3821-3834 | CHEBI:23447;CHEBI:23447 | denotes | dinucleosides |
| T675 | 3850-3858 | CHEBI:16240;CHEBI:16240 | denotes | Hydrogen |
| T92636 | 25-33 | SP_10 | denotes | bases of |
| T13128 | 51-63 | SO:0000409 | denotes | hibition by |
| T59040 | 181-192 | CHEBI:50325;CHEBI:50325 | denotes | g was based |
| T77249 | 251-254 | GO:0008541 | denotes | ese |
| T32020 | 274-277 | GO:0008541 | denotes | S-C |
| T86739 | 278-290 | SO:0000409 | denotes | V nsp14 is a |
| T64964 | 478-501 | CHEBI:53325;CHEBI:53325 | denotes | roofreading. The N7-MTa |
| T31763 | 622-639 | CHEBI:8102;CHEBI:8102 | denotes | stricted pocket t |
| T69050 | 678-690 | SO:0000409 | denotes | 13 was model |
| T17926 | 763-769 | CHEBI:30396;CHEBI:30396 | denotes | T [35] |
| T63901 | 781-790 | CHEBI:36357;CHEBI:36357 | denotes | NFY [36]) |
| T43396 | 800-809 | CHEBI:36357;CHEBI:36357 | denotes | sight, t |
| T13822 | 1001-1024 | CHEBI:53325;CHEBI:53325 | denotes | into a SARS-CoV nsp14 w |
| T64700 | 1041-1049 | CHEBI:33910;CHEBI:33910 | denotes | site fo |
| T43485 | 1050-1054 | CHEBI:33250;CHEBI:33250 | denotes | med |
| T54022 | 1063-1070 | CHEBI:24473;CHEBI:24473 | denotes | , Phe40 |
| T87115 | 1071-1075 | CHEBI:29826;CHEBI:29826 | denotes | , Ty |
| T54439 | 1181-1192 | CHEBI:29785;CHEBI:29785 | denotes | se amino ac |
| T79740 | 1245-1260 | CHEBI:32958;CHEBI:32958 | denotes | re. In this cap |
| T7539 | 1293-1296 | GO:0008541 | denotes | o h |
| T99491 | 1343-1350 | CHEBI:33543;CHEBI:33543 | denotes | ity, an |
| T98599 | 1351-1356 | CHEBI:24433;CHEBI:24433 | denotes | F426 |
| T48190 | 1558-1567 | CHEBI:36357;CHEBI:36357 | denotes | e other h |
| T94528 | 1594-1609 | CHEBI:50728;CHEBI:50728 | denotes | ween the phenyl |
| T4393 | 1625-1632 | CHEBI:33543;CHEBI:33543 | denotes | ty and |
| T43807 | 1688-1697 | CHEBI:22260;CHEBI:22260 | denotes | tions may |
| T48643 | 1839-1848 | CHEBI:22260;CHEBI:22260 | denotes | the meth |
| T7774 | 2002-2014 | SO:0000409 | denotes | de core of 1 |
| T50836 | 2166-2174 | SP_10 | denotes | group a |
| T42328 | 2175-2180 | PR:000000125 | denotes | d Arg |
| T83174 | 2206-2215 | CHEBI:36357;CHEBI:36357 | denotes | s with th |
| T31439 | 2268-2276 | SP_10 | denotes | the cap |
| T26736 | 2362-2370 | CHEBI:16240;CHEBI:16240 | denotes | f the N- |
| T45707 | 2375-2382 | CHEBI:30563;CHEBI:30563 | denotes | substi |
| T63105 | 2682-2690 | SP_10 | denotes | ed to a |
| T65347 | 2755-2778 | CHEBI:53325;CHEBI:53325 | denotes | by the formation of in |
| T36376 | 2826-2835 | CHEBI:22260;CHEBI:22260 | denotes | e and Gly |
| T55564 | 2843-2855 | CHEBI:23447;CHEBI:23447 | denotes | H), Ile338 ( |
| T92854 | 2871-2879 | CHEBI:16240;CHEBI:16240 | denotes | 7) and H |
| T676 | 3249-3257 | SP_10 | denotes | SARS-CoV |
| T677 | 3343-3351 | CHEBI:16240;CHEBI:16240 | denotes | Hydrogen |
| T678 | 3356-3363 | CHEBI:30563;CHEBI:30563 | denotes | halogen |
| T679 | 3660-3668 | SP_10 | denotes | SARS-CoV |
| T680 | 3733-3756 | CHEBI:53325;CHEBI:53325 | denotes | nitrobenzenesulfonamide |
| T681 | 3804-3813 | CHEBI:22260;CHEBI:22260 | denotes | adenosine |
| T682 | 3821-3834 | CHEBI:23447;CHEBI:23447 | denotes | dinucleosides |
| T683 | 3850-3858 | CHEBI:16240;CHEBI:16240 | denotes | Hydrogen |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T84 | 320-323 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T85 | 328-335 | Body_part | denotes | guanine | http://purl.org/sig/ont/fma/fma82775 |
| T86 | 374-378 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
| T87 | 565-568 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T88 | 576-579 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T89 | 1184-1195 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T90 | 1219-1226 | Body_part | denotes | guanine | http://purl.org/sig/ont/fma/fma82775 |
| T91 | 1899-1906 | Body_part | denotes | guanine | http://purl.org/sig/ont/fma/fma82775 |
| T92 | 3034-3037 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T93 | 3302-3313 | Body_part | denotes | Amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T94 | 3972-3979 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id | tao:has_standard_notation |
|---|---|---|---|---|---|---|
| 462 | 3326-3338 | Chemical | denotes | dinucleoside | ||
| 463 | 3343-3351 | Chemical | denotes | Hydrogen | MESH:D006859 | |
| 468 | 3733-3756 | Chemical | denotes | nitrobenzenesulfonamide | ||
| 469 | 3804-3813 | Chemical | denotes | adenosine | MESH:D000241 | |
| 470 | 3821-3834 | Chemical | denotes | dinucleosides | ||
| 471 | 3850-3858 | Chemical | denotes | Hydrogen | MESH:D006859 | |
| 504 | 67-80 | Chemical | denotes | dinucleosides | ||
| 505 | 328-335 | Chemical | denotes | guanine | MESH:D006147 | |
| 506 | 829-838 | Chemical | denotes | adenosine | MESH:D000241 | |
| 507 | 854-863 | Chemical | denotes | adenosine | MESH:D000241 | |
| 508 | 960-983 | Chemical | denotes | nitrobenzenesulfonamide | ||
| 509 | 1057-1063 | Chemical | denotes | Trp385 | ||
| 510 | 1065-1071 | Chemical | denotes | Phe401 | ||
| 511 | 1073-1079 | Chemical | denotes | Tyr420 | ||
| 512 | 1081-1087 | Chemical | denotes | Phe426 | ||
| 513 | 1092-1098 | Chemical | denotes | Phe506 | ||
| 514 | 1219-1226 | Chemical | denotes | guanine | MESH:D006147 | |
| 515 | 1275-1281 | Chemical | denotes | Phe426 | ||
| 516 | 1430-1436 | Chemical | denotes | Phe426 | ||
| 517 | 1460-1483 | Chemical | denotes | nitrobenzenesulfonamide | ||
| 518 | 1603-1620 | Chemical | denotes | phenylsulfonamide | ||
| 519 | 1806-1812 | Chemical | denotes | Asn386 | ||
| 520 | 1875-1883 | Chemical | denotes | hydrogen | MESH:D006859 | |
| 521 | 1899-1906 | Chemical | denotes | guanine | MESH:D006147 | |
| 522 | 1981-2004 | Chemical | denotes | nitrobenzenesulfonamide | ||
| 523 | 2021-2029 | Chemical | denotes | chlorine | MESH:D002713 | |
| 524 | 2061-2067 | Chemical | denotes | Asn386 | ||
| 525 | 2110-2118 | Chemical | denotes | hydrogen | MESH:D006859 | |
| 526 | 2161-2166 | Chemical | denotes | nitro | ||
| 527 | 2177-2183 | Chemical | denotes | Arg310 | ||
| 528 | 2224-2233 | Chemical | denotes | phosphate | MESH:D010710 | |
| 529 | 2247-2259 | Chemical | denotes | triphosphate | MESH:C005692 | |
| 530 | 2322-2329 | Chemical | denotes | sulfone | MESH:D013450 | |
| 531 | 2604-2611 | Chemical | denotes | sulfone | MESH:D013450 | |
| 532 | 2668-2677 | Chemical | denotes | adenosine | MESH:D000241 | |
| 533 | 2692-2701 | Chemical | denotes | adenosine | MESH:D000241 | |
| 534 | 2818-2827 | Chemical | denotes | adenosine | MESH:D000241 | |
| 535 | 1352-1357 | Mutation | denotes | F426A | p.F426A |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T84 | 200-208 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T85 | 271-279 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T86 | 726-734 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T87 | 1008-1016 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T88 | 3145-3153 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T89 | 3249-3257 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T90 | 3660-3668 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T226 | 266-268 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T227 | 289-290 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T228 | 426-430 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 3′-5 |
| T229 | 610-611 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T230 | 766-768 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T231 | 786-788 | http://purl.obolibrary.org/obo/CLO_0001313 | denotes | 36 |
| T232 | 1006-1007 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T233 | 1138-1140 | http://purl.obolibrary.org/obo/CLO_0008933 | denotes | S5 |
| T234 | 1143-1145 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T235 | 1338-1346 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T236 | 1381-1389 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T237 | 2041-2042 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T238 | 2101-2102 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T239 | 2484-2492 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T240 | 2571-2572 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T241 | 2688-2689 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T242 | 2951-2952 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T243 | 3294-3300 | http://purl.obolibrary.org/obo/CLO_0001627 | denotes | Å). (A |
| T244 | 3474-3475 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | Å |
| T245 | 3705-3711 | http://purl.obolibrary.org/obo/CLO_0001627 | denotes | Å). (A |
| T246 | 3770-3771 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T472 | 25-30 | Chemical | denotes | bases | http://purl.obolibrary.org/obo/CHEBI_22695 |
| T473 | 137-146 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T474 | 261-264 | Chemical | denotes | SAM | http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040 |
| T476 | 328-335 | Chemical | denotes | guanine | http://purl.obolibrary.org/obo/CHEBI_16235 |
| T477 | 545-551 | Chemical | denotes | methyl | http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309 |
| T479 | 585-588 | Chemical | denotes | SAM | http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040 |
| T481 | 700-703 | Chemical | denotes | SAM | http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040 |
| T483 | 756-758 | Chemical | denotes | ID | http://purl.obolibrary.org/obo/CHEBI_141439 |
| T484 | 776-778 | Chemical | denotes | ID | http://purl.obolibrary.org/obo/CHEBI_141439 |
| T485 | 829-838 | Chemical | denotes | adenosine | http://purl.obolibrary.org/obo/CHEBI_16335 |
| T486 | 854-863 | Chemical | denotes | adenosine | http://purl.obolibrary.org/obo/CHEBI_16335 |
| T487 | 867-870 | Chemical | denotes | SAM | http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040 |
| T489 | 931-933 | Chemical | denotes | S4 | http://purl.obolibrary.org/obo/CHEBI_29401 |
| T490 | 1138-1140 | Chemical | denotes | S5 | http://purl.obolibrary.org/obo/CHEBI_29386 |
| T491 | 1184-1195 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T492 | 1184-1189 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T493 | 1190-1195 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T494 | 1208-1218 | Chemical | denotes | nucleobase | http://purl.obolibrary.org/obo/CHEBI_18282 |
| T495 | 1219-1226 | Chemical | denotes | guanine | http://purl.obolibrary.org/obo/CHEBI_16235 |
| T496 | 1742-1748 | Chemical | denotes | phenyl | http://purl.obolibrary.org/obo/CHEBI_30396 |
| T497 | 1875-1883 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T498 | 1899-1906 | Chemical | denotes | guanine | http://purl.obolibrary.org/obo/CHEBI_16235 |
| T499 | 2021-2034 | Chemical | denotes | chlorine atom | http://purl.obolibrary.org/obo/CHEBI_23116 |
| T500 | 2021-2029 | Chemical | denotes | chlorine | http://purl.obolibrary.org/obo/CHEBI_29310 |
| T501 | 2030-2034 | Chemical | denotes | atom | http://purl.obolibrary.org/obo/CHEBI_33250 |
| T502 | 2043-2050 | Chemical | denotes | halogen | http://purl.obolibrary.org/obo/CHEBI_24473 |
| T503 | 2110-2118 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T504 | 2161-2172 | Chemical | denotes | nitro group | http://purl.obolibrary.org/obo/CHEBI_29785 |
| T505 | 2167-2172 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T506 | 2224-2239 | Chemical | denotes | phosphate group | http://purl.obolibrary.org/obo/CHEBI_32958|http://purl.obolibrary.org/obo/CHEBI_68546 |
| T508 | 2224-2233 | Chemical | denotes | phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474 |
| T512 | 2234-2239 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T513 | 2247-2259 | Chemical | denotes | triphosphate | http://purl.obolibrary.org/obo/CHEBI_18036 |
| T514 | 2322-2329 | Chemical | denotes | sulfone | http://purl.obolibrary.org/obo/CHEBI_35850 |
| T515 | 2330-2335 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T516 | 2573-2588 | Chemical | denotes | methylene group | http://purl.obolibrary.org/obo/CHEBI_50728 |
| T517 | 2573-2582 | Chemical | denotes | methylene | http://purl.obolibrary.org/obo/CHEBI_29357|http://purl.obolibrary.org/obo/CHEBI_29358 |
| T519 | 2583-2588 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T520 | 2604-2611 | Chemical | denotes | sulfone | http://purl.obolibrary.org/obo/CHEBI_35850 |
| T521 | 2668-2677 | Chemical | denotes | adenosine | http://purl.obolibrary.org/obo/CHEBI_16335 |
| T522 | 2692-2701 | Chemical | denotes | adenosine | http://purl.obolibrary.org/obo/CHEBI_16335 |
| T523 | 2791-2799 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T524 | 2818-2827 | Chemical | denotes | adenosine | http://purl.obolibrary.org/obo/CHEBI_16335 |
| T525 | 3227-3230 | Chemical | denotes | SAM | http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040 |
| T527 | 3269-3271 | Chemical | denotes | ID | http://purl.obolibrary.org/obo/CHEBI_141439 |
| T528 | 3302-3313 | Chemical | denotes | Amino acids | http://purl.obolibrary.org/obo/CHEBI_33704 |
| T529 | 3308-3313 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T530 | 3343-3351 | Chemical | denotes | Hydrogen | http://purl.obolibrary.org/obo/CHEBI_18276 |
| T531 | 3356-3363 | Chemical | denotes | halogen | http://purl.obolibrary.org/obo/CHEBI_24473 |
| T532 | 3638-3641 | Chemical | denotes | SAM | http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040 |
| T534 | 3680-3682 | Chemical | denotes | ID | http://purl.obolibrary.org/obo/CHEBI_141439 |
| T535 | 3804-3813 | Chemical | denotes | adenosine | http://purl.obolibrary.org/obo/CHEBI_16335 |
| T536 | 3850-3858 | Chemical | denotes | Hydrogen | http://purl.obolibrary.org/obo/CHEBI_18276 |
| T537 | 3875-3882 | Chemical | denotes | halogen | http://purl.obolibrary.org/obo/CHEBI_24473 |
| T538 | 3972-3979 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T539 | 3980-3986 | Chemical | denotes | ligand | http://purl.obolibrary.org/obo/CHEBI_52214 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T37 | 374-386 | http://purl.obolibrary.org/obo/GO_0006370 | denotes | mRNA capping |
| T38 | 1497-1506 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T39 | 1844-1855 | http://purl.obolibrary.org/obo/GO_0032259 | denotes | methylation |
| T40 | 1949-1960 | http://purl.obolibrary.org/obo/GO_0032259 | denotes | methylation |
| T41 | 2088-2097 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T42 | 2763-2772 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32563813-26159422-29105590 | 266-268 | 26159422 | denotes | 35 |
| 32563813-26159422-29105591 | 766-768 | 26159422 | denotes | 35 |
| 32563813-29279395-29105592 | 786-788 | 29279395 | denotes | 36 |
| 32563813-26159422-29105593 | 1143-1145 | 26159422 | denotes | 35 |
| 32563813-15557000-29105594 | 2079-2081 | 15557000 | denotes | 37 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T202 | 0-170 | Sentence | denotes | To address the molecular bases of N7-MTase nsp14 inhibition by the dinucleosides, we performed computational docking studies of the best inhibitor 13 using Autodock Vina. |
| T203 | 171-270 | Sentence | denotes | The docking was based on the SARS-CoV nsp14-nsp10 complex structure solved in presence of SAM [35]. |
| T204 | 271-490 | Sentence | denotes | SARS-CoV nsp14 is a bifunctional enzyme carrying RNA cap guanine N7-MTase at the C-terminal domain for mRNA capping (which is not influenced by nsp10) and 3′-5′-exoribonuclease at the N-terminal domain for proofreading. |
| T205 | 491-664 | Sentence | denotes | The N7-MTase domain exhibits an original fold and the methyl receptor cap RNA (GpppA-RNA) and SAM bind in proximity in a highly constricted pocket to achieve methyltransfer. |
| T206 | 665-759 | Sentence | denotes | The compound 13 was modeled in the SAM binding pocket of the SARS-CoV nsp14 structure (PDB ID: |
| T207 | 760-779 | Sentence | denotes | 5C8T [35] & PDB ID: |
| T208 | 780-791 | Sentence | denotes | 5NFY [36]). |
| T209 | 792-935 | Sentence | denotes | At first sight, the overlay of the N-adenosine of 13 with the adenosine of SAM bounded structure is suitable (Supporting Information, Fig. S4). |
| T210 | 936-1147 | Sentence | denotes | More interestingly, the nitrobenzenesulfonamide core of 13 binds into a SARS-CoV nsp14 well known binding site formed by Trp385, Phe401, Tyr420, Phe426 and Phe506 (Fig. 3 , Supporting Information, Fig. S5) [35]. |
| T211 | 1148-1248 | Sentence | denotes | Naturally, the side chains of these amino acids enclose the nucleobase guanine of the cap structure. |
| T212 | 1249-1397 | Sentence | denotes | In this cap-binding site, Phe426 was shown to have the largest influence on the N7-MTase activity, and F426A mutation reduced MTase activity by 50%. |
| T213 | 1398-1536 | Sentence | denotes | With 13, the orientation of the Phe426 residue all around the nitrobenzenesulfonamide leads to the formation of π-π stacking interactions. |
| T214 | 1537-1670 | Sentence | denotes | In addition, there are other hydrophobic interactions between the phenylsulfonamide moiety and aromatic residues of the binding site. |
| T215 | 1671-1795 | Sentence | denotes | All these interactions may explain the strong inhibition observed with phenyl-containing compounds, notably compounds 13–15. |
| T216 | 1796-1961 | Sentence | denotes | Moreover, Asn386 is located in proximity to the methylation site and forms two hydrogen bonds with the guanine moiety favoring its right orientation for methylation. |
| T217 | 1962-2083 | Sentence | denotes | Here, fixed on the nitrobenzenesulfonamide core of 13, the chlorine atom forms a halogen bond with Asn386 (Fig. 4 ) [37]. |
| T218 | 2084-2286 | Sentence | denotes | The formation of a double hydrogen bond interaction was observed between the nitro group and Arg310 that normally interacts with the second phosphate group of the triphosphate bond in the cap structure. |
| T219 | 2287-2437 | Sentence | denotes | The docking also suggests that the sulfone group of 13 avoids flexibility of the N-nosyl substituent, thus increasing its orientation into the pocket. |
| T220 | 2438-2612 | Sentence | denotes | This constraint may explain the difference in activity (IC50) and stabilizing effect (T m) between compounds 13 and 15 that contains a methylene group instead of the sulfone. |
| T221 | 2613-2722 | Sentence | denotes | Finally, the common element of all dinucleosides is an adenosine linked to a N-adenosine by the 2′O position. |
| T222 | 2723-2908 | Sentence | denotes | Its contribution is well defined by the formation of intermolecular hydrogen bonds between the adenosine and Gly333 (3′OH), Ile338 (5′OH), Lys336 (N7) and His424 (N1) residues (Fig. 4). |
| T223 | 2909-3038 | Sentence | denotes | All the major interactions maintain 13 in a suitable orientation in the binding site in place of the natural substrate GpppA-RNA. |
| T224 | 3039-3195 | Sentence | denotes | The docking model of 13 is consistent with our inhibition experimental data and high thermal stability of SARS-CoV nsp14 in the presence of these compounds. |
| T225 | 3196-3272 | Sentence | denotes | Fig. 3 Modeling results in the SAM binding pocket of SARS-CoV nsp14 (PDB ID: |
| T226 | 3273-3342 | Sentence | denotes | 5C8T, resolution 3.2 Å). (A) Amino acids surrounding dinucleoside 13. |
| T227 | 3343-3450 | Sentence | denotes | Hydrogen and halogen bonds are indicated by red dashes. π-π stacking interaction is indicated by red curve. |
| T228 | 3451-3606 | Sentence | denotes | Distances are given in Å. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.) |
| T229 | 3607-3683 | Sentence | denotes | Fig. 4 Modeling results in the SAM binding pocket of SARS-CoV nsp14 (PDB ID: |
| T230 | 3684-3849 | Sentence | denotes | 5C8T, resolution 3.2 Å). (A) Contribution of the nitrobenzenesulfonamide core of 13. (B) Contribution of the 2′O linked adenosine of all dinucleosides, including 13. |
| T231 | 3850-4170 | Sentence | denotes | Hydrogen bonds (yellow), halogen bond (green) and π-π stacking interaction (cyan) are represented. (Atoms not involved in protein-ligand interaction are not represented for clarity purpose). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.) |
MyTest
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32563813-26159422-29105590 | 266-268 | 26159422 | denotes | 35 |
| 32563813-26159422-29105591 | 766-768 | 26159422 | denotes | 35 |
| 32563813-29279395-29105592 | 786-788 | 29279395 | denotes | 36 |
| 32563813-26159422-29105593 | 1143-1145 | 26159422 | denotes | 35 |
| 32563813-15557000-29105594 | 2079-2081 | 15557000 | denotes | 37 |