PMC:7291971 / 27467-28031 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T588	31-39	SP_10	denotes	SARS-CoV
T589	40-45	PR:000000125	denotes	nsp14
T590	98-110	CHEBI:23447;CHEBI:23447	denotes	dinucleoside
T591	111-121	CHEBI:35222;CHEBI:35222	denotes	inhibitors
T592	155-163	SP_10	denotes	SARS-CoV
T593	164-169	PR:000000125	denotes	nsp14
T594	278-285	CHEBI:60004;CHEBI:60004	denotes	mixture
T595	293-298	CHEBI:46756;CHEBI:46756	denotes	HEPES
T596	316-320	CHEBI:26710;CHEBI:26710	denotes	NaCl
T597	331-337	CHEBI:51461;CHEBI:51461	denotes	orange
T598	338-341	CHEBI:37958;CHEBI:37958	denotes	dye
T599	367-375	SP_10	denotes	SARS-CoV
T600	376-381	PR:000000125	denotes	nsp14
T601	399-407	CHEBI:36357;CHEBI:36357	denotes	compound
T602	437-441	CHEBI:51231;CHEBI:51231	denotes	DMSO
T92038	28-34	SO:0000417	denotes	of SAR
T47756	130-136	SO:0000417	denotes	16. Th
T8747	168-174	SO:0000417	denotes	4 upon
T58585	387-395	SP_10	denotes	in and 1
T5949	490-499	CHEBI:37886;CHEBI:37886	denotes	values fr
T90084	515-524	CHEBI:28748;CHEBI:28748	denotes	dent meas

Id	Subject	Object	Predicate	Lexical cue	fma_id
T83	382-389	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
439	81-91	Chemical	denotes	sinefungin	MESH:C006235
440	293-298	Chemical	denotes	HEPES	MESH:D006531
441	316-320	Chemical	denotes	NaCl	MESH:D012965
442	325-337	Chemical	denotes	SYPRO orange
443	437-441	Chemical	denotes	DMSO	MESH:D004121

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T80	31-39	Disease	denotes	SARS-CoV	http://purl.obolibrary.org/obo/MONDO_0005091
T81	155-163	Disease	denotes	SARS-CoV	http://purl.obolibrary.org/obo/MONDO_0005091
T82	367-375	Disease	denotes	SARS-CoV	http://purl.obolibrary.org/obo/MONDO_0005091

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T460	24-26	Chemical	denotes	Tm	http://purl.obolibrary.org/obo/CHEBI_33380
T461	76-79	Chemical	denotes	SAM	http://purl.obolibrary.org/obo/CHEBI_15414\|http://purl.obolibrary.org/obo/CHEBI_67040
T463	81-91	Chemical	denotes	sinefungin	http://purl.obolibrary.org/obo/CHEBI_45453
T464	111-121	Chemical	denotes	inhibitors	http://purl.obolibrary.org/obo/CHEBI_35222
T465	175-181	Chemical	denotes	ligand	http://purl.obolibrary.org/obo/CHEBI_52214
T466	278-285	Chemical	denotes	mixture	http://purl.obolibrary.org/obo/CHEBI_60004
T467	293-298	Chemical	denotes	HEPES	http://purl.obolibrary.org/obo/CHEBI_46756
T468	316-320	Chemical	denotes	NaCl	http://purl.obolibrary.org/obo/CHEBI_26710
T469	338-341	Chemical	denotes	dye	http://purl.obolibrary.org/obo/CHEBI_37958
T470	382-389	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080
T471	437-441	Chemical	denotes	DMSO	http://purl.obolibrary.org/obo/CHEBI_28262

Id	Subject	Object	Predicate	Lexical cue
T197	0-133	Sentence	denotes	Fig. 2 Thermal shifts (ΔTm) of SARS-CoV nsp14 in the absence or presence of SAM, sinefungin and 9 dinucleoside inhibitors 6 and 9–16.
T198	134-241	Sentence	denotes	Thermal stability of SARS-CoV nsp14 upon ligand binding was monitored by differential scanning fluorimetry.
T199	242-442	Sentence	denotes	Assays were carried out in reaction mixture [20 mM HEPES (pH 7.5), 150 mM NaCl, 1x SYPRO orange dye] in the presence of 5 μM SARS-CoV nsp14 protein and 1 mM compound previously dissolved in 100% DMSO.
T200	443-564	Sentence	denotes	The bars and error bars correspond to the mean values from three independent measurements and their s.d.’s, respectively.