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PMC:7291971 / 19374-20163 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T426 29-34 SP_6;NCBITaxon:9606 denotes human
T427 49-54 PR:O43148 denotes hRNMT
T428 109-113 CHEBI:51231;CHEBI:51231 denotes DMSO
T443 187-196 CHEBI:36357;CHEBI:36357 denotes compounds
T444 243-255 NCBITaxon:31032 denotes flaviviruses
T445 259-270 NCBITaxon:11118 denotes coronavirus
T446 271-279 SP_10 denotes SARS-CoV
T447 306-315 CHEBI:36357;CHEBI:36357 denotes compounds
T448 449-454 NCBITaxon:10239 denotes viral
T449 491-499 NCBITaxon:7742 denotes Vaccinia
T450 515-523 SP_10 denotes SARS-CoV
T451 540-548 CHEBI:36357;CHEBI:36357 denotes compound
T452 589-594 PR:O43148 denotes hRNMT
T453 620-625 NCBITaxon:10239 denotes viral
T454 674-679 SP_6;NCBITaxon:9606 denotes human
T455 684-689 NCBITaxon:10239 denotes viral
T456 714-719 CHEBI:24433;CHEBI:24433 denotes group
T41 187-196 CHEBI:36357;CHEBI:36357 denotes compounds

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T68 35-38 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T69 378-388 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T70 703-713 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
373 109-113 Chemical denotes DMSO MESH:D004121
396 351-363 Chemical denotes Dinucleoside

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T47 271-279 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 491-499 Disease denotes Vaccinia http://purl.obolibrary.org/obo/MONDO_0002595
T49 515-523 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T159 22-24 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T160 29-34 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T161 209-215 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T162 378-394 http://purl.obolibrary.org/obo/PR_000018263 denotes amino acid chain
T163 470-471 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T164 479-487 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T165 566-567 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T166 644-645 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T167 674-679 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T168 778-779 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T337 109-113 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T338 378-388 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T339 378-383 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T340 384-388 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T341 402-405 Chemical denotes SAM http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040
T343 703-713 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T344 703-708 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T345 709-713 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T346 714-719 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T137 65-152 Sentence denotes Compounds were previously dissolved in 100% DMSO. n.i: no inhibition detected at 50 μM.
T138 153-280 Sentence denotes Unexpectedly, all the bisubstrate compounds were barely active against the 2′-O MTases of flaviviruses or coronavirus SARS-CoV.
T139 281-350 Sentence denotes In contrast, most of the compounds displayed inhibition of N7-MTases.
T140 351-530 Sentence denotes Dinucleoside 2 bearing the amino acid chain of the SAM showed some significant inhibition of both viral N7-MTases with a better activity on Vaccinia D1-D12 than on SARS-CoV nsp14.
T141 531-698 Sentence denotes However, compound 2 also displayed a potent inhibition of hRNMT in the same range as the viral MTases displaying a lack of specificity against human and viral enzymes.