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PMC:7291971 / 135-1755 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T5 21-28 NCBITaxon:10239 denotes viruses
T6 56-61 SP_6;NCBITaxon:9606 denotes human
T7 89-97 SP_7 denotes COVID-19
T8 138-149 NCBITaxon:11118 denotes coronavirus
T9 150-160 SP_7 denotes SARS-CoV-2
T10 235-239 UBERON:0001456 denotes face
T11 268-275 NCBITaxon:10239 denotes viruses
T12 360-370 CHEBI:35222;CHEBI:35222 denotes inhibitors
T13 495-502 NCBITaxon:10239 denotes viruses
T14 658-668 CHEBI:35222;CHEBI:35222 denotes inhibitors
T15 734-737 GO:0008541 denotes cap
T16 760-765 NCBITaxon:10239 denotes viral
T17 853-863 CHEBI:22260;CHEBI:22260 denotes adenosines
T18 948-957 CHEBI:36357;CHEBI:36357 denotes compounds
T19 1008-1020 NCBITaxon:31032 denotes flaviviruses
T20 1024-1032 SP_10 denotes SARS-CoV
T21 1114-1122 SP_10 denotes SARS-CoV
T22 1198-1203 PR:000000125 denotes nsp14
T23 1204-1213 CHEBI:35222;CHEBI:35222 denotes inhibitor
T24 1302-1311 CHEBI:35222;CHEBI:35222 denotes inhibitor
T25 1361-1370 CHEBI:35222;CHEBI:35222 denotes inhibitor
T26 1435-1438 GO:0008541 denotes cap
T27 1443-1456 SO:0000409 denotes binding sites
T28 1474-1482 SP_10 denotes SARS-CoV
T29 1579-1589 CHEBI:35222;CHEBI:35222 denotes inhibitors
T30 1594-1604 SP_7 denotes SARS-CoV-2
T19641 21-28 NCBITaxon:10239 denotes viruses
T61309 56-61 SP_6;NCBITaxon:9606 denotes human
T57953 89-97 SP_7 denotes COVID-19
T43008 138-149 NCBITaxon:11118 denotes coronavirus
T77356 150-160 SP_7 denotes SARS-CoV-2
T38673 235-239 UBERON:0001456 denotes face
T98319 268-275 NCBITaxon:10239 denotes viruses
T93340 360-370 CHEBI:35222;CHEBI:35222 denotes inhibitors
T49466 495-502 NCBITaxon:10239 denotes viruses
T50627 658-668 CHEBI:35222;CHEBI:35222 denotes inhibitors
T65425 734-737 GO:0008541 denotes cap
T87174 760-765 NCBITaxon:10239 denotes viral
T40194 853-863 CHEBI:22260;CHEBI:22260 denotes adenosines
T7397 948-957 CHEBI:36357;CHEBI:36357 denotes compounds
T53306 1008-1020 NCBITaxon:31032 denotes flaviviruses
T48802 1024-1032 SP_10 denotes SARS-CoV
T86425 1114-1122 SP_10 denotes SARS-CoV
T66103 1198-1203 PR:000000125 denotes nsp14
T45404 1204-1213 CHEBI:35222;CHEBI:35222 denotes inhibitor
T10534 1302-1311 CHEBI:35222;CHEBI:35222 denotes inhibitor
T99394 1361-1370 CHEBI:35222;CHEBI:35222 denotes inhibitor
T71458 1435-1438 GO:0008541 denotes cap
T73912 1443-1456 SO:0000409 denotes binding sites
T91482 1474-1482 SP_10 denotes SARS-CoV
T91494 1579-1589 CHEBI:35222;CHEBI:35222 denotes inhibitors
T20499 1594-1604 SP_7 denotes SARS-CoV-2

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T4 235-239 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T5 525-528 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T6 738-741 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T7 821-828 Body_part denotes adenine http://purl.org/sig/ont/fma/fma82774
T8 1414-1424 Body_part denotes methionine http://purl.org/sig/ont/fma/fma82759
T9 1439-1442 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 235-239 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
10 821-842 Chemical denotes adenine dinucleosides
11 853-863 Chemical denotes adenosines MESH:D000241
12 885-893 Chemical denotes nitrogen MESH:D009584
13 1313-1323 Chemical denotes sinefungin MESH:C006235
14 1414-1424 Chemical denotes methionine MESH:D008715
15 1426-1429 Chemical denotes SAM MESH:D012436
16 1496-1512 Chemical denotes dinucleoside SAM
17 89-97 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 89-97 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 150-158 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 1024-1032 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 1114-1122 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 1474-1482 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 1594-1602 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 21-28 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T2 56-61 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T3 235-239 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T4 268-275 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T5 495-502 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T6 970-976 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T7 1191-1197 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T8 1380-1381 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T6 350-359 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T7 360-370 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T8 610-619 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T9 658-668 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T10 821-828 Chemical denotes adenine http://purl.obolibrary.org/obo/CHEBI_16708
T11 853-863 Chemical denotes adenosines http://purl.obolibrary.org/obo/CHEBI_22260
T12 885-893 Chemical denotes nitrogen http://purl.obolibrary.org/obo/CHEBI_25555
T13 1204-1213 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T14 1302-1311 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T15 1313-1323 Chemical denotes sinefungin http://purl.obolibrary.org/obo/CHEBI_45453
T16 1361-1370 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T17 1403-1424 Chemical denotes S-adenosyl methionine http://purl.obolibrary.org/obo/CHEBI_15414
T18 1405-1413 Chemical denotes adenosyl http://purl.obolibrary.org/obo/CHEBI_33505
T19 1414-1424 Chemical denotes methionine http://purl.obolibrary.org/obo/CHEBI_16811|http://purl.obolibrary.org/obo/CHEBI_64558
T21 1426-1429 Chemical denotes SAM http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040
T23 1509-1512 Chemical denotes SAM http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040
T25 1579-1589 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T2 715-726 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T3 805-814 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T3 0-76 Sentence denotes The spreading of new viruses is known to provoke global human health threat.
T4 77-312 Sentence denotes The current COVID-19 pandemic caused by the recently emerged coronavirus SARS-CoV-2 is one significant and unfortunate example of what the world will have to face in the future with emerging viruses in absence of appropriate treatment.
T5 313-451 Sentence denotes The discovery of potent and specific antiviral inhibitors and/or vaccines to fight these massive outbreaks is an urgent research priority.
T6 452-633 Sentence denotes Enzymes involved in the capping pathway of viruses and more specifically RNA N7- or 2′O-methyltransferases (MTases) are now admitted as potential targets for antiviral chemotherapy.
T7 634-778 Sentence denotes We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases.
T8 779-913 Sentence denotes This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers.
T9 914-1181 Sentence denotes Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range.
T10 1182-1324 Sentence denotes The most active nsp14 inhibitor identified is as potent as but particularly more specific than the broad-spectrum MTase inhibitor, sinefungin.
T11 1325-1489 Sentence denotes Molecular docking suggests that the inhibitor binds to a pocket formed by the S-adenosyl methionine (SAM) and cap RNA binding sites, conserved among SARS-CoV nsp14.
T12 1490-1620 Sentence denotes These dinucleoside SAM analogs will serve as starting points for the development of next inhibitors for SARS-CoV-2 nsp14 N7-MTase.