PMC:7291971 / 1178-1499 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T21","span":{"begin":71,"end":79},"obj":"SP_10"},{"id":"T22","span":{"begin":155,"end":160},"obj":"PR:000000125"},{"id":"T23","span":{"begin":161,"end":170},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T24","span":{"begin":259,"end":268},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T86425","span":{"begin":71,"end":79},"obj":"SP_10"},{"id":"T66103","span":{"begin":155,"end":160},"obj":"PR:000000125"},{"id":"T45404","span":{"begin":161,"end":170},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T10534","span":{"begin":259,"end":268},"obj":"CHEBI:35222;CHEBI:35222"}],"text":"singly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. The most active nsp14 inhibitor identified is as potent as but particularly more specific than the broad-spectrum MTase inhibitor, sinefungin. Molecular docking suggests that the inh"}

{"project":"LitCovid-PubTator","denotations":[{"id":"13","span":{"begin":270,"end":280},"obj":"Chemical"}],"attributes":[{"id":"A13","pred":"tao:has_database_id","subj":"13","obj":"MESH:C006235"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"singly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. The most active nsp14 inhibitor identified is as potent as but particularly more specific than the broad-spectrum MTase inhibitor, sinefungin. Molecular docking suggests that the inh"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T5","span":{"begin":71,"end":79},"obj":"Disease"}],"attributes":[{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"singly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. The most active nsp14 inhibitor identified is as potent as but particularly more specific than the broad-spectrum MTase inhibitor, sinefungin. Molecular docking suggests that the inh"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T7","span":{"begin":148,"end":154},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"singly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. The most active nsp14 inhibitor identified is as potent as but particularly more specific than the broad-spectrum MTase inhibitor, sinefungin. Molecular docking suggests that the inh"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T13","span":{"begin":161,"end":170},"obj":"Chemical"},{"id":"T14","span":{"begin":259,"end":268},"obj":"Chemical"},{"id":"T15","span":{"begin":270,"end":280},"obj":"Chemical"}],"attributes":[{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_45453"}],"text":"singly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. The most active nsp14 inhibitor identified is as potent as but particularly more specific than the broad-spectrum MTase inhibitor, sinefungin. Molecular docking suggests that the inh"}

{"project":"LitCovid-sentences","denotations":[{"id":"T10","span":{"begin":139,"end":281},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"singly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. The most active nsp14 inhibitor identified is as potent as but particularly more specific than the broad-spectrum MTase inhibitor, sinefungin. Molecular docking suggests that the inh"}