PMC:7289100 / 43-1790 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7289100","sourcedb":"PMC","sourceid":"7289100","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7289100","text":"Though the exact etiology of autoimmune diseases still remains unknown, there are various factors which are believed to contribute to the emergence of an autoimmune disease in a host including the genetic predisposition, the environmental triggers such as bacterial infections, including the gut microbiota, viral fungal and parasitic infections, as well as physical and environmental agents, hormonal factors and the hosts immune system dysregulation. All these factors interplay was coined by Shoenfeld et al., many years ago “The Mosaic of Autoimmunity” [[1], [2], [3], [4]]. The most prominent pathogenic viruses which have been proposed in the triggering and initiation of autoimmune diseases include: Parvovirus B19, Epstein-Barr-virus (EBV), Cytomegalovirus (CMV), Herpes virus-6, HTLV-1, Hepatitis A and C virus, and Rubella virus [[5], [6], [7], [8], [9], [10], [11]]. These viruses have been implicated in the initiation of chronic inflammatory or autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, primary billiary cholangitis, multiple sclerosis, polymoysitis, uveitis, Henoch Schonlein Puprpura, Systemic Juvenile Idiopathic arthritis, systemic sclerosis, Hashimoto thyroiditis and autoimmune hepatitis [12,13]. Suggested mechanisms of induction of the autoimmunity include both molecular mimicry [14] as well as “bystander activation” whereby the infection may lead to activation of antigen presenting cells that may in turn activate pre-primed auto-reactive T-cells, thus leading to the production of pro-inflammatory mediators, which in turn may lead to tissue damage [15]. Alternative suggested mechanisms include epitope spreading as well as presentation of cryptic antigens [16].","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":292,"end":295},"obj":"Body_part"},{"id":"T2","span":{"begin":424,"end":437},"obj":"Body_part"},{"id":"T3","span":{"begin":1228,"end":1243},"obj":"Body_part"},{"id":"T4","span":{"begin":1446,"end":1470},"obj":"Body_part"},{"id":"T5","span":{"begin":1465,"end":1470},"obj":"Body_part"},{"id":"T6","span":{"begin":1524,"end":1529},"obj":"Body_part"},{"id":"T7","span":{"begin":1619,"end":1625},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma9603"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma9637"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":424,"end":437},"obj":"Body_part"},{"id":"T2","span":{"begin":1619,"end":1625},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":29,"end":48},"obj":"Disease"},{"id":"T2","span":{"begin":154,"end":172},"obj":"Disease"},{"id":"T3","span":{"begin":256,"end":276},"obj":"Disease"},{"id":"T4","span":{"begin":325,"end":345},"obj":"Disease"},{"id":"T5","span":{"begin":678,"end":697},"obj":"Disease"},{"id":"T6","span":{"begin":788,"end":794},"obj":"Disease"},{"id":"T7","span":{"begin":796,"end":807},"obj":"Disease"},{"id":"T8","span":{"begin":796,"end":805},"obj":"Disease"},{"id":"T9","span":{"begin":825,"end":832},"obj":"Disease"},{"id":"T10","span":{"begin":958,"end":977},"obj":"Disease"},{"id":"T11","span":{"begin":986,"end":1006},"obj":"Disease"},{"id":"T12","span":{"begin":997,"end":1006},"obj":"Disease"},{"id":"T13","span":{"begin":1008,"end":1036},"obj":"Disease"},{"id":"T14","span":{"begin":1017,"end":1036},"obj":"Disease"},{"id":"T15","span":{"begin":1038,"end":1056},"obj":"Disease"},{"id":"T16","span":{"begin":1075,"end":1086},"obj":"Disease"},{"id":"T17","span":{"begin":1088,"end":1106},"obj":"Disease"},{"id":"T18","span":{"begin":1122,"end":1129},"obj":"Disease"},{"id":"T19","span":{"begin":1158,"end":1196},"obj":"Disease"},{"id":"T20","span":{"begin":1167,"end":1196},"obj":"Disease"},{"id":"T21","span":{"begin":1187,"end":1196},"obj":"Disease"},{"id":"T22","span":{"begin":1198,"end":1216},"obj":"Disease"},{"id":"T23","span":{"begin":1218,"end":1239},"obj":"Disease"},{"id":"T24","span":{"begin":1228,"end":1239},"obj":"Disease"},{"id":"T25","span":{"begin":1244,"end":1264},"obj":"Disease"},{"id":"T26","span":{"begin":1255,"end":1264},"obj":"Disease"},{"id":"T27","span":{"begin":1410,"end":1419},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0007179"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0007179"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005113"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005135"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0007179"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005801"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005790"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0002251"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0004656"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0007179"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0008383"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0005578"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0007915"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0004670"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0010030"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0004789"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0005301"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0020283"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0019434"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0011429"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/MONDO_0005578"},{"id":"A22","pred":"mondo_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/MONDO_0005100"},{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0007699"},{"id":"A24","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0004126"},{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0016264"},{"id":"A26","pred":"mondo_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/MONDO_0002251"},{"id":"A27","pred":"mondo_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":176,"end":177},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":292,"end":295},"obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"T3","span":{"begin":292,"end":295},"obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"T4","span":{"begin":292,"end":295},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T5","span":{"begin":424,"end":437},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T6","span":{"begin":569,"end":575},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T7","span":{"begin":609,"end":616},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T8","span":{"begin":718,"end":721},"obj":"http://purl.obolibrary.org/obo/CLO_0001798"},{"id":"T9","span":{"begin":736,"end":741},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T10","span":{"begin":779,"end":784},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T11","span":{"begin":806,"end":807},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T12","span":{"begin":814,"end":819},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T13","span":{"begin":833,"end":838},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T14","span":{"begin":872,"end":874},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T15","span":{"begin":884,"end":891},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T16","span":{"begin":1386,"end":1396},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T17","span":{"begin":1432,"end":1442},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T18","span":{"begin":1465,"end":1470},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T19","span":{"begin":1488,"end":1496},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T20","span":{"begin":1522,"end":1529},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":1446,"end":1453},"obj":"Chemical"},{"id":"T2","span":{"begin":1680,"end":1687},"obj":"Chemical"},{"id":"T3","span":{"begin":1733,"end":1741},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T2","span":{"begin":29,"end":48},"obj":"Phenotype"},{"id":"T3","span":{"begin":154,"end":172},"obj":"Phenotype"},{"id":"T4","span":{"begin":543,"end":555},"obj":"Phenotype"},{"id":"T5","span":{"begin":678,"end":697},"obj":"Phenotype"},{"id":"T6","span":{"begin":796,"end":805},"obj":"Phenotype"},{"id":"T7","span":{"begin":958,"end":977},"obj":"Phenotype"},{"id":"T8","span":{"begin":986,"end":1006},"obj":"Phenotype"},{"id":"T9","span":{"begin":1008,"end":1036},"obj":"Phenotype"},{"id":"T10","span":{"begin":1075,"end":1086},"obj":"Phenotype"},{"id":"T11","span":{"begin":1122,"end":1129},"obj":"Phenotype"},{"id":"T12","span":{"begin":1167,"end":1196},"obj":"Phenotype"},{"id":"T13","span":{"begin":1218,"end":1239},"obj":"Phenotype"},{"id":"T14","span":{"begin":1255,"end":1264},"obj":"Phenotype"},{"id":"T15","span":{"begin":1315,"end":1327},"obj":"Phenotype"}],"attributes":[{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0012115"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0001370"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0002725"},{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0030151"},{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0000554"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0005681"},{"id":"A13","pred":"hp_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/HP_0000872"},{"id":"A14","pred":"hp_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/HP_0012115"},{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":1446,"end":1464},"obj":"http://purl.obolibrary.org/obo/GO_0019882"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T3","span":{"begin":0,"end":452},"obj":"Sentence"},{"id":"T4","span":{"begin":453,"end":578},"obj":"Sentence"},{"id":"T5","span":{"begin":579,"end":706},"obj":"Sentence"},{"id":"T6","span":{"begin":707,"end":877},"obj":"Sentence"},{"id":"T7","span":{"begin":878,"end":1273},"obj":"Sentence"},{"id":"T8","span":{"begin":1274,"end":1638},"obj":"Sentence"},{"id":"T9","span":{"begin":1639,"end":1747},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T2","span":{"begin":29,"end":39},"obj":"UBERON:0002405"},{"id":"T3","span":{"begin":154,"end":164},"obj":"UBERON:0002405"},{"id":"T4","span":{"begin":197,"end":204},"obj":"SO:0000704"},{"id":"T5","span":{"begin":256,"end":265},"obj":"NCBITaxon:2"},{"id":"T6","span":{"begin":292,"end":295},"obj":"UBERON:0001555"},{"id":"T7","span":{"begin":308,"end":313},"obj":"NCBITaxon:10239"},{"id":"T8","span":{"begin":314,"end":320},"obj":"NCBITaxon:4751"},{"id":"T9","span":{"begin":424,"end":437},"obj":"UBERON:0002405"},{"id":"T10","span":{"begin":438,"end":451},"obj":"GO:0065007"},{"id":"T11","span":{"begin":609,"end":616},"obj":"NCBITaxon:10376"},{"id":"T12","span":{"begin":678,"end":688},"obj":"UBERON:0002405"},{"id":"T13","span":{"begin":707,"end":717},"obj":"NCBITaxon:6040"},{"id":"T14","span":{"begin":723,"end":741},"obj":"NCBITaxon:10376"},{"id":"T15","span":{"begin":743,"end":746},"obj":"NCBITaxon:10376"},{"id":"T16","span":{"begin":749,"end":764},"obj":"NCBITaxon:6073"},{"id":"T17","span":{"begin":766,"end":769},"obj":"NCBITaxon:10358"},{"id":"T18","span":{"begin":772,"end":785},"obj":"NCBITaxon:10376"},{"id":"T19","span":{"begin":788,"end":792},"obj":"NCBITaxon:10298"},{"id":"T20","span":{"begin":796,"end":805},"obj":"NCBITaxon:9606"},{"id":"T21","span":{"begin":812,"end":813},"obj":"NCBITaxon:10358"},{"id":"T22","span":{"begin":814,"end":819},"obj":"NCBITaxon:10239"},{"id":"T23","span":{"begin":825,"end":832},"obj":"NCBITaxon:7729"},{"id":"T24","span":{"begin":833,"end":838},"obj":"NCBITaxon:10376"},{"id":"T25","span":{"begin":884,"end":891},"obj":"NCBITaxon:10239"},{"id":"T26","span":{"begin":958,"end":968},"obj":"UBERON:0002405"},{"id":"T27","span":{"begin":1122,"end":1129},"obj":"UBERON:0001768"},{"id":"T28","span":{"begin":1228,"end":1239},"obj":"UBERON:0002046"},{"id":"T29","span":{"begin":1244,"end":1254},"obj":"UBERON:0002405"},{"id":"T30","span":{"begin":1446,"end":1453},"obj":"CHEBI:59132;CHEBI:59132"},{"id":"T31","span":{"begin":1522,"end":1529},"obj":"CL:0000084"},{"id":"T32","span":{"begin":1565,"end":1591},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T33","span":{"begin":1619,"end":1625},"obj":"UBERON:0000479"},{"id":"T34","span":{"begin":1680,"end":1687},"obj":"BV_9"},{"id":"T35","span":{"begin":1733,"end":1741},"obj":"CHEBI:59132;CHEBI:59132"},{"id":"T29290","span":{"begin":29,"end":39},"obj":"UBERON:0002405"},{"id":"T97833","span":{"begin":154,"end":164},"obj":"UBERON:0002405"},{"id":"T91717","span":{"begin":197,"end":204},"obj":"SO:0000704"},{"id":"T22401","span":{"begin":256,"end":265},"obj":"NCBITaxon:2"},{"id":"T83994","span":{"begin":292,"end":295},"obj":"UBERON:0001555"},{"id":"T63404","span":{"begin":308,"end":313},"obj":"NCBITaxon:10239"},{"id":"T63609","span":{"begin":314,"end":320},"obj":"NCBITaxon:4751"},{"id":"T48223","span":{"begin":424,"end":437},"obj":"UBERON:0002405"},{"id":"T49490","span":{"begin":438,"end":451},"obj":"GO:0065007"},{"id":"T88052","span":{"begin":609,"end":616},"obj":"NCBITaxon:10376"},{"id":"T79031","span":{"begin":678,"end":688},"obj":"UBERON:0002405"},{"id":"T36063","span":{"begin":707,"end":717},"obj":"NCBITaxon:6040"},{"id":"T39167","span":{"begin":723,"end":741},"obj":"NCBITaxon:10376"},{"id":"T51095","span":{"begin":743,"end":746},"obj":"NCBITaxon:10376"},{"id":"T77366","span":{"begin":749,"end":764},"obj":"NCBITaxon:6073"},{"id":"T1883","span":{"begin":766,"end":769},"obj":"NCBITaxon:10358"},{"id":"T38809","span":{"begin":772,"end":785},"obj":"NCBITaxon:10376"},{"id":"T46887","span":{"begin":788,"end":792},"obj":"NCBITaxon:10298"},{"id":"T98080","span":{"begin":796,"end":805},"obj":"NCBITaxon:9606"},{"id":"T34829","span":{"begin":812,"end":813},"obj":"NCBITaxon:10358"},{"id":"T2359","span":{"begin":814,"end":819},"obj":"NCBITaxon:10239"},{"id":"T1159","span":{"begin":825,"end":832},"obj":"NCBITaxon:7729"},{"id":"T37338","span":{"begin":833,"end":838},"obj":"NCBITaxon:10376"},{"id":"T5588","span":{"begin":884,"end":891},"obj":"NCBITaxon:10239"},{"id":"T42990","span":{"begin":958,"end":968},"obj":"UBERON:0002405"},{"id":"T67754","span":{"begin":1122,"end":1129},"obj":"UBERON:0001768"},{"id":"T74890","span":{"begin":1228,"end":1239},"obj":"UBERON:0002046"},{"id":"T93660","span":{"begin":1244,"end":1254},"obj":"UBERON:0002405"},{"id":"T73885","span":{"begin":1446,"end":1453},"obj":"CHEBI:59132;CHEBI:59132"},{"id":"T85769","span":{"begin":1522,"end":1529},"obj":"CL:0000084"},{"id":"T88270","span":{"begin":1565,"end":1591},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T6238","span":{"begin":1619,"end":1625},"obj":"UBERON:0000479"},{"id":"T84806","span":{"begin":1680,"end":1687},"obj":"BV_9"},{"id":"T88129","span":{"begin":1733,"end":1741},"obj":"CHEBI:59132;CHEBI:59132"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T3","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T4","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T5","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T6","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T7","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T8","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T17","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T18","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T19","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T20","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T21","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T22","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T23","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T24","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T25","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T26","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T27","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T28","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T29","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T30","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T31","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T32","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T33","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T34","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T35","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T29290","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T97833","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T91717","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T22401","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T83994","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T63404","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T63609","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T48223","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T49490","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T88052","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T79031","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T36063","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T39167","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T51095","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T77366","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1883","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T38809","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T46887","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T98080","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T34829","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T2359","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1159","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T37338","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T5588","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T42990","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T67754","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T74890","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T93660","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T73885","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T85769","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T88270","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T6238","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T84806","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T88129","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"24","span":{"begin":707,"end":721},"obj":"Species"},{"id":"25","span":{"begin":788,"end":794},"obj":"Species"},{"id":"26","span":{"begin":825,"end":838},"obj":"Species"},{"id":"27","span":{"begin":743,"end":746},"obj":"Species"},{"id":"28","span":{"begin":29,"end":48},"obj":"Disease"},{"id":"29","span":{"begin":154,"end":172},"obj":"Disease"},{"id":"30","span":{"begin":256,"end":276},"obj":"Disease"},{"id":"31","span":{"begin":325,"end":345},"obj":"Disease"},{"id":"32","span":{"begin":678,"end":697},"obj":"Disease"},{"id":"33","span":{"begin":796,"end":807},"obj":"Disease"},{"id":"34","span":{"begin":958,"end":977},"obj":"Disease"},{"id":"35","span":{"begin":986,"end":1006},"obj":"Disease"},{"id":"36","span":{"begin":1008,"end":1036},"obj":"Disease"},{"id":"37","span":{"begin":1038,"end":1056},"obj":"Disease"},{"id":"38","span":{"begin":1075,"end":1086},"obj":"Disease"},{"id":"39","span":{"begin":1088,"end":1106},"obj":"Disease"},{"id":"40","span":{"begin":1108,"end":1156},"obj":"Disease"},{"id":"41","span":{"begin":1167,"end":1196},"obj":"Disease"},{"id":"42","span":{"begin":1198,"end":1216},"obj":"Disease"},{"id":"43","span":{"begin":1218,"end":1239},"obj":"Disease"},{"id":"44","span":{"begin":1244,"end":1264},"obj":"Disease"},{"id":"45","span":{"begin":1410,"end":1419},"obj":"Disease"}],"attributes":[{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Tax:10798"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Tax:11908"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Tax:11041"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Tax:10376"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"MESH:D001327"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:D001327"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:D001424"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"MESH:D010272"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:D001327"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:D056486"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:D001327"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:D001172"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"MESH:D008180"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:D012859"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"MESH:D002761"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"MESH:D009103"},{"id":"A40","pred":"tao:has_database_id","subj":"40","obj":"MESH:D011695"},{"id":"A41","pred":"tao:has_database_id","subj":"41","obj":"MESH:D001171"},{"id":"A42","pred":"tao:has_database_id","subj":"42","obj":"MESH:D012595"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"MESH:D050031"},{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"MESH:D019693"},{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"MESH:D007239"},{"subj":"24","pred":"source","obj":"LitCovid-PubTator"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"26","pred":"source","obj":"LitCovid-PubTator"},{"subj":"27","pred":"source","obj":"LitCovid-PubTator"},{"subj":"28","pred":"source","obj":"LitCovid-PubTator"},{"subj":"29","pred":"source","obj":"LitCovid-PubTator"},{"subj":"30","pred":"source","obj":"LitCovid-PubTator"},{"subj":"31","pred":"source","obj":"LitCovid-PubTator"},{"subj":"32","pred":"source","obj":"LitCovid-PubTator"},{"subj":"33","pred":"source","obj":"LitCovid-PubTator"},{"subj":"34","pred":"source","obj":"LitCovid-PubTator"},{"subj":"35","pred":"source","obj":"LitCovid-PubTator"},{"subj":"36","pred":"source","obj":"LitCovid-PubTator"},{"subj":"37","pred":"source","obj":"LitCovid-PubTator"},{"subj":"38","pred":"source","obj":"LitCovid-PubTator"},{"subj":"39","pred":"source","obj":"LitCovid-PubTator"},{"subj":"40","pred":"source","obj":"LitCovid-PubTator"},{"subj":"41","pred":"source","obj":"LitCovid-PubTator"},{"subj":"42","pred":"source","obj":"LitCovid-PubTator"},{"subj":"43","pred":"source","obj":"LitCovid-PubTator"},{"subj":"44","pred":"source","obj":"LitCovid-PubTator"},{"subj":"45","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"2_test","denotations":[{"id":"32535093-16765709-4828840","span":{"begin":564,"end":565},"obj":"16765709"},{"id":"32535093-9412982-4828841","span":{"begin":569,"end":570},"obj":"9412982"},{"id":"32535093-8546799-4828842","span":{"begin":574,"end":575},"obj":"8546799"},{"id":"32535093-17917546-4828843","span":{"begin":841,"end":842},"obj":"17917546"},{"id":"32535093-26168641-4828844","span":{"begin":846,"end":847},"obj":"26168641"},{"id":"32535093-17894021-4828845","span":{"begin":851,"end":852},"obj":"17894021"},{"id":"32535093-18270862-4828846","span":{"begin":856,"end":857},"obj":"18270862"},{"id":"32535093-20511275-4828847","span":{"begin":861,"end":862},"obj":"20511275"},{"id":"32535093-27629582-4828848","span":{"begin":866,"end":868},"obj":"27629582"},{"id":"32535093-22749494-4828849","span":{"begin":1266,"end":1268},"obj":"22749494"},{"id":"32535093-19076824-4828850","span":{"begin":1360,"end":1362},"obj":"19076824"},{"id":"32535093-16418524-4828851","span":{"begin":1634,"end":1636},"obj":"16418524"},{"id":"32535093-31145640-4828852","span":{"begin":1743,"end":1745},"obj":"31145640"}],"attributes":[{"subj":"32535093-16765709-4828840","pred":"source","obj":"2_test"},{"subj":"32535093-9412982-4828841","pred":"source","obj":"2_test"},{"subj":"32535093-8546799-4828842","pred":"source","obj":"2_test"},{"subj":"32535093-17917546-4828843","pred":"source","obj":"2_test"},{"subj":"32535093-26168641-4828844","pred":"source","obj":"2_test"},{"subj":"32535093-17894021-4828845","pred":"source","obj":"2_test"},{"subj":"32535093-18270862-4828846","pred":"source","obj":"2_test"},{"subj":"32535093-20511275-4828847","pred":"source","obj":"2_test"},{"subj":"32535093-27629582-4828848","pred":"source","obj":"2_test"},{"subj":"32535093-22749494-4828849","pred":"source","obj":"2_test"},{"subj":"32535093-19076824-4828850","pred":"source","obj":"2_test"},{"subj":"32535093-16418524-4828851","pred":"source","obj":"2_test"},{"subj":"32535093-31145640-4828852","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#bb93ec","default":true},{"id":"LitCovid-PD-UBERON","color":"#93eca1"},{"id":"LitCovid-PD-MONDO","color":"#ec939e"},{"id":"LitCovid-PD-CLO","color":"#93b8ec"},{"id":"LitCovid-PD-CHEBI","color":"#d2ec93"},{"id":"LitCovid-PD-HP","color":"#ec93ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ecd2"},{"id":"LitCovid-sentences","color":"#ecb893"},{"id":"LitCovid-PMC-OGER-BB","color":"#9d93ec"},{"id":"LitCovid-PubTator","color":"#a2ec93"},{"id":"2_test","color":"#ec93bc"}]}]}}