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PMC:7289100 / 31024-38201 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T105 179-192 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T106 209-214 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T107 2129-2134 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T108 2915-2920 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T109 2969-2974 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T110 3657-3674 Body_part denotes connective tissue http://purl.org/sig/ont/fma/fma9640
T111 4045-4062 Body_part denotes connective tissue http://purl.org/sig/ont/fma/fma9640
T112 5736-5740 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T113 6101-6114 Body_part denotes interleukin-6 http://purl.org/sig/ont/fma/fma264829
T114 6771-6779 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T115 6841-6849 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T43 179-192 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T44 209-214 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T45 2915-2920 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443
T46 3657-3674 Body_part denotes connective tissue http://purl.obolibrary.org/obo/UBERON_0002384
T47 3668-3674 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T48 4045-4062 Body_part denotes connective tissue http://purl.obolibrary.org/obo/UBERON_0002384
T49 4056-4062 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T50 5431-5437 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T51 5736-5740 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T387 14-17 Disease denotes SLE http://purl.obolibrary.org/obo/MONDO_0007915
T388 149-159 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T389 312-315 Disease denotes SLE http://purl.obolibrary.org/obo/MONDO_0007915
T390 531-536 Disease denotes lupus http://purl.obolibrary.org/obo/MONDO_0004670
T391 626-639 Disease denotes tenosynovitis http://purl.obolibrary.org/obo/MONDO_0004855
T392 697-705 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T393 782-800 Disease denotes rheumatic diseases http://purl.obolibrary.org/obo/MONDO_0005554
T394 830-838 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T395 885-890 Disease denotes lupus http://purl.obolibrary.org/obo/MONDO_0004670
T396 933-938 Disease denotes lupus http://purl.obolibrary.org/obo/MONDO_0004670
T397 968-976 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T398 1029-1049 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T399 1040-1049 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T400 1075-1092 Disease denotes rheumatic disease http://purl.obolibrary.org/obo/MONDO_0005554
T401 1169-1172 Disease denotes SLE http://purl.obolibrary.org/obo/MONDO_0007915
T402 1218-1227 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T403 1297-1312 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T404 1303-1312 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T405 1469-1492 Disease denotes end-stage renal disease http://purl.obolibrary.org/obo/MONDO_0004375
T406 1479-1492 Disease denotes renal disease http://purl.obolibrary.org/obo/MONDO_0002118|http://purl.obolibrary.org/obo/MONDO_0005240
T408 1539-1574 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T409 1545-1574 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T410 1751-1768 Disease denotes rheumatic disease http://purl.obolibrary.org/obo/MONDO_0005554
T411 1966-1986 Disease denotes inflammatory disease http://purl.obolibrary.org/obo/MONDO_0021166
T412 2035-2055 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T413 2046-2055 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T414 2057-2076 Disease denotes psoriatic arthritis http://purl.obolibrary.org/obo/MONDO_0011849
T415 2067-2076 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T416 2078-2100 Disease denotes ankylosing spondylitis http://purl.obolibrary.org/obo/MONDO_0005306
T417 2089-2100 Disease denotes spondylitis http://purl.obolibrary.org/obo/MONDO_0003937
T418 2102-2111 Disease denotes psoriasis http://purl.obolibrary.org/obo/MONDO_0005083
T419 2116-2142 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T420 2782-2799 Disease denotes rheumatic disease http://purl.obolibrary.org/obo/MONDO_0005554
T421 2842-2862 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T422 2853-2862 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T423 2876-2894 Disease denotes systemic sclerosis http://purl.obolibrary.org/obo/MONDO_0005100
T424 3081-3098 Disease denotes rheumatic disease http://purl.obolibrary.org/obo/MONDO_0005554
T425 3384-3404 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T426 3395-3404 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T427 3657-3682 Disease denotes connective tissue disease http://purl.obolibrary.org/obo/MONDO_0003900|http://purl.obolibrary.org/obo/MONDO_0005554
T429 3775-3784 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T430 3826-3843 Disease denotes rheumatic disease http://purl.obolibrary.org/obo/MONDO_0005554
T431 3960-3988 Disease denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0007915
T432 3969-3988 Disease denotes lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0004670
T433 3999-4017 Disease denotes systemic sclerosis http://purl.obolibrary.org/obo/MONDO_0005100
T434 4028-4070 Disease denotes undifferentiated connective tissue disease http://purl.obolibrary.org/obo/MONDO_0019527
T435 4045-4070 Disease denotes connective tissue disease http://purl.obolibrary.org/obo/MONDO_0003900|http://purl.obolibrary.org/obo/MONDO_0005554
T437 4083-4099 Disease denotes Sjogren syndrome http://purl.obolibrary.org/obo/MONDO_0010030
T438 4339-4357 Disease denotes systemic sclerosis http://purl.obolibrary.org/obo/MONDO_0005100
T439 4446-4455 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T440 4604-4619 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T441 4610-4619 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T442 5010-5028 Disease denotes rheumatic diseases http://purl.obolibrary.org/obo/MONDO_0005554
T443 5199-5207 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T444 5263-5272 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T445 5438-5448 Disease denotes vasculitis http://purl.obolibrary.org/obo/MONDO_0018882
T446 5453-5485 Disease denotes granulomatosis with polyangiitis http://purl.obolibrary.org/obo/MONDO_0012105
T447 5511-5520 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T448 5685-5703 Disease denotes systemic sclerosis http://purl.obolibrary.org/obo/MONDO_0005100
T449 5723-5748 Disease denotes interstitial lung disease http://purl.obolibrary.org/obo/MONDO_0015925
T450 5736-5748 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T451 5750-5753 Disease denotes ILD http://purl.obolibrary.org/obo/MONDO_0015925
T452 5809-5818 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T453 5877-5895 Disease denotes systemic sclerosis http://purl.obolibrary.org/obo/MONDO_0005100
T454 6013-6024 Disease denotes scleroderma http://purl.obolibrary.org/obo/MONDO_0019340
T455 6036-6039 Disease denotes ILD http://purl.obolibrary.org/obo/MONDO_0015925
T456 6044-6057 Disease denotes polyarthritis http://purl.obolibrary.org/obo/MONDO_0024280
T457 6439-6452 Disease denotes acute disease http://purl.obolibrary.org/obo/MONDO_0020683
T458 6628-6632 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T459 6993-7012 Disease denotes autoimmune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T460 7044-7053 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T239 28-29 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T240 179-192 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T241 209-214 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T242 297-298 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T243 370-371 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T244 456-461 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T245 609-610 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T246 646-647 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T247 1059-1060 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T248 1124-1125 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T249 1239-1240 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T250 1851-1852 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T251 1922-1923 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T252 2173-2175 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T253 2915-2920 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T254 2969-2974 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T255 3325-3326 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T256 3657-3674 http://purl.obolibrary.org/obo/UBERON_0002384 denotes connective tissue
T257 3657-3674 http://www.ebi.ac.uk/efo/EFO_0000952 denotes connective tissue
T258 3885-3887 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T259 3946-3953 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T260 4045-4062 http://purl.obolibrary.org/obo/UBERON_0002384 denotes connective tissue
T261 4045-4062 http://www.ebi.ac.uk/efo/EFO_0000952 denotes connective tissue
T262 4180-4181 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T263 4319-4325 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T264 4410-4411 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T265 4529-4530 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T266 4602-4603 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T267 4647-4648 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T268 4654-4658 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T269 4670-4671 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T270 4946-4947 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T271 5292-5293 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T272 5388-5391 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T273 5431-5437 http://purl.obolibrary.org/obo/UBERON_0000055 denotes vessel
T274 5736-5740 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T275 5736-5740 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T276 5994-5995 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T277 6101-6114 http://purl.obolibrary.org/obo/PR_000001393 denotes interleukin-6
T278 6151-6152 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T279 6291-6292 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T280 6352-6357 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T281 6361-6362 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T282 6467-6468 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T283 6901-6914 http://purl.obolibrary.org/obo/OBI_0000245 denotes organizations
T284 7033-7034 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T129 81-86 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T130 287-292 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T131 1924-1929 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T132 2297-2302 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T133 2505-2510 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T134 2581-2586 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T135 3009-3025 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T136 3027-3038 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T137 4220-4235 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T138 4516-4527 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T139 5152-5161 Chemical denotes rituximab http://purl.obolibrary.org/obo/CHEBI_64357
T140 5165-5176 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T141 6256-6267 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T142 6529-6540 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T143 6683-6685 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T145 6816-6818 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T180 14-17 Phenotype denotes SLE http://purl.obolibrary.org/obo/HP_0002725
T181 142-159 Phenotype denotes severe infections http://purl.obolibrary.org/obo/HP_0032169
T182 312-315 Phenotype denotes SLE http://purl.obolibrary.org/obo/HP_0002725
T183 1029-1049 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T184 1169-1172 Phenotype denotes SLE http://purl.obolibrary.org/obo/HP_0002725
T185 1469-1492 Phenotype denotes end-stage renal disease http://purl.obolibrary.org/obo/HP_0003774
T186 1545-1565 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T187 2035-2055 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T188 2067-2076 Phenotype denotes arthritis http://purl.obolibrary.org/obo/HP_0001369
T189 2102-2111 Phenotype denotes psoriasis http://purl.obolibrary.org/obo/HP_0003765
T190 2116-2142 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T191 2842-2862 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T192 3384-3404 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T193 3960-3988 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725
T194 4446-4455 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T195 5263-5272 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T196 5425-5448 Phenotype denotes large-vessel vasculitis http://purl.obolibrary.org/obo/HP_0005310
T197 5453-5467 Phenotype denotes granulomatosis http://purl.obolibrary.org/obo/HP_0002955
T198 5723-5748 Phenotype denotes interstitial lung disease http://purl.obolibrary.org/obo/HP_0006530
T199 5750-5753 Phenotype denotes ILD http://purl.obolibrary.org/obo/HP_0006530
T200 5809-5818 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T201 6013-6024 Phenotype denotes scleroderma http://purl.obolibrary.org/obo/HP_0100324
T202 6036-6039 Phenotype denotes ILD http://purl.obolibrary.org/obo/HP_0006530
T203 6771-6785 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T204 6993-7012 Phenotype denotes autoimmune diseases http://purl.obolibrary.org/obo/HP_0002960

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T15 1297-1312 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T16 4604-4619 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T195 0-75 Sentence denotes Patients with SLE had posed a serious concern during the Covid-19 pandemia.
T196 76-293 Sentence denotes This group of patients is well known to bear an increased risk of severe infections, due to both their immune system and the related organ damage as well as due to the therapies used including immunosuppressive drugs.
T197 294-645 Sentence denotes In a report of 19 SLE patients from France who were clinically quiescent on a long-term treatment with Hydroxychloroquine (HCQ) and were infected by the Covid-19 virus, the authors were able to conclude that the clinical course of these lupus patients did not show any signs of the disease exacerbation, except for a single case of tenosynovitis [85].
T198 646-896 Sentence denotes A preliminary analysis of patients included in the COVID-19 Global Rheumatology Alliance registry, showed that 17% of 110 patients with rheumatic diseases who have been diagnosed with COVID-19 as of April the 1st, 2020- were patients with lupus [86].
T199 897-1120 Sentence denotes Thus the frequency of patients with lupus who have been diagnosed with COVID-19 was over-represented, at about twice as compared to rheumatoid arthritis which is a much commoner rheumatic disease among the adult population.
T200 1121-1580 Sentence denotes In a recent small report from northern Italy of SLE patients with either swab confirmed Covid-19 infection (n = 4) or a clinical diagnosis, based on 3 out of 4 symptoms of the viral infection (n = 8), the authors stated that the disease course was generally mild and self-resolving although one of the four patients who was on haemodialysis due to end-stage renal disease, needed intensive care for the development of acute respiratory distress syndrome [87].
T201 1581-1847 Sentence denotes Based on the clinical information published to date from the new and previous outbreaks caused by the coronaviruses, there is no overwhelming evidence that patients with rheumatic disease are at an increased risk compared with other comorbidities [[88], [89], [90]].
T202 1848-2225 Sentence denotes In a rather larger prospective report from New York, the authors reviewed a group of 86 patients with immune-mediated inflammatory disease including 59 cases of inflammatory arthritides (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, psoriasis and inflammatory bowel disease) with confirmed Covid-19, and 27 additional patients with suspected Covid-19 [91].
T203 2226-2303 Sentence denotes Two-thirds of the patients were on biologics or other immunomodulatory drugs.
T204 2304-2438 Sentence denotes Hospitalized patients, as compared to those who were only followed on an out-patient basis, had more classical Covid-19 comorbidities.
T205 2439-2599 Sentence denotes Conventional DMARDs were used more frequently in the hospitalized group of patients, whereas biologics were more often used in the ambulatory group of patients.
T206 2600-2727 Sentence denotes The authors suggest that based on their findings the baseline use of biologics was not associated with worse Covid-19 outcomes.
T207 2728-2832 Sentence denotes In another small report from China five patients with rheumatic disease and Covid-19 are described [92].
T208 2833-2895 Sentence denotes Four had rheumatoid arthritis and one with systemic sclerosis.
T209 2896-2975 Sentence denotes All 5 patients had chest CT showing patchy ground glass opacities in the lungs.
T210 2976-3099 Sentence denotes All 5 patients were treated with antiviral agents, antibiotics and the immunomodulatory agents for their rheumatic disease.
T211 3100-3313 Sentence denotes Two of the 5 patients remained in stable condition in the course of the hospitalization, 2 progressed to severe Covid-19 and one was critically ill, though all patients recovered and were discharged from hospital.
T212 3314-3587 Sentence denotes Similarly, a report by Monti et al. [93] suggested that patients with rheumatoid arthritis treated with biological DMARDs or targeted synthetic DMARDs did not seem to be at increased risk of life-threatening complications from Covid-19 compared with the general population.
T213 3588-3889 Sentence denotes Another recent study from Italy supports the approach of encouraging connective tissue disease patients to maintain the ongoing rheumatologic therapy as well as adhere to the measures of infection prevention, thus avoiding relapse of the rheumatic disease without increasing the risk of Covid-19 [94].
T214 3890-4109 Sentence denotes Their study population included 123 adult patients (110 females) with systemic lupus erythematosus (n = 61), systemic sclerosis (n = 43), undifferentiated connective tissue disease (n = 9) and Sjogren syndrome (n = 10).
T215 4110-4244 Sentence denotes About 60% of the patients were treated with conventional DMARDs, with a similar percentage of patients taking corticosteroids as well.
T216 4245-4296 Sentence denotes Twenty five of the 110 patients received biologics.
T217 4297-4528 Sentence denotes Only one rather young female patient with systemic sclerosis was found to be positive for Covid-19 and developed a critical course with interstitial pneumonia leading to her death despite intubation and an attempt with tocilizumab.
T218 4529-4705 Sentence denotes A further 14 patients reported mild respiratory symptoms compatible with a viral infection but did not have access to a swab test and showed a rapid recovery of their symptoms.
T219 4706-4897 Sentence denotes The authors concluded that only 5 out of their 123 patients had discontinued their current rheumatological therapy, with none of the rest 115 patients experiencing flare-ups of their disease.
T220 4898-5107 Sentence denotes Similarly, Conticini et al recently reported of a large cohort of 859 patients from Italy affected by different rheumatic diseases, which were treated by biological DMARDs or by targeted synthetic DMARDs [95].
T221 5108-5273 Sentence denotes Only 2 patients who were both on biologics (rituximab or tocilizumab), were diagnosed with COVID-19, one of which even with bilateral diffuse interstitial pneumonia.
T222 5274-5361 Sentence denotes Both patients had a complete recovery without interruption of the biological treatment.
T223 5362-5529 Sentence denotes Similar favorable outcome has been reported for few cases with large-vessel vasculitis and granulomatosis with polyangiitis associated with Covid-19 infection [96,97].
T224 5530-5622 Sentence denotes Thus it seems that baseline use of biologics is not associated with worse Covid-19 outcomes.
T225 5623-5839 Sentence denotes The situation might be different with patients suffering from systemic sclerosis, where the typical interstitial lung disease (ILD) could share some CT features with Covid-19 associated pneumonia [[98], [99], [100]].
T226 5840-5988 Sentence denotes Currently the impact of pre-existing systemic sclerosis associated with pulmonary and cardiac involvement, on the course of Covid-19 is yet unknown.
T227 5989-6201 Sentence denotes Such a single case with scleroderma associated ILD and polyarthritis, who had been previously treated with anti-interleukin-6 receptor blocker (Tocilizumab) with a favorable response, was recently reported [101].
T228 6202-6383 Sentence denotes In the course of this therapy, 4 weeks after the last tocilizumab infusion, she reported a contact with Covid-19 and was found to be positive for the virus by a nasopharyngeal swab.
T229 6384-6551 Sentence denotes Her condition remained stable during the course of the acute disease and following a negative swab and cure, she had received the next scheduled tocilizumab injection.
T230 6552-6786 Sentence denotes It should be noted that early reports from China during the outbreak of the SARS-Cov2 were able to demonstrate increased levels of IL-6 and CRP, suggesting that this subgroup of patients may develop the Covid19 related cytokine storm.
T231 6787-6872 Sentence denotes Randomized trials using anti-IL-6 receptor monoclonal antibody are currently ongoing.
T232 6873-7054 Sentence denotes Recently many countries and organizations have set up registries incorporating patients with pre-existing rheumatic and autoimmune diseases who had encountered a Covid-19 infection.
T233 7055-7177 Sentence denotes The largest international registries include The Global Rheumatology Alliance of Covid-19 and the Eular Covid-19 database.

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T432 57-65 SP_7 denotes Covid-19
T433 179-192 UBERON:0002405 denotes immune system
T434 209-214 UBERON:0000062 denotes organ
T435 269-286 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T436 287-292 CHEBI:23888;CHEBI:23888 denotes drugs
T437 357-366 GO:0044838 denotes quiescent
T438 397-415 CHEBI:5801;DG_20;CHEBI:5801 denotes Hydroxychloroquine
T439 447-455 SP_7 denotes Covid-19
T440 456-461 NCBITaxon:10239 denotes virus
T441 697-705 SP_7 denotes COVID-19
T442 830-838 SP_7 denotes COVID-19
T443 968-976 SP_7 denotes COVID-19
T444 1103-1108 UBERON:0007023 denotes adult
T445 1209-1217 SP_7 denotes Covid-19
T446 1297-1302 NCBITaxon:10239 denotes viral
T447 1479-1484 UBERON:0002113 denotes renal
T448 1545-1556 UBERON:0001004 denotes respiratory
T449 1683-1696 NCBITaxon:11118 denotes coronaviruses
T450 1950-1956 UBERON:0002405 denotes immune
T451 2116-2134 UBERON:0000160 denotes inflammatory bowel
T452 2159-2167 SP_7 denotes Covid-19
T453 2211-2219 SP_7 denotes Covid-19
T454 2280-2296 CHEBI:35705;CHEBI:35705 denotes immunomodulatory
T455 2297-2302 CHEBI:23888;CHEBI:23888 denotes drugs
T456 2415-2423 SP_7 denotes Covid-19
T457 2570-2580 GO:0040011 denotes ambulatory
T458 2709-2717 SP_7 denotes Covid-19
T459 2804-2812 SP_7 denotes Covid-19
T460 2915-2920 UBERON:0001443 denotes chest
T461 2969-2974 UBERON:0000170 denotes lungs
T462 3009-3025 CHEBI:22587;CHEBI:22587 denotes antiviral agents
T463 3027-3038 CHEBI:33282;CHEBI:33282 denotes antibiotics
T464 3212-3220 SP_7 denotes Covid-19
T465 3505-3509 UBERON:0000104 denotes life
T466 3541-3549 SP_7 denotes Covid-19
T467 3657-3674 UBERON:0002384 denotes connective tissue
T468 3875-3883 SP_7 denotes Covid-19
T469 3926-3931 UBERON:0007023 denotes adult
T470 4045-4062 UBERON:0002384 denotes connective tissue
T471 4220-4235 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T472 4387-4395 SP_7 denotes Covid-19
T473 4433-4445 UBERON:0005169 denotes interstitial
T474 4471-4476 GO:0016265 denotes death
T475 4516-4527 DG_35 denotes tocilizumab
T476 4565-4576 UBERON:0001004 denotes respiratory
T477 4604-4609 NCBITaxon:10239 denotes viral
T478 5165-5176 DG_35 denotes tocilizumab
T479 5199-5207 SP_7 denotes COVID-19
T480 5250-5262 UBERON:0005169 denotes interstitial
T481 5431-5437 UBERON:0000055 denotes vessel
T482 5502-5510 SP_7 denotes Covid-19
T483 5604-5612 SP_7 denotes Covid-19
T484 5723-5735 UBERON:0005169 denotes interstitial
T485 5736-5740 UBERON:0002048 denotes lung
T486 5789-5797 SP_7 denotes Covid-19
T487 5912-5921 UBERON:0002048 denotes pulmonary
T488 5926-5933 UBERON:0000948 denotes cardiac
T489 5964-5972 SP_7 denotes Covid-19
T490 6101-6114 PR:000001393 denotes interleukin-6
T491 6133-6144 DG_35 denotes Tocilizumab
T492 6256-6267 DG_35 denotes tocilizumab
T493 6306-6314 SP_7 denotes Covid-19
T494 6352-6357 NCBITaxon:10239 denotes virus
T495 6363-6377 UBERON:0001728 denotes nasopharyngeal
T496 6529-6540 DG_35 denotes tocilizumab
T497 6628-6637 SP_7 denotes SARS-Cov2
T498 6683-6687 PR:000001393 denotes IL-6
T499 6755-6762 SP_7 denotes Covid19
T500 6816-6820 PR:000001393 denotes IL-6
T501 6841-6849 GO:0042571 denotes antibody
T502 6993-7003 UBERON:0002405 denotes autoimmune
T503 7035-7043 SP_7 denotes Covid-19
T504 7136-7144 SP_7 denotes Covid-19
T505 7159-7167 SP_7 denotes Covid-19
T848 57-65 SP_7 denotes Covid-19
T48434 179-192 UBERON:0002405 denotes immune system
T57744 209-214 UBERON:0000062 denotes organ
T20754 269-286 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T36897 287-292 CHEBI:23888;CHEBI:23888 denotes drugs
T93117 357-366 GO:0044838 denotes quiescent
T45177 397-415 CHEBI:5801;DG_20;CHEBI:5801 denotes Hydroxychloroquine
T67338 447-455 SP_7 denotes Covid-19
T28381 456-461 NCBITaxon:10239 denotes virus
T79311 697-705 SP_7 denotes COVID-19
T26923 830-838 SP_7 denotes COVID-19
T22974 968-976 SP_7 denotes COVID-19
T3514 1103-1108 UBERON:0007023 denotes adult
T1056 1209-1217 SP_7 denotes Covid-19
T19195 1297-1302 NCBITaxon:10239 denotes viral
T29423 1479-1484 UBERON:0002113 denotes renal
T93140 1545-1556 UBERON:0001004 denotes respiratory
T35890 1683-1696 NCBITaxon:11118 denotes coronaviruses
T73009 1950-1956 UBERON:0002405 denotes immune
T96076 2116-2134 UBERON:0000160 denotes inflammatory bowel
T43599 2159-2167 SP_7 denotes Covid-19
T64476 2211-2219 SP_7 denotes Covid-19
T42270 2280-2296 CHEBI:35705;CHEBI:35705 denotes immunomodulatory
T34744 2297-2302 CHEBI:23888;CHEBI:23888 denotes drugs
T12090 2415-2423 SP_7 denotes Covid-19
T59595 2570-2580 GO:0040011 denotes ambulatory
T84418 2709-2717 SP_7 denotes Covid-19
T45430 2804-2812 SP_7 denotes Covid-19
T51324 2915-2920 UBERON:0001443 denotes chest
T62297 2969-2974 UBERON:0000170 denotes lungs
T33738 3009-3025 CHEBI:22587;CHEBI:22587 denotes antiviral agents
T66845 3027-3038 CHEBI:33282;CHEBI:33282 denotes antibiotics
T46583 3212-3220 SP_7 denotes Covid-19
T18343 3505-3509 UBERON:0000104 denotes life
T20545 3541-3549 SP_7 denotes Covid-19
T41868 3657-3674 UBERON:0002384 denotes connective tissue
T17556 3875-3883 SP_7 denotes Covid-19
T37618 3926-3931 UBERON:0007023 denotes adult
T25019 4045-4062 UBERON:0002384 denotes connective tissue
T19419 4220-4235 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T66532 4387-4395 SP_7 denotes Covid-19
T36067 4433-4445 UBERON:0005169 denotes interstitial
T49106 4471-4476 GO:0016265 denotes death
T46616 4516-4527 DG_35 denotes tocilizumab
T85742 4565-4576 UBERON:0001004 denotes respiratory
T13050 4604-4609 NCBITaxon:10239 denotes viral
T83995 5165-5176 DG_35 denotes tocilizumab
T99552 5199-5207 SP_7 denotes COVID-19
T95971 5250-5262 UBERON:0005169 denotes interstitial
T71752 5431-5437 UBERON:0000055 denotes vessel
T6802 5502-5510 SP_7 denotes Covid-19
T77426 5604-5612 SP_7 denotes Covid-19
T77304 5723-5735 UBERON:0005169 denotes interstitial
T76641 5736-5740 UBERON:0002048 denotes lung
T15000 5789-5797 SP_7 denotes Covid-19
T82223 5912-5921 UBERON:0002048 denotes pulmonary
T59648 5926-5933 UBERON:0000948 denotes cardiac
T14806 5964-5972 SP_7 denotes Covid-19
T10790 6101-6114 PR:000001393 denotes interleukin-6
T98744 6133-6144 DG_35 denotes Tocilizumab
T10818 6256-6267 DG_35 denotes tocilizumab
T52732 6306-6314 SP_7 denotes Covid-19
T62313 6352-6357 NCBITaxon:10239 denotes virus
T34080 6363-6377 UBERON:0001728 denotes nasopharyngeal
T52079 6529-6540 DG_35 denotes tocilizumab
T92642 6628-6637 SP_7 denotes SARS-Cov2
T18190 6683-6687 PR:000001393 denotes IL-6
T44717 6755-6762 SP_7 denotes Covid19
T61028 6816-6820 PR:000001393 denotes IL-6
T59222 6841-6849 GO:0042571 denotes antibody
T19494 6993-7003 UBERON:0002405 denotes autoimmune
T95414 7035-7043 SP_7 denotes Covid-19
T23446 7136-7144 SP_7 denotes Covid-19
T9228 7159-7167 SP_7 denotes Covid-19

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1151 6683-6687 Gene denotes IL-6 Gene:3569
1152 6692-6695 Gene denotes CRP Gene:1401
1153 0-8 Species denotes Patients Tax:9606
1154 90-98 Species denotes patients Tax:9606
1155 316-324 Species denotes patients Tax:9606
1156 447-461 Species denotes Covid-19 virus Tax:2697049
1157 537-545 Species denotes patients Tax:9606
1158 672-680 Species denotes patients Tax:9606
1159 768-776 Species denotes patients Tax:9606
1160 871-879 Species denotes patients Tax:9606
1161 919-927 Species denotes patients Tax:9606
1162 1173-1181 Species denotes patients Tax:9606
1163 1428-1436 Species denotes patients Tax:9606
1164 1683-1696 Species denotes coronaviruses Tax:11118
1165 1737-1745 Species denotes patients Tax:9606
1166 1936-1944 Species denotes patients Tax:9606
1167 2187-2195 Species denotes patients Tax:9606
1168 2244-2252 Species denotes patients Tax:9606
1169 2317-2325 Species denotes patients Tax:9606
1170 2381-2388 Species denotes patient Tax:9606
1171 2514-2522 Species denotes patients Tax:9606
1172 2590-2598 Species denotes patients Tax:9606
1173 2768-2776 Species denotes patients Tax:9606
1174 2902-2910 Species denotes patients Tax:9606
1175 2982-2990 Species denotes patients Tax:9606
1176 3113-3121 Species denotes patients Tax:9606
1177 3260-3268 Species denotes patients Tax:9606
1178 3370-3378 Species denotes patients Tax:9606
1179 3683-3691 Species denotes patients Tax:9606
1180 3932-3940 Species denotes patients Tax:9606
1181 4127-4135 Species denotes patients Tax:9606
1182 4204-4212 Species denotes patients Tax:9606
1183 4268-4276 Species denotes patients Tax:9606
1184 4326-4333 Species denotes patient Tax:9606
1185 4542-4550 Species denotes patients Tax:9606
1186 4757-4765 Species denotes patients Tax:9606
1187 4848-4856 Species denotes patients Tax:9606
1188 4968-4976 Species denotes patients Tax:9606
1189 5115-5123 Species denotes patients Tax:9606
1190 5279-5287 Species denotes patients Tax:9606
1191 5661-5669 Species denotes patients Tax:9606
1192 6628-6637 Species denotes SARS-Cov2 Tax:2697049
1193 6730-6738 Species denotes patients Tax:9606
1194 6952-6960 Species denotes patients Tax:9606
1195 397-415 Chemical denotes Hydroxychloroquine MESH:D006886
1196 417-420 Chemical denotes HCQ MESH:D006886
1197 4516-4527 Chemical denotes tocilizumab MESH:C502936
1198 5152-5161 Chemical denotes rituximab MESH:D000069283
1199 5165-5176 Chemical denotes tocilizumab MESH:C502936
1200 6133-6144 Chemical denotes Tocilizumab MESH:C502936
1201 6256-6267 Chemical denotes tocilizumab MESH:C502936
1202 6529-6540 Chemical denotes tocilizumab MESH:C502936
1203 14-17 Disease denotes SLE MESH:D008180
1204 57-65 Disease denotes Covid-19 MESH:C000657245
1205 149-159 Disease denotes infections MESH:D007239
1206 312-315 Disease denotes SLE MESH:D008180
1207 431-439 Disease denotes infected MESH:D007239
1208 531-536 Disease denotes lupus MESH:D008180
1209 626-639 Disease denotes tenosynovitis MESH:D013717
1210 697-705 Disease denotes COVID-19 MESH:C000657245
1211 782-800 Disease denotes rheumatic diseases MESH:D012216
1212 830-838 Disease denotes COVID-19 MESH:C000657245
1213 885-890 Disease denotes lupus MESH:D008180
1214 933-938 Disease denotes lupus MESH:D008180
1215 968-976 Disease denotes COVID-19 MESH:C000657245
1216 1029-1049 Disease denotes rheumatoid arthritis MESH:D001172
1217 1075-1092 Disease denotes rheumatic disease MESH:D012216
1218 1169-1172 Disease denotes SLE MESH:D008180
1219 1209-1217 Disease denotes Covid-19 MESH:C000657245
1220 1218-1227 Disease denotes infection MESH:D007239
1221 1297-1312 Disease denotes viral infection MESH:D001102
1222 1479-1492 Disease denotes renal disease MESH:D007674
1223 1539-1574 Disease denotes acute respiratory distress syndrome MESH:D012128
1224 1751-1768 Disease denotes rheumatic disease MESH:D012216
1225 2035-2055 Disease denotes rheumatoid arthritis MESH:D001172
1226 2057-2076 Disease denotes psoriatic arthritis MESH:D015535
1227 2078-2100 Disease denotes ankylosing spondylitis MESH:D013167
1228 2102-2111 Disease denotes psoriasis MESH:D011565
1229 2116-2142 Disease denotes inflammatory bowel disease MESH:D015212
1230 2159-2167 Disease denotes Covid-19 MESH:C000657245
1231 2211-2219 Disease denotes Covid-19 MESH:C000657245
1232 2415-2423 Disease denotes Covid-19 MESH:C000657245
1233 2709-2717 Disease denotes Covid-19 MESH:C000657245
1234 2782-2799 Disease denotes rheumatic disease MESH:D012216
1235 2804-2812 Disease denotes Covid-19 MESH:C000657245
1236 2842-2862 Disease denotes rheumatoid arthritis MESH:D001172
1237 2876-2894 Disease denotes systemic sclerosis MESH:D012595
1238 3081-3098 Disease denotes rheumatic disease MESH:D012216
1239 3212-3220 Disease denotes Covid-19 MESH:C000657245
1240 3233-3247 Disease denotes critically ill MESH:D016638
1241 3384-3404 Disease denotes rheumatoid arthritis MESH:D001172
1242 3448-3464 Disease denotes synthetic DMARDs OMIM:146820
1243 3541-3549 Disease denotes Covid-19 MESH:C000657245
1244 3775-3784 Disease denotes infection MESH:D007239
1245 3826-3843 Disease denotes rheumatic disease MESH:D012216
1246 3875-3883 Disease denotes Covid-19 MESH:C000657245
1247 3960-3988 Disease denotes systemic lupus erythematosus MESH:D008180
1248 3999-4017 Disease denotes systemic sclerosis MESH:D012595
1249 4083-4099 Disease denotes Sjogren syndrome MESH:D012859
1250 4339-4357 Disease denotes systemic sclerosis MESH:D012595
1251 4387-4395 Disease denotes Covid-19 MESH:C000657245
1252 4433-4455 Disease denotes interstitial pneumonia MESH:D009395
1253 4471-4476 Disease denotes death MESH:D003643
1254 4565-4585 Disease denotes respiratory symptoms MESH:D012818
1255 4604-4619 Disease denotes viral infection MESH:D001102
1256 5010-5028 Disease denotes rheumatic diseases MESH:D012216
1257 5085-5101 Disease denotes synthetic DMARDs OMIM:146820
1258 5199-5207 Disease denotes COVID-19 MESH:C000657245
1259 5263-5272 Disease denotes pneumonia MESH:D011014
1260 5438-5467 Disease denotes vasculitis and granulomatosis MESH:D014657
1261 5473-5485 Disease denotes polyangiitis MESH:D014890
1262 5502-5510 Disease denotes Covid-19 MESH:C000657245
1263 5511-5520 Disease denotes infection MESH:D007239
1264 5604-5612 Disease denotes Covid-19 MESH:C000657245
1265 5685-5703 Disease denotes systemic sclerosis MESH:D012595
1266 5736-5748 Disease denotes lung disease MESH:D008171
1267 5750-5753 Disease denotes ILD MESH:D017563
1268 5789-5797 Disease denotes Covid-19 MESH:C000657245
1269 5809-5818 Disease denotes pneumonia MESH:D011014
1270 5877-5895 Disease denotes systemic sclerosis MESH:D012595
1271 5964-5972 Disease denotes Covid-19 MESH:C000657245
1272 6013-6024 Disease denotes scleroderma MESH:C543759
1273 6036-6039 Disease denotes ILD MESH:D017563
1274 6044-6057 Disease denotes polyarthritis MESH:D001168
1275 6306-6314 Disease denotes Covid-19 MESH:C000657245
1276 6439-6452 Disease denotes acute disease MESH:D000208
1277 6993-7012 Disease denotes autoimmune diseases MESH:D001327
1278 7035-7043 Disease denotes Covid-19 MESH:C000657245
1279 7044-7053 Disease denotes infection MESH:D007239
1280 7136-7144 Disease denotes Covid-19 MESH:C000657245
1281 7159-7167 Disease denotes Covid-19 MESH:C000657245

2_test

Id Subject Object Predicate Lexical cue
32535093-32109013-4828883 1842-1844 32109013 denotes 90