PMC:7289100 / 27583-28061 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T95","span":{"begin":333,"end":338},"obj":"Body_part"},{"id":"T96","span":{"begin":357,"end":365},"obj":"Body_part"},{"id":"T97","span":{"begin":399,"end":402},"obj":"Body_part"},{"id":"T98","span":{"begin":472,"end":477},"obj":"Body_part"}],"attributes":[{"id":"A95","pred":"fma_id","subj":"T95","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A96","pred":"fma_id","subj":"T96","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A97","pred":"fma_id","subj":"T97","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A98","pred":"fma_id","subj":"T98","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Other possible mechanisms by which SARS-CoV-2 could induce a hyperinflammatory syndrome are: i) the autoantibodies formation through “molecular mimicry”, as in Acute Rheumatic Fever (although this mechanism would not justify the occurrence of shock); ii) a vascular damage secondary to the deposition of immune-complexes as in acute serum sickness; iii) an antibody-dependent enhancement (ADE) with IgG immune complexes that enhance virus infection in Fc-receptor-bearing cells."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T40","span":{"begin":333,"end":338},"obj":"Body_part"}],"attributes":[{"id":"A40","pred":"uberon_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"Other possible mechanisms by which SARS-CoV-2 could induce a hyperinflammatory syndrome are: i) the autoantibodies formation through “molecular mimicry”, as in Acute Rheumatic Fever (although this mechanism would not justify the occurrence of shock); ii) a vascular damage secondary to the deposition of immune-complexes as in acute serum sickness; iii) an antibody-dependent enhancement (ADE) with IgG immune complexes that enhance virus infection in Fc-receptor-bearing cells."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T352","span":{"begin":35,"end":43},"obj":"Disease"},{"id":"T353","span":{"begin":35,"end":39},"obj":"Disease"},{"id":"T354","span":{"begin":166,"end":181},"obj":"Disease"},{"id":"T355","span":{"begin":333,"end":347},"obj":"Disease"},{"id":"T356","span":{"begin":389,"end":392},"obj":"Disease"},{"id":"T357","span":{"begin":433,"end":448},"obj":"Disease"},{"id":"T358","span":{"begin":439,"end":448},"obj":"Disease"}],"attributes":[{"id":"A352","pred":"mondo_id","subj":"T352","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A353","pred":"mondo_id","subj":"T353","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A354","pred":"mondo_id","subj":"T354","obj":"http://purl.obolibrary.org/obo/MONDO_0017767"},{"id":"A355","pred":"mondo_id","subj":"T355","obj":"http://purl.obolibrary.org/obo/MONDO_0043789"},{"id":"A356","pred":"mondo_id","subj":"T356","obj":"http://purl.obolibrary.org/obo/MONDO_0019383"},{"id":"A357","pred":"mondo_id","subj":"T357","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A358","pred":"mondo_id","subj":"T358","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Other possible mechanisms by which SARS-CoV-2 could induce a hyperinflammatory syndrome are: i) the autoantibodies formation through “molecular mimicry”, as in Acute Rheumatic Fever (although this mechanism would not justify the occurrence of shock); ii) a vascular damage secondary to the deposition of immune-complexes as in acute serum sickness; iii) an antibody-dependent enhancement (ADE) with IgG immune complexes that enhance virus infection in Fc-receptor-bearing cells."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T221","span":{"begin":59,"end":60},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T222","span":{"begin":255,"end":256},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T223","span":{"begin":433,"end":438},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T224","span":{"begin":452,"end":454},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T225","span":{"begin":472,"end":477},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Other possible mechanisms by which SARS-CoV-2 could induce a hyperinflammatory syndrome are: i) the autoantibodies formation through “molecular mimicry”, as in Acute Rheumatic Fever (although this mechanism would not justify the occurrence of shock); ii) a vascular damage secondary to the deposition of immune-complexes as in acute serum sickness; iii) an antibody-dependent enhancement (ADE) with IgG immune complexes that enhance virus infection in Fc-receptor-bearing cells."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T177","span":{"begin":176,"end":181},"obj":"Phenotype"},{"id":"T178","span":{"begin":243,"end":248},"obj":"Phenotype"}],"attributes":[{"id":"A177","pred":"hp_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A178","pred":"hp_id","subj":"T178","obj":"http://purl.obolibrary.org/obo/HP_0031273"}],"text":"Other possible mechanisms by which SARS-CoV-2 could induce a hyperinflammatory syndrome are: i) the autoantibodies formation through “molecular mimicry”, as in Acute Rheumatic Fever (although this mechanism would not justify the occurrence of shock); ii) a vascular damage secondary to the deposition of immune-complexes as in acute serum sickness; iii) an antibody-dependent enhancement (ADE) with IgG immune complexes that enhance virus infection in Fc-receptor-bearing cells."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T12","span":{"begin":115,"end":124},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"Other possible mechanisms by which SARS-CoV-2 could induce a hyperinflammatory syndrome are: i) the autoantibodies formation through “molecular mimicry”, as in Acute Rheumatic Fever (although this mechanism would not justify the occurrence of shock); ii) a vascular damage secondary to the deposition of immune-complexes as in acute serum sickness; iii) an antibody-dependent enhancement (ADE) with IgG immune complexes that enhance virus infection in Fc-receptor-bearing cells."}

{"project":"LitCovid-sentences","denotations":[{"id":"T179","span":{"begin":0,"end":478},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Other possible mechanisms by which SARS-CoV-2 could induce a hyperinflammatory syndrome are: i) the autoantibodies formation through “molecular mimicry”, as in Acute Rheumatic Fever (although this mechanism would not justify the occurrence of shock); ii) a vascular damage secondary to the deposition of immune-complexes as in acute serum sickness; iii) an antibody-dependent enhancement (ADE) with IgG immune complexes that enhance virus infection in Fc-receptor-bearing cells."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T389","span":{"begin":35,"end":45},"obj":"SP_7"},{"id":"T390","span":{"begin":100,"end":114},"obj":"GO:0042571"},{"id":"T391","span":{"begin":304,"end":310},"obj":"UBERON:0002405"},{"id":"T392","span":{"begin":311,"end":320},"obj":"GO:0032991"},{"id":"T393","span":{"begin":333,"end":338},"obj":"UBERON:0001977"},{"id":"T394","span":{"begin":357,"end":365},"obj":"GO:0042571"},{"id":"T395","span":{"begin":399,"end":402},"obj":"GO:0071735"},{"id":"T396","span":{"begin":403,"end":409},"obj":"UBERON:0002405"},{"id":"T397","span":{"begin":410,"end":419},"obj":"GO:0032991"},{"id":"T398","span":{"begin":433,"end":438},"obj":"NCBITaxon:10239"},{"id":"T76353","span":{"begin":35,"end":45},"obj":"SP_7"},{"id":"T6122","span":{"begin":100,"end":114},"obj":"GO:0042571"},{"id":"T45069","span":{"begin":304,"end":310},"obj":"UBERON:0002405"},{"id":"T99998","span":{"begin":311,"end":320},"obj":"GO:0032991"},{"id":"T26306","span":{"begin":333,"end":338},"obj":"UBERON:0001977"},{"id":"T68672","span":{"begin":357,"end":365},"obj":"GO:0042571"},{"id":"T8993","span":{"begin":399,"end":402},"obj":"GO:0071735"},{"id":"T23253","span":{"begin":403,"end":409},"obj":"UBERON:0002405"},{"id":"T18082","span":{"begin":410,"end":419},"obj":"GO:0032991"},{"id":"T58686","span":{"begin":433,"end":438},"obj":"NCBITaxon:10239"}],"text":"Other possible mechanisms by which SARS-CoV-2 could induce a hyperinflammatory syndrome are: i) the autoantibodies formation through “molecular mimicry”, as in Acute Rheumatic Fever (although this mechanism would not justify the occurrence of shock); ii) a vascular damage secondary to the deposition of immune-complexes as in acute serum sickness; iii) an antibody-dependent enhancement (ADE) with IgG immune complexes that enhance virus infection in Fc-receptor-bearing cells."}

{"project":"LitCovid-PubTator","denotations":[{"id":"954","span":{"begin":35,"end":45},"obj":"Species"},{"id":"955","span":{"begin":61,"end":87},"obj":"Disease"},{"id":"956","span":{"begin":160,"end":181},"obj":"Disease"},{"id":"957","span":{"begin":433,"end":448},"obj":"Disease"}],"attributes":[{"id":"A954","pred":"tao:has_database_id","subj":"954","obj":"Tax:2697049"},{"id":"A955","pred":"tao:has_database_id","subj":"955","obj":"MESH:D061325"},{"id":"A956","pred":"tao:has_database_id","subj":"956","obj":"MESH:D012213"},{"id":"A957","pred":"tao:has_database_id","subj":"957","obj":"MESH:D001102"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Other possible mechanisms by which SARS-CoV-2 could induce a hyperinflammatory syndrome are: i) the autoantibodies formation through “molecular mimicry”, as in Acute Rheumatic Fever (although this mechanism would not justify the occurrence of shock); ii) a vascular damage secondary to the deposition of immune-complexes as in acute serum sickness; iii) an antibody-dependent enhancement (ADE) with IgG immune complexes that enhance virus infection in Fc-receptor-bearing cells."}