PMC:7283670 / 14263-14742 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T45844","span":{"begin":125,"end":130},"obj":"Body_part"},{"id":"T65421","span":{"begin":202,"end":205},"obj":"Body_part"},{"id":"T45087","span":{"begin":213,"end":217},"obj":"Body_part"}],"attributes":[{"id":"A6881","pred":"fma_id","subj":"T45844","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A79515","pred":"fma_id","subj":"T65421","obj":"http://purl.org/sig/ont/fma/fma24890"},{"id":"A67556","pred":"fma_id","subj":"T45087","obj":"http://purl.org/sig/ont/fma/fma12520"}],"text":"trointestinal, and renal symptoms: homeostasis of electrolytes\nAn essential player in maintenance of electrolyte balance and blood pressure, ACE2 is regarded by many as the principal counter‐regulatory arm in the axis of renin–angiotensin‐aldosterone system (RAAS; Santos, Ferreira, \u0026 Simões e Silva, 2008). Upon infection, SARS‐CoV‐2 binds ACE2. This results in degradation of ACE2, which subsequently dampens the counter‐effect of ACE2 on RAAS. The final effect of ACE2 in an o"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T24","span":{"begin":125,"end":130},"obj":"Body_part"},{"id":"T25","span":{"begin":202,"end":205},"obj":"Body_part"}],"attributes":[{"id":"A24","pred":"uberon_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A25","pred":"uberon_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/UBERON_0001460"}],"text":"trointestinal, and renal symptoms: homeostasis of electrolytes\nAn essential player in maintenance of electrolyte balance and blood pressure, ACE2 is regarded by many as the principal counter‐regulatory arm in the axis of renin–angiotensin‐aldosterone system (RAAS; Santos, Ferreira, \u0026 Simões e Silva, 2008). Upon infection, SARS‐CoV‐2 binds ACE2. This results in degradation of ACE2, which subsequently dampens the counter‐effect of ACE2 on RAAS. The final effect of ACE2 in an o"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T72","span":{"begin":313,"end":322},"obj":"Disease"},{"id":"T73","span":{"begin":324,"end":328},"obj":"Disease"}],"attributes":[{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"trointestinal, and renal symptoms: homeostasis of electrolytes\nAn essential player in maintenance of electrolyte balance and blood pressure, ACE2 is regarded by many as the principal counter‐regulatory arm in the axis of renin–angiotensin‐aldosterone system (RAAS; Santos, Ferreira, \u0026 Simões e Silva, 2008). Upon infection, SARS‐CoV‐2 binds ACE2. This results in degradation of ACE2, which subsequently dampens the counter‐effect of ACE2 on RAAS. The final effect of ACE2 in an o"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T99674","span":{"begin":125,"end":130},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T84772","span":{"begin":125,"end":130},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T30692","span":{"begin":202,"end":205},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"}],"text":"trointestinal, and renal symptoms: homeostasis of electrolytes\nAn essential player in maintenance of electrolyte balance and blood pressure, ACE2 is regarded by many as the principal counter‐regulatory arm in the axis of renin–angiotensin‐aldosterone system (RAAS; Santos, Ferreira, \u0026 Simões e Silva, 2008). Upon infection, SARS‐CoV‐2 binds ACE2. This results in degradation of ACE2, which subsequently dampens the counter‐effect of ACE2 on RAAS. The final effect of ACE2 in an o"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T22","span":{"begin":227,"end":238},"obj":"Chemical"},{"id":"T23","span":{"begin":239,"end":250},"obj":"Chemical"}],"attributes":[{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_27584"},{"id":"A24","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_30834"}],"text":"trointestinal, and renal symptoms: homeostasis of electrolytes\nAn essential player in maintenance of electrolyte balance and blood pressure, ACE2 is regarded by many as the principal counter‐regulatory arm in the axis of renin–angiotensin‐aldosterone system (RAAS; Santos, Ferreira, \u0026 Simões e Silva, 2008). Upon infection, SARS‐CoV‐2 binds ACE2. This results in degradation of ACE2, which subsequently dampens the counter‐effect of ACE2 on RAAS. The final effect of ACE2 in an o"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T19456","span":{"begin":35,"end":46},"obj":"http://purl.obolibrary.org/obo/GO_0042592"},{"id":"T94048","span":{"begin":363,"end":374},"obj":"http://purl.obolibrary.org/obo/GO_0009056"}],"text":"trointestinal, and renal symptoms: homeostasis of electrolytes\nAn essential player in maintenance of electrolyte balance and blood pressure, ACE2 is regarded by many as the principal counter‐regulatory arm in the axis of renin–angiotensin‐aldosterone system (RAAS; Santos, Ferreira, \u0026 Simões e Silva, 2008). Upon infection, SARS‐CoV‐2 binds ACE2. This results in degradation of ACE2, which subsequently dampens the counter‐effect of ACE2 on RAAS. The final effect of ACE2 in an o"}

{"project":"LitCovid-sentences","denotations":[{"id":"T110","span":{"begin":63,"end":307},"obj":"Sentence"},{"id":"T111","span":{"begin":308,"end":346},"obj":"Sentence"},{"id":"T112","span":{"begin":347,"end":446},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"trointestinal, and renal symptoms: homeostasis of electrolytes\nAn essential player in maintenance of electrolyte balance and blood pressure, ACE2 is regarded by many as the principal counter‐regulatory arm in the axis of renin–angiotensin‐aldosterone system (RAAS; Santos, Ferreira, \u0026 Simões e Silva, 2008). Upon infection, SARS‐CoV‐2 binds ACE2. This results in degradation of ACE2, which subsequently dampens the counter‐effect of ACE2 on RAAS. The final effect of ACE2 in an o"}

{"project":"LitCovid-PubTator","denotations":[{"id":"279","span":{"begin":19,"end":33},"obj":"Disease"},{"id":"294","span":{"begin":141,"end":145},"obj":"Gene"},{"id":"295","span":{"begin":341,"end":345},"obj":"Gene"},{"id":"296","span":{"begin":378,"end":382},"obj":"Gene"},{"id":"297","span":{"begin":433,"end":437},"obj":"Gene"},{"id":"298","span":{"begin":467,"end":471},"obj":"Gene"},{"id":"299","span":{"begin":324,"end":334},"obj":"Species"},{"id":"300","span":{"begin":239,"end":250},"obj":"Chemical"},{"id":"306","span":{"begin":313,"end":322},"obj":"Disease"}],"attributes":[{"id":"A279","pred":"tao:has_database_id","subj":"279","obj":"MESH:D004421"},{"id":"A294","pred":"tao:has_database_id","subj":"294","obj":"Gene:59272"},{"id":"A295","pred":"tao:has_database_id","subj":"295","obj":"Gene:59272"},{"id":"A296","pred":"tao:has_database_id","subj":"296","obj":"Gene:59272"},{"id":"A297","pred":"tao:has_database_id","subj":"297","obj":"Gene:59272"},{"id":"A298","pred":"tao:has_database_id","subj":"298","obj":"Gene:59272"},{"id":"A299","pred":"tao:has_database_id","subj":"299","obj":"Tax:2697049"},{"id":"A300","pred":"tao:has_database_id","subj":"300","obj":"MESH:D000450"},{"id":"A306","pred":"tao:has_database_id","subj":"306","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"trointestinal, and renal symptoms: homeostasis of electrolytes\nAn essential player in maintenance of electrolyte balance and blood pressure, ACE2 is regarded by many as the principal counter‐regulatory arm in the axis of renin–angiotensin‐aldosterone system (RAAS; Santos, Ferreira, \u0026 Simões e Silva, 2008). Upon infection, SARS‐CoV‐2 binds ACE2. This results in degradation of ACE2, which subsequently dampens the counter‐effect of ACE2 on RAAS. The final effect of ACE2 in an o"}