PMC:7283670 / 13343-14241 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7283670","sourcedb":"PMC","sourceid":"7283670","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7283670","text":"2.3 Liver damage\nImpaired liver function tests have been reported for a number of patients with SARS‐CoV‐2 infection, suggesting hepatic damage as an extrapulmonary complication of COVID‐19 in almost one half of the patients (Chen, Zhou, et al., 2020; Wang, Hu, et al., 2020). A recent study has concluded that liver function abnormality might stem from infection of bile duct cells with SARS‐CoV‐2. Nonetheless, the alkaline phosphatase value, which is an index of bile duct damage, were not specific in patients with COVID‐19 (Chen, Zhou, et al., 2020; Wang, Hu, et al., 2020). Investigation of liver biopsy specimens was accompanied by new pathological findings. Scientists have reported moderate microvascular steatosis, and mild lobular and portal activity in these patients, that suggests liver damage may have arisen from either SARS‐CoV‐2 infection or drug‐induced liver (Xu et al., 2020).","divisions":[{"label":"label","span":{"begin":0,"end":3}},{"label":"title","span":{"begin":5,"end":17}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T83088","span":{"begin":5,"end":10},"obj":"Body_part"},{"id":"T78439","span":{"begin":27,"end":32},"obj":"Body_part"},{"id":"T25717","span":{"begin":312,"end":317},"obj":"Body_part"},{"id":"T73445","span":{"begin":368,"end":377},"obj":"Body_part"},{"id":"T72041","span":{"begin":378,"end":383},"obj":"Body_part"},{"id":"T58247","span":{"begin":467,"end":476},"obj":"Body_part"},{"id":"T31815","span":{"begin":598,"end":603},"obj":"Body_part"},{"id":"T15072","span":{"begin":796,"end":801},"obj":"Body_part"},{"id":"T14190","span":{"begin":874,"end":879},"obj":"Body_part"}],"attributes":[{"id":"A63303","pred":"fma_id","subj":"T83088","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A19843","pred":"fma_id","subj":"T78439","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A97931","pred":"fma_id","subj":"T25717","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A24343","pred":"fma_id","subj":"T73445","obj":"http://purl.org/sig/ont/fma/fma9706"},{"id":"A52949","pred":"fma_id","subj":"T72041","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A64145","pred":"fma_id","subj":"T58247","obj":"http://purl.org/sig/ont/fma/fma9706"},{"id":"A39321","pred":"fma_id","subj":"T31815","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A23156","pred":"fma_id","subj":"T15072","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A8042","pred":"fma_id","subj":"T14190","obj":"http://purl.org/sig/ont/fma/fma7197"},{"subj":"T83088","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T78439","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T25717","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T73445","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T72041","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T58247","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T31815","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T15072","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T14190","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T12","span":{"begin":5,"end":10},"obj":"Body_part"},{"id":"T13","span":{"begin":27,"end":32},"obj":"Body_part"},{"id":"T14","span":{"begin":312,"end":317},"obj":"Body_part"},{"id":"T15","span":{"begin":368,"end":377},"obj":"Body_part"},{"id":"T16","span":{"begin":368,"end":372},"obj":"Body_part"},{"id":"T17","span":{"begin":373,"end":377},"obj":"Body_part"},{"id":"T18","span":{"begin":467,"end":476},"obj":"Body_part"},{"id":"T19","span":{"begin":467,"end":471},"obj":"Body_part"},{"id":"T20","span":{"begin":472,"end":476},"obj":"Body_part"},{"id":"T21","span":{"begin":598,"end":603},"obj":"Body_part"},{"id":"T22","span":{"begin":796,"end":801},"obj":"Body_part"},{"id":"T23","span":{"begin":874,"end":879},"obj":"Body_part"}],"attributes":[{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0002394"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0001970"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0000058"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0002394"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0001970"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0000058"},{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A23","pred":"uberon_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T64","span":{"begin":97,"end":101},"obj":"Disease"},{"id":"T65","span":{"begin":108,"end":117},"obj":"Disease"},{"id":"T66","span":{"begin":182,"end":190},"obj":"Disease"},{"id":"T67","span":{"begin":355,"end":364},"obj":"Disease"},{"id":"T68","span":{"begin":389,"end":393},"obj":"Disease"},{"id":"T69","span":{"begin":520,"end":528},"obj":"Disease"},{"id":"T70","span":{"begin":837,"end":841},"obj":"Disease"},{"id":"T71","span":{"begin":848,"end":857},"obj":"Disease"}],"attributes":[{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A67","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A68","pred":"mondo_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A69","pred":"mondo_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A70","pred":"mondo_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A71","pred":"mondo_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T58177","span":{"begin":5,"end":10},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T38626","span":{"begin":5,"end":10},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T20037","span":{"begin":27,"end":32},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T23913","span":{"begin":27,"end":32},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T51401","span":{"begin":42,"end":47},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T41552","span":{"begin":71,"end":72},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T51587","span":{"begin":278,"end":279},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T97632","span":{"begin":293,"end":296},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T65016","span":{"begin":312,"end":317},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T10091","span":{"begin":312,"end":317},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T93522","span":{"begin":368,"end":377},"obj":"http://purl.obolibrary.org/obo/UBERON_0002394"},{"id":"T2425","span":{"begin":378,"end":383},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14278","span":{"begin":418,"end":438},"obj":"http://purl.obolibrary.org/obo/PR_000023540"},{"id":"T40828","span":{"begin":467,"end":476},"obj":"http://purl.obolibrary.org/obo/UBERON_0002394"},{"id":"T25173","span":{"begin":598,"end":603},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T60607","span":{"begin":598,"end":603},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T43711","span":{"begin":754,"end":762},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T50046","span":{"begin":796,"end":801},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T12394","span":{"begin":796,"end":801},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T44962","span":{"begin":874,"end":879},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T50968","span":{"begin":874,"end":879},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"}],"attributes":[{"subj":"T58177","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T38626","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T20037","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T23913","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T51401","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T41552","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T51587","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T97632","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T65016","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10091","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T93522","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2425","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14278","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T40828","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T25173","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T60607","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T43711","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T50046","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12394","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T44962","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T50968","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T21","span":{"begin":861,"end":865},"obj":"Chemical"}],"attributes":[{"id":"A21","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T50590","span":{"begin":427,"end":438},"obj":"http://purl.obolibrary.org/obo/GO_0016791"}],"attributes":[{"subj":"T50590","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T103","span":{"begin":0,"end":17},"obj":"Sentence"},{"id":"T104","span":{"begin":18,"end":277},"obj":"Sentence"},{"id":"T105","span":{"begin":278,"end":400},"obj":"Sentence"},{"id":"T106","span":{"begin":401,"end":580},"obj":"Sentence"},{"id":"T107","span":{"begin":581,"end":666},"obj":"Sentence"},{"id":"T108","span":{"begin":667,"end":898},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T103","pred":"source","obj":"LitCovid-sentences"},{"subj":"T104","pred":"source","obj":"LitCovid-sentences"},{"subj":"T105","pred":"source","obj":"LitCovid-sentences"},{"subj":"T106","pred":"source","obj":"LitCovid-sentences"},{"subj":"T107","pred":"source","obj":"LitCovid-sentences"},{"subj":"T108","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T14","span":{"begin":715,"end":724},"obj":"Phenotype"}],"attributes":[{"id":"A14","pred":"hp_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/HP_0001397"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"249","span":{"begin":5,"end":17},"obj":"Disease"},{"id":"264","span":{"begin":83,"end":91},"obj":"Species"},{"id":"265","span":{"begin":217,"end":225},"obj":"Species"},{"id":"266","span":{"begin":389,"end":399},"obj":"Species"},{"id":"267","span":{"begin":506,"end":514},"obj":"Species"},{"id":"268","span":{"begin":772,"end":780},"obj":"Species"},{"id":"269","span":{"begin":97,"end":117},"obj":"Disease"},{"id":"270","span":{"begin":130,"end":144},"obj":"Disease"},{"id":"271","span":{"begin":182,"end":190},"obj":"Disease"},{"id":"272","span":{"begin":355,"end":364},"obj":"Disease"},{"id":"273","span":{"begin":467,"end":483},"obj":"Disease"},{"id":"274","span":{"begin":520,"end":528},"obj":"Disease"},{"id":"275","span":{"begin":701,"end":724},"obj":"Disease"},{"id":"276","span":{"begin":796,"end":808},"obj":"Disease"},{"id":"277","span":{"begin":837,"end":857},"obj":"Disease"}],"attributes":[{"id":"A249","pred":"tao:has_database_id","subj":"249","obj":"MESH:D056486"},{"id":"A264","pred":"tao:has_database_id","subj":"264","obj":"Tax:9606"},{"id":"A265","pred":"tao:has_database_id","subj":"265","obj":"Tax:9606"},{"id":"A266","pred":"tao:has_database_id","subj":"266","obj":"Tax:2697049"},{"id":"A267","pred":"tao:has_database_id","subj":"267","obj":"Tax:9606"},{"id":"A268","pred":"tao:has_database_id","subj":"268","obj":"Tax:9606"},{"id":"A269","pred":"tao:has_database_id","subj":"269","obj":"MESH:C000657245"},{"id":"A270","pred":"tao:has_database_id","subj":"270","obj":"MESH:D056486"},{"id":"A271","pred":"tao:has_database_id","subj":"271","obj":"MESH:C000657245"},{"id":"A272","pred":"tao:has_database_id","subj":"272","obj":"MESH:D007239"},{"id":"A273","pred":"tao:has_database_id","subj":"273","obj":"MESH:D001649"},{"id":"A274","pred":"tao:has_database_id","subj":"274","obj":"MESH:C000657245"},{"id":"A275","pred":"tao:has_database_id","subj":"275","obj":"MESH:D005234"},{"id":"A276","pred":"tao:has_database_id","subj":"276","obj":"MESH:D056486"},{"id":"A277","pred":"tao:has_database_id","subj":"277","obj":"MESH:C000657245"},{"subj":"249","pred":"source","obj":"LitCovid-PubTator"},{"subj":"264","pred":"source","obj":"LitCovid-PubTator"},{"subj":"265","pred":"source","obj":"LitCovid-PubTator"},{"subj":"266","pred":"source","obj":"LitCovid-PubTator"},{"subj":"267","pred":"source","obj":"LitCovid-PubTator"},{"subj":"268","pred":"source","obj":"LitCovid-PubTator"},{"subj":"269","pred":"source","obj":"LitCovid-PubTator"},{"subj":"270","pred":"source","obj":"LitCovid-PubTator"},{"subj":"271","pred":"source","obj":"LitCovid-PubTator"},{"subj":"272","pred":"source","obj":"LitCovid-PubTator"},{"subj":"273","pred":"source","obj":"LitCovid-PubTator"},{"subj":"274","pred":"source","obj":"LitCovid-PubTator"},{"subj":"275","pred":"source","obj":"LitCovid-PubTator"},{"subj":"276","pred":"source","obj":"LitCovid-PubTator"},{"subj":"277","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93b2","default":true},{"id":"LitCovid-PD-UBERON","color":"#93ccec"},{"id":"LitCovid-PD-MONDO","color":"#e6ec93"},{"id":"LitCovid-PD-CLO","color":"#d893ec"},{"id":"LitCovid-PD-CHEBI","color":"#93ecbe"},{"id":"LitCovid-PD-GO-BP","color":"#eca393"},{"id":"LitCovid-sentences","color":"#939cec"},{"id":"LitCovid-PD-HP","color":"#b6ec93"},{"id":"LitCovid-PubTator","color":"#ec93d0"}]}]}}