PMC:7283670 / 123005-123447 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T84","span":{"begin":184,"end":193},"obj":"Body_part"},{"id":"T85","span":{"begin":251,"end":255},"obj":"Body_part"}],"attributes":[{"id":"A84","pred":"fma_id","subj":"T84","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"It has been suggested that the broad‐spectrum antiviral activity of chloroquine phosphate lies within the complicated pharmacodynamics of the drug that results in a basic shift in the endosomal pH required for successful fusion of virus onto the host cell. chloroquine phosphate also seems to have disruptive effects on glycosylation of cellular receptors of SARS‐CoV (Yin \u0026 Wunderink, 2018; Zumla et al., 2020), rendering them nonfunctional."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T669","span":{"begin":359,"end":363},"obj":"Disease"}],"attributes":[{"id":"A669","pred":"mondo_id","subj":"T669","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"It has been suggested that the broad‐spectrum antiviral activity of chloroquine phosphate lies within the complicated pharmacodynamics of the drug that results in a basic shift in the endosomal pH required for successful fusion of virus onto the host cell. chloroquine phosphate also seems to have disruptive effects on glycosylation of cellular receptors of SARS‐CoV (Yin \u0026 Wunderink, 2018; Zumla et al., 2020), rendering them nonfunctional."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T156","span":{"begin":3,"end":6},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T157","span":{"begin":56,"end":64},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T158","span":{"begin":163,"end":164},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T159","span":{"begin":231,"end":236},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T160","span":{"begin":251,"end":255},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T161","span":{"begin":386,"end":390},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"}],"text":"It has been suggested that the broad‐spectrum antiviral activity of chloroquine phosphate lies within the complicated pharmacodynamics of the drug that results in a basic shift in the endosomal pH required for successful fusion of virus onto the host cell. chloroquine phosphate also seems to have disruptive effects on glycosylation of cellular receptors of SARS‐CoV (Yin \u0026 Wunderink, 2018; Zumla et al., 2020), rendering them nonfunctional."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T49099","span":{"begin":46,"end":55},"obj":"Chemical"},{"id":"T47561","span":{"begin":68,"end":79},"obj":"Chemical"},{"id":"T3955","span":{"begin":80,"end":89},"obj":"Chemical"},{"id":"T238","span":{"begin":142,"end":146},"obj":"Chemical"},{"id":"T64771","span":{"begin":257,"end":268},"obj":"Chemical"},{"id":"T240","span":{"begin":269,"end":278},"obj":"Chemical"}],"attributes":[{"id":"A45011","pred":"chebi_id","subj":"T49099","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A91565","pred":"chebi_id","subj":"T47561","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A41137","pred":"chebi_id","subj":"T3955","obj":"http://purl.obolibrary.org/obo/CHEBI_18367"},{"id":"A29766","pred":"chebi_id","subj":"T3955","obj":"http://purl.obolibrary.org/obo/CHEBI_26020"},{"id":"A82934","pred":"chebi_id","subj":"T3955","obj":"http://purl.obolibrary.org/obo/CHEBI_35780"},{"id":"A59775","pred":"chebi_id","subj":"T3955","obj":"http://purl.obolibrary.org/obo/CHEBI_43474"},{"id":"A52407","pred":"chebi_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A79819","pred":"chebi_id","subj":"T64771","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A85310","pred":"chebi_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/CHEBI_18367"},{"id":"A22874","pred":"chebi_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/CHEBI_26020"},{"id":"A35025","pred":"chebi_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/CHEBI_35780"},{"id":"A60351","pred":"chebi_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/CHEBI_43474"}],"text":"It has been suggested that the broad‐spectrum antiviral activity of chloroquine phosphate lies within the complicated pharmacodynamics of the drug that results in a basic shift in the endosomal pH required for successful fusion of virus onto the host cell. chloroquine phosphate also seems to have disruptive effects on glycosylation of cellular receptors of SARS‐CoV (Yin \u0026 Wunderink, 2018; Zumla et al., 2020), rendering them nonfunctional."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T15","span":{"begin":320,"end":333},"obj":"http://purl.obolibrary.org/obo/GO_0070085"}],"text":"It has been suggested that the broad‐spectrum antiviral activity of chloroquine phosphate lies within the complicated pharmacodynamics of the drug that results in a basic shift in the endosomal pH required for successful fusion of virus onto the host cell. chloroquine phosphate also seems to have disruptive effects on glycosylation of cellular receptors of SARS‐CoV (Yin \u0026 Wunderink, 2018; Zumla et al., 2020), rendering them nonfunctional."}

{"project":"LitCovid-sentences","denotations":[{"id":"T1026","span":{"begin":0,"end":442},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"It has been suggested that the broad‐spectrum antiviral activity of chloroquine phosphate lies within the complicated pharmacodynamics of the drug that results in a basic shift in the endosomal pH required for successful fusion of virus onto the host cell. chloroquine phosphate also seems to have disruptive effects on glycosylation of cellular receptors of SARS‐CoV (Yin \u0026 Wunderink, 2018; Zumla et al., 2020), rendering them nonfunctional."}

{"project":"LitCovid-PubTator","denotations":[{"id":"2502","span":{"begin":359,"end":367},"obj":"Species"},{"id":"2506","span":{"begin":68,"end":89},"obj":"Chemical"},{"id":"2507","span":{"begin":257,"end":278},"obj":"Chemical"}],"attributes":[{"id":"A2502","pred":"tao:has_database_id","subj":"2502","obj":"Tax:694009"},{"id":"A2506","pred":"tao:has_database_id","subj":"2506","obj":"MESH:C023676"},{"id":"A2507","pred":"tao:has_database_id","subj":"2507","obj":"MESH:C023676"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"It has been suggested that the broad‐spectrum antiviral activity of chloroquine phosphate lies within the complicated pharmacodynamics of the drug that results in a basic shift in the endosomal pH required for successful fusion of virus onto the host cell. chloroquine phosphate also seems to have disruptive effects on glycosylation of cellular receptors of SARS‐CoV (Yin \u0026 Wunderink, 2018; Zumla et al., 2020), rendering them nonfunctional."}