PMC:7283670 / 107929-109337
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T16 | 37-45 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T17 | 196-204 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T18 | 297-301 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
| T19 | 484-496 | Body_part | denotes | Femoral vein | http://purl.org/sig/ont/fma/fma21185 |
| T20 | 970-986 | Body_part | denotes | white blood cell | http://purl.org/sig/ont/fma/fma62852 |
| T21 | 982-986 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T22 | 1215-1224 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T23 | 1225-1229 | Body_part | denotes | IL‐1 | http://purl.org/sig/ont/fma/fma86583 |
| T24 | 1345-1350 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T205 | 484-496 | Body_part | denotes | Femoral vein | http://purl.obolibrary.org/obo/UBERON_0001361 |
| T206 | 492-496 | Body_part | denotes | vein | http://purl.obolibrary.org/obo/UBERON_0001638 |
| T207 | 976-981 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T566 | 64-67 | Disease | denotes | CRS | http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361 |
| T568 | 72-80 | Disease | denotes | COVID‐19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T569 | 191-195 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T26 | 236-238 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T27 | 492-496 | http://purl.obolibrary.org/obo/UBERON_0001638 | denotes | vein |
| T28 | 492-496 | http://www.ebi.ac.uk/efo/EFO_0000816 | denotes | vein |
| T29 | 626-631 | http://purl.obolibrary.org/obo/CLO_0007225 | denotes | label |
| T30 | 976-981 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T31 | 982-986 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T32 | 1071-1076 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T33 | 1084-1088 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
| T34 | 1253-1257 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL‐8 |
| T35 | 1323-1326 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T36 | 1329-1332 | http://purl.obolibrary.org/obo/CLO_0052882 | denotes | CD3 |
| T37 | 1329-1332 | http://purl.obolibrary.org/obo/CLO_0053434 | denotes | CD3 |
| T38 | 1333-1336 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T39 | 1339-1342 | http://purl.obolibrary.org/obo/CLO_0052882 | denotes | CD3 |
| T40 | 1339-1342 | http://purl.obolibrary.org/obo/CLO_0053434 | denotes | CD3 |
| T41 | 1343-1350 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T72462 | 88-99 | Chemical | denotes | tocilizumab | http://purl.obolibrary.org/obo/CHEBI_64360 |
| T7025 | 349-357 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
| T65846 | 626-631 | Chemical | denotes | label | http://purl.obolibrary.org/obo/CHEBI_35209 |
| T33991 | 800-806 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
| T19624 | 1064-1070 | Chemical | denotes | corona | http://purl.obolibrary.org/obo/CHEBI_37409 |
| T15741 | 1225-1227 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T28024 | 1232-1234 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T87 | 1247-1249 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T26286 | 1253-1255 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T922 | 0-269 | Sentence | denotes | Tocilizumab vs CRRT in management of cytokine release syndrome (CRS) in COVID‐19 Drug: tocilizumab, other: standard of care, procedure: continuous renal replacement therapy China, Covid‐19 SARS cytokine storm (and 2 more…) 120, all, 18–80 Observational Tocilizumab |
| T923 | 270-407 | Sentence | denotes | Subjects received 8 mg/kg (body weight) Tocilizumab once in 100 ml 0.9% saline solution and administered intravenously within no <60 min. |
| T924 | 408-483 | Sentence | denotes | Tocilizumab was administered according—continuous renal replacement therapy |
| T925 | 484-631 | Sentence | denotes | Femoral vein catheterization was performed to complete continuous renal replacement therapy for consecutive three times or more. to the local label |
| T926 | 632-645 | Sentence | denotes | Standard care |
| T927 | 646-740 | Sentence | denotes | Standard of care therapy per local written policies or guidelines – Primary (up to 14 days): |
| T928 | 741-817 | Sentence | denotes | Proportion of participants with normalization of fever and oxygen saturation |
| T929 | 818-828 | Sentence | denotes | Secondary: |
| T930 | 829-1408 | Sentence | denotes | Duration of hospitalization (Up to 28 days), proportion of participants with normalization of fever (up to 14 days), change from baseline in white blood cell and differential count (up to 28 days), time to first negative in 2019 novel corona virus RT‐PCR test (Up to 28 days), all‐cause mortality (up to 12 weeks), change from baseline in hsCRP (Up to 28 days), change from baseline in cytokines IL‐1β, IL‐10, sIL‐2R, IL‐6, IL‐8 and TNF‐α (Up to 28 days), change from baseline in proportion of CD4 + CD3/CD8 + CD3 T cells (Up to 28 days) NCT04306705/Recruiting, Feb20‐Jun20 2020 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T298 | 37-62 | Phenotype | denotes | cytokine release syndrome | http://purl.obolibrary.org/obo/HP_0033041 |
| T299 | 196-210 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T300 | 790-795 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
| T301 | 923-928 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1872 | 1225-1230 | Gene | denotes | IL‐1β | Gene:3552 |
| 1873 | 1232-1237 | Gene | denotes | IL‐10 | Gene:3586 |
| 1874 | 1247-1251 | Gene | denotes | IL‐6 | Gene:3569 |
| 1875 | 1253-1257 | Gene | denotes | IL‐8 | Gene:3576 |
| 1876 | 1262-1267 | Gene | denotes | TNF‐α | Gene:7124 |
| 1877 | 1323-1326 | Gene | denotes | CD4 | Gene:920 |
| 1878 | 1333-1336 | Gene | denotes | CD8 | Gene:925 |
| 2036 | 755-767 | Species | denotes | participants | Tax:9606 |
| 2037 | 888-900 | Species | denotes | participants | Tax:9606 |
| 2038 | 1053-1076 | Species | denotes | 2019 novel corona virus | Tax:2697049 |
| 2092 | 408-419 | Chemical | denotes | Tocilizumab | MESH:C502936 |