PMC:7281546 / 7400-9214
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T13 | 179-186 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T14 | 317-329 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T15 | 384-395 | Body_part | denotes | enterocytes | http://purl.org/sig/ont/fma/fma62122 |
| T16 | 427-437 | Body_part | denotes | amino-acid | http://purl.org/sig/ont/fma/fma82739 |
| T17 | 491-498 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T18 | 601-606 | Body_part | denotes | sugar | http://purl.org/sig/ont/fma/fma82737 |
| T19 | 673-677 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T20 | 799-804 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T21 | 889-904 | Body_part | denotes | cell components | http://purl.org/sig/ont/fma/fma86454 |
| T22 | 889-893 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T23 | 1462-1475 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 1462-1475 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T33 | 45-53 | Disease | denotes | diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T34 | 626-641 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T35 | 632-641 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T44 | 99-102 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T45 | 230-231 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T46 | 286-287 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T47 | 365-373 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T48 | 397-399 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T49 | 487-489 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T50 | 500-502 | http://purl.obolibrary.org/obo/CLO_0001302 | denotes | 34 |
| T51 | 559-561 | http://purl.obolibrary.org/obo/CLO_0001313 | denotes | 36 |
| T52 | 673-683 | http://purl.obolibrary.org/obo/CLO_0000031 | denotes | cell lines |
| T53 | 717-720 | http://purl.obolibrary.org/obo/NCBITaxon_9397 | denotes | bat |
| T54 | 725-732 | http://purl.obolibrary.org/obo/NCBITaxon_9443 | denotes | primate |
| T55 | 734-739 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T56 | 748-753 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T57 | 799-804 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T58 | 845-850 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T59 | 889-893 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T60 | 1098-1099 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T61 | 1365-1370 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T62 | 1377-1380 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T63 | 1462-1475 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T18 | 179-186 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T19 | 292-294 | Chemical | denotes | KD | http://purl.obolibrary.org/obo/CHEBI_73601 |
| T20 | 300-302 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T21 | 317-329 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T22 | 427-432 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T23 | 433-437 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T24 | 491-498 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T25 | 545-557 | Chemical | denotes | sialic acids | http://purl.obolibrary.org/obo/CHEBI_26667 |
| T26 | 552-557 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T27 | 1648-1663 | Chemical | denotes | antiviral drugs | http://purl.obolibrary.org/obo/CHEBI_36044 |
| T28 | 1648-1657 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T29 | 1658-1663 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T19 | 45-53 | Phenotype | denotes | diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T16 | 133-145 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T17 | 626-641 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
| T18 | 1262-1271 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | virulence |
| T19 | 1262-1271 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | virulence |
| T20 | 1323-1337 | http://purl.obolibrary.org/obo/GO_0042783 | denotes | immune evasion |
| T21 | 1455-1468 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune |
| T22 | 1592-1604 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T23 | 1790-1813 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune responses |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T49 | 0-65 | Sentence | denotes | PEDV is the main causative pathogen of viral diarrhea in piglets. |
| T50 | 66-161 | Sentence | denotes | Over the years, significant work has been done to investigate PEDV pathogenesis and prevention. |
| T51 | 162-280 | Sentence | denotes | Aminopeptidase N protein (APN, also known as CD13) is identified as a functional receptor of PEDV and TGEV [32,33,34]. |
| T52 | 281-401 | Sentence | denotes | APN, a 150 KD type II transmembrane glycoprotein, is mainly expressed on the apical membrane of mature enterocytes [35]. |
| T53 | 402-504 | Sentence | denotes | APN binds to the 477-629 amino-acid region in the C-terminal region of PEDV spike 1 (S1) protein [34]. |
| T54 | 505-563 | Sentence | denotes | Apart from APN, PEDV is able to bind to sialic acids [36]. |
| T55 | 564-650 | Sentence | denotes | It remains unknown whether PEDV uses sugar coreceptors during viral infection [34,36]. |
| T56 | 651-764 | Sentence | denotes | PEDV infects multiple cell lines from different species including bat and primate (human and non-human) in vitro. |
| T57 | 765-1016 | Sentence | denotes | The ability of PEDV to infect the cells of different species indicates that the virus utilizes the evolutionarily conserved cell components as receptors, thereby enhancing the potential for cross-species and potentially, zoonotic transmission [37,38]. |
| T58 | 1017-1252 | Sentence | denotes | The highly pathogenic variant strains of PEDV were identified in 2010 and caused a high morbidity of up to 100% in piglets, and since then, these strains become dominant, leading to most of the acute outbreaks of PED worldwide [1,7,8]. |
| T59 | 1253-1371 | Sentence | denotes | The high virulence of these strains is critically associated with the immune evasion mechanisms employed by the virus. |
| T60 | 1372-1501 | Sentence | denotes | PEDV has evolved different strategies to delicately manipulate and damage the host innate immune system for their multiplication. |
| T61 | 1502-1699 | Sentence | denotes | Clarification of these mechanisms is critical for understanding the host range, tropisms, pathogenesis, and for developing effective vaccines and antiviral drugs to curb the spread of PEDV in pigs. |
| T62 | 1700-1814 | Sentence | denotes | In this review, we provide an overview of different mechanisms used by PEDV to evade host innate immune responses. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32403318-17467767-82827250 | 270-272 | 17467767 | denotes | 32 |
| 32403318-20074871-82827251 | 273-275 | 20074871 | denotes | 33 |
| 32403318-26907329-82827252 | 276-278 | 26907329 | denotes | 34 |
| 32403318-18603472-82827253 | 397-399 | 18603472 | denotes | 35 |
| 32403318-26907329-82827254 | 500-502 | 26907329 | denotes | 34 |
| 32403318-25787280-82827255 | 559-561 | 25787280 | denotes | 36 |
| 32403318-26907329-82827256 | 643-645 | 26907329 | denotes | 34 |
| 32403318-25787280-82827257 | 646-648 | 25787280 | denotes | 36 |
| 32403318-23486053-82827258 | 1009-1011 | 23486053 | denotes | 37 |
| 32403318-23486063-82827259 | 1012-1014 | 23486063 | denotes | 38 |
| 32403318-22261231-82827260 | 1245-1246 | 22261231 | denotes | 1 |
| 32403318-22840964-82827261 | 1247-1248 | 22840964 | denotes | 7 |
| 32403318-23797760-82827262 | 1249-1250 | 23797760 | denotes | 8 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 270 | 162-178 | Gene | denotes | Aminopeptidase N | Gene:290 |
| 271 | 188-191 | Gene | denotes | APN | Gene:290 |
| 272 | 281-284 | Gene | denotes | APN | Gene:290 |
| 273 | 402-405 | Gene | denotes | APN | Gene:290 |
| 274 | 516-519 | Gene | denotes | APN | Gene:290 |
| 275 | 0-4 | Species | denotes | PEDV | Tax:28295 |
| 276 | 128-132 | Species | denotes | PEDV | Tax:28295 |
| 277 | 255-259 | Species | denotes | PEDV | Tax:28295 |
| 278 | 264-268 | Species | denotes | TGEV | Tax:11149 |
| 279 | 521-525 | Species | denotes | PEDV | Tax:28295 |
| 280 | 591-595 | Species | denotes | PEDV | Tax:28295 |
| 281 | 651-655 | Species | denotes | PEDV | Tax:28295 |
| 282 | 734-739 | Species | denotes | human | Tax:9606 |
| 283 | 748-753 | Species | denotes | human | Tax:9606 |
| 284 | 780-784 | Species | denotes | PEDV | Tax:28295 |
| 285 | 1058-1062 | Species | denotes | PEDV | Tax:28295 |
| 286 | 1372-1376 | Species | denotes | PEDV | Tax:28295 |
| 287 | 1686-1690 | Species | denotes | PEDV | Tax:28295 |
| 288 | 1694-1698 | Species | denotes | pigs | Tax:9823 |
| 289 | 1771-1775 | Species | denotes | PEDV | Tax:28295 |
| 290 | 545-557 | Chemical | denotes | sialic acids | MESH:D012794 |
| 291 | 39-53 | Disease | denotes | viral diarrhea | |
| 292 | 626-641 | Disease | denotes | viral infection | MESH:D001102 |
| 293 | 986-994 | Disease | denotes | zoonotic | MESH:D015047 |