PMC:7281546 / 54078-54900 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7281546","sourcedb":"PMC","sourceid":"7281546","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7281546","text":"The action model of PEDV interferons (IFNs) antagonists. For type I IFN, PEDV PLP2 removes ubiquitinated conjugates from RIG-I; PEDV nsp5 induces cleavage of NEMO; PEDV N protein directly interacts with TBK1 to obstruct the association between TBK1 and IRF3; PEDV nsp1 causes degradation of CBP and IκBα, as well as inhibition of IκBα phosphorylation and p65 activation. PEDV nsp16 inhibits type I IFN production and nsp10 enhances the inhibitory effect of nsp16 on type I IFN production. For type III IFN, PEDV N protein blocks the nuclear translocation of NF-κB; PEDV nsp1 blocks the nuclear translocation of IRF1 and reduces the amounts of peroxisomes. PEDV nsp15 inhibits the type I IFN and type III IFN responses by unknown mechanisms. PEDV nsp7 interacts with STAT1 and STAT2 to block nuclear translocation of ISGF3.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T329","span":{"begin":171,"end":178},"obj":"Body_part"},{"id":"T330","span":{"begin":514,"end":521},"obj":"Body_part"},{"id":"T331","span":{"begin":643,"end":654},"obj":"Body_part"}],"attributes":[{"id":"A329","pred":"fma_id","subj":"T329","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A330","pred":"fma_id","subj":"T330","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A331","pred":"fma_id","subj":"T331","obj":"http://purl.org/sig/ont/fma/fma63845"},{"subj":"T329","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T330","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T331","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T119","span":{"begin":291,"end":294},"obj":"Disease"}],"attributes":[{"id":"A119","pred":"mondo_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/MONDO_0010565"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T506","span":{"begin":301,"end":302},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T507","span":{"begin":332,"end":333},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T508","span":{"begin":359,"end":369},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T509","span":{"begin":562,"end":563},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T510","span":{"begin":687,"end":703},"obj":"http://purl.obolibrary.org/obo/PR_000024990"}],"attributes":[{"subj":"T506","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T507","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T508","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T509","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T510","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T92358","span":{"begin":44,"end":55},"obj":"Chemical"},{"id":"T77304","span":{"begin":171,"end":178},"obj":"Chemical"},{"id":"T51413","span":{"begin":514,"end":521},"obj":"Chemical"},{"id":"T11713","span":{"begin":558,"end":560},"obj":"Chemical"}],"attributes":[{"id":"A92618","pred":"chebi_id","subj":"T92358","obj":"http://purl.obolibrary.org/obo/CHEBI_48706"},{"id":"A85411","pred":"chebi_id","subj":"T77304","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A71584","pred":"chebi_id","subj":"T51413","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A75887","pred":"chebi_id","subj":"T11713","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A50412","pred":"chebi_id","subj":"T11713","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A43437","pred":"chebi_id","subj":"T11713","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"subj":"T92358","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T77304","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T51413","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T11713","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T418","span":{"begin":203,"end":207},"obj":"http://purl.obolibrary.org/obo/GO_0008384"},{"id":"T419","span":{"begin":244,"end":248},"obj":"http://purl.obolibrary.org/obo/GO_0008384"},{"id":"T420","span":{"begin":276,"end":287},"obj":"http://purl.obolibrary.org/obo/GO_0009056"},{"id":"T421","span":{"begin":335,"end":350},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T422","span":{"begin":391,"end":412},"obj":"http://purl.obolibrary.org/obo/GO_0032606"},{"id":"T423","span":{"begin":466,"end":487},"obj":"http://purl.obolibrary.org/obo/GO_0032606"}],"attributes":[{"subj":"T418","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T419","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T420","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T421","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T422","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T423","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T414","span":{"begin":57,"end":370},"obj":"Sentence"},{"id":"T415","span":{"begin":371,"end":488},"obj":"Sentence"},{"id":"T416","span":{"begin":489,"end":655},"obj":"Sentence"},{"id":"T417","span":{"begin":656,"end":740},"obj":"Sentence"},{"id":"T418","span":{"begin":741,"end":822},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T414","pred":"source","obj":"LitCovid-sentences"},{"subj":"T415","pred":"source","obj":"LitCovid-sentences"},{"subj":"T416","pred":"source","obj":"LitCovid-sentences"},{"subj":"T417","pred":"source","obj":"LitCovid-sentences"},{"subj":"T418","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2494","span":{"begin":78,"end":82},"obj":"Gene"},{"id":"2495","span":{"begin":121,"end":126},"obj":"Gene"},{"id":"2496","span":{"begin":133,"end":137},"obj":"Gene"},{"id":"2497","span":{"begin":158,"end":162},"obj":"Gene"},{"id":"2498","span":{"begin":203,"end":207},"obj":"Gene"},{"id":"2499","span":{"begin":244,"end":248},"obj":"Gene"},{"id":"2500","span":{"begin":253,"end":257},"obj":"Gene"},{"id":"2501","span":{"begin":264,"end":268},"obj":"Gene"},{"id":"2502","span":{"begin":291,"end":294},"obj":"Gene"},{"id":"2503","span":{"begin":299,"end":303},"obj":"Gene"},{"id":"2504","span":{"begin":330,"end":334},"obj":"Gene"},{"id":"2505","span":{"begin":355,"end":358},"obj":"Gene"},{"id":"2506","span":{"begin":558,"end":563},"obj":"Gene"},{"id":"2507","span":{"begin":570,"end":574},"obj":"Gene"},{"id":"2508","span":{"begin":611,"end":615},"obj":"Gene"},{"id":"2509","span":{"begin":766,"end":771},"obj":"Gene"},{"id":"2510","span":{"begin":776,"end":781},"obj":"Gene"},{"id":"2511","span":{"begin":816,"end":821},"obj":"Gene"},{"id":"2512","span":{"begin":20,"end":24},"obj":"Species"},{"id":"2513","span":{"begin":73,"end":77},"obj":"Species"},{"id":"2514","span":{"begin":128,"end":132},"obj":"Species"},{"id":"2515","span":{"begin":164,"end":168},"obj":"Species"},{"id":"2516","span":{"begin":259,"end":263},"obj":"Species"},{"id":"2517","span":{"begin":371,"end":375},"obj":"Species"},{"id":"2518","span":{"begin":565,"end":569},"obj":"Species"},{"id":"2519","span":{"begin":656,"end":660},"obj":"Species"},{"id":"2520","span":{"begin":741,"end":745},"obj":"Species"},{"id":"2521","span":{"begin":502,"end":505},"obj":"Gene"}],"attributes":[{"id":"A2494","pred":"tao:has_database_id","subj":"2494","obj":"Gene:5355"},{"id":"A2495","pred":"tao:has_database_id","subj":"2495","obj":"Gene:23586"},{"id":"A2496","pred":"tao:has_database_id","subj":"2496","obj":"Gene:92521"},{"id":"A2497","pred":"tao:has_database_id","subj":"2497","obj":"Gene:8517"},{"id":"A2498","pred":"tao:has_database_id","subj":"2498","obj":"Gene:29110"},{"id":"A2499","pred":"tao:has_database_id","subj":"2499","obj":"Gene:29110"},{"id":"A2500","pred":"tao:has_database_id","subj":"2500","obj":"Gene:3661"},{"id":"A2501","pred":"tao:has_database_id","subj":"2501","obj":"Gene:10045"},{"id":"A2502","pred":"tao:has_database_id","subj":"2502","obj":"Gene:1387"},{"id":"A2503","pred":"tao:has_database_id","subj":"2503","obj":"Gene:4792"},{"id":"A2504","pred":"tao:has_database_id","subj":"2504","obj":"Gene:4792"},{"id":"A2505","pred":"tao:has_database_id","subj":"2505","obj":"Gene:5970"},{"id":"A2506","pred":"tao:has_database_id","subj":"2506","obj":"Gene:4790"},{"id":"A2507","pred":"tao:has_database_id","subj":"2507","obj":"Gene:10045"},{"id":"A2508","pred":"tao:has_database_id","subj":"2508","obj":"Gene:3659"},{"id":"A2509","pred":"tao:has_database_id","subj":"2509","obj":"Gene:6772"},{"id":"A2510","pred":"tao:has_database_id","subj":"2510","obj":"Gene:6773"},{"id":"A2511","pred":"tao:has_database_id","subj":"2511","obj":"Gene:10379"},{"id":"A2512","pred":"tao:has_database_id","subj":"2512","obj":"Tax:28295"},{"id":"A2513","pred":"tao:has_database_id","subj":"2513","obj":"Tax:28295"},{"id":"A2514","pred":"tao:has_database_id","subj":"2514","obj":"Tax:28295"},{"id":"A2515","pred":"tao:has_database_id","subj":"2515","obj":"Tax:28295"},{"id":"A2516","pred":"tao:has_database_id","subj":"2516","obj":"Tax:28295"},{"id":"A2517","pred":"tao:has_database_id","subj":"2517","obj":"Tax:28295"},{"id":"A2518","pred":"tao:has_database_id","subj":"2518","obj":"Tax:28295"},{"id":"A2519","pred":"tao:has_database_id","subj":"2519","obj":"Tax:28295"},{"id":"A2520","pred":"tao:has_database_id","subj":"2520","obj":"Tax:28295"},{"id":"A2521","pred":"tao:has_database_id","subj":"2521","obj":"Gene:3439"},{"subj":"2494","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2495","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2496","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2497","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2498","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2499","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2500","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2501","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2502","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2503","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2504","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2505","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2506","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2507","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2508","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2509","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2510","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2511","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2512","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2513","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2514","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2515","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2516","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2517","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2518","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2519","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2520","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2521","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93a7","default":true},{"id":"LitCovid-PD-MONDO","color":"#93c1ec"},{"id":"LitCovid-PD-CLO","color":"#dbec93"},{"id":"LitCovid-PD-CHEBI","color":"#e293ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ecc8"},{"id":"LitCovid-sentences","color":"#ecae93"},{"id":"LitCovid-PubTator","color":"#9493ec"}]}]}}