PMC:7281546 / 47213-48795 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7281546","sourcedb":"PMC","sourceid":"7281546","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7281546","text":"4.3. Modulation of Apoptosis\nViral infection triggers host immune response to induce IFNs’ and inflammatory cytokines’ production. Released IFNs elicit the expression of numerous ISGs which limit viral replication in the infected cells. However, the release of excessive amounts of IFNs and inflammatory cytokines will lead to autoimmune and auto-inflammatory diseases. The concomitant uncontrolled apoptosis is also one outcome that is harmful to the host. To maintain the reaction in a proper balance, hosts have evolved a series of effective mechanisms to control the antiviral innate immune response [230]. In contrast, viruses often break this balance, causing improper apoptosis reaction, which benefits viral replication.\nPEDV infects various host cells including Vero, PK-15 and Marc-145 and cause obvious cytopathic effects. PEDV-induced apoptosis of the infected cell has been demonstrated both in vitro and in vivo [231]. Apoptosis is induced through the activation of apoptotic caspases, including caspase-2, -3, -6, -7, -8, -9, and -10 [232]. PEDV infection results in obvious caspase-3 and caspase-8 activation, as well as the cleavage of apoptosis-inducing factor mitochondria-associated 1 (AIFM1) and poly ADP-ribose polymerase (PARP), which leads to apoptotic nuclear fragmentation. PEDV spike protein S1 significantly elicits host cell apoptosis, while the nsp1–16 and other structural proteins (M, N, E, S2, and ORF3) have none or few effects on cell apoptosis. Therefore, S1 protein is probably the critical protein mediating the apoptosis induced by PEDV [128].","divisions":[{"label":"title","span":{"begin":0,"end":28}},{"label":"p","span":{"begin":29,"end":728}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T268","span":{"begin":108,"end":117},"obj":"Body_part"},{"id":"T269","span":{"begin":230,"end":235},"obj":"Body_part"},{"id":"T270","span":{"begin":304,"end":313},"obj":"Body_part"},{"id":"T271","span":{"begin":755,"end":760},"obj":"Body_part"},{"id":"T272","span":{"begin":873,"end":877},"obj":"Body_part"},{"id":"T273","span":{"begin":1311,"end":1318},"obj":"Body_part"},{"id":"T274","span":{"begin":1349,"end":1353},"obj":"Body_part"},{"id":"T275","span":{"begin":1404,"end":1412},"obj":"Body_part"},{"id":"T276","span":{"begin":1465,"end":1469},"obj":"Body_part"},{"id":"T277","span":{"begin":1495,"end":1502},"obj":"Body_part"},{"id":"T278","span":{"begin":1528,"end":1535},"obj":"Body_part"}],"attributes":[{"id":"A268","pred":"fma_id","subj":"T268","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A269","pred":"fma_id","subj":"T269","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A270","pred":"fma_id","subj":"T270","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A271","pred":"fma_id","subj":"T271","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A272","pred":"fma_id","subj":"T272","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A273","pred":"fma_id","subj":"T273","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A274","pred":"fma_id","subj":"T274","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A275","pred":"fma_id","subj":"T275","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A276","pred":"fma_id","subj":"T276","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A277","pred":"fma_id","subj":"T277","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A278","pred":"fma_id","subj":"T278","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T268","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T269","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T270","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T271","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T272","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T273","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T274","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T275","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T276","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T277","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T278","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T111","span":{"begin":29,"end":44},"obj":"Disease"},{"id":"T112","span":{"begin":35,"end":44},"obj":"Disease"},{"id":"T113","span":{"begin":347,"end":368},"obj":"Disease"},{"id":"T114","span":{"begin":1061,"end":1070},"obj":"Disease"}],"attributes":[{"id":"A111","pred":"mondo_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A112","pred":"mondo_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A113","pred":"mondo_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A114","pred":"mondo_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T111","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T112","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T113","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T114","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T448","span":{"begin":230,"end":235},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T449","span":{"begin":486,"end":487},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T450","span":{"begin":523,"end":524},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T451","span":{"begin":624,"end":631},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T452","span":{"begin":755,"end":760},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T453","span":{"begin":771,"end":775},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T454","span":{"begin":771,"end":775},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T455","span":{"begin":777,"end":782},"obj":"http://purl.obolibrary.org/obo/CLO_0050908"},{"id":"T456","span":{"begin":787,"end":795},"obj":"http://purl.obolibrary.org/obo/CLO_0007536"},{"id":"T457","span":{"begin":873,"end":877},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T458","span":{"begin":878,"end":881},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T459","span":{"begin":966,"end":976},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T460","span":{"begin":1022,"end":1027},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T461","span":{"begin":1050,"end":1053},"obj":"http://purl.obolibrary.org/obo/CLO_0001203"},{"id":"T462","span":{"begin":1114,"end":1124},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T463","span":{"begin":1319,"end":1321},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T464","span":{"begin":1349,"end":1353},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T465","span":{"begin":1417,"end":1421},"obj":"http://purl.obolibrary.org/obo/CLO_0008149"},{"id":"T466","span":{"begin":1423,"end":1425},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T467","span":{"begin":1423,"end":1425},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T468","span":{"begin":1465,"end":1469},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T469","span":{"begin":1492,"end":1494},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"}],"attributes":[{"subj":"T448","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T449","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T450","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T451","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T452","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T453","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T454","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T455","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T456","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T457","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T458","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T459","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T460","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T461","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T462","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T463","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T464","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T465","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T466","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T467","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T468","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T469","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T378","span":{"begin":571,"end":580},"obj":"Chemical"},{"id":"T379","span":{"begin":777,"end":779},"obj":"Chemical"},{"id":"T380","span":{"begin":1222,"end":1225},"obj":"Chemical"},{"id":"T383","span":{"begin":1226,"end":1232},"obj":"Chemical"},{"id":"T385","span":{"begin":1245,"end":1249},"obj":"Chemical"},{"id":"T386","span":{"begin":1311,"end":1318},"obj":"Chemical"},{"id":"T387","span":{"begin":1404,"end":1412},"obj":"Chemical"},{"id":"T388","span":{"begin":1423,"end":1425},"obj":"Chemical"},{"id":"T389","span":{"begin":1495,"end":1502},"obj":"Chemical"},{"id":"T390","span":{"begin":1528,"end":1535},"obj":"Chemical"}],"attributes":[{"id":"A378","pred":"chebi_id","subj":"T378","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A379","pred":"chebi_id","subj":"T379","obj":"http://purl.obolibrary.org/obo/CHEBI_74792"},{"id":"A380","pred":"chebi_id","subj":"T380","obj":"http://purl.obolibrary.org/obo/CHEBI_16761"},{"id":"A381","pred":"chebi_id","subj":"T380","obj":"http://purl.obolibrary.org/obo/CHEBI_456216"},{"id":"A382","pred":"chebi_id","subj":"T380","obj":"http://purl.obolibrary.org/obo/CHEBI_73342"},{"id":"A383","pred":"chebi_id","subj":"T383","obj":"http://purl.obolibrary.org/obo/CHEBI_33942"},{"id":"A384","pred":"chebi_id","subj":"T383","obj":"http://purl.obolibrary.org/obo/CHEBI_47013"},{"id":"A385","pred":"chebi_id","subj":"T385","obj":"http://purl.obolibrary.org/obo/CHEBI_62913"},{"id":"A386","pred":"chebi_id","subj":"T386","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A387","pred":"chebi_id","subj":"T387","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A388","pred":"chebi_id","subj":"T388","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A389","pred":"chebi_id","subj":"T389","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A390","pred":"chebi_id","subj":"T390","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T378","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T379","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T380","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T383","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T385","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T386","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T387","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T388","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T389","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T390","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T337","span":{"begin":19,"end":28},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T338","span":{"begin":19,"end":28},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T339","span":{"begin":29,"end":44},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T340","span":{"begin":59,"end":74},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T341","span":{"begin":108,"end":129},"obj":"http://purl.obolibrary.org/obo/GO_0001816"},{"id":"T342","span":{"begin":196,"end":213},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T343","span":{"begin":196,"end":213},"obj":"http://purl.obolibrary.org/obo/GO_0019058"},{"id":"T344","span":{"begin":399,"end":408},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T345","span":{"begin":399,"end":408},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T346","span":{"begin":571,"end":603},"obj":"http://purl.obolibrary.org/obo/GO_0140374"},{"id":"T347","span":{"begin":581,"end":603},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T348","span":{"begin":588,"end":603},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T349","span":{"begin":675,"end":684},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T350","span":{"begin":675,"end":684},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T351","span":{"begin":710,"end":727},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T352","span":{"begin":710,"end":727},"obj":"http://purl.obolibrary.org/obo/GO_0019058"},{"id":"T353","span":{"begin":847,"end":856},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T354","span":{"begin":847,"end":856},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T355","span":{"begin":933,"end":942},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T356","span":{"begin":933,"end":942},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T357","span":{"begin":1153,"end":1162},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T358","span":{"begin":1153,"end":1162},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T359","span":{"begin":1267,"end":1298},"obj":"http://purl.obolibrary.org/obo/GO_0030264"},{"id":"T360","span":{"begin":1354,"end":1363},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T361","span":{"begin":1354,"end":1363},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T362","span":{"begin":1470,"end":1479},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T363","span":{"begin":1470,"end":1479},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T364","span":{"begin":1550,"end":1559},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T365","span":{"begin":1550,"end":1559},"obj":"http://purl.obolibrary.org/obo/GO_0006915"}],"attributes":[{"subj":"T337","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T338","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T339","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T340","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T341","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T342","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T343","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T344","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T345","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T346","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T347","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T348","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T349","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T350","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T351","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T352","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T353","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T354","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T355","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T356","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T357","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T358","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T359","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T360","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T361","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T362","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T363","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T364","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T365","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T350","span":{"begin":0,"end":4},"obj":"Sentence"},{"id":"T351","span":{"begin":5,"end":28},"obj":"Sentence"},{"id":"T352","span":{"begin":29,"end":130},"obj":"Sentence"},{"id":"T353","span":{"begin":131,"end":236},"obj":"Sentence"},{"id":"T354","span":{"begin":237,"end":369},"obj":"Sentence"},{"id":"T355","span":{"begin":370,"end":457},"obj":"Sentence"},{"id":"T356","span":{"begin":458,"end":610},"obj":"Sentence"},{"id":"T357","span":{"begin":611,"end":728},"obj":"Sentence"},{"id":"T358","span":{"begin":729,"end":833},"obj":"Sentence"},{"id":"T359","span":{"begin":834,"end":932},"obj":"Sentence"},{"id":"T360","span":{"begin":933,"end":1055},"obj":"Sentence"},{"id":"T361","span":{"begin":1056,"end":1299},"obj":"Sentence"},{"id":"T362","span":{"begin":1300,"end":1480},"obj":"Sentence"},{"id":"T363","span":{"begin":1481,"end":1582},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T350","pred":"source","obj":"LitCovid-sentences"},{"subj":"T351","pred":"source","obj":"LitCovid-sentences"},{"subj":"T352","pred":"source","obj":"LitCovid-sentences"},{"subj":"T353","pred":"source","obj":"LitCovid-sentences"},{"subj":"T354","pred":"source","obj":"LitCovid-sentences"},{"subj":"T355","pred":"source","obj":"LitCovid-sentences"},{"subj":"T356","pred":"source","obj":"LitCovid-sentences"},{"subj":"T357","pred":"source","obj":"LitCovid-sentences"},{"subj":"T358","pred":"source","obj":"LitCovid-sentences"},{"subj":"T359","pred":"source","obj":"LitCovid-sentences"},{"subj":"T360","pred":"source","obj":"LitCovid-sentences"},{"subj":"T361","pred":"source","obj":"LitCovid-sentences"},{"subj":"T362","pred":"source","obj":"LitCovid-sentences"},{"subj":"T363","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32403318-28690332-82827498","span":{"begin":605,"end":608},"obj":"28690332"},{"id":"32403318-17082813-82827499","span":{"begin":1050,"end":1053},"obj":"17082813"},{"id":"32403318-30404647-82827500","span":{"begin":1577,"end":1580},"obj":"30404647"}],"attributes":[{"subj":"32403318-28690332-82827498","pred":"source","obj":"2_test"},{"subj":"32403318-17082813-82827499","pred":"source","obj":"2_test"},{"subj":"32403318-30404647-82827500","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1596","span":{"begin":29,"end":44},"obj":"Disease"},{"id":"1597","span":{"begin":221,"end":229},"obj":"Disease"},{"id":"1612","span":{"begin":1090,"end":1099},"obj":"Gene"},{"id":"1613","span":{"begin":1104,"end":1113},"obj":"Gene"},{"id":"1614","span":{"begin":1153,"end":1204},"obj":"Gene"},{"id":"1615","span":{"begin":1206,"end":1211},"obj":"Gene"},{"id":"1616","span":{"begin":1217,"end":1243},"obj":"Gene"},{"id":"1617","span":{"begin":1245,"end":1249},"obj":"Gene"},{"id":"1618","span":{"begin":1431,"end":1435},"obj":"Gene"},{"id":"1619","span":{"begin":729,"end":733},"obj":"Species"},{"id":"1620","span":{"begin":834,"end":838},"obj":"Species"},{"id":"1621","span":{"begin":1056,"end":1060},"obj":"Species"},{"id":"1622","span":{"begin":1300,"end":1304},"obj":"Species"},{"id":"1623","span":{"begin":1571,"end":1575},"obj":"Species"},{"id":"1624","span":{"begin":864,"end":872},"obj":"Disease"},{"id":"1625","span":{"begin":1061,"end":1070},"obj":"Disease"}],"attributes":[{"id":"A1596","pred":"tao:has_database_id","subj":"1596","obj":"MESH:D001102"},{"id":"A1597","pred":"tao:has_database_id","subj":"1597","obj":"MESH:D007239"},{"id":"A1612","pred":"tao:has_database_id","subj":"1612","obj":"Gene:836"},{"id":"A1613","pred":"tao:has_database_id","subj":"1613","obj":"Gene:841"},{"id":"A1614","pred":"tao:has_database_id","subj":"1614","obj":"Gene:9131"},{"id":"A1615","pred":"tao:has_database_id","subj":"1615","obj":"Gene:9131"},{"id":"A1616","pred":"tao:has_database_id","subj":"1616","obj":"Gene:142"},{"id":"A1617","pred":"tao:has_database_id","subj":"1617","obj":"Gene:142"},{"id":"A1618","pred":"tao:has_database_id","subj":"1618","obj":"Gene:136991"},{"id":"A1619","pred":"tao:has_database_id","subj":"1619","obj":"Tax:28295"},{"id":"A1620","pred":"tao:has_database_id","subj":"1620","obj":"Tax:28295"},{"id":"A1621","pred":"tao:has_database_id","subj":"1621","obj":"Tax:28295"},{"id":"A1622","pred":"tao:has_database_id","subj":"1622","obj":"Tax:28295"},{"id":"A1623","pred":"tao:has_database_id","subj":"1623","obj":"Tax:28295"},{"id":"A1624","pred":"tao:has_database_id","subj":"1624","obj":"MESH:D007239"},{"id":"A1625","pred":"tao:has_database_id","subj":"1625","obj":"MESH:D007239"},{"subj":"1596","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1597","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1612","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1613","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1614","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1615","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1616","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1617","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1618","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1619","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1620","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1621","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1622","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1623","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1624","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1625","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#eca493","default":true},{"id":"LitCovid-PD-MONDO","color":"#939cec"},{"id":"LitCovid-PD-CLO","color":"#b6ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93d0"},{"id":"LitCovid-PD-GO-BP","color":"#93eaec"},{"id":"LitCovid-sentences","color":"#ecd493"},{"id":"2_test","color":"#ba93ec"},{"id":"LitCovid-PubTator","color":"#93eca0"}]}]}}