PMC:7281546 / 45909-47211
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T261 | 11-18 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T262 | 62-70 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T263 | 126-133 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T264 | 611-616 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T265 | 636-641 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T266 | 717-721 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
| T267 | 754-759 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T106 | 297-306 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T107 | 351-360 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T108 | 537-546 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T109 | 1051-1054 | Disease | denotes | HSP | http://purl.obolibrary.org/obo/MONDO_0006785|http://purl.obolibrary.org/obo/MONDO_0019064 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T425 | 19-21 | http://purl.obolibrary.org/obo/CLO_0050509 | denotes | 27 |
| T426 | 85-88 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T427 | 108-109 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T428 | 369-376 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T429 | 606-610 | http://purl.obolibrary.org/obo/CLO_0009524 | denotes | Vero |
| T430 | 606-610 | http://purl.obolibrary.org/obo/CLO_0050515 | denotes | Vero |
| T431 | 611-616 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T432 | 618-621 | http://purl.obolibrary.org/obo/CLO_0001196 | denotes | 225 |
| T433 | 627-635 | http://purl.obolibrary.org/obo/CLO_0007536 | denotes | MARC-145 |
| T434 | 636-641 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T435 | 655-664 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T436 | 692-693 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T437 | 745-753 | http://purl.obolibrary.org/obo/CLO_0007536 | denotes | MARC-145 |
| T438 | 754-759 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T439 | 815-824 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T440 | 900-903 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T441 | 914-915 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T442 | 1025-1030 | http://purl.obolibrary.org/obo/CLO_0053923 | denotes | HSP70 |
| T443 | 1051-1054 | http://purl.obolibrary.org/obo/CLO_0050624 | denotes | HSP |
| T444 | 1133-1138 | http://purl.obolibrary.org/obo/CLO_0053923 | denotes | HSP70 |
| T445 | 1156-1157 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T446 | 1194-1201 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T447 | 1249-1254 | http://purl.obolibrary.org/obo/CLO_0053923 | denotes | HSP70 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T369 | 11-18 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T370 | 62-70 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T371 | 126-133 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T372 | 688-690 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T375 | 736-739 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T376 | 798-807 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T377 | 1051-1054 | Chemical | denotes | HSP | http://purl.obolibrary.org/obo/CHEBI_50430 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T27 | 5-10 | Phenotype | denotes | shock | http://purl.obolibrary.org/obo/HP_0031273 |
| T28 | 56-61 | Phenotype | denotes | shock | http://purl.obolibrary.org/obo/HP_0031273 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T325 | 205-228 | http://purl.obolibrary.org/obo/GO_0043066 | denotes | inhibition of apoptosis |
| T326 | 219-228 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T327 | 219-228 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T328 | 449-458 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T329 | 449-458 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T330 | 494-511 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T331 | 494-511 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
| T332 | 655-684 | http://purl.obolibrary.org/obo/GO_0042327 | denotes | activates the phosphorylation |
| T333 | 669-684 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T334 | 815-824 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T335 | 995-1017 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune response |
| T336 | 1002-1017 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T340 | 0-239 | Sentence | denotes | Heat shock protein 27 (HSP27) belongs to the small heat shock proteins family, which has been identified as a multifunctional protein involved in cytoskeletal stability, proinflammatory processes, and the inhibition of apoptosis [222,223]. |
| T341 | 240-338 | Sentence | denotes | Several HSPs have been reported to be implicated in PEDV infection in vitro and in vivo [224,225]. |
| T342 | 339-522 | Sentence | denotes | Indeed, the infection of many viruses up-regulates HSP27 expression by different mechanisms to delay cellular apoptosis, then supplies sufficient time for viral replication [226,227]. |
| T343 | 523-648 | Sentence | denotes | However, PEDV infection significantly induces the decreased expression of HSP27 in Vero cells [225] and MARC-145 cells [228]. |
| T344 | 649-760 | Sentence | denotes | HSP27 activates the phosphorylation of NF-κB, and thus promotes the mRNA expression of IFN-β in MARC-145 cells. |
| T345 | 761-894 | Sentence | denotes | As HSP27 is an upstream regulator of antiviral immune signaling, overexpression of HSP27 significantly inhibits the PEDV replication. |
| T346 | 895-1024 | Sentence | denotes | PEDV has developed a strategy via mediating the suppression of HSP27 production to escape from host innate immune response [228]. |
| T347 | 1025-1113 | Sentence | denotes | HSP70, the most conserved HSP, is also important for the multiplication of several CoVs. |
| T348 | 1114-1223 | Sentence | denotes | The recruitment of HSP70 is thought to be a viral survival strategy for several viruses in their hosts [229]. |
| T349 | 1224-1302 | Sentence | denotes | The relationship between HSP70 and PEDV should be exploited further in future. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32403318-18007587-82827489 | 230-233 | 18007587 | denotes | 222 |
| 32403318-22564335-82827490 | 234-237 | 22564335 | denotes | 223 |
| 32403318-27916855-82827491 | 329-332 | 27916855 | denotes | 224 |
| 32403318-25604190-82827492 | 333-336 | 25604190 | denotes | 225 |
| 32403318-24465692-82827493 | 513-516 | 24465692 | denotes | 226 |
| 32403318-18604870-82827494 | 517-520 | 18604870 | denotes | 227 |
| 32403318-25604190-82827495 | 618-621 | 25604190 | denotes | 225 |
| 32403318-28622863-82827496 | 643-646 | 28622863 | denotes | 228 |
| 32403318-28622863-82827497 | 1019-1022 | 28622863 | denotes | 228 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1571 | 23-28 | Gene | denotes | HSP27 | Gene:3315 |
| 1572 | 390-395 | Gene | denotes | HSP27 | Gene:3315 |
| 1573 | 597-602 | Gene | denotes | HSP27 | Gene:3315 |
| 1574 | 649-654 | Gene | denotes | HSP27 | Gene:3315 |
| 1575 | 688-693 | Gene | denotes | NF-κB | Gene:4790 |
| 1576 | 736-741 | Gene | denotes | IFN-β | Gene:3439 |
| 1577 | 764-769 | Gene | denotes | HSP27 | Gene:3315 |
| 1578 | 844-849 | Gene | denotes | HSP27 | Gene:3315 |
| 1579 | 958-963 | Gene | denotes | HSP27 | Gene:3315 |
| 1580 | 1025-1030 | Gene | denotes | HSP70 | Gene:3308 |
| 1581 | 1133-1138 | Gene | denotes | HSP70 | Gene:3308 |
| 1582 | 1249-1254 | Gene | denotes | HSP70 | Gene:3308 |
| 1583 | 292-296 | Species | denotes | PEDV | Tax:28295 |
| 1584 | 532-536 | Species | denotes | PEDV | Tax:28295 |
| 1585 | 877-881 | Species | denotes | PEDV | Tax:28295 |
| 1586 | 895-899 | Species | denotes | PEDV | Tax:28295 |
| 1587 | 1108-1112 | Species | denotes | CoVs | Tax:11118 |
| 1588 | 1259-1263 | Species | denotes | PEDV | Tax:28295 |
| 1589 | 297-306 | Disease | denotes | infection | MESH:D007239 |
| 1590 | 351-360 | Disease | denotes | infection | MESH:D007239 |
| 1591 | 537-546 | Disease | denotes | infection | MESH:D007239 |
| 1592 | 627-635 | CellLine | denotes | MARC-145 | CVCL:4540 |
| 1593 | 745-753 | CellLine | denotes | MARC-145 | CVCL:4540 |