PMC:7281546 / 45821-47211
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T260 | 32-39 | Body_part | denotes | Protein | http://purl.org/sig/ont/fma/fma67257 |
| T261 | 99-106 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T262 | 150-158 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T263 | 214-221 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T264 | 699-704 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T265 | 724-729 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T266 | 805-809 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
| T267 | 842-847 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T106 | 385-394 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T107 | 439-448 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T108 | 625-634 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T109 | 1139-1142 | Disease | denotes | HSP | http://purl.obolibrary.org/obo/MONDO_0006785|http://purl.obolibrary.org/obo/MONDO_0019064 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T423 | 40-42 | http://purl.obolibrary.org/obo/CLO_0050509 | denotes | 27 |
| T424 | 78-87 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | Signaling |
| T425 | 107-109 | http://purl.obolibrary.org/obo/CLO_0050509 | denotes | 27 |
| T426 | 173-176 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T427 | 196-197 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T428 | 457-464 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T429 | 694-698 | http://purl.obolibrary.org/obo/CLO_0009524 | denotes | Vero |
| T430 | 694-698 | http://purl.obolibrary.org/obo/CLO_0050515 | denotes | Vero |
| T431 | 699-704 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T432 | 706-709 | http://purl.obolibrary.org/obo/CLO_0001196 | denotes | 225 |
| T433 | 715-723 | http://purl.obolibrary.org/obo/CLO_0007536 | denotes | MARC-145 |
| T434 | 724-729 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T435 | 743-752 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T436 | 780-781 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T437 | 833-841 | http://purl.obolibrary.org/obo/CLO_0007536 | denotes | MARC-145 |
| T438 | 842-847 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T439 | 903-912 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T440 | 988-991 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T441 | 1002-1003 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T442 | 1113-1118 | http://purl.obolibrary.org/obo/CLO_0053923 | denotes | HSP70 |
| T443 | 1139-1142 | http://purl.obolibrary.org/obo/CLO_0050624 | denotes | HSP |
| T444 | 1221-1226 | http://purl.obolibrary.org/obo/CLO_0053923 | denotes | HSP70 |
| T445 | 1244-1245 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T446 | 1282-1289 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T447 | 1337-1342 | http://purl.obolibrary.org/obo/CLO_0053923 | denotes | HSP70 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T368 | 32-39 | Chemical | denotes | Protein | http://purl.obolibrary.org/obo/CHEBI_16541 |
| T369 | 99-106 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T370 | 150-158 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T371 | 214-221 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T372 | 776-778 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T375 | 824-827 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T376 | 886-895 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T377 | 1139-1142 | Chemical | denotes | HSP | http://purl.obolibrary.org/obo/CHEBI_50430 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T26 | 26-31 | Phenotype | denotes | Shock | http://purl.obolibrary.org/obo/HP_0031273 |
| T27 | 93-98 | Phenotype | denotes | shock | http://purl.obolibrary.org/obo/HP_0031273 |
| T28 | 144-149 | Phenotype | denotes | shock | http://purl.obolibrary.org/obo/HP_0031273 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T324 | 78-87 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | Signaling |
| T325 | 293-316 | http://purl.obolibrary.org/obo/GO_0043066 | denotes | inhibition of apoptosis |
| T326 | 307-316 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T327 | 307-316 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T328 | 537-546 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T329 | 537-546 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T330 | 582-599 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T331 | 582-599 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
| T332 | 743-772 | http://purl.obolibrary.org/obo/GO_0042327 | denotes | activates the phosphorylation |
| T333 | 757-772 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T334 | 903-912 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T335 | 1083-1105 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune response |
| T336 | 1090-1105 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T338 | 0-6 | Sentence | denotes | 4.2.6. |
| T339 | 7-87 | Sentence | denotes | PEDV Inhibits Heat Shock Protein 27 Expression to Impair Innate Immune Signaling |
| T340 | 88-327 | Sentence | denotes | Heat shock protein 27 (HSP27) belongs to the small heat shock proteins family, which has been identified as a multifunctional protein involved in cytoskeletal stability, proinflammatory processes, and the inhibition of apoptosis [222,223]. |
| T341 | 328-426 | Sentence | denotes | Several HSPs have been reported to be implicated in PEDV infection in vitro and in vivo [224,225]. |
| T342 | 427-610 | Sentence | denotes | Indeed, the infection of many viruses up-regulates HSP27 expression by different mechanisms to delay cellular apoptosis, then supplies sufficient time for viral replication [226,227]. |
| T343 | 611-736 | Sentence | denotes | However, PEDV infection significantly induces the decreased expression of HSP27 in Vero cells [225] and MARC-145 cells [228]. |
| T344 | 737-848 | Sentence | denotes | HSP27 activates the phosphorylation of NF-κB, and thus promotes the mRNA expression of IFN-β in MARC-145 cells. |
| T345 | 849-982 | Sentence | denotes | As HSP27 is an upstream regulator of antiviral immune signaling, overexpression of HSP27 significantly inhibits the PEDV replication. |
| T346 | 983-1112 | Sentence | denotes | PEDV has developed a strategy via mediating the suppression of HSP27 production to escape from host innate immune response [228]. |
| T347 | 1113-1201 | Sentence | denotes | HSP70, the most conserved HSP, is also important for the multiplication of several CoVs. |
| T348 | 1202-1311 | Sentence | denotes | The recruitment of HSP70 is thought to be a viral survival strategy for several viruses in their hosts [229]. |
| T349 | 1312-1390 | Sentence | denotes | The relationship between HSP70 and PEDV should be exploited further in future. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32403318-18007587-82827489 | 318-321 | 18007587 | denotes | 222 |
| 32403318-22564335-82827490 | 322-325 | 22564335 | denotes | 223 |
| 32403318-27916855-82827491 | 417-420 | 27916855 | denotes | 224 |
| 32403318-25604190-82827492 | 421-424 | 25604190 | denotes | 225 |
| 32403318-24465692-82827493 | 601-604 | 24465692 | denotes | 226 |
| 32403318-18604870-82827494 | 605-608 | 18604870 | denotes | 227 |
| 32403318-25604190-82827495 | 706-709 | 25604190 | denotes | 225 |
| 32403318-28622863-82827496 | 731-734 | 28622863 | denotes | 228 |
| 32403318-28622863-82827497 | 1107-1110 | 28622863 | denotes | 228 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1547 | 7-11 | Species | denotes | PEDV | Tax:28295 |
| 1571 | 111-116 | Gene | denotes | HSP27 | Gene:3315 |
| 1572 | 478-483 | Gene | denotes | HSP27 | Gene:3315 |
| 1573 | 685-690 | Gene | denotes | HSP27 | Gene:3315 |
| 1574 | 737-742 | Gene | denotes | HSP27 | Gene:3315 |
| 1575 | 776-781 | Gene | denotes | NF-κB | Gene:4790 |
| 1576 | 824-829 | Gene | denotes | IFN-β | Gene:3439 |
| 1577 | 852-857 | Gene | denotes | HSP27 | Gene:3315 |
| 1578 | 932-937 | Gene | denotes | HSP27 | Gene:3315 |
| 1579 | 1046-1051 | Gene | denotes | HSP27 | Gene:3315 |
| 1580 | 1113-1118 | Gene | denotes | HSP70 | Gene:3308 |
| 1581 | 1221-1226 | Gene | denotes | HSP70 | Gene:3308 |
| 1582 | 1337-1342 | Gene | denotes | HSP70 | Gene:3308 |
| 1583 | 380-384 | Species | denotes | PEDV | Tax:28295 |
| 1584 | 620-624 | Species | denotes | PEDV | Tax:28295 |
| 1585 | 965-969 | Species | denotes | PEDV | Tax:28295 |
| 1586 | 983-987 | Species | denotes | PEDV | Tax:28295 |
| 1587 | 1196-1200 | Species | denotes | CoVs | Tax:11118 |
| 1588 | 1347-1351 | Species | denotes | PEDV | Tax:28295 |
| 1589 | 385-394 | Disease | denotes | infection | MESH:D007239 |
| 1590 | 439-448 | Disease | denotes | infection | MESH:D007239 |
| 1591 | 625-634 | Disease | denotes | infection | MESH:D007239 |
| 1592 | 715-723 | CellLine | denotes | MARC-145 | CVCL:4540 |
| 1593 | 833-841 | CellLine | denotes | MARC-145 | CVCL:4540 |