PMC:7281546 / 41478-43269
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T235 | 227-238 | Body_part | denotes | fibroblasts | http://purl.org/sig/ont/fma/fma63877 |
| T236 | 403-406 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T237 | 591-594 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T238 | 616-623 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T239 | 720-723 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T240 | 731-738 | Body_part | denotes | cytosol | http://purl.org/sig/ont/fma/fma66836 |
| T241 | 856-859 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T242 | 892-895 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T243 | 1168-1179 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T244 | 1239-1255 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T245 | 1250-1255 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T246 | 1345-1361 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T247 | 1356-1361 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T101 | 297-305 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T102 | 749-765 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T374 | 10-13 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T375 | 30-38 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T376 | 74-75 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T377 | 90-95 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T378 | 166-167 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T379 | 218-223 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T380 | 227-238 | http://purl.obolibrary.org/obo/CL_0000057 | denotes | fibroblasts |
| T381 | 365-373 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T382 | 434-437 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T383 | 466-467 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T384 | 551-559 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T385 | 822-827 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T386 | 997-1005 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T387 | 1006-1009 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T388 | 1065-1074 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T389 | 1092-1100 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T390 | 1239-1249 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T391 | 1250-1255 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T392 | 1345-1355 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T393 | 1356-1361 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T394 | 1596-1603 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animals |
| T395 | 1690-1698 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T396 | 1719-1720 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T348 | 215-217 | Chemical | denotes | WT | http://purl.obolibrary.org/obo/CHEBI_141450 |
| T349 | 472-475 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T350 | 476-486 | Chemical | denotes | antagonist | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T351 | 616-623 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T352 | 905-914 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T353 | 1061-1064 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T354 | 1144-1147 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T355 | 1215-1218 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T356 | 1748-1757 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T298 | 185-202 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T299 | 185-202 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
| T300 | 403-416 | http://purl.obolibrary.org/obo/GO_0032774 | denotes | RNA synthesis |
| T301 | 407-416 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T302 | 749-765 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
| T303 | 1065-1074 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T304 | 1467-1491 | http://purl.obolibrary.org/obo/GO_0034343 | denotes | type III IFNs production |
| T305 | 1622-1636 | http://purl.obolibrary.org/obo/GO_0019076 | denotes | viral shedding |
| T306 | 1758-1773 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immunity |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T303 | 0-108 | Sentence | denotes | CoV nsp15 has EndoU catalytic activity that was initially thought to play a vital role in virus replication. |
| T304 | 109-245 | Sentence | denotes | However, the catalytic-defective EndoU of MHV shows only a subtle defect in viral replication compared to WT virus in fibroblasts [215]. |
| T305 | 246-326 | Sentence | denotes | Similar results are found for the nsp15 mutants of SARS-CoV and HCoV-229E [216]. |
| T306 | 327-417 | Sentence | denotes | These findings suggest that the EndoU activity of nsp15 is not required for RNA synthesis. |
| T307 | 418-509 | Sentence | denotes | Recently, nsp15 has been demonstrated to act as a new IFN antagonist of CoVs [117,118,217]. |
| T308 | 510-669 | Sentence | denotes | Recent reports indicate that CoVs’ EndoU activity is essential for prevention of RNA recognition by MDA5, protein kinase R (PKR), and OAS/RNAse L system [118]. |
| T309 | 670-766 | Sentence | denotes | PKR and OAS/RNAse L recognize and destroy foreign RNA in the cytosol to defend viral infections. |
| T310 | 767-915 | Sentence | denotes | To counteract the function of PKR and OAS/RNAse L, the virus hides or modifies its viral RNA, to avoid the exposure of viral RNA to these molecules. |
| T311 | 916-985 | Sentence | denotes | In all CoVs, the EndoU catalytic domain in nsp15 is highly conserved. |
| T312 | 986-1081 | Sentence | denotes | PEDV EndoU activity has been indicated as having an antagonistic effect on IFN signaling [135]. |
| T313 | 1082-1256 | Sentence | denotes | The EndoU activity of PEDV nsp15 not only inhibits the type I IFN response in porcine macrophages, but also antagonizes the type III IFN response in porcine epithelial cells. |
| T314 | 1257-1405 | Sentence | denotes | The replication of EndoU-mutant PEDV (icPEDV-EnUmt) is considerably impaired in porcine epithelial cells compared to the wild type PEDV (icPEDV-wt). |
| T315 | 1406-1561 | Sentence | denotes | The icPEDV-EnUmt clearly induces early and robust type I and type III IFNs production, as well as ISGs’ expression compared with that induced by icPEDV-wt. |
| T316 | 1562-1651 | Sentence | denotes | The EndoU-deficient PEDV infected animals also show reduced viral shedding and mortality. |
| T317 | 1652-1791 | Sentence | denotes | These results indicate that the EndoU activity of PEDV nsp15 plays a vital role in evading host antiviral innate immunity (Figure 2) [135]. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32403318-17898055-82827463 | 240-243 | 17898055 | denotes | 215 |
| 32403318-21422822-82827464 | 321-324 | 21422822 | denotes | 216 |
| 32403318-28158275-82827465 | 496-499 | 28158275 | denotes | 117 |
| 32403318-28484023-82827466 | 500-503 | 28484023 | denotes | 118 |
| 32403318-29307596-82827467 | 504-507 | 29307596 | denotes | 217 |
| 32403318-28484023-82827468 | 664-667 | 28484023 | denotes | 118 |
| 32403318-30728254-82827469 | 1076-1079 | 30728254 | denotes | 135 |
| 32403318-30728254-82827470 | 1786-1789 | 30728254 | denotes | 135 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1458 | 14-19 | Gene | denotes | EndoU | Gene:8909 |
| 1459 | 359-364 | Gene | denotes | EndoU | Gene:8909 |
| 1460 | 472-475 | Gene | denotes | IFN | Gene:3439 |
| 1461 | 545-550 | Gene | denotes | EndoU | Gene:8909 |
| 1462 | 610-614 | Gene | denotes | MDA5 | Gene:64135 |
| 1463 | 616-632 | Gene | denotes | protein kinase R | Gene:5610 |
| 1464 | 991-996 | Gene | denotes | EndoU | Gene:8909 |
| 1465 | 1061-1064 | Gene | denotes | IFN | Gene:3439 |
| 1466 | 1086-1091 | Gene | denotes | EndoU | Gene:8909 |
| 1467 | 1276-1281 | Gene | denotes | EndoU | Gene:8909 |
| 1468 | 1684-1689 | Gene | denotes | EndoU | Gene:8909 |
| 1469 | 142-147 | Gene | denotes | EndoU | Gene:8909 |
| 1470 | 0-3 | Species | denotes | CoV | Tax:11118 |
| 1471 | 297-305 | Species | denotes | SARS-CoV | Tax:694009 |
| 1472 | 310-319 | Species | denotes | HCoV-229E | Tax:11137 |
| 1473 | 490-494 | Species | denotes | CoVs | Tax:11118 |
| 1474 | 539-543 | Species | denotes | CoVs | Tax:11118 |
| 1475 | 923-927 | Species | denotes | CoVs | Tax:11118 |
| 1476 | 986-990 | Species | denotes | PEDV | Tax:28295 |
| 1477 | 1104-1108 | Species | denotes | PEDV | Tax:28295 |
| 1478 | 1289-1293 | Species | denotes | PEDV | Tax:28295 |
| 1479 | 1388-1392 | Species | denotes | PEDV | Tax:28295 |
| 1480 | 1702-1706 | Species | denotes | PEDV | Tax:28295 |
| 1481 | 1160-1167 | Species | denotes | porcine | Tax:2018513 |
| 1482 | 1231-1238 | Species | denotes | porcine | Tax:2018513 |
| 1483 | 1337-1344 | Species | denotes | porcine | Tax:2018513 |
| 1484 | 151-154 | Species | denotes | MHV | Tax:11138 |
| 1485 | 933-938 | Gene | denotes | EndoU | Gene:8909 |
| 1486 | 644-647 | Disease | denotes | OAS | MESH:C537769 |
| 1487 | 678-681 | Disease | denotes | OAS | MESH:C537769 |
| 1488 | 749-765 | Disease | denotes | viral infections | MESH:D001102 |
| 1489 | 805-808 | Disease | denotes | OAS | MESH:C537769 |
| 1490 | 1566-1595 | Disease | denotes | EndoU-deficient PEDV infected | MESH:D007239 |
| 1491 | 1641-1650 | Disease | denotes | mortality | MESH:D003643 |