PMC:7281546 / 38457-40562
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T219 | 80-83 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T220 | 199-207 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T221 | 429-432 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T222 | 2058-2066 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T99 | 625-635 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T100 | 1952-1961 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T349 | 84-91 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T350 | 353-354 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T351 | 433-438 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T352 | 447-457 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T353 | 465-466 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T354 | 531-541 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T355 | 570-580 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T356 | 736-741 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T357 | 812-820 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T358 | 888-897 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T359 | 1102-1111 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T360 | 1167-1170 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T361 | 1292-1293 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T362 | 1433-1434 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T363 | 1567-1576 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T364 | 1596-1599 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T365 | 1653-1663 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T366 | 2011-2020 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T367 | 2095-2104 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T333 | 199-207 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T334 | 315-318 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T335 | 349-351 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T338 | 461-463 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T341 | 756-759 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T342 | 1335-1344 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T343 | 1563-1566 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T344 | 2007-2010 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T345 | 2058-2066 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T274 | 308-329 | http://purl.obolibrary.org/obo/GO_0032606 | denotes | type I IFN production |
| T275 | 584-588 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | TBK1 |
| T276 | 671-694 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune responses |
| T277 | 762-771 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T278 | 803-820 | http://purl.obolibrary.org/obo/GO_0008233 | denotes | protease activity |
| T279 | 888-897 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T280 | 926-930 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | TBK1 |
| T281 | 1102-1111 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T282 | 1206-1220 | http://purl.obolibrary.org/obo/GO_0042783 | denotes | immune evasion |
| T283 | 1266-1279 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune |
| T284 | 1335-1354 | http://purl.obolibrary.org/obo/GO_0051607 | denotes | antiviral responses |
| T285 | 1567-1584 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathway |
| T286 | 1567-1576 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T287 | 1825-1842 | http://purl.obolibrary.org/obo/GO_0051169 | denotes | nuclear transport |
| T288 | 1833-1842 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transport |
| T289 | 1872-1887 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T290 | 2011-2020 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T291 | 2095-2104 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T275 | 0-92 | Sentence | denotes | CoV nsp5 is called 3C-like protease (3CLpro), that resembles the 3Cpro of other RNA viruses. |
| T276 | 93-218 | Sentence | denotes | For CoV, the polyprotein precursors (pp1a and pp1b) are mainly processed to generate mature nonstructural proteins by 3CLpro. |
| T277 | 219-406 | Sentence | denotes | To date, the 3CLpro of CoVs, including PEDV and PDCoV, have been confirmed to antagonize type I IFN production by the cleavage of NF-κB essential modulator (NEMO) and STAT2 [100,207,208]. |
| T278 | 407-489 | Sentence | denotes | NEMO is essential for RNA virus-induced activation of NF-κB, IRF3, and IRF7 [209]. |
| T279 | 490-600 | Sentence | denotes | NEMO is required for MAVS-induced IKKα/β activation and is also crucial for the activation of TBK1/IKKε [149]. |
| T280 | 601-695 | Sentence | denotes | To establish successful infections, PEDV targets NEMO to subvert host innate immune responses. |
| T281 | 696-827 | Sentence | denotes | PEDV nsp5 significantly inhibits Sendai virus (SeV)-induced IFN-β synthesis and the process depends on its protease activity [100]. |
| T282 | 828-931 | Sentence | denotes | Further experiments show that PEDV nsp5 inhibits RIG-I/MDA5 signaling and targets the upstream of TBK1. |
| T283 | 932-1017 | Sentence | denotes | The cleavage of NEMO by nsp5 is identified as responsible for this inhibitive effect. |
| T284 | 1018-1112 | Sentence | denotes | The PEDV nsp5-mediated cleavage of NEMO efficiently blocks NEMO-mediated downstream signaling. |
| T285 | 1113-1187 | Sentence | denotes | The cleavage site within NEMO that is grasped by nsp5 has been determined. |
| T286 | 1188-1355 | Sentence | denotes | Of these reported immune evasion strategies employed by CoVs, the cleavage of innate immune adaptors is a particularly effective manner to disrupt antiviral responses. |
| T287 | 1356-1426 | Sentence | denotes | Nsp5 is essential for the life cycle of PEDV and other CoVs [210,211]. |
| T288 | 1427-1505 | Sentence | denotes | It is a potential target for the development of anti-coronaviral therapeutics. |
| T289 | 1506-1678 | Sentence | denotes | Although PEDV nsp5 does not target STAT2 mediated type Ⅰ IFN signaling pathway, PEDV nsp7 has been reported to inhibit the STAT1 and STAT2 induced activation of ISRE [212]. |
| T290 | 1679-1843 | Sentence | denotes | Nsp7 competes with Karyopherin α (KPNA1), which is an adaptor mediating nuclear translocation of ISGF3, in combination with STAT1, to block ISGF3 nuclear transport. |
| T291 | 1844-1937 | Sentence | denotes | However, the expression and phosphorylation of STAT1 and STAT2 are not affected by PEDV nsp7. |
| T292 | 1938-2027 | Sentence | denotes | In fact, PEDV infection degrades STAT1, leading to the inhibition of IFN signaling [170]. |
| T293 | 2028-2105 | Sentence | denotes | Therefore, other PEDV encoded proteins likely target IFNs mediated signaling. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32403318-26656704-82827451 | 393-396 | 26656704 | denotes | 100 |
| 32403318-27984784-82827452 | 397-400 | 27984784 | denotes | 207 |
| 32403318-17468758-82827453 | 484-487 | 17468758 | denotes | 209 |
| 32403318-29125880-82827454 | 595-598 | 29125880 | denotes | 149 |
| 32403318-26656704-82827455 | 822-825 | 26656704 | denotes | 100 |
| 32403318-27173881-82827456 | 1417-1420 | 27173881 | denotes | 210 |
| 32403318-27128350-82827457 | 1421-1424 | 27128350 | denotes | 211 |
| 32403318-27384656-82827458 | 2022-2025 | 27384656 | denotes | 170 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1353 | 4-8 | Gene | denotes | nsp5 | Gene:92521 |
| 1354 | 130-134 | Gene | denotes | pp1a | Gene:5499 |
| 1355 | 349-374 | Gene | denotes | NF-κB essential modulator | Gene:8517 |
| 1356 | 376-380 | Gene | denotes | NEMO | Gene:8517 |
| 1357 | 386-391 | Gene | denotes | STAT2 | Gene:6773 |
| 1358 | 407-411 | Gene | denotes | NEMO | Gene:8517 |
| 1359 | 461-466 | Gene | denotes | NF-κB | Gene:4790 |
| 1360 | 468-472 | Gene | denotes | IRF3 | Gene:3661 |
| 1361 | 478-482 | Gene | denotes | IRF7 | Gene:3665 |
| 1362 | 490-494 | Gene | denotes | NEMO | Gene:8517 |
| 1363 | 511-515 | Gene | denotes | MAVS | Gene:57506 |
| 1364 | 584-588 | Gene | denotes | TBK1 | Gene:29110 |
| 1365 | 589-593 | Gene | denotes | IKKε | Gene:9641 |
| 1366 | 701-705 | Gene | denotes | nsp5 | Gene:92521 |
| 1367 | 756-761 | Gene | denotes | IFN-β | Gene:3439 |
| 1368 | 863-867 | Gene | denotes | nsp5 | Gene:92521 |
| 1369 | 877-882 | Gene | denotes | RIG-I | Gene:23586 |
| 1370 | 883-887 | Gene | denotes | MDA5 | Gene:64135 |
| 1371 | 926-930 | Gene | denotes | TBK1 | Gene:29110 |
| 1372 | 948-952 | Gene | denotes | NEMO | Gene:8517 |
| 1373 | 956-960 | Gene | denotes | nsp5 | Gene:92521 |
| 1374 | 1027-1031 | Gene | denotes | nsp5 | Gene:92521 |
| 1375 | 1053-1057 | Gene | denotes | NEMO | Gene:8517 |
| 1376 | 1077-1081 | Gene | denotes | NEMO | Gene:8517 |
| 1377 | 1138-1142 | Gene | denotes | NEMO | Gene:8517 |
| 1378 | 1162-1166 | Gene | denotes | nsp5 | Gene:92521 |
| 1379 | 1356-1360 | Gene | denotes | Nsp5 | Gene:92521 |
| 1380 | 1520-1524 | Gene | denotes | nsp5 | Gene:92521 |
| 1381 | 1541-1546 | Gene | denotes | STAT2 | Gene:6773 |
| 1382 | 1629-1634 | Gene | denotes | STAT1 | Gene:6772 |
| 1383 | 1639-1644 | Gene | denotes | STAT2 | Gene:6773 |
| 1384 | 1713-1718 | Gene | denotes | KPNA1 | Gene:3836 |
| 1385 | 1776-1781 | Gene | denotes | ISGF3 | Gene:10379 |
| 1386 | 1803-1808 | Gene | denotes | STAT1 | Gene:6772 |
| 1387 | 1819-1824 | Gene | denotes | ISGF3 | Gene:10379 |
| 1388 | 1891-1896 | Gene | denotes | STAT1 | Gene:6772 |
| 1389 | 1901-1906 | Gene | denotes | STAT2 | Gene:6773 |
| 1390 | 1971-1976 | Gene | denotes | STAT1 | Gene:6772 |
| 1391 | 2007-2010 | Gene | denotes | IFN | Gene:3439 |
| 1392 | 0-3 | Species | denotes | CoV | Tax:11118 |
| 1393 | 97-100 | Species | denotes | CoV | Tax:11118 |
| 1394 | 242-246 | Species | denotes | CoVs | Tax:11118 |
| 1395 | 258-262 | Species | denotes | PEDV | Tax:28295 |
| 1396 | 637-641 | Species | denotes | PEDV | Tax:28295 |
| 1397 | 696-700 | Species | denotes | PEDV | Tax:28295 |
| 1398 | 729-741 | Species | denotes | Sendai virus | Tax:11191 |
| 1399 | 858-862 | Species | denotes | PEDV | Tax:28295 |
| 1400 | 1022-1026 | Species | denotes | PEDV | Tax:28295 |
| 1401 | 1244-1248 | Species | denotes | CoVs | Tax:11118 |
| 1402 | 1396-1400 | Species | denotes | PEDV | Tax:28295 |
| 1403 | 1411-1415 | Species | denotes | CoVs | Tax:11118 |
| 1404 | 1515-1519 | Species | denotes | PEDV | Tax:28295 |
| 1405 | 1586-1590 | Species | denotes | PEDV | Tax:28295 |
| 1406 | 1927-1931 | Species | denotes | PEDV | Tax:28295 |
| 1407 | 1947-1951 | Species | denotes | PEDV | Tax:28295 |
| 1408 | 2045-2049 | Species | denotes | PEDV | Tax:28295 |
| 1409 | 743-746 | Species | denotes | SeV | Tax:11191 |
| 1410 | 1480-1491 | Species | denotes | coronaviral | Tax:11118 |
| 1411 | 650-654 | Gene | denotes | NEMO | Gene:8517 |
| 1412 | 625-635 | Disease | denotes | infections | MESH:D007239 |
| 1413 | 1952-1961 | Disease | denotes | infection | MESH:D007239 |