> top > docs > PMC:7281546 > spans > 31111-34134 > annotations

PMC:7281546 / 31111-34134 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T196 146-157 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T197 291-295 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T198 385-389 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T199 408-415 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T200 667-674 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T201 865-869 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T202 899-910 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T203 1002-1009 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T204 1406-1413 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T205 1576-1583 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T206 2024-2033 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T207 2203-2212 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T208 2412-2421 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T209 2734-2745 Body_part denotes peroxisomes http://purl.org/sig/ont/fma/fma63845
T210 2831-2838 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T68 330-338 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 486-494 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T70 597-612 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T71 603-612 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T72 693-708 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T73 699-708 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T74 806-814 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 1049-1057 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T76 1415-1418 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T77 1434-1437 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T78 1503-1506 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T79 1653-1656 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T80 1711-1714 Disease denotes PRD http://purl.obolibrary.org/obo/MONDO_0010722
T81 2066-2081 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T82 2072-2081 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T83 2222-2231 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T84 2952-2961 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T273 94-95 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T274 291-295 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T275 315-324 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T276 544-549 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T277 570-576 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T278 597-602 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T279 865-869 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T280 917-919 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T281 952-953 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T282 1080-1083 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T283 1173-1181 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T284 1220-1230 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T285 1534-1543 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T286 1544-1548 http://purl.obolibrary.org/obo/CLO_0053428 denotes cAMP
T287 1598-1599 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T288 1617-1626 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T289 1785-1786 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T290 1863-1868 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T291 1950-1959 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activated
T292 1964-1965 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T293 2093-2096 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T294 2134-2135 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T295 2136-2144 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T296 2286-2287 http://purl.obolibrary.org/obo/CLO_0001021 denotes B

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T272 146-157 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T273 146-151 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T274 152-157 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T275 311-314 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T276 408-415 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T277 460-463 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T278 530-533 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T279 667-674 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T280 899-910 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T281 899-904 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T282 905-910 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T283 1002-1009 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T284 1106-1109 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T285 1110-1120 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T286 1158-1161 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T287 1234-1237 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T288 1406-1413 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T289 1457-1464 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T290 1544-1548 Chemical denotes cAMP http://purl.obolibrary.org/obo/CHEBI_17489
T291 1576-1583 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T292 1635-1642 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T293 1731-1734 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T294 1781-1783 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T297 1859-1862 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T298 1919-1922 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T299 1941-1948 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T300 1960-1962 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T303 2130-2132 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T306 2363-2366 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T307 2461-2464 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T308 2570-2573 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T309 2574-2585 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T310 2599-2610 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T311 2831-2838 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T312 2855-2858 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T187 291-306 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T188 315-324 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T189 408-427 http://purl.obolibrary.org/obo/GO_0006412 denotes protein translation
T190 453-474 http://purl.obolibrary.org/obo/GO_0032606 denotes type I IFN production
T191 570-589 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T192 577-589 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T193 693-708 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T194 865-880 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T195 1002-1019 http://purl.obolibrary.org/obo/GO_0006412 denotes protein synthesis
T196 1010-1019 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T197 1301-1316 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T198 1438-1449 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T199 1517-1530 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T200 1835-1848 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T201 1912-1933 http://purl.obolibrary.org/obo/GO_0032606 denotes type I IFN production
T202 2066-2081 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T203 2236-2264 http://purl.obolibrary.org/obo/GO_0042326 denotes inhibits the phosphorylation
T204 2249-2264 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T205 2269-2280 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T206 2452-2475 http://purl.obolibrary.org/obo/GO_0034343 denotes type III IFN production
T207 2917-2939 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T208 2924-2939 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T220 0-6 Sentence denotes 4.2.2.
T221 7-16 Sentence denotes PEDV nsp1
T222 17-177 Sentence denotes PEDV nsp1 is the N-terminal cleavage product from polyproteins pp1a and pp1a/b processed by nsp3 and nsp5 [177] and is about 110 amino acids in length [74,178].
T223 178-325 Sentence denotes Nsp1 of many α-CoV and β-CoV exhibits both functional conservation and mechanistic diversity in suppressing host gene expression and IFN signaling.
T224 326-485 Sentence denotes For SARS-CoV, nsp1 triggers the decay and cleavage of host mRNA and inhibits host protein translation, subsequently inhibiting type I IFN production [179,180].
T225 486-623 Sentence denotes SARS-CoV nsp1 also blocks the expression of IFN-inducible genes, by restraining the signal transduction during virus infection [181,182].
T226 624-714 Sentence denotes The TGEV nsp1 considerably suppresses host protein expression during viral infection [77].
T227 715-840 Sentence denotes Structural studies show that the core structure of PEDV nsp1 is highly similar to those of SARS-CoV nsp1 and TGEV nsp1 [183].
T228 841-1069 Sentence denotes PEDV nsp1 inhibits host gene expression and three motifs (amino acids 67 to 71, 78 to 85, and 103 to 110) form a stable functional region for inhibition of host protein synthesis, differing considerably from SARS-CoV nsp1 [183].
T229 1070-1187 Sentence denotes PEDV nsp1 has been identified as an IFN antagonist, which constrains poly (I:C)-induced IFN-β promoter activity [65].
T230 1188-1347 Sentence denotes Nsp1 significantly inhibits the activation of IFN-β promoter triggered by IRF3, whereas it does not inhibit IRF3 phosphorylation and its nuclear translocation.
T231 1348-1502 Sentence denotes Nsp1 interrupts the association of IRF3 with CREB-binding protein (CBP), by promoting CBP degradation in the nucleus via the proteasome-dependent pathway.
T232 1503-1643 Sentence denotes CBP/p300, the transcription co-activator cAMP responsive element binding protein (CREB), forms a complex with the activated IRF3 in nucleus.
T233 1644-1883 Sentence denotes The IRF3-CBP/p300 complex binds to the positive regulatory domain (PRD) regions of the IFN-β promoter, to assemble the enhanceosome with NF-κB and other factors, which ultimately turn on the transcription of type I IFN genes [184,185,186].
T234 1884-1949 Sentence denotes Therefore, PEDV nsp1 blocks type I IFN production in the nucleus.
T235 1950-2082 Sentence denotes Activated NF-κB induces the production of type I IFNs and proinflammatory cytokines and is important for inhibiting viral infection.
T236 2083-2232 Sentence denotes PEDV nsp1 has been shown to interfere with the NF-κB activity [78] and is the most potent suppressor of proinflammatory cytokines at early infection.
T237 2233-2427 Sentence denotes It inhibits the phosphorylation and degradation of IκBα, and blocks p65 nuclear translocation, leading to the suppression of both IFN and the early production of pro-inflammatory cytokines [78].
T238 2428-2586 Sentence denotes Moreover, PEDV inhibits type III IFN production and nsp1, nsp3, nsp5, nsp8, nsp14, nsp15, nsp16, ORF3, E, M, and N are identified as type III IFN antagonists.
T239 2587-2653 Sentence denotes Among these antagonists, nsp1 is the most potent suppressor [130].
T240 2654-2794 Sentence denotes PEDV nsp1 blocks the nuclear translocation of IRF1 and decreases the amounts of peroxisomes and then suppresses IRF1-mediated type III IFNs.
T241 2795-2877 Sentence denotes The conserved residues of PEDV nsp1 protein are crucial for IFN suppression [130].
T242 2878-3023 Sentence denotes Multiple effects of nsp1 on modulating innate immune response during PEDV infection suggest the vital role of nsp1 in the PEDV replication cycle.

2_test

Id Subject Object Predicate Lexical cue
32403318-17251282-82827412 124-127 17251282 denotes 177
32403318-23269811-82827413 169-171 23269811 denotes 74
32403318-17202208-82827414 172-175 17202208 denotes 178
32403318-18305050-82827415 476-479 18305050 denotes 179
32403318-22174690-82827416 480-483 22174690 denotes 180
32403318-16912115-82827417 614-617 16912115 denotes 181
32403318-17715225-82827418 618-621 17715225 denotes 182
32403318-31350335-82827419 710-712 31350335 denotes 77
32403318-29237834-82827420 835-838 29237834 denotes 183
32403318-29237834-82827421 1064-1067 29237834 denotes 183
32403318-26773386-82827422 1183-1185 26773386 denotes 65
32403318-17483521-82827423 1870-1873 17483521 denotes 184
32403318-9566918-82827424 1874-1877 9566918 denotes 185
32403318-17574024-82827425 1878-1881 17574024 denotes 186
32403318-28715653-82827426 2146-2148 28715653 denotes 78
32403318-28715653-82827427 2423-2425 28715653 denotes 78

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
984 22-26 Gene denotes nsp1 Gene:10045
985 118-122 Gene denotes nsp5 Gene:92521
986 178-182 Gene denotes Nsp1 Gene:10045
987 311-314 Gene denotes IFN Gene:3439
988 340-344 Gene denotes nsp1 Gene:10045
989 495-499 Gene denotes nsp1 Gene:10045
990 633-637 Gene denotes nsp1 Gene:10045
991 771-775 Gene denotes nsp1 Gene:10045
992 815-819 Gene denotes nsp1 Gene:10045
993 829-833 Gene denotes nsp1 Gene:10045
994 846-850 Gene denotes nsp1 Gene:10045
995 1058-1062 Gene denotes nsp1 Gene:10045
996 530-533 Gene denotes IFN Gene:3439
997 17-21 Species denotes PEDV Tax:28295
998 193-196 Species denotes CoV Tax:11118
999 201-206 Species denotes β-CoV Tax:694002
1000 330-338 Species denotes SARS-CoV Tax:694009
1001 486-494 Species denotes SARS-CoV Tax:694009
1002 628-632 Species denotes TGEV Tax:11149
1003 766-770 Species denotes PEDV Tax:28295
1004 806-814 Species denotes SARS-CoV Tax:694009
1005 824-828 Species denotes TGEV Tax:11149
1006 841-845 Species denotes PEDV Tax:28295
1007 1049-1057 Species denotes SARS-CoV Tax:694009
1008 597-612 Disease denotes virus infection MESH:D001102
1009 693-708 Disease denotes viral infection MESH:D001102
1064 1075-1079 Gene denotes nsp1 Gene:10045
1065 1106-1109 Gene denotes IFN Gene:3439
1066 1158-1163 Gene denotes IFN-β Gene:3439
1067 1188-1192 Gene denotes Nsp1 Gene:10045
1068 1234-1239 Gene denotes IFN-β Gene:3439
1069 1262-1266 Gene denotes IRF3 Gene:3661
1070 1296-1300 Gene denotes IRF3 Gene:3661
1071 1348-1352 Gene denotes Nsp1 Gene:10045
1072 1383-1387 Gene denotes IRF3 Gene:3661
1073 1393-1413 Gene denotes CREB-binding protein Gene:1387
1074 1415-1418 Gene denotes CBP Gene:1387
1075 1434-1437 Gene denotes CBP Gene:1387
1076 1503-1507 Gene denotes CBP/ Gene:1387
1077 1507-1511 Gene denotes p300 Gene:2033
1078 1585-1589 Gene denotes CREB Gene:1385
1079 1627-1631 Gene denotes IRF3 Gene:3661
1080 1648-1652 Gene denotes IRF3 Gene:3661
1081 1653-1657 Gene denotes CBP/ Gene:1387
1082 1657-1661 Gene denotes p300 Gene:2033
1083 1731-1736 Gene denotes IFN-β Gene:3439
1084 1781-1786 Gene denotes NF-κB Gene:4790
1085 1900-1904 Gene denotes nsp1 Gene:10045
1086 1960-1965 Gene denotes NF-κB Gene:4790
1087 2088-2092 Gene denotes nsp1 Gene:10045
1088 2130-2135 Gene denotes NF-κB Gene:4790
1089 2284-2288 Gene denotes IκBα Gene:4792
1090 2301-2304 Gene denotes p65 Gene:5970
1091 2363-2366 Gene denotes IFN Gene:3439
1092 2461-2464 Gene denotes IFN Gene:3439
1093 2480-2484 Gene denotes nsp1 Gene:10045
1094 2492-2496 Gene denotes nsp5 Gene:92521
1095 2525-2529 Gene denotes ORF3 Gene:136991
1096 2612-2616 Gene denotes nsp1 Gene:10045
1097 2659-2663 Gene denotes nsp1 Gene:10045
1098 2700-2704 Gene denotes IRF1 Gene:3659
1099 2766-2770 Gene denotes IRF1 Gene:3659
1100 2826-2830 Gene denotes nsp1 Gene:10045
1101 2855-2858 Gene denotes IFN Gene:3439
1102 2898-2902 Gene denotes nsp1 Gene:10045
1103 2988-2992 Gene denotes nsp1 Gene:10045
1104 1070-1074 Species denotes PEDV Tax:28295
1105 1895-1899 Species denotes PEDV Tax:28295
1106 2083-2087 Species denotes PEDV Tax:28295
1107 2438-2442 Species denotes PEDV Tax:28295
1108 2654-2658 Species denotes PEDV Tax:28295
1109 2821-2825 Species denotes PEDV Tax:28295
1110 2947-2951 Species denotes PEDV Tax:28295
1111 3000-3004 Species denotes PEDV Tax:28295
1112 1859-1862 Gene denotes IFN Gene:3439
1113 1139-1149 Chemical denotes poly (I:C) MESH:D011070
1114 1544-1548 Chemical denotes cAMP
1115 2066-2081 Disease denotes viral infection MESH:D001102
1116 2222-2231 Disease denotes infection MESH:D007239
1117 2952-2961 Disease denotes infection MESH:D007239