PMC:7281546 / 10865-19948
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T41 | 32-40 | Body_part | denotes | Proteins | http://purl.org/sig/ont/fma/fma67257 |
| T42 | 51-59 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T43 | 179-186 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T44 | 206-218 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T45 | 219-226 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T46 | 387-398 | Body_part | denotes | cytoplasmic | http://purl.org/sig/ont/fma/fma66835 |
| T47 | 433-440 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T48 | 723-737 | Body_part | denotes | cell membranes | http://purl.org/sig/ont/fma/fma63841 |
| T49 | 723-727 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T50 | 776-783 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T51 | 798-810 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T52 | 798-802 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T53 | 987-991 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T54 | 1028-1035 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T55 | 1105-1113 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T56 | 1117-1124 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T57 | 1152-1159 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T58 | 1212-1217 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T59 | 1241-1249 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T60 | 1276-1283 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T61 | 1339-1346 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T62 | 1390-1393 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T63 | 1502-1509 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T64 | 1513-1523 | Body_part | denotes | intestinal | http://purl.org/sig/ont/fma/fma7199 |
| T65 | 1524-1540 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T66 | 1535-1540 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T67 | 1564-1568 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T68 | 1583-1604 | Body_part | denotes | endoplasmic reticulum | http://purl.org/sig/ont/fma/fma63842 |
| T69 | 1606-1608 | Body_part | denotes | ER | http://purl.org/sig/ont/fma/fma63842 |
| T70 | 1634-1647 | Body_part | denotes | interleukin-8 | http://purl.org/sig/ont/fma/fma264827 |
| T71 | 1681-1689 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T72 | 1934-1941 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T73 | 2031-2039 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T74 | 2126-2133 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T75 | 2164-2173 | Body_part | denotes | cytoplasm | http://purl.org/sig/ont/fma/fma66835 |
| T76 | 2190-2194 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T77 | 2217-2227 | Body_part | denotes | intestinal | http://purl.org/sig/ont/fma/fma7199 |
| T78 | 2228-2244 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T79 | 2239-2244 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T80 | 2267-2272 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T81 | 2310-2317 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T82 | 2410-2417 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T83 | 2510-2512 | Body_part | denotes | ER | http://purl.org/sig/ont/fma/fma63842 |
| T84 | 2534-2538 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T85 | 2547-2551 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T86 | 2609-2611 | Body_part | denotes | ER | http://purl.org/sig/ont/fma/fma63842 |
| T87 | 2745-2752 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T88 | 2893-2902 | Body_part | denotes | cytoplasm | http://purl.org/sig/ont/fma/fma66835 |
| T89 | 2927-2932 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T90 | 3073-3080 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T91 | 3221-3224 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T92 | 3359-3363 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T93 | 3376-3379 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T94 | 3484-3491 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T95 | 3690-3697 | Body_part | denotes | genomes | http://purl.org/sig/ont/fma/fma84116 |
| T96 | 3844-3851 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T97 | 4062-4069 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T98 | 4222-4226 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T99 | 4417-4427 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T100 | 4542-4545 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T101 | 4695-4702 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T102 | 5022-5025 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T103 | 5508-5511 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T104 | 6004-6007 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T105 | 6686-6689 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T106 | 6737-6744 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T107 | 6775-6781 | Body_part | denotes | finger | http://purl.org/sig/ont/fma/fma9666 |
| T108 | 6782-6789 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T109 | 6866-6869 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T110 | 6914-6917 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T111 | 6928-6931 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T112 | 7553-7560 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T113 | 7694-7697 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T114 | 7968-7971 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T115 | 7987-7991 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
| T116 | 8162-8172 | Body_part | denotes | nucleotide | http://purl.org/sig/ont/fma/fma82740 |
| T117 | 8248-8256 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T118 | 8352-8355 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T119 | 8766-8769 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T3 | 399-403 | Body_part | denotes | tail | http://purl.obolibrary.org/obo/UBERON_0002415 |
| T4 | 6775-6781 | Body_part | denotes | finger | http://purl.obolibrary.org/obo/UBERON_0002389 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T36 | 538-541 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T38 | 1186-1195 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T39 | 1743-1751 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T40 | 1763-1772 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T41 | 4317-4320 | Disease | denotes | CBP | http://purl.obolibrary.org/obo/MONDO_0010565 |
| T42 | 4511-4519 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T43 | 5573-5581 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T44 | 5647-5655 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T45 | 6600-6608 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T46 | 6722-6726 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T47 | 7007-7011 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T48 | 7291-7299 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T49 | 9074-9082 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T78 | 188-189 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T79 | 197-205 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T80 | 258-263 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T81 | 291-297 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T82 | 298-305 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
| T83 | 307-308 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T84 | 337-338 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T85 | 379-380 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T86 | 399-403 | http://purl.obolibrary.org/obo/UBERON_0002415 | denotes | tail |
| T87 | 451-453 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T88 | 458-460 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T89 | 458-460 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T90 | 486-488 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T91 | 535-537 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T92 | 546-548 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T93 | 619-627 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T94 | 637-639 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T95 | 637-639 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T96 | 723-727 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T97 | 728-737 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membranes |
| T98 | 798-802 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T99 | 823-824 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T100 | 863-865 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T101 | 987-991 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T102 | 1212-1217 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T103 | 1284-1287 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T104 | 1326-1327 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T105 | 1513-1523 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestinal |
| T106 | 1513-1523 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestinal |
| T107 | 1524-1534 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T108 | 1535-1540 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T109 | 1564-1568 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T110 | 1757-1762 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T111 | 1773-1778 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T112 | 1978-1983 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T113 | 2190-2194 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T114 | 2217-2227 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestinal |
| T115 | 2217-2227 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestinal |
| T116 | 2228-2238 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T117 | 2239-2244 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T118 | 2267-2272 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T119 | 2439-2444 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T120 | 2534-2538 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T121 | 2547-2551 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T122 | 2569-2570 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T123 | 2623-2632 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T124 | 2653-2654 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T125 | 2660-2661 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T126 | 2717-2721 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
| T127 | 2781-2784 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T128 | 2927-2932 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T129 | 3022-3023 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T130 | 3232-3237 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T131 | 3300-3305 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T132 | 3359-3363 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T133 | 3419-3420 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T134 | 3471-3473 | http://purl.obolibrary.org/obo/CLO_0054055 | denotes | 71 |
| T135 | 3476-3479 | http://purl.obolibrary.org/obo/CLO_0001618 | denotes | a 9 |
| T136 | 3476-3479 | http://purl.obolibrary.org/obo/CLO_0001619 | denotes | a 9 |
| T137 | 3476-3479 | http://purl.obolibrary.org/obo/CLO_0001620 | denotes | a 9 |
| T138 | 3751-3752 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T139 | 3803-3806 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T140 | 4020-4021 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T141 | 4222-4226 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T142 | 4329-4330 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T143 | 4572-4575 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T144 | 4632-4637 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T145 | 4792-4793 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T146 | 4856-4865 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T147 | 4929-4930 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T148 | 5026-5033 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T149 | 5042-5052 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membranous |
| T150 | 5196-5204 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T151 | 5236-5245 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membranes |
| T152 | 5264-5265 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T153 | 5540-5549 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membranes |
| T154 | 5551-5553 | http://purl.obolibrary.org/obo/CLO_0001527 | denotes | 94 |
| T155 | 5661-5664 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T156 | 5665-5673 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T157 | 5833-5834 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T158 | 5858-5866 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T159 | 5933-5934 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T160 | 6099-6103 | http://purl.obolibrary.org/obo/CLO_0053943 | denotes | a 3C |
| T161 | 6275-6276 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T162 | 6293-6298 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T163 | 6535-6543 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T164 | 6768-6769 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T165 | 6878-6886 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T166 | 6905-6906 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T167 | 7096-7097 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T168 | 7391-7399 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T169 | 7432-7433 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T170 | 7535-7536 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T171 | 7566-7570 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 3′-5 |
| T172 | 7588-7596 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T173 | 7631-7639 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T174 | 7706-7707 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T175 | 7801-7802 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T176 | 7860-7868 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T177 | 8098-8099 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T178 | 8667-8671 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 3′-5 |
| T179 | 8689-8697 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T180 | 8722-8723 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T41 | 51-59 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T42 | 179-186 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T43 | 206-218 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T44 | 219-226 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T45 | 298-305 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T46 | 433-440 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T47 | 458-460 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T48 | 637-639 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T49 | 776-783 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T50 | 1028-1035 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T51 | 1117-1124 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T52 | 1152-1159 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T53 | 1241-1249 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T54 | 1276-1283 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T55 | 1339-1346 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T56 | 1502-1509 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T57 | 1681-1689 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T58 | 1826-1837 | Chemical | denotes | antagonists | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T59 | 1934-1941 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T60 | 2031-2039 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T61 | 2126-2133 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T62 | 2310-2317 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T63 | 2338-2348 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T64 | 2350-2353 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T65 | 2355-2365 | Chemical | denotes | antagonist | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T66 | 2410-2417 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T67 | 2656-2658 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T70 | 2717-2719 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T72 | 2745-2752 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T73 | 3073-3080 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T74 | 3484-3491 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T75 | 3844-3851 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T76 | 4062-4069 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T77 | 4325-4327 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T80 | 4340-4343 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T81 | 4417-4427 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T82 | 4417-4422 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T83 | 4423-4427 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T84 | 4695-4702 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T85 | 4852-4855 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T86 | 4966-4969 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T87 | 4970-4980 | Chemical | denotes | antagonist | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T88 | 6501-6504 | Chemical | denotes | ADP | http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342 |
| T91 | 6505-6511 | Chemical | denotes | ribose | http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013 |
| T93 | 6737-6744 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T94 | 6770-6774 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T96 | 6782-6789 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T97 | 7148-7160 | Chemical | denotes | nucleic acid | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T98 | 7156-7160 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T99 | 7553-7560 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T100 | 8055-8064 | Chemical | denotes | guanosine | http://purl.obolibrary.org/obo/CHEBI_16750 |
| T101 | 8065-8075 | Chemical | denotes | nucleoside | http://purl.obolibrary.org/obo/CHEBI_33838 |
| T102 | 8100-8112 | Chemical | denotes | methyl group | http://purl.obolibrary.org/obo/CHEBI_32875 |
| T103 | 8100-8106 | Chemical | denotes | methyl | http://purl.obolibrary.org/obo/CHEBI_29309 |
| T104 | 8107-8112 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T105 | 8125-8131 | Chemical | denotes | ribose | http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013 |
| T107 | 8162-8172 | Chemical | denotes | nucleotide | http://purl.obolibrary.org/obo/CHEBI_36976 |
| T108 | 8248-8256 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T20 | 1763-1772 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
| T21 | 2195-2213 | Phenotype | denotes | growth retardation | http://purl.obolibrary.org/obo/HP_0001510 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T28 | 850-857 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
| T29 | 1422-1439 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T30 | 1422-1439 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
| T31 | 1441-1454 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T32 | 1553-1560 | http://purl.obolibrary.org/obo/GO_0051320 | denotes | S-phase |
| T33 | 1564-1574 | http://purl.obolibrary.org/obo/GO_0007049 | denotes | cell cycle |
| T34 | 1810-1825 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immunity |
| T35 | 1958-1973 | http://purl.obolibrary.org/obo/GO_0019068 | denotes | virion assembly |
| T36 | 1978-1991 | http://purl.obolibrary.org/obo/GO_0046755 | denotes | virus budding |
| T37 | 1984-1991 | http://purl.obolibrary.org/obo/GO_0007114 | denotes | budding |
| T38 | 2190-2201 | http://purl.obolibrary.org/obo/GO_0016049 | denotes | cell growth |
| T39 | 2195-2201 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T40 | 2276-2283 | http://purl.obolibrary.org/obo/GO_0051320 | denotes | S-phase |
| T41 | 2459-2466 | http://purl.obolibrary.org/obo/GO_0007114 | denotes | budding |
| T42 | 2534-2545 | http://purl.obolibrary.org/obo/GO_0016049 | denotes | cell growth |
| T43 | 2539-2545 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T44 | 2547-2557 | http://purl.obolibrary.org/obo/GO_0007049 | denotes | cell cycle |
| T45 | 2562-2568 | http://purl.obolibrary.org/obo/GO_0016538 | denotes | cyclin |
| T46 | 2703-2713 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T47 | 2936-2943 | http://purl.obolibrary.org/obo/GO_0051320 | denotes | S-phase |
| T48 | 2958-2975 | http://purl.obolibrary.org/obo/GO_0006900 | denotes | vesicle formation |
| T49 | 2966-2975 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T50 | 3128-3145 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T51 | 3128-3145 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
| T52 | 3188-3197 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T53 | 3232-3255 | http://purl.obolibrary.org/obo/GO_0019048 | denotes | virus-host interactions |
| T54 | 3353-3374 | http://purl.obolibrary.org/obo/GO_0019080 | denotes | viral gene expression |
| T55 | 3359-3374 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
| T56 | 3376-3389 | http://purl.obolibrary.org/obo/GO_0032774 | denotes | RNA synthesis |
| T57 | 3380-3389 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T58 | 4222-4237 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
| T59 | 4264-4273 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | virulence |
| T60 | 4264-4273 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | virulence |
| T61 | 4302-4313 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
| T62 | 4542-4555 | http://purl.obolibrary.org/obo/GO_0032774 | denotes | RNA synthesis |
| T63 | 4546-4555 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T64 | 4632-4655 | http://purl.obolibrary.org/obo/GO_0019048 | denotes | virus-host interactions |
| T65 | 4660-4669 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | virulence |
| T66 | 4660-4669 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | virulence |
| T67 | 4800-4814 | http://purl.obolibrary.org/obo/GO_0004843 | denotes | deubiquitinase |
| T68 | 4816-4819 | http://purl.obolibrary.org/obo/GO_0004843 | denotes | DUB |
| T69 | 4856-4865 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T70 | 4947-4950 | http://purl.obolibrary.org/obo/GO_0004843 | denotes | DUB |
| T71 | 5320-5337 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T72 | 5320-5337 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
| T73 | 5342-5355 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T74 | 5508-5521 | http://purl.obolibrary.org/obo/GO_0032774 | denotes | RNA synthesis |
| T75 | 5512-5521 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T76 | 5736-5745 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T77 | 6004-6019 | http://purl.obolibrary.org/obo/GO_0039703 | denotes | RNA replication |
| T78 | 6109-6119 | http://purl.obolibrary.org/obo/GO_0004175 | denotes | proteinase |
| T79 | 6332-6355 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune responses |
| T80 | 6516-6527 | http://purl.obolibrary.org/obo/GO_0016791 | denotes | phosphatase |
| T81 | 7497-7514 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T82 | 7497-7514 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
| T83 | 7569-7596 | http://purl.obolibrary.org/obo/GO_0008859 | denotes | 5′ exoribonuclease activity |
| T84 | 7572-7596 | http://purl.obolibrary.org/obo/GO_0004532 | denotes | exoribonuclease activity |
| T85 | 7674-7685 | http://purl.obolibrary.org/obo/GO_0032259 | denotes | methylation |
| T86 | 7843-7868 | http://purl.obolibrary.org/obo/GO_0004521 | denotes | endoribonuclease activity |
| T87 | 8227-8238 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | translation |
| T88 | 8486-8497 | http://purl.obolibrary.org/obo/GO_0032259 | denotes | methylation |
| T89 | 8670-8697 | http://purl.obolibrary.org/obo/GO_0008859 | denotes | 5′ exoribonuclease activity |
| T90 | 8673-8697 | http://purl.obolibrary.org/obo/GO_0004532 | denotes | exoribonuclease activity |
| T91 | 8736-8751 | http://purl.obolibrary.org/obo/GO_0006298 | denotes | mismatch repair |
| T92 | 8766-8779 | http://purl.obolibrary.org/obo/GO_0032774 | denotes | RNA synthesis |
| T93 | 8770-8779 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T94 | 8904-8921 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T95 | 8904-8921 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
| T96 | 8923-8936 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T97 | 8949-8962 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | translational |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T76 | 0-2 | Sentence | denotes | 3. |
| T77 | 3-40 | Sentence | denotes | Biological Functions of PEDV Proteins |
| T78 | 41-171 | Sentence | denotes | The viral proteins of PEDV perform different biological functions during viral entry, replication cycle and propagation (Table 1). |
| T79 | 172-412 | Sentence | denotes | PEDV S protein, a type I membrane glycoprotein protein located on the envelope of the virus, consists of an N-terminal signal peptide, a large extracellular region, a single transmembrane domain, as well as a short cytoplasmic tail [48,49]. |
| T80 | 413-470 | Sentence | denotes | The ectodomain of S protein comprises S1 and S2 subunits. |
| T81 | 471-603 | Sentence | denotes | The N-terminal S1 region, containing N- and C-terminal domains (S1-NTD and S1-CTD), is mainly responsible for receptor binding [50]. |
| T82 | 604-746 | Sentence | denotes | The C-terminal membrane-anchored S2 region is mainly involved in triggering the fusion of the viral envelope with host cell membranes [48,49]. |
| T83 | 747-858 | Sentence | denotes | The interaction of the CoV S protein with its host cell surface receptor is a key determinant for host tropism. |
| T84 | 859-1012 | Sentence | denotes | The S1-CTD of most known members of α-CoV genus, including PEDV, interacts with aminopeptidase N (APN) to entry into the target cell [32,36,51,52,53,54]. |
| T85 | 1013-1114 | Sentence | denotes | In addition, S protein contains the epitopes that are the major targets of the neutralizing antibody. |
| T86 | 1115-1223 | Sentence | denotes | N protein is the most abundant viral protein during the early phase of infection in CoV-infected cells [55]. |
| T87 | 1224-1477 | Sentence | denotes | Similar to the N proteins of other CoVs, the PEDV N protein has multiple functions, such as acting as a structural protein that forms nucleocapsid with viral genomic RNA, playing important roles in viral replication, transcription, and assembly [56,57]. |
| T88 | 1478-1664 | Sentence | denotes | The expression of the N protein in intestinal epithelial cells extends the S-phase of cell cycle, causes endoplasmic reticulum (ER) stress, and upregulates interleukin-8 expression [44]. |
| T89 | 1665-1852 | Sentence | denotes | Moreover, the N proteins of several α-CoVs and β-CoVs, including PEDV, PDCoV, SARS-CoV, and mouse hepatitis virus (MHV), have been identified as innate immunity antagonists [58,59,60,61]. |
| T90 | 1853-1926 | Sentence | denotes | However, the involved antagonistic mechanisms are particularly different. |
| T91 | 1927-2118 | Sentence | denotes | PEDV M protein participates in virion assembly and virus budding through collaboration with other viral proteins, and engages in the induction of neutralizing antibodies against PEDV [62,63]. |
| T92 | 2119-2174 | Sentence | denotes | PEDV M protein is distributed throughout the cytoplasm. |
| T93 | 2175-2289 | Sentence | denotes | It induces the cell growth retardation in intestinal epithelial cells (IEC) and arrests the cells in S-phase [64]. |
| T94 | 2290-2402 | Sentence | denotes | In addition, PEDV M protein is identified as an interferon (IFN) antagonist with an unrecognized mechanism [65]. |
| T95 | 2403-2472 | Sentence | denotes | PEDV E protein is important for the virus packaging and budding [66]. |
| T96 | 2473-2589 | Sentence | denotes | It is predominantly localized in the ER, having no effect on cell growth, cell cycle and cyclin A expression in IEC. |
| T97 | 2590-2775 | Sentence | denotes | However, it causes ER stress and activates the nuclear factor-κB (NF-κB) pathway which is responsible for the up-regulation of IL-8 and the anti-apoptotic protein Bcl-2 expression [67]. |
| T98 | 2776-2908 | Sentence | denotes | ORF3 has been predicted to possess multiple transmembrane domains [68], while it is predominantly distributed in the cytoplasm [69]. |
| T99 | 2909-3021 | Sentence | denotes | ORF3 also detains cells at S-phase, facilitating vesicle formation, and thus promoting PEDV multiplication [69]. |
| T100 | 3022-3151 | Sentence | denotes | A recent study suggests that ORF3 interacts with S protein during PEDV assembly and consequently benefits viral replication [70]. |
| T101 | 3152-3536 | Sentence | denotes | CoV nsps play multiple roles in the synthesis or processing of viral RNA, or in virus-host interactions aiming to create an optimal environment for virus replication, such as facilitating viral entry, viral gene expression, RNA synthesis, and virion release. nsp1 is a N-terminal cleavage product of ORF1a polyprotein [71], a 9-kDa protein, that exists only in α-CoVs and β-CoVs [72]. |
| T102 | 3537-3641 | Sentence | denotes | The nsp1 of α-CoVs is not very similar to β-CoVs nsp1 with regard to sequence homology and size [73,74]. |
| T103 | 3642-3780 | Sentence | denotes | Based on the sequence alignment analysis of the genomes of different CoVs, the viral nsp1 can be regarded as a genus-specific marker [75]. |
| T104 | 3781-3863 | Sentence | denotes | Moreover, β-CoVs nsp1 has been widely reported to inhibit host protein expression. |
| T105 | 3864-3936 | Sentence | denotes | However, the biological functions of α-CoVs nsp1 remain largely unknown. |
| T106 | 3937-4086 | Sentence | denotes | Despite the lack of overall sequence similarity, the nsp1 of different CoVs shares a similar function to interfere with host protein expression [76]. |
| T107 | 4087-4180 | Sentence | denotes | These studies suggest the importance of nsp1 in the life cycle of different lineages of CoVs. |
| T108 | 4181-4279 | Sentence | denotes | It is shown that TGEV nsp1 inhibits host gene expression and is critical for viral virulence [77]. |
| T109 | 4280-4402 | Sentence | denotes | PEDV nsp1 induces the degradation of CBP and NF-κB to abate IFN response [78], but the detailed mechanisms remain unclear. |
| T110 | 4403-4494 | Sentence | denotes | The sizes and amino acid sequence identity of nsp 2 are variable among different CoVs [76]. |
| T111 | 4495-4561 | Sentence | denotes | Nsp2 of MHV and SARS-CoV are involved in viral RNA synthesis [79]. |
| T112 | 4562-4670 | Sentence | denotes | PEDV nsp2 has unknown functions in replication, and may implicate the virus-host interactions and virulence. |
| T113 | 4671-4871 | Sentence | denotes | Nsp3 is the largest nsp protein, containing two papain-like protease (PLP1 and PLP2) domains, of which PEDV PLP2 acts as a viral deubiquitinase (DUB), to negatively regulate type I IFN signaling [80]. |
| T114 | 4872-4986 | Sentence | denotes | CoVs PLPs domains exhibit multiple functions, serving as a viral protease, DUB, as well as an IFN antagonist [81]. |
| T115 | 4987-5138 | Sentence | denotes | CoVs, like other positive-stranded RNA viruses, induce membranous rearrangements of varying morphologies that are essential for RTCs anchoring [82,83]. |
| T116 | 5139-5388 | Sentence | denotes | The CoV-induced replicative structures consist of double-membrane vesicles (DMVs) and convoluted membranes (CMs), which form a large reticulovesicular network that are critical for viral replication and transcription [84,85,86,87,88,89,90,91,92,93]. |
| T117 | 5389-5555 | Sentence | denotes | Among the CoV nsps, nsp3, nsp4, and nsp6 include the hydrophobic transmembrane domains engaging in anchoring the viral RNA synthesis components to the membranes [94]. |
| T118 | 5556-5646 | Sentence | denotes | For MERS-CoV and SARS-CoV, co-expression of nsp3 and nsp4 is required to induce DMVs [95]. |
| T119 | 5647-5751 | Sentence | denotes | SARS-CoV nsp6 has membrane proliferation ability as well, which also contributes to DMVs formation [96]. |
| T120 | 5752-5819 | Sentence | denotes | The structure and functions of α-CoV nsp3 are largely unknown [97]. |
| T121 | 5820-6080 | Sentence | denotes | Nsp4 is also a marker for CoV-induced membrane structures; some results indicate that the nsp4–10 of pp1a act as a large complex through multidomain structure or scaffold during viral RNA replication progress, before its cleavage into individual products [98]. |
| T122 | 6081-6129 | Sentence | denotes | CoVs nsp5 encodes a 3C-like proteinase (3CLpro). |
| T123 | 6130-6248 | Sentence | denotes | The polyproteins pp1a and pp1ab are processed into individual elements of replicase by 3C-like protease and PLPs [99]. |
| T124 | 6249-6362 | Sentence | denotes | Moreover, PEDV nsp5 plays a crucial role in virus replication and also blocks host innate immune responses [100]. |
| T125 | 6363-6574 | Sentence | denotes | Crystallographic or nuclear magnetic resonance structures have shown that nsp3, nsp5, nsp7, nsp8, nsp9, and nsp10 have the PLprob and the ADP-ribose 1′′-phosphatase (ADRP) activity [101,102,103,104,105,106,107]. |
| T126 | 6575-6696 | Sentence | denotes | The crystal structure of SARS-CoV nsp9 suggests that nsp9 is dimeric and it is able to bind to single-stranded RNA [108]. |
| T127 | 6697-6842 | Sentence | denotes | The crystal structure of SARS CoV nsp10 protein suggests that nsp10 is a zinc-finger protein, which is existent exclusively in CoVs so far [107]. |
| T128 | 6843-6950 | Sentence | denotes | Moreover, nsp7–10 have RNA binding activity and nsp12 encodes a single RNA-dependent RNA polymerase (RdRp). |
| T129 | 6951-7117 | Sentence | denotes | The biochemical characterization and crystallization of SARS CoV nsp7 and nsp8 manifests that eight copies of nsp8 and eight copies of nsp7 form a supercomplex [106]. |
| T130 | 7118-7237 | Sentence | denotes | The complex is supportive for nucleic acid binding and may be associated with the processivity of viral RdRp [102,106]. |
| T131 | 7238-7420 | Sentence | denotes | Recently, structural studies have described that the SARS-CoV nsp12 polymerase binds to the nsp7 and nsp8 complex [109] that may increase the polymerase activity of nsp12 RdRp [110]. |
| T132 | 7421-7521 | Sentence | denotes | CoV nsp13, a NTPase/helicase, is also determined to play essential roles in viral replication [111]. |
| T133 | 7522-7650 | Sentence | denotes | CoV nsp14 is a multifunctional protein with 3′-5′ exoribonuclease activity and N-7-methyltransferase [MTase] activity [112,113]. |
| T134 | 7651-7724 | Sentence | denotes | Nsp14 catalyzes the N7-methylation of Gppp-RNA to form a cap-0 structure. |
| T135 | 7725-7838 | Sentence | denotes | CoV nsp15 encodes an endoribonuclease (EndoU), performing functions through a hexamer in many CoVs [114,115,116]. |
| T136 | 7839-7925 | Sentence | denotes | The endoribonuclease activity of nsp15 is not essential for CoV replication [117,118]. |
| T137 | 7926-8179 | Sentence | denotes | For CoVs, the 5′ end of the viral genomic RNA and subgenomic mRNA (sgmRNA) is supposed to have cap structures: an N-7 methylated guanosine nucleoside (m7GpppN) (cap 0) and a methyl group at the 2′-O-ribose position (cap 1) of the first nucleotide [119]. |
| T138 | 8180-8388 | Sentence | denotes | These cap structures enhance the initiation of translation of viral proteins, protect viral mRNAs against cellular 5′-3′-exoribonuclease and limit the recognition of viral RNA by host innate system [120,121]. |
| T139 | 8389-8481 | Sentence | denotes | Nsp13 is proposed to catalyze the first step of the 5′-capping reaction of viral RNAs [122]. |
| T140 | 8482-8649 | Sentence | denotes | The methylation of the two sites in the 5′ cap are catalyzed by three nsps; nsp14 (the N-7-MTase), nsp16 (the 2′-O-methyltransferase), and nsp10 [112,123,124,125,126]. |
| T141 | 8650-8833 | Sentence | denotes | In addition, the 3′-5′ exoribonuclease activity of nsp14 is involved in a replicative mismatch repair system during RNA synthesis, which improves the replication fidelity of CoV [42]. |
| T142 | 8834-9083 | Sentence | denotes | Although these nsps have been demonstrated to play essential roles in viral replication, transcription and/or post-translational polyprotein processing [127], the nsp12–16 of PEDV and other CoVs are poorly characterized to date, except for SARS-CoV. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32403318-27578435-82827272 | 405-407 | 27578435 | denotes | 48 |
| 32403318-27712627-82827273 | 408-410 | 27712627 | denotes | 49 |
| 32403318-26855426-82827274 | 599-601 | 26855426 | denotes | 50 |
| 32403318-27578435-82827275 | 739-741 | 27578435 | denotes | 48 |
| 32403318-27712627-82827276 | 742-744 | 27712627 | denotes | 49 |
| 32403318-17467767-82827277 | 993-995 | 17467767 | denotes | 32 |
| 32403318-25787280-82827278 | 996-998 | 25787280 | denotes | 36 |
| 32403318-8970993-82827279 | 999-1001 | 8970993 | denotes | 51 |
| 32403318-1350661-82827280 | 1002-1004 | 1350661 | denotes | 52 |
| 32403318-8764078-82827281 | 1005-1007 | 8764078 | denotes | 53 |
| 32403318-1350662-82827282 | 1008-1010 | 1350662 | denotes | 54 |
| 32403318-23389550-82827283 | 1219-1221 | 23389550 | denotes | 55 |
| 32403318-16971454-82827284 | 1470-1472 | 16971454 | denotes | 56 |
| 32403318-16338414-82827285 | 1473-1475 | 16338414 | denotes | 57 |
| 32403318-23562137-82827286 | 1660-1662 | 23562137 | denotes | 44 |
| 32403318-24872591-82827287 | 1839-1841 | 24872591 | denotes | 58 |
| 32403318-20976535-82827288 | 1842-1844 | 20976535 | denotes | 59 |
| 32403318-17182678-82827289 | 1845-1847 | 17182678 | denotes | 60 |
| 32403318-28591694-82827290 | 1848-1850 | 28591694 | denotes | 61 |
| 32403318-1645905-82827291 | 2111-2113 | 1645905 | denotes | 62 |
| 32403318-9658133-82827292 | 2114-2116 | 9658133 | denotes | 63 |
| 32403318-26435150-82827293 | 2285-2287 | 26435150 | denotes | 64 |
| 32403318-26773386-82827294 | 2398-2400 | 26773386 | denotes | 65 |
| 32403318-15609507-82827295 | 2468-2470 | 15609507 | denotes | 66 |
| 32403318-23332027-82827296 | 2771-2773 | 23332027 | denotes | 67 |
| 32403318-22245155-82827297 | 2843-2845 | 22245155 | denotes | 68 |
| 32403318-26531166-82827298 | 2904-2906 | 26531166 | denotes | 69 |
| 32403318-26531166-82827299 | 3017-3019 | 26531166 | denotes | 69 |
| 32403318-15609509-82827300 | 3471-3473 | 15609509 | denotes | 71 |
| 32403318-21994708-82827301 | 3532-3534 | 21994708 | denotes | 72 |
| 32403318-17207625-82827302 | 3634-3636 | 17207625 | denotes | 73 |
| 32403318-23269811-82827303 | 3637-3639 | 23269811 | denotes | 74 |
| 32403318-12927536-82827304 | 3776-3778 | 12927536 | denotes | 75 |
| 32403318-25432065-82827305 | 4082-4084 | 25432065 | denotes | 76 |
| 32403318-31350335-82827306 | 4275-4277 | 31350335 | denotes | 77 |
| 32403318-28715653-82827307 | 4354-4356 | 28715653 | denotes | 78 |
| 32403318-25432065-82827308 | 4490-4492 | 25432065 | denotes | 76 |
| 32403318-16227261-82827309 | 4557-4559 | 16227261 | denotes | 79 |
| 32403318-23596270-82827310 | 4867-4869 | 23596270 | denotes | 80 |
| 32403318-20181693-82827311 | 4982-4984 | 20181693 | denotes | 81 |
| 32403318-18414501-82827312 | 5131-5133 | 18414501 | denotes | 82 |
| 32403318-15609503-82827313 | 5134-5136 | 15609503 | denotes | 83 |
| 32403318-18798692-82827314 | 5357-5359 | 18798692 | denotes | 84 |
| 32403318-11907209-82827315 | 5360-5362 | 11907209 | denotes | 85 |
| 32403318-16731931-82827316 | 5366-5368 | 16731931 | denotes | 87 |
| 32403318-15030705-82827317 | 5369-5371 | 15030705 | denotes | 88 |
| 32403318-20088951-82827318 | 5372-5374 | 20088951 | denotes | 89 |
| 32403318-19844604-82827319 | 5375-5377 | 19844604 | denotes | 90 |
| 32403318-27218226-82827320 | 5381-5383 | 27218226 | denotes | 92 |
| 32403318-20542253-82827321 | 5384-5386 | 20542253 | denotes | 93 |
| 32403318-16928755-82827322 | 5551-5553 | 16928755 | denotes | 94 |
| 32403318-20668092-82827323 | 5815-5817 | 20668092 | denotes | 97 |
| 32403318-16341254-82827324 | 6076-6078 | 16341254 | denotes | 98 |
| 32403318-19430490-82827325 | 6244-6246 | 19430490 | denotes | 99 |
| 32403318-26656704-82827326 | 6357-6360 | 26656704 | denotes | 100 |
| 32403318-12093723-82827327 | 6545-6548 | 12093723 | denotes | 101 |
| 32403318-16188992-82827328 | 6549-6552 | 16188992 | denotes | 102 |
| 32403318-16581910-82827329 | 6553-6556 | 16581910 | denotes | 103 |
| 32403318-16271890-82827330 | 6557-6560 | 16271890 | denotes | 104 |
| 32403318-14962394-82827331 | 6561-6564 | 14962394 | denotes | 105 |
| 32403318-16228002-82827332 | 6565-6568 | 16228002 | denotes | 106 |
| 32403318-16873246-82827333 | 6569-6572 | 16873246 | denotes | 107 |
| 32403318-15007178-82827334 | 6691-6694 | 15007178 | denotes | 108 |
| 32403318-16873246-82827335 | 6837-6840 | 16873246 | denotes | 107 |
| 32403318-16228002-82827336 | 7112-7115 | 16228002 | denotes | 106 |
| 32403318-16188992-82827337 | 7228-7231 | 16188992 | denotes | 102 |
| 32403318-16228002-82827338 | 7232-7235 | 16228002 | denotes | 106 |
| 32403318-31138817-82827339 | 7353-7356 | 31138817 | denotes | 109 |
| 32403318-25197083-82827340 | 7415-7418 | 25197083 | denotes | 110 |
| 32403318-16979681-82827341 | 7516-7519 | 16979681 | denotes | 111 |
| 32403318-19208801-82827342 | 7641-7644 | 19208801 | denotes | 112 |
| 32403318-16549795-82827343 | 7645-7648 | 16549795 | denotes | 113 |
| 32403318-19023218-82827344 | 7825-7828 | 19023218 | denotes | 114 |
| 32403318-16873248-82827345 | 7829-7832 | 16873248 | denotes | 115 |
| 32403318-16216269-82827346 | 7833-7836 | 16216269 | denotes | 116 |
| 32403318-28158275-82827347 | 7916-7919 | 28158275 | denotes | 117 |
| 32403318-28484023-82827348 | 7920-7923 | 28484023 | denotes | 118 |
| 32403318-21217758-82827349 | 8383-8386 | 21217758 | denotes | 121 |
| 32403318-15140959-82827350 | 8476-8479 | 15140959 | denotes | 122 |
| 32403318-19208801-82827351 | 8628-8631 | 19208801 | denotes | 112 |
| 32403318-18417574-82827352 | 8632-8635 | 18417574 | denotes | 123 |
| 32403318-22022266-82827353 | 8636-8639 | 22022266 | denotes | 124 |
| 32403318-26159422-82827354 | 8640-8643 | 26159422 | denotes | 125 |
| 32403318-25074927-82827355 | 8644-8647 | 25074927 | denotes | 126 |
| 32403318-24269475-82827356 | 8829-8831 | 24269475 | denotes | 42 |
| 32403318-12917450-82827357 | 8987-8990 | 12917450 | denotes | 127 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 323 | 27-31 | Species | denotes | PEDV | Tax:28295 |
| 359 | 939-955 | Gene | denotes | aminopeptidase N | Gene:290 |
| 360 | 957-960 | Gene | denotes | APN | Gene:290 |
| 361 | 1634-1647 | Gene | denotes | interleukin-8 | Gene:3576 |
| 362 | 2350-2353 | Gene | denotes | IFN | Gene:3439 |
| 363 | 2562-2570 | Gene | denotes | cyclin A | Gene:890 |
| 364 | 2656-2661 | Gene | denotes | NF-κB | Gene:4790 |
| 365 | 2717-2721 | Gene | denotes | IL-8 | Gene:3576 |
| 366 | 2753-2758 | Gene | denotes | Bcl-2 | Gene:596 |
| 367 | 2776-2780 | Gene | denotes | ORF3 | Gene:136991 |
| 368 | 2909-2913 | Gene | denotes | ORF3 | Gene:136991 |
| 369 | 3051-3055 | Gene | denotes | ORF3 | Gene:136991 |
| 370 | 63-67 | Species | denotes | PEDV | Tax:28295 |
| 371 | 172-176 | Species | denotes | PEDV | Tax:28295 |
| 372 | 770-773 | Species | denotes | CoV | Tax:11118 |
| 373 | 897-900 | Species | denotes | CoV | Tax:11118 |
| 374 | 918-922 | Species | denotes | PEDV | Tax:28295 |
| 375 | 1259-1263 | Species | denotes | CoVs | Tax:11118 |
| 376 | 1703-1707 | Species | denotes | CoVs | Tax:11118 |
| 377 | 1714-1718 | Species | denotes | CoVs | Tax:11118 |
| 378 | 1730-1734 | Species | denotes | PEDV | Tax:28295 |
| 379 | 1743-1751 | Species | denotes | SARS-CoV | Tax:694009 |
| 380 | 1757-1778 | Species | denotes | mouse hepatitis virus | Tax:11138 |
| 381 | 1927-1931 | Species | denotes | PEDV | Tax:28295 |
| 382 | 2105-2109 | Species | denotes | PEDV | Tax:28295 |
| 383 | 2119-2123 | Species | denotes | PEDV | Tax:28295 |
| 384 | 2303-2307 | Species | denotes | PEDV | Tax:28295 |
| 385 | 2403-2407 | Species | denotes | PEDV | Tax:28295 |
| 386 | 2996-3000 | Species | denotes | PEDV | Tax:28295 |
| 387 | 3088-3092 | Species | denotes | PEDV | Tax:28295 |
| 388 | 1780-1783 | Species | denotes | MHV | Tax:11138 |
| 389 | 1186-1195 | Disease | denotes | infection | MESH:D007239 |
| 390 | 1199-1211 | Disease | denotes | CoV-infected | MESH:D018352 |
| 391 | 1610-1616 | Disease | denotes | stress | MESH:D000079225 |
| 392 | 2202-2213 | Disease | denotes | retardation | MESH:D008607 |
| 393 | 2612-2618 | Disease | denotes | stress | MESH:D000079225 |
| 429 | 3411-3415 | Gene | denotes | nsp1 | Gene:10045 |
| 430 | 3541-3545 | Gene | denotes | nsp1 | Gene:10045 |
| 431 | 3586-3590 | Gene | denotes | nsp1 | Gene:10045 |
| 432 | 3727-3731 | Gene | denotes | nsp1 | Gene:10045 |
| 433 | 3798-3802 | Gene | denotes | nsp1 | Gene:10045 |
| 434 | 3908-3912 | Gene | denotes | nsp1 | Gene:10045 |
| 435 | 3990-3994 | Gene | denotes | nsp1 | Gene:10045 |
| 436 | 4127-4131 | Gene | denotes | nsp1 | Gene:10045 |
| 437 | 4203-4207 | Gene | denotes | nsp1 | Gene:10045 |
| 438 | 4285-4289 | Gene | denotes | nsp1 | Gene:10045 |
| 439 | 4317-4320 | Gene | denotes | CBP | Gene:1387 |
| 440 | 4325-4330 | Gene | denotes | NF-κB | Gene:4790 |
| 441 | 4340-4343 | Gene | denotes | IFN | Gene:3439 |
| 442 | 4741-4745 | Gene | denotes | PLP1 | Gene:5354 |
| 443 | 4750-4754 | Gene | denotes | PLP2 | Gene:5355 |
| 444 | 4779-4783 | Gene | denotes | PLP2 | Gene:5355 |
| 445 | 4966-4969 | Gene | denotes | IFN | Gene:3439 |
| 446 | 3152-3155 | Species | denotes | CoV | Tax:11118 |
| 447 | 3515-3519 | Species | denotes | CoVs | Tax:11118 |
| 448 | 3526-3530 | Species | denotes | CoVs | Tax:11118 |
| 449 | 3551-3555 | Species | denotes | CoVs | Tax:11118 |
| 450 | 3581-3585 | Species | denotes | CoVs | Tax:11118 |
| 451 | 3711-3715 | Species | denotes | CoVs | Tax:11118 |
| 452 | 3793-3797 | Species | denotes | CoVs | Tax:11118 |
| 453 | 3903-3907 | Species | denotes | CoVs | Tax:11118 |
| 454 | 4008-4012 | Species | denotes | CoVs | Tax:11118 |
| 455 | 4175-4179 | Species | denotes | CoVs | Tax:11118 |
| 456 | 4198-4202 | Species | denotes | TGEV | Tax:11149 |
| 457 | 4280-4284 | Species | denotes | PEDV | Tax:28295 |
| 458 | 4484-4488 | Species | denotes | CoVs | Tax:11118 |
| 459 | 4511-4519 | Species | denotes | SARS-CoV | Tax:694009 |
| 460 | 4562-4566 | Species | denotes | PEDV | Tax:28295 |
| 461 | 4774-4778 | Species | denotes | PEDV | Tax:28295 |
| 462 | 4872-4876 | Species | denotes | CoVs | Tax:11118 |
| 463 | 4503-4506 | Species | denotes | MHV | Tax:11138 |
| 500 | 5921-5925 | Gene | denotes | pp1a | Gene:5499 |
| 501 | 6086-6090 | Gene | denotes | nsp5 | Gene:92521 |
| 502 | 6147-6151 | Gene | denotes | pp1a | Gene:5499 |
| 503 | 6264-6268 | Gene | denotes | nsp5 | Gene:92521 |
| 504 | 6443-6447 | Gene | denotes | nsp5 | Gene:92521 |
| 505 | 7441-7449 | Gene | denotes | helicase | Gene:164045 |
| 506 | 7764-7769 | Gene | denotes | EndoU | Gene:8909 |
| 507 | 4987-4991 | Species | denotes | CoVs | Tax:11118 |
| 508 | 5143-5146 | Species | denotes | CoV | Tax:11118 |
| 509 | 5399-5402 | Species | denotes | CoV | Tax:11118 |
| 510 | 5560-5568 | Species | denotes | MERS-CoV | Tax:1335626 |
| 511 | 5573-5581 | Species | denotes | SARS-CoV | Tax:694009 |
| 512 | 5647-5655 | Species | denotes | SARS-CoV | Tax:694009 |
| 513 | 5785-5788 | Species | denotes | CoV | Tax:11118 |
| 514 | 5846-5849 | Species | denotes | CoV | Tax:11118 |
| 515 | 6081-6085 | Species | denotes | CoVs | Tax:11118 |
| 516 | 6259-6263 | Species | denotes | PEDV | Tax:28295 |
| 517 | 6600-6608 | Species | denotes | SARS-CoV | Tax:694009 |
| 518 | 6722-6730 | Species | denotes | SARS CoV | Tax:694009 |
| 519 | 6824-6828 | Species | denotes | CoVs | Tax:11118 |
| 520 | 7007-7015 | Species | denotes | SARS CoV | Tax:694009 |
| 521 | 7291-7299 | Species | denotes | SARS-CoV | Tax:694009 |
| 522 | 7421-7424 | Species | denotes | CoV | Tax:11118 |
| 523 | 7522-7525 | Species | denotes | CoV | Tax:11118 |
| 524 | 7725-7728 | Species | denotes | CoV | Tax:11118 |
| 525 | 7819-7823 | Species | denotes | CoVs | Tax:11118 |
| 526 | 7899-7902 | Species | denotes | CoV | Tax:11118 |
| 527 | 7930-7934 | Species | denotes | CoVs | Tax:11118 |
| 528 | 8824-8827 | Species | denotes | CoV | Tax:11118 |
| 529 | 9009-9013 | Species | denotes | PEDV | Tax:28295 |
| 530 | 9024-9028 | Species | denotes | CoVs | Tax:11118 |
| 531 | 9074-9082 | Species | denotes | SARS-CoV | Tax:694009 |
| 532 | 5731-5735 | Chemical | denotes | DMVs | |
| 533 | 8055-8075 | Chemical | denotes | guanosine nucleoside | |
| 534 | 8077-8084 | Chemical | denotes | m7GpppN | |
| 535 | 8125-8131 | Chemical | denotes | ribose | MESH:D012266 |