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PMC:7281546 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 411-420 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T2 918-921 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T3 953-956 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T4 3340-3343 Body_part denotes IgA http://purl.org/sig/ont/fma/fma62874
T5 3934-3938 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T6 4445-4455 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T7 4456-4461 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T8 4596-4604 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T9 5900-5906 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T10 7121-7137 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T11 7132-7137 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T12 7142-7162 Body_part denotes alveolar macrophages http://purl.org/sig/ont/fma/fma83023
T13 7579-7586 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T14 7717-7729 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T15 7784-7795 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T16 7827-7837 Body_part denotes amino-acid http://purl.org/sig/ont/fma/fma82739
T17 7891-7898 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18 8001-8006 Body_part denotes sugar http://purl.org/sig/ont/fma/fma82737
T19 8073-8077 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T20 8199-8204 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T21 8289-8304 Body_part denotes cell components http://purl.org/sig/ont/fma/fma86454
T22 8289-8293 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T23 8862-8875 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T24 9299-9302 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T25 9319-9325 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T26 9388-9394 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T27 9756-9764 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T28 9856-9864 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T29 9929-9937 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T30 10316-10322 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T31 10367-10375 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T32 10383-10390 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T33 10411-10423 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T34 10438-10450 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T35 10473-10480 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T36 10523-10530 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T37 10581-10588 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T38 10607-10615 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T39 10707-10710 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T40 10742-10745 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T41 10897-10905 Body_part denotes Proteins http://purl.org/sig/ont/fma/fma67257
T42 10916-10924 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T43 11044-11051 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T44 11071-11083 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T45 11084-11091 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T46 11252-11263 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T47 11298-11305 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T48 11588-11602 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T49 11588-11592 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T50 11641-11648 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T51 11663-11675 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T52 11663-11667 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T53 11852-11856 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T54 11893-11900 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T55 11970-11978 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T56 11982-11989 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T57 12017-12024 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T58 12077-12082 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T59 12106-12114 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T60 12141-12148 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T61 12204-12211 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T62 12255-12258 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T63 12367-12374 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T64 12378-12388 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T65 12389-12405 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T66 12400-12405 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T67 12429-12433 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T68 12448-12469 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T69 12471-12473 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T70 12499-12512 Body_part denotes interleukin-8 http://purl.org/sig/ont/fma/fma264827
T71 12546-12554 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T72 12799-12806 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T73 12896-12904 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T74 12991-12998 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T75 13029-13038 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T76 13055-13059 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T77 13082-13092 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T78 13093-13109 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T79 13104-13109 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T80 13132-13137 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T81 13175-13182 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T82 13275-13282 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T83 13375-13377 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T84 13399-13403 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T85 13412-13416 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T86 13474-13476 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T87 13610-13617 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T88 13758-13767 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T89 13792-13797 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T90 13938-13945 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T91 14086-14089 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T92 14224-14228 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T93 14241-14244 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T94 14349-14356 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T95 14555-14562 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T96 14709-14716 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T97 14927-14934 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T98 15087-15091 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T99 15282-15292 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T100 15407-15410 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T101 15560-15567 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T102 15887-15890 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T103 16373-16376 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T104 16869-16872 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T105 17551-17554 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T106 17602-17609 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T107 17640-17646 Body_part denotes finger http://purl.org/sig/ont/fma/fma9666
T108 17647-17654 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T109 17731-17734 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T110 17779-17782 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T111 17793-17796 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T112 18418-18425 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T113 18559-18562 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T114 18833-18836 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T115 18852-18856 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T116 19027-19037 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T117 19113-19121 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T118 19217-19220 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T119 19631-19634 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T120 19996-20001 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T121 20305-20318 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T122 20349-20357 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T123 20403-20411 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T124 20935-20939 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T125 20992-20995 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T126 21003-21012 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T127 21089-21092 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T128 21096-21099 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T129 21107-21115 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180
T130 21175-21178 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T131 21258-21267 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T132 21297-21304 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T133 21361-21364 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T134 21393-21396 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T135 21546-21550 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T136 21934-21942 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T137 21961-21964 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T138 21985-21988 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T139 22161-22164 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T140 22460-22468 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T141 22573-22580 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T142 23316-23320 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T143 23410-23431 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T144 23433-23435 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T145 23838-23844 Body_part denotes lysine http://purl.org/sig/ont/fma/fma82758
T146 24284-24291 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T147 24509-24514 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T148 24530-24535 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T149 24730-24742 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T150 24730-24734 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T151 24764-24772 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T152 25347-25352 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T153 25549-25554 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T154 25585-25590 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T155 25610-25619 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T156 25628-25642 Body_part denotes interleukin-12 http://purl.org/sig/ont/fma/fma86579
T157 25644-25649 Body_part denotes IL-12 http://purl.org/sig/ont/fma/fma86579
T158 26175-26186 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T159 26311-26315 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T160 27144-27152 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T161 27404-27412 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T162 28289-28292 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T163 28324-28327 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T164 28414-28421 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T165 28577-28586 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T166 28628-28633 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T167 28660-28667 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T168 28670-28677 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T169 28716-28723 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T170 28744-28749 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T171 28849-28856 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T172 29004-29011 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T173 29417-29424 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T174 29485-29492 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T175 29713-29718 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T176 29762-29769 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T177 29880-29887 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T178 29986-29994 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T179 30028-30035 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T180 30049-30056 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T181 30242-30249 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T182 30308-30315 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T183 30519-30527 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T184 30537-30541 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T185 30580-30587 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T186 30605-30612 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T187 30685-30692 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T188 30718-30726 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T189 30798-30800 Body_part denotes A1 http://purl.org/sig/ont/fma/fma66592
T190 30816-30825 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T191 30852-30857 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T192 30882-30890 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T193 30945-30951 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T194 30987-30995 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T195 31020-31028 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T196 31257-31268 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T197 31402-31406 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T198 31496-31500 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T199 31519-31526 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T200 31778-31785 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T201 31976-31980 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T202 32010-32021 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T203 32113-32120 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T204 32517-32524 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T205 32687-32694 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T206 33135-33144 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T207 33314-33323 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T208 33523-33532 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T209 33845-33856 Body_part denotes peroxisomes http://purl.org/sig/ont/fma/fma63845
T210 33942-33949 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T211 35010-35013 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T212 35045-35049 Body_part denotes foot http://purl.org/sig/ont/fma/fma9664
T213 35054-35059 Body_part denotes mouth http://purl.org/sig/ont/fma/fma49184
T214 36425-36430 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T215 37270-37278 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T216 37324-37332 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T217 37747-37754 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T218 37959-37961 Body_part denotes A6 http://purl.org/sig/ont/fma/fma66574
T219 38537-38540 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T220 38656-38664 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T221 38886-38889 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T222 40515-40523 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T223 40588-40591 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T224 40619-40622 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T225 40654-40657 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T226 40699-40702 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T227 40752-40755 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T228 40829-40839 Body_part denotes organelles http://purl.org/sig/ont/fma/fma63832
T229 40849-40852 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T230 41142-41149 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T231 41215-41218 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T232 41271-41281 Body_part denotes organelles http://purl.org/sig/ont/fma/fma63832
T233 41330-41333 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T234 41403-41406 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T235 41705-41716 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T236 41881-41884 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T237 42069-42072 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T238 42094-42101 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T239 42198-42201 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T240 42209-42216 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T241 42334-42337 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T242 42370-42373 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T243 42646-42657 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T244 42717-42733 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T245 42728-42733 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T246 42823-42839 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T247 42834-42839 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T248 43454-43457 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T249 43493-43496 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T250 43525-43529 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T251 43530-43534 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T252 43589-43592 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T253 45224-45228 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T254 45271-45275 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T255 45387-45391 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T256 45484-45489 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T257 45513-45517 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T258 45728-45731 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T259 45755-45758 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T260 45853-45860 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T261 45920-45927 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T262 45971-45979 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T263 46035-46042 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T264 46520-46525 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T265 46545-46550 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T266 46626-46630 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T267 46663-46668 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T268 47321-47330 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T269 47443-47448 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T270 47517-47526 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T271 47968-47973 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T272 48086-48090 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T273 48524-48531 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T274 48562-48566 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T275 48617-48625 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T276 48678-48682 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T277 48708-48715 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T278 48741-48748 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T279 48802-48804 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T280 48885-48902 Body_part denotes cellular membrane http://purl.org/sig/ont/fma/fma63841
T281 48903-48915 Body_part denotes compartments http://purl.org/sig/ont/fma/fma76577
T282 48932-48953 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T283 48955-48957 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T284 48987-48989 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T285 49077-49084 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T286 49180-49188 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T287 49196-49198 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T288 49208-49210 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T289 49233-49238 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T290 49321-49328 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T291 49411-49418 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T292 49470-49472 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T293 49473-49480 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T294 49542-49549 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T295 49761-49768 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T296 49770-49773 Body_part denotes MAP http://purl.org/sig/ont/fma/fma67847
T297 49868-49870 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T298 49894-49899 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T299 49940-49947 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T300 50265-50274 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T301 50318-50339 Body_part denotes transmembrane protein http://purl.org/sig/ont/fma/fma67858
T302 50430-50432 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T303 50447-50449 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T304 50662-50664 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T305 50701-50703 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T306 50751-50758 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T307 50841-50848 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T308 50947-50952 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T309 51410-51418 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T310 51438-51446 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T311 51559-51566 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T312 51702-51710 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T313 51788-51796 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T314 51896-51903 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T315 51993-52001 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T316 52101-52103 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T317 52112-52116 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T318 53093-53099 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T319 53124-53130 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T320 53257-53265 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T321 53308-53315 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T322 53471-53474 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T323 53485-53488 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T324 53541-53545 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T325 53743-53746 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T326 53762-53765 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T327 53850-53854 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T328 54049-54052 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T329 54249-54256 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T330 54592-54599 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T331 54721-54732 Body_part denotes peroxisomes http://purl.org/sig/ont/fma/fma63845
T332 54938-54946 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T333 54953-54961 Body_part denotes Proteins http://purl.org/sig/ont/fma/fma67257
T334 55108-55112 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T335 55224-55228 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T336 55236-55257 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T337 55259-55261 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T338 55331-55338 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T339 55441-55445 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T340 55577-55579 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T341 55647-55652 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T342 56726-56729 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T343 56844-56847 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 8862-8875 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T2 9473-9477 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T3 11264-11268 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T4 17640-17646 Body_part denotes finger http://purl.obolibrary.org/obo/UBERON_0002389
T5 20305-20318 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T6 23316-23320 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T7 35045-35049 Body_part denotes foot http://purl.obolibrary.org/obo/UBERON_0002387
T8 35054-35059 Body_part denotes mouth http://purl.obolibrary.org/obo/UBERON_0000165
T9 55200-55209 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 17-25 Disease denotes Diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T2 95-103 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T3 205-213 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T4 246-254 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T5 570-586 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T6 593-602 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T7 1223-1231 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T8 1290-1298 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T9 1356-1372 Disease denotes disease of swine http://purl.obolibrary.org/obo/MONDO_0024990
T10 1400-1408 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T11 1488-1496 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T12 1798-1806 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T13 2392-2401 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T14 2697-2706 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T15 4715-4724 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T16 6202-6235 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T17 6249-6257 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 6356-6360 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T19 6368-6376 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T20 6411-6430 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T21 6551-6560 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T22 6565-6600 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T23 6571-6600 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T24 6602-6606 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T25 6657-6661 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T26 6761-6769 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T27 6786-6796 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T28 6812-6820 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T29 6947-6955 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T30 6993-7008 Disease denotes gastroenteritis http://purl.obolibrary.org/obo/MONDO_0002269
T31 7091-7120 Disease denotes infects the upper respiratory http://purl.obolibrary.org/obo/MONDO_0024355
T32 7273-7281 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T33 7445-7453 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T34 8026-8041 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T35 8032-8041 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T36 11403-11406 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T38 12051-12060 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T39 12608-12616 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T40 12628-12637 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T41 15182-15185 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T42 15376-15384 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T43 16438-16446 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 16512-16520 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 17465-17473 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 17587-17591 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T47 17872-17876 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T48 18156-18164 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 19939-19947 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T50 19981-19990 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T51 20027-20042 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T52 20033-20042 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T53 20120-20129 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T54 20269-20285 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T55 21510-21518 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T56 21861-21865 Disease denotes CARD http://purl.obolibrary.org/obo/MONDO_0002145
T57 21895-21899 Disease denotes CARD http://purl.obolibrary.org/obo/MONDO_0002145
T58 23768-23772 Disease denotes CARD http://purl.obolibrary.org/obo/MONDO_0002145
T59 23800-23804 Disease denotes CARD http://purl.obolibrary.org/obo/MONDO_0002145
T60 24267-24272 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T61 24292-24296 Disease denotes CYLD http://purl.obolibrary.org/obo/MONDO_0007565
T62 27605-27613 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T63 27733-27742 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T64 29751-29759 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 29975-29983 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T66 30557-30572 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T67 30563-30572 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T68 31441-31449 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 31597-31605 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T70 31708-31723 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T71 31714-31723 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T72 31804-31819 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T73 31810-31819 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T74 31917-31925 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 32160-32168 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T76 32526-32529 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T77 32545-32548 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T78 32614-32617 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T79 32764-32767 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T80 32822-32825 Disease denotes PRD http://purl.obolibrary.org/obo/MONDO_0010722
T81 33177-33192 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T82 33183-33192 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T83 33333-33342 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T84 34063-34072 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T85 34514-34529 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T86 34520-34529 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T87 35014-35030 Disease denotes virus infections http://purl.obolibrary.org/obo/MONDO_0005108
T88 35045-35067 Disease denotes foot-and-mouth disease http://purl.obolibrary.org/obo/MONDO_0005765
T89 35054-35067 Disease denotes mouth disease http://purl.obolibrary.org/obo/MONDO_0006858
T90 35116-35161 Disease denotes porcine reproductive and respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0025494
T91 35415-35424 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T92 35452-35456 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T93 35711-35715 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T94 36686-36694 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T95 36872-36881 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T96 37860-37871 Disease denotes hepatitis A http://purl.obolibrary.org/obo/MONDO_0005790
T97 37860-37869 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T98 37912-37914 Disease denotes EV http://purl.obolibrary.org/obo/MONDO_0009176
T99 39082-39092 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T100 40409-40418 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T101 41775-41783 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 42227-42243 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T103 43797-43805 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T104 45075-45085 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T105 45797-45806 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T106 46206-46215 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T107 46260-46269 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T108 46446-46455 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T109 46960-46963 Disease denotes HSP http://purl.obolibrary.org/obo/MONDO_0006785|http://purl.obolibrary.org/obo/MONDO_0019064
T111 47242-47257 Disease denotes Viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T112 47248-47257 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T113 47560-47581 Disease denotes inflammatory diseases http://purl.obolibrary.org/obo/MONDO_0021166
T114 48274-48283 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T115 51068-51081 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T116 53071-53079 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T117 53989-54004 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T118 53995-54004 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T119 54369-54372 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T120 55809-55812 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 26-31 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T2 104-109 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T3 118-119 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 273-276 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T5 337-338 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 492-493 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 619-620 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 681-686 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T9 1232-1237 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T10 1581-1582 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 1938-1939 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 2457-2459 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T13 3461-3466 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T14 3573-3578 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T15 3618-3623 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T16 3682-3687 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T17 3934-3938 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T18 4387-4395 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T19 4445-4455 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T20 4445-4455 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T21 4456-4461 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T22 4477-4478 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 4678-4679 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T24 4726-4728 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T25 4972-4973 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 5161-5168 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T27 5305-5306 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 5404-5405 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 5604-5605 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30 5622-5629 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T31 5703-5705 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T32 5950-5951 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 5981-5987 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T34 5992-5999 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T35 6114-6115 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 6186-6192 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T37 6624-6625 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 6643-6645 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T39 6751-6757 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T40 6800-6806 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T41 7009-7014 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T42 7121-7131 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T43 7132-7137 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T44 7499-7502 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T45 7630-7631 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 7686-7687 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T47 7765-7773 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T48 7797-7799 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T49 7887-7889 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T50 7900-7902 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T51 7959-7961 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T52 8073-8083 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines
T53 8117-8120 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T54 8125-8132 http://purl.obolibrary.org/obo/NCBITaxon_9443 denotes primate
T55 8134-8139 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T56 8148-8153 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T57 8199-8204 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T58 8245-8250 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T59 8289-8293 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T60 8498-8499 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T61 8765-8770 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T62 8777-8780 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T63 8862-8875 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T64 9303-9308 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T65 9350-9351 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T66 9415-9417 http://purl.obolibrary.org/obo/CLO_0007074 denotes kb
T67 9415-9417 http://purl.obolibrary.org/obo/CLO_0051988 denotes kb
T68 9440-9441 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T69 9459-9462 http://purl.obolibrary.org/obo/CLO_0001577 denotes a 3
T70 9470-9471 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T71 9473-9477 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T72 9573-9578 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T73 9839-9841 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T74 10175-10176 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T75 10429-10437 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T76 10498-10499 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T77 10622-10623 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78 11053-11054 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 11062-11070 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T80 11123-11128 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T81 11156-11162 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T82 11163-11170 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T83 11172-11173 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T84 11202-11203 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T85 11244-11245 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T86 11264-11268 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T87 11316-11318 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T88 11323-11325 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T89 11323-11325 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T90 11351-11353 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T91 11400-11402 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T92 11411-11413 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T93 11484-11492 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T94 11502-11504 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T95 11502-11504 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T96 11588-11592 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T97 11593-11602 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T98 11663-11667 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T99 11688-11689 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 11728-11730 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T101 11852-11856 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T102 12077-12082 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T103 12149-12152 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T104 12191-12192 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T105 12378-12388 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T106 12378-12388 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T107 12389-12399 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T108 12400-12405 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T109 12429-12433 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T110 12622-12627 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T111 12638-12643 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T112 12843-12848 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T113 13055-13059 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T114 13082-13092 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T115 13082-13092 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T116 13093-13103 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T117 13104-13109 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T118 13132-13137 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T119 13304-13309 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T120 13399-13403 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T121 13412-13416 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T122 13434-13435 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T123 13488-13497 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T124 13518-13519 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T125 13525-13526 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T126 13582-13586 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T127 13646-13649 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T128 13792-13797 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T129 13887-13888 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T130 14097-14102 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T131 14165-14170 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T132 14224-14228 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T133 14284-14285 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T134 14336-14338 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T135 14341-14344 http://purl.obolibrary.org/obo/CLO_0001618 denotes a 9
T136 14341-14344 http://purl.obolibrary.org/obo/CLO_0001619 denotes a 9
T137 14341-14344 http://purl.obolibrary.org/obo/CLO_0001620 denotes a 9
T138 14616-14617 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T139 14668-14671 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T140 14885-14886 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T141 15087-15091 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T142 15194-15195 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T143 15437-15440 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T144 15497-15502 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T145 15657-15658 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T146 15721-15730 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T147 15794-15795 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T148 15891-15898 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T149 15907-15917 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranous
T150 16061-16069 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T151 16101-16110 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T152 16129-16130 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T153 16405-16414 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T154 16416-16418 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T155 16526-16529 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T156 16530-16538 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T157 16698-16699 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T158 16723-16731 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T159 16798-16799 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T160 16964-16968 http://purl.obolibrary.org/obo/CLO_0053943 denotes a 3C
T161 17140-17141 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T162 17158-17163 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T163 17400-17408 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T164 17633-17634 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T165 17743-17751 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T166 17770-17771 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T167 17961-17962 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T168 18256-18264 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T169 18297-18298 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T170 18400-18401 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T171 18431-18435 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3′-5
T172 18453-18461 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T173 18496-18504 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T174 18571-18572 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T175 18666-18667 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T176 18725-18733 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T177 18963-18964 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T178 19532-19536 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3′-5
T179 19554-19562 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T180 19587-19588 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T181 19996-20001 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T182 20027-20032 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T183 20209-20216 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T184 20305-20318 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T185 20482-20492 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T186 20745-20750 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T187 20935-20939 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T188 21025-21033 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T189 21135-21136 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T190 21546-21550 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T191 21671-21680 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T192 21710-21720 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T193 21767-21768 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T194 21948-21949 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 22121-22122 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T196 22243-22253 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T197 22288-22297 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activated
T198 22379-22388 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T199 22423-22432 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T200 22668-22678 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T201 22684-22685 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T202 22747-22748 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T203 22762-22763 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T204 22801-22802 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T205 22839-22840 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T206 22849-22858 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T207 22977-22986 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T208 23148-23157 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activated
T209 23437-23445 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T210 23641-23651 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T211 24147-24156 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T212 24160-24170 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T213 24307-24310 http://purl.obolibrary.org/obo/CLO_0001564 denotes A20
T214 24307-24310 http://purl.obolibrary.org/obo/CLO_0050194 denotes A20
T215 24322-24323 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T216 24417-24418 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T217 24509-24514 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T218 24530-24535 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T219 24625-24626 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T220 24730-24734 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T221 24750-24759 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T222 24811-24817 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T223 25274-25279 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T224 25347-25352 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T225 25544-25554 http://purl.obolibrary.org/obo/CL_0000623 denotes (NK) cells
T226 25559-25568 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T227 25569-25572 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T228 25578-25581 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T229 25583-25590 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T230 25658-25660 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T231 25907-25917 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T232 25988-25993 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T233 26151-26157 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T234 26287-26296 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T235 26311-26315 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T236 26514-26517 http://purl.obolibrary.org/obo/CLO_0001003 denotes 163
T237 26596-26606 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T238 26652-26653 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T239 26665-26666 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T240 26806-26807 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T241 26869-26875 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T242 27034-27035 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T243 27106-27116 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T244 27662-27663 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T245 27822-27823 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T246 27860-27861 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T247 27959-27964 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T248 28143-28153 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T249 28232-28238 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T250 28476-28491 http://purl.obolibrary.org/obo/PR_000024990 denotes IFN or type III
T251 28628-28633 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T252 28744-28749 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T253 28751-28754 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T254 28785-28790 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T255 28857-28860 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T256 28978-28979 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T257 28980-28990 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T258 29025-29035 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T259 29146-29156 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T260 29452-29455 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T261 29617-29618 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T262 29713-29718 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T263 30036-30045 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T264 30110-30118 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T265 30166-30175 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T266 30537-30541 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T267 30591-30592 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T268 30625-30630 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T269 30852-30857 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T270 30859-30860 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T271 30934-30939 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T272 31077-31082 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T273 31205-31206 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T274 31402-31406 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T275 31426-31435 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T276 31655-31660 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T277 31681-31687 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T278 31708-31713 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T279 31976-31980 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T280 32028-32030 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T281 32063-32064 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T282 32191-32194 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T283 32284-32292 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T284 32331-32341 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T285 32645-32654 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T286 32655-32659 http://purl.obolibrary.org/obo/CLO_0053428 denotes cAMP
T287 32709-32710 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T288 32728-32737 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T289 32896-32897 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T290 32974-32979 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T291 33061-33070 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activated
T292 33075-33076 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T293 33204-33207 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T294 33245-33246 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T295 33247-33255 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T296 33397-33398 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T297 34176-34185 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T298 34378-34379 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T299 34432-34440 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T300 34487-34496 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T301 34531-34532 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T302 34732-34737 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T303 34757-34766 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T304 34852-34861 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T305 34903-34904 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T306 35014-35019 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T307 35054-35059 http://www.ebi.ac.uk/efo/EFO_0000825 denotes mouth
T308 35068-35073 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T309 35162-35167 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T310 35218-35226 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T311 35349-35357 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T312 35409-35414 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T313 35425-35430 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T314 35468-35473 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T315 35492-35500 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T316 35547-35550 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T317 35575-35576 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T318 35592-35600 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T319 35926-35934 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T320 36052-36062 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T321 36125-36134 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T322 36403-36413 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T323 36425-36430 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T324 36440-36448 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T325 36494-36502 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T326 36654-36659 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T327 36721-36726 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T328 36850-36859 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T329 37063-37064 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T330 37183-37192 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T331 37209-37210 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T332 37221-37229 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T333 37382-37383 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T334 37406-37407 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T335 37673-37681 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T336 37719-37720 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T337 37800-37807 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T338 37870-37871 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T339 37872-37877 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T340 37959-37961 http://purl.obolibrary.org/obo/CLO_0001602 denotes A6
T341 37959-37961 http://purl.obolibrary.org/obo/CLO_0001603 denotes A6
T342 37959-37961 http://purl.obolibrary.org/obo/CLO_0050248 denotes A6
T343 37959-37961 http://purl.obolibrary.org/obo/CLO_0052463 denotes A6
T344 38007-38016 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T345 38091-38092 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T346 38135-38140 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T347 38148-38151 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T348 38272-38281 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T349 38541-38548 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T350 38810-38811 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T351 38890-38895 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T352 38904-38914 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T353 38922-38923 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T354 38988-38998 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T355 39027-39037 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T356 39193-39198 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T357 39269-39277 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T358 39345-39354 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T359 39559-39568 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T360 39624-39627 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T361 39749-39750 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T362 39890-39891 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T363 40024-40033 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T364 40053-40056 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T365 40110-40120 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T366 40468-40477 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T367 40552-40561 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T368 40623-40630 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T369 40708-40709 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T370 40899-40909 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranous
T371 40979-41002 http://purl.obolibrary.org/obo/GO_0031988 denotes membrane-bound vesicles
T372 41079-41080 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T373 41304-41312 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T374 41488-41491 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T375 41508-41516 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T376 41552-41553 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T377 41568-41573 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T378 41644-41645 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T379 41696-41701 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T380 41705-41716 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblasts
T381 41843-41851 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T382 41912-41915 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T383 41944-41945 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T384 42029-42037 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T385 42300-42305 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T386 42475-42483 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T387 42484-42487 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T388 42543-42552 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T389 42570-42578 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T390 42717-42727 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T391 42728-42733 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T392 42823-42833 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T393 42834-42839 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T394 43074-43081 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T395 43168-43176 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T396 43197-43198 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T397 43297-43300 http://purl.obolibrary.org/obo/CLO_0001562 denotes a 2
T398 43297-43300 http://purl.obolibrary.org/obo/CLO_0001563 denotes a 2
T399 43525-43529 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T400 43820-43823 http://purl.obolibrary.org/obo/CLO_0001562 denotes a 2
T401 43820-43823 http://purl.obolibrary.org/obo/CLO_0001563 denotes a 2
T402 44099-44100 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T403 44163-44166 http://purl.obolibrary.org/obo/CLO_0054061 denotes 132
T404 44178-44179 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T405 44289-44292 http://purl.obolibrary.org/obo/CLO_0001195 denotes 219
T406 44338-44346 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T407 44389-44395 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T408 44400-44403 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T409 44441-44449 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T410 44485-44486 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T411 44671-44677 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T412 44686-44696 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T413 44969-44972 http://purl.obolibrary.org/obo/CLO_0054061 denotes 132
T414 45039-45040 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T415 45230-45238 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T416 45246-45247 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T417 45345-45346 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T418 45392-45400 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T419 45484-45489 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T420 45518-45526 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T421 45668-45671 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T422 45784-45785 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T423 45861-45863 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T424 45899-45908 http://purl.obolibrary.org/obo/SO_0000418 denotes Signaling
T425 45928-45930 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T426 45994-45997 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T427 46017-46018 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T428 46278-46285 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T429 46515-46519 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T430 46515-46519 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T431 46520-46525 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T432 46527-46530 http://purl.obolibrary.org/obo/CLO_0001196 denotes 225
T433 46536-46544 http://purl.obolibrary.org/obo/CLO_0007536 denotes MARC-145
T434 46545-46550 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T435 46564-46573 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T436 46601-46602 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T437 46654-46662 http://purl.obolibrary.org/obo/CLO_0007536 denotes MARC-145
T438 46663-46668 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T439 46724-46733 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T440 46809-46812 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T441 46823-46824 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T442 46934-46939 http://purl.obolibrary.org/obo/CLO_0053923 denotes HSP70
T443 46960-46963 http://purl.obolibrary.org/obo/CLO_0050624 denotes HSP
T444 47042-47047 http://purl.obolibrary.org/obo/CLO_0053923 denotes HSP70
T445 47065-47066 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T446 47103-47110 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T447 47158-47163 http://purl.obolibrary.org/obo/CLO_0053923 denotes HSP70
T448 47443-47448 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T449 47699-47700 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T450 47736-47737 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T451 47837-47844 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T452 47968-47973 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T453 47984-47988 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T454 47984-47988 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T455 47990-47995 http://purl.obolibrary.org/obo/CLO_0050908 denotes PK-15
T456 48000-48008 http://purl.obolibrary.org/obo/CLO_0007536 denotes Marc-145
T457 48086-48090 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T458 48091-48094 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T459 48179-48189 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T460 48235-48240 http://purl.obolibrary.org/obo/CLO_0001313 denotes 3, -6
T461 48263-48266 http://purl.obolibrary.org/obo/CLO_0001203 denotes 232
T462 48327-48337 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T463 48532-48534 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T464 48562-48566 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T465 48630-48634 http://purl.obolibrary.org/obo/CLO_0008149 denotes N, E
T466 48636-48638 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T467 48636-48638 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T468 48678-48682 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T469 48705-48707 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T470 48894-48902 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T471 49153-49154 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T472 49233-49238 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T473 49248-49249 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T474 49647-49657 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T475 49675-49676 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T476 49693-49702 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T477 49751-49760 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T478 49782-49792 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T479 49894-49899 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T480 49993-49998 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T481 50038-50039 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T482 50316-50317 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T483 50778-50788 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T484 50807-50816 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T485 50947-50952 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T486 51036-51039 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T487 51120-51123 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T488 51131-51132 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T489 51241-51250 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T490 51336-51345 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T491 51780-51782 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T492 51881-51890 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T493 51929-51932 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T494 52112-52116 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T495 52172-52177 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T496 52748-52751 http://purl.obolibrary.org/obo/CLO_0008693 denotes R&D
T497 52748-52751 http://purl.obolibrary.org/obo/CLO_0008770 denotes R&D
T498 52827-52830 http://purl.obolibrary.org/obo/CLO_0008693 denotes R&D
T499 52827-52830 http://purl.obolibrary.org/obo/CLO_0008770 denotes R&D
T500 52952-52956 http://purl.obolibrary.org/obo/CLO_0052855 denotes CAAS
T501 53080-53085 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T502 53283-53284 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T503 53509-53512 http://purl.obolibrary.org/obo/CLO_0003679 denotes HEL
T504 53879-53887 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T505 53953-53961 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T506 54379-54380 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T507 54410-54411 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T508 54437-54447 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T509 54640-54641 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T510 54765-54781 http://purl.obolibrary.org/obo/PR_000024990 denotes IFN and type III
T511 55012-55014 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T512 55019-55021 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T513 55019-55021 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T514 55056-55064 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T515 55108-55112 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T516 55224-55228 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T517 55383-55388 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T518 55441-55445 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T519 55533-55538 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T520 55591-55601 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T521 55609-55610 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T522 55647-55652 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T523 55746-55763 http://purl.obolibrary.org/obo/PR_000024990 denotes IFNs and type III
T524 55866-55867 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T525 56064-56065 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T526 56166-56175 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T527 56242-56247 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T528 56318-56319 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T529 56569-56570 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T530 56609-56610 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T531 56738-56739 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T532 56757-56761 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3′-5
T533 56779-56787 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T534 56800-56801 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T535 56954-56974 http://purl.obolibrary.org/obo/PR_000024990 denotes IFN and the type III

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 509-518 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T2 628-631 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T3 844-847 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T4 848-859 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T5 1164-1174 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T6 3429-3434 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T7 3532-3537 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T8 3910-3912 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T9 4382-4386 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T10 4596-4604 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T11 4766-4775 Chemical denotes adjuvants http://purl.obolibrary.org/obo/CHEBI_60809
T12 5049-5057 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T13 5138-5146 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T14 5207-5215 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T15 5279-5288 Chemical denotes adjuvants http://purl.obolibrary.org/obo/CHEBI_60809
T16 5444-5452 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T17 5480-5491 Chemical denotes polypeptide http://purl.obolibrary.org/obo/CHEBI_15841
T18 7579-7586 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T19 7692-7694 Chemical denotes KD http://purl.obolibrary.org/obo/CHEBI_73601
T20 7700-7702 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T21 7717-7729 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T22 7827-7832 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T23 7833-7837 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T24 7891-7898 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T25 7945-7957 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T26 7952-7957 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T27 9048-9063 Chemical denotes antiviral drugs http://purl.obolibrary.org/obo/CHEBI_36044
T28 9048-9057 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T29 9058-9063 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T30 9756-9764 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T31 9856-9864 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T32 9929-9937 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T33 10367-10375 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T34 10383-10390 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T35 10411-10423 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T36 10438-10450 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T37 10473-10480 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T38 10523-10530 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T39 10581-10588 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T40 10607-10615 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T41 10916-10924 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T42 11044-11051 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43 11071-11083 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T44 11084-11091 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T45 11163-11170 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T46 11298-11305 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T47 11323-11325 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T48 11502-11504 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T49 11641-11648 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T50 11893-11900 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T51 11982-11989 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T52 12017-12024 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T53 12106-12114 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T54 12141-12148 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T55 12204-12211 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T56 12367-12374 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T57 12546-12554 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T58 12691-12702 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T59 12799-12806 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T60 12896-12904 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T61 12991-12998 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T62 13175-13182 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T63 13203-13213 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T64 13215-13218 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T65 13220-13230 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T66 13275-13282 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T67 13521-13523 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T70 13582-13584 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T72 13610-13617 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T73 13938-13945 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T74 14349-14356 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T75 14709-14716 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T76 14927-14934 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T77 15190-15192 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T80 15205-15208 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T81 15282-15292 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T82 15282-15287 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T83 15288-15292 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T84 15560-15567 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T85 15717-15720 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T86 15831-15834 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T87 15835-15845 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T88 17366-17369 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T91 17370-17376 Chemical denotes ribose http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013
T93 17602-17609 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T94 17635-17639 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T96 17647-17654 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T97 18013-18025 Chemical denotes nucleic acid http://purl.obolibrary.org/obo/CHEBI_33696
T98 18021-18025 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T99 18418-18425 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T100 18920-18929 Chemical denotes guanosine http://purl.obolibrary.org/obo/CHEBI_16750
T101 18930-18940 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T102 18965-18977 Chemical denotes methyl group http://purl.obolibrary.org/obo/CHEBI_32875
T103 18965-18971 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_29309
T104 18972-18977 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T105 18990-18996 Chemical denotes ribose http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013
T107 19027-19037 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T108 19113-19121 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T109 20065-20074 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T110 20349-20357 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T111 20464-20467 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T112 20503-20506 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T113 20720-20729 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T114 20730-20733 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T115 20788-20797 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T116 20886-20899 Chemical denotes nucleic acids http://purl.obolibrary.org/obo/CHEBI_33696
T117 20894-20899 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T118 20911-20924 Chemical denotes retinoic acid http://purl.obolibrary.org/obo/CHEBI_26536
T119 20920-20924 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T120 21096-21099 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T121 21160-21165 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T122 21175-21178 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T123 21200-21214 Chemical denotes cyclic GMP-AMP http://purl.obolibrary.org/obo/CHEBI_71580
T124 21207-21210 Chemical denotes GMP http://purl.obolibrary.org/obo/CHEBI_17345|http://purl.obolibrary.org/obo/CHEBI_58115
T126 21211-21214 Chemical denotes AMP http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215
T129 21275-21282 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T130 21763-21765 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T133 21934-21942 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T134 22111-22116 Chemical denotes dsRNA http://purl.obolibrary.org/obo/CHEBI_67208
T135 22204-22207 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T136 22320-22329 Chemical denotes oligomers http://purl.obolibrary.org/obo/CHEBI_132554
T137 22369-22378 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T138 22460-22468 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T139 22573-22580 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T140 22624-22632 Chemical denotes pyruvate http://purl.obolibrary.org/obo/CHEBI_15361
T141 22646-22648 Chemical denotes PC http://purl.obolibrary.org/obo/CHEBI_16110|http://purl.obolibrary.org/obo/CHEBI_49183|http://purl.obolibrary.org/obo/CHEBI_53201|http://purl.obolibrary.org/obo/CHEBI_55395|http://purl.obolibrary.org/obo/CHEBI_57643|http://purl.obolibrary.org/obo/CHEBI_61433
T147 22743-22745 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T150 22749-22758 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T151 22835-22837 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T154 22885-22892 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T155 22949-22952 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T156 23183-23186 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T157 23261-23268 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T158 23287-23290 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T159 23681-23686 Chemical denotes dsRNA http://purl.obolibrary.org/obo/CHEBI_67208
T160 23838-23844 Chemical denotes lysine http://purl.obolibrary.org/obo/CHEBI_18019|http://purl.obolibrary.org/obo/CHEBI_25094
T162 24284-24291 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T163 24673-24676 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T164 24764-24772 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T165 24958-24961 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T166 25081-25088 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T167 25112-25115 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T168 25259-25262 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T169 25321-25330 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T170 25390-25392 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T171 25440-25442 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T172 25480-25482 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T173 25501-25504 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T174 25508-25511 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T175 25644-25646 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T177 25655-25657 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T179 25668-25671 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T180 25692-25694 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T181 25695-25698 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T182 25861-25868 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T183 25901-25904 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T184 25972-25975 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T185 26167-26170 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T186 26191-26193 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T188 26200-26203 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T189 26208-26210 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T191 26217-26220 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T192 26225-26227 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T194 26238-26241 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T195 26648-26650 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T198 26688-26691 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T199 26781-26784 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T200 26802-26804 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T203 26843-26846 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T204 26921-26924 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T205 26946-26948 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T207 26964-26966 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T209 26999-27002 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T210 27014-27016 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T212 27144-27152 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T213 27404-27412 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T214 27418-27427 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T215 27498-27501 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T216 27570-27579 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T217 27762-27765 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T218 27919-27928 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T219 28096-28099 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T220 28195-28198 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T221 28259-28262 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T222 28414-28421 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T223 28476-28479 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T224 28660-28667 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T225 28670-28677 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T226 28716-28723 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T227 28849-28856 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T228 28883-28886 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T229 28887-28897 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T230 28928-28931 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T231 28974-28976 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T234 29004-29011 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T235 29043-29046 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T236 29098-29101 Chemical denotes MDA http://purl.obolibrary.org/obo/CHEBI_566274
T237 29164-29167 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T238 29363-29366 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T239 29417-29424 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T240 29437-29440 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T241 29485-29492 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T242 29502-29533 Chemical denotes polyinosinic-polycytidylic acid http://purl.obolibrary.org/obo/CHEBI_84491
T243 29515-29533 Chemical denotes polycytidylic acid http://purl.obolibrary.org/obo/CHEBI_84498
T244 29529-29533 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T245 29535-29544 Chemical denotes poly(I:C) http://purl.obolibrary.org/obo/CHEBI_84491
T246 29554-29557 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T247 29613-29615 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T250 29663-29665 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T251 29666-29669 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T252 29692-29701 Chemical denotes poly(I:C) http://purl.obolibrary.org/obo/CHEBI_84491
T253 29762-29769 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T254 29786-29789 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T255 29880-29887 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T256 29900-29903 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T257 29986-29994 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T258 30028-30035 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T259 30049-30056 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T260 30119-30122 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T261 30162-30165 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T262 30242-30249 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T263 30308-30315 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T264 30519-30527 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T265 30580-30587 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T266 30605-30612 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T267 30685-30692 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T268 30718-30726 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T269 30882-30890 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T270 30987-30995 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T271 31020-31028 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T272 31257-31268 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T273 31257-31262 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T274 31263-31268 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T275 31422-31425 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T276 31519-31526 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T277 31571-31574 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T278 31641-31644 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T279 31778-31785 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T280 32010-32021 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T281 32010-32015 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T282 32016-32021 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T283 32113-32120 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T284 32217-32220 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T285 32221-32231 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T286 32269-32272 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T287 32345-32348 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T288 32517-32524 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T289 32568-32575 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T290 32655-32659 Chemical denotes cAMP http://purl.obolibrary.org/obo/CHEBI_17489
T291 32687-32694 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T292 32746-32753 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T293 32842-32845 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T294 32892-32894 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T297 32970-32973 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T298 33030-33033 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T299 33052-33059 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T300 33071-33073 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T303 33241-33243 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T306 33474-33477 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T307 33572-33575 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T308 33681-33684 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T309 33685-33696 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T310 33710-33721 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T311 33942-33949 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T312 33966-33969 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T313 34152-34161 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T314 34753-34756 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T315 34983-34986 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T316 35295-35304 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T317 35516-35519 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T318 35966-35969 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T319 36125-36144 Chemical denotes signaling molecules http://purl.obolibrary.org/obo/CHEBI_62488
T320 36135-36144 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T321 36388-36391 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T322 36668-36671 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T323 36846-36849 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T324 37116-37119 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T325 37270-37278 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T326 37324-37332 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T327 37730-37733 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T328 37747-37754 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T329 38061-38064 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T330 38203-38212 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T331 38326-38329 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T332 38427-38436 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T333 38656-38664 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T334 38772-38775 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T335 38806-38808 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T338 38918-38920 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T341 39213-39216 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T342 39792-39801 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T343 40020-40023 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T344 40464-40467 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T345 40515-40523 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T346 40675-40680 Chemical denotes dsRNA http://purl.obolibrary.org/obo/CHEBI_67208
T347 40713-40725 Chemical denotes triphosphate http://purl.obolibrary.org/obo/CHEBI_18036
T348 41693-41695 Chemical denotes WT http://purl.obolibrary.org/obo/CHEBI_141450
T349 41950-41953 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T350 41954-41964 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T351 42094-42101 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T352 42383-42392 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T353 42539-42542 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T354 42622-42625 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T355 42693-42696 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T356 43226-43235 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T357 43972-43975 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T358 43976-43987 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T359 44055-44058 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T360 44529-44532 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T361 44733-44736 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T362 44920-44929 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T363 44985-44995 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T364 45098-45108 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T365 45302-45307 Chemical denotes dsRNA http://purl.obolibrary.org/obo/CHEBI_67208
T366 45355-45364 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T367 45557-45566 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T368 45853-45860 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T369 45920-45927 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T370 45971-45979 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T371 46035-46042 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T372 46597-46599 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T375 46645-46648 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T376 46707-46716 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T377 46960-46963 Chemical denotes HSP http://purl.obolibrary.org/obo/CHEBI_50430
T378 47784-47793 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T379 47990-47992 Chemical denotes PK http://purl.obolibrary.org/obo/CHEBI_74792
T380 48435-48438 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T383 48439-48445 Chemical denotes ribose http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013
T385 48458-48462 Chemical denotes PARP http://purl.obolibrary.org/obo/CHEBI_62913
T386 48524-48531 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T387 48617-48625 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T388 48636-48638 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T389 48708-48715 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T390 48741-48748 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T391 49077-49084 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T392 49180-49188 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T393 49321-49328 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T394 49411-49418 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T395 49473-49480 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T396 49489-49493 Chemical denotes PERK http://purl.obolibrary.org/obo/CHEBI_17300
T397 49542-49549 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T398 49743-49750 Chemical denotes mitogen http://purl.obolibrary.org/obo/CHEBI_52290
T399 49761-49768 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T400 49770-49773 Chemical denotes MAP http://purl.obolibrary.org/obo/CHEBI_6716
T44393 49940-49947 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T7950 50126-50129 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T20871 50332-50339 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T56942 50584-50586 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T13643 50751-50758 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T23638 50796-50800 Chemical denotes PERK http://purl.obolibrary.org/obo/CHEBI_17300
T56939 50841-50848 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T28194 50873-50883 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T8400 51241-51260 Chemical denotes signaling molecules http://purl.obolibrary.org/obo/CHEBI_62488
T14097 51251-51260 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T82131 51410-51418 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T14813 51438-51446 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T90443 51482-51493 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T63691 51559-51566 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T46155 51702-51710 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T17979 51788-51796 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T84679 51836-51847 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T52253 51896-51903 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T21929 51993-52001 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T60041 53257-53265 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T25148 53308-53315 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T35154 53594-53600 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T79378 53672-53678 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T92358 54122-54133 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T77304 54249-54256 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T51413 54592-54599 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T11713 54636-54638 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T93052 54938-54946 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T12139 55019-55021 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T83472 55297-55307 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T27461 55331-55338 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T5121 55481-55491 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T63271 55605-55607 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T43488 55768-55779 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T25687 56314-56316 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T36475 56377-56387 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T7051 56446-56458 Chemical denotes nucleic acid http://purl.obolibrary.org/obo/CHEBI_33696
T70647 56454-56458 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T40947 56863-56873 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T25370 56917-56927 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T67576 57072-57082 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 17-25 Phenotype denotes Diarrhea http://purl.obolibrary.org/obo/HP_0002014
T2 95-103 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T3 205-213 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T4 246-254 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T5 1223-1231 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T6 1290-1298 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T7 1390-1398 Phenotype denotes vomiting http://purl.obolibrary.org/obo/HP_0002013
T8 1400-1408 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T9 1410-1421 Phenotype denotes dehydration http://purl.obolibrary.org/obo/HP_0001944
T10 1427-1435 Phenotype denotes anorexia http://purl.obolibrary.org/obo/HP_0002039
T11 1488-1496 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T12 1798-1806 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T13 6161-6182 Phenotype denotes respiratory illnesses http://purl.obolibrary.org/obo/HP_0002086
T14 6551-6560 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T15 6571-6591 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T16 6947-6955 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T17 7273-7281 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T18 7283-7291 Phenotype denotes vomiting http://purl.obolibrary.org/obo/HP_0002013
T19 7445-7453 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T20 12628-12637 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T21 13060-13078 Phenotype denotes growth retardation http://purl.obolibrary.org/obo/HP_0001510
T22 21510-21518 Phenotype denotes melanoma http://purl.obolibrary.org/obo/HP_0002861
T23 24267-24272 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T24 35415-35424 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T25 37860-37869 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T26 45847-45852 Phenotype denotes Shock http://purl.obolibrary.org/obo/HP_0031273
T27 45914-45919 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T28 45965-45970 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T29 53071-53079 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T30 55446-55464 Phenotype denotes growth retardation http://purl.obolibrary.org/obo/HP_0001510

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 45-67 http://purl.obolibrary.org/obo/GO_0045087 denotes Innate Immune Response
T2 52-67 http://purl.obolibrary.org/obo/GO_0006955 denotes Immune Response
T3 438-451 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T4 570-586 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T5 710-732 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T6 717-732 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T7 775-797 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T8 782-797 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T9 871-884 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T10 1003-1017 http://purl.obolibrary.org/obo/GO_0042783 denotes immune evasion
T11 2419-2425 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T12 4644-4668 http://purl.obolibrary.org/obo/GO_0002385 denotes mucosal immune responses
T13 4805-4829 http://purl.obolibrary.org/obo/GO_0002250 denotes adaptive immune response
T14 4814-4829 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T15 5095-5110 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T16 7533-7545 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T17 8026-8041 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T18 8662-8671 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T19 8662-8671 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T20 8723-8737 http://purl.obolibrary.org/obo/GO_0042783 denotes immune evasion
T21 8855-8868 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T22 8992-9004 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T23 9190-9213 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune responses
T24 10646-10659 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T25 10707-10720 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T26 10711-10720 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T27 10836-10849 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T28 11715-11722 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T29 12287-12304 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T30 12287-12304 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T31 12306-12319 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T32 12418-12425 http://purl.obolibrary.org/obo/GO_0051320 denotes S-phase
T33 12429-12439 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T34 12675-12690 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T35 12823-12838 http://purl.obolibrary.org/obo/GO_0019068 denotes virion assembly
T36 12843-12856 http://purl.obolibrary.org/obo/GO_0046755 denotes virus budding
T37 12849-12856 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T38 13055-13066 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T39 13060-13066 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T40 13141-13148 http://purl.obolibrary.org/obo/GO_0051320 denotes S-phase
T41 13324-13331 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T42 13399-13410 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T43 13404-13410 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T44 13412-13422 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T45 13427-13433 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin
T46 13568-13578 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T47 13801-13808 http://purl.obolibrary.org/obo/GO_0051320 denotes S-phase
T48 13823-13840 http://purl.obolibrary.org/obo/GO_0006900 denotes vesicle formation
T49 13831-13840 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T50 13993-14010 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T51 13993-14010 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T52 14053-14062 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T53 14097-14120 http://purl.obolibrary.org/obo/GO_0019048 denotes virus-host interactions
T54 14218-14239 http://purl.obolibrary.org/obo/GO_0019080 denotes viral gene expression
T55 14224-14239 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T56 14241-14254 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T57 14245-14254 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T58 15087-15102 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T59 15129-15138 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T60 15129-15138 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T61 15167-15178 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T62 15407-15420 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T63 15411-15420 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T64 15497-15520 http://purl.obolibrary.org/obo/GO_0019048 denotes virus-host interactions
T65 15525-15534 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T66 15525-15534 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T67 15665-15679 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinase
T68 15681-15684 http://purl.obolibrary.org/obo/GO_0004843 denotes DUB
T69 15721-15730 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T70 15812-15815 http://purl.obolibrary.org/obo/GO_0004843 denotes DUB
T71 16185-16202 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T72 16185-16202 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T73 16207-16220 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T74 16373-16386 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T75 16377-16386 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T76 16601-16610 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T77 16869-16884 http://purl.obolibrary.org/obo/GO_0039703 denotes RNA replication
T78 16974-16984 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinase
T79 17197-17220 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune responses
T80 17381-17392 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T81 18362-18379 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T82 18362-18379 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T83 18434-18461 http://purl.obolibrary.org/obo/GO_0008859 denotes 5′ exoribonuclease activity
T84 18437-18461 http://purl.obolibrary.org/obo/GO_0004532 denotes exoribonuclease activity
T85 18539-18550 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T86 18708-18733 http://purl.obolibrary.org/obo/GO_0004521 denotes endoribonuclease activity
T87 19092-19103 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T88 19351-19362 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T89 19535-19562 http://purl.obolibrary.org/obo/GO_0008859 denotes 5′ exoribonuclease activity
T90 19538-19562 http://purl.obolibrary.org/obo/GO_0004532 denotes exoribonuclease activity
T91 19601-19616 http://purl.obolibrary.org/obo/GO_0006298 denotes mismatch repair
T92 19631-19644 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T93 19635-19644 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T94 19769-19786 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T95 19769-19786 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T96 19788-19801 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T97 19814-19827 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T98 19953-19968 http://purl.obolibrary.org/obo/GO_0045087 denotes Innate Immunity
T99 20075-20090 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T100 20155-20179 http://purl.obolibrary.org/obo/GO_0002250 denotes adaptive immune response
T101 20164-20179 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T102 20269-20285 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T103 20298-20311 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T104 20413-20422 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T105 20413-20422 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T106 20424-20433 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T107 20424-20433 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T108 20623-20632 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T109 21310-21319 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T110 21657-21688 http://purl.obolibrary.org/obo/GO_0035556 denotes intracellular signaling cascade
T111 21671-21688 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling cascade
T112 21671-21680 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T113 21724-21745 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factors
T114 21724-21737 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T115 22379-22388 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T116 22410-22419 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T117 22423-22432 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T118 22729-22742 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylate
T119 22822-22833 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T120 22987-22991 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T121 23035-23039 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T122 23095-23099 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T123 23158-23162 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T124 23168-23182 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylates
T125 23245-23268 http://purl.obolibrary.org/obo/GO_0051170 denotes import into the nucleus
T126 23280-23301 http://purl.obolibrary.org/obo/GO_0032606 denotes type I IFN production
T127 23521-23525 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T128 23538-23551 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylate
T129 23577-23593 http://purl.obolibrary.org/obo/GO_0016579 denotes deubiquitination
T130 23614-23624 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T131 23854-23867 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T132 24119-24129 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T133 24133-24146 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T134 24147-24156 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T135 24174-24178 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T136 24211-24224 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T137 24250-24254 http://purl.obolibrary.org/obo/GO_0004843 denotes DUBs
T138 24267-24283 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressor
T139 24337-24366 http://purl.obolibrary.org/obo/GO_0050777 denotes downregulate immune responses
T140 24350-24366 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T141 24393-24409 http://purl.obolibrary.org/obo/GO_0016579 denotes deubiquitination
T142 24458-24469 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T143 24549-24558 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T144 24572-24581 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T145 24865-24880 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T146 24884-24905 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factors
T147 24884-24897 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T148 25594-25619 http://purl.obolibrary.org/obo/GO_0034097 denotes response to the cytokines
T149 25782-25791 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T150 25955-25968 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T151 26109-26132 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune responses
T152 26287-26305 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T153 26287-26296 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T154 26311-26326 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T155 26551-26574 http://purl.obolibrary.org/obo/GO_0000981 denotes transcriptional factors
T156 26551-26566 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T157 26869-26888 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T158 26876-26888 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T159 27189-27202 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylate
T160 27297-27310 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T161 27451-27465 http://purl.obolibrary.org/obo/GO_0042783 denotes Immune Evasion
T162 27570-27603 http://purl.obolibrary.org/obo/GO_0140374 denotes antiviral innate immune responses
T163 27762-27776 http://purl.obolibrary.org/obo/GO_0072647 denotes IFN production
T164 27919-27951 http://purl.obolibrary.org/obo/GO_0140374 denotes antiviral innate immune response
T165 27929-27951 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T166 27936-27951 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T167 28096-28110 http://purl.obolibrary.org/obo/GO_0072647 denotes IFN production
T168 28157-28178 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factors
T169 28157-28170 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T170 28483-28507 http://purl.obolibrary.org/obo/GO_0034343 denotes type III IFNs production
T171 28804-28817 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T172 29069-29073 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T173 29254-29258 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T174 29295-29299 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T175 29325-29329 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T176 29343-29358 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T177 29428-29451 http://purl.obolibrary.org/obo/GO_0034343 denotes type III IFN production
T178 29779-29800 http://purl.obolibrary.org/obo/GO_0032606 denotes type I IFN production
T179 29900-29914 http://purl.obolibrary.org/obo/GO_0072647 denotes IFN production
T180 30119-30133 http://purl.obolibrary.org/obo/GO_0072647 denotes IFN production
T181 30166-30175 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T182 30253-30291 http://purl.obolibrary.org/obo/GO_0052167 denotes modulating host innate immune response
T183 30269-30291 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T184 30276-30291 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T185 30308-30323 http://purl.obolibrary.org/obo/GO_0006605 denotes protein targets
T186 30557-30572 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T187 31402-31417 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T188 31426-31435 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T189 31519-31538 http://purl.obolibrary.org/obo/GO_0006412 denotes protein translation
T190 31564-31585 http://purl.obolibrary.org/obo/GO_0032606 denotes type I IFN production
T191 31681-31700 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T192 31688-31700 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T193 31804-31819 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T194 31976-31991 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T195 32113-32130 http://purl.obolibrary.org/obo/GO_0006412 denotes protein synthesis
T196 32121-32130 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T197 32412-32427 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T198 32549-32560 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T199 32628-32641 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T200 32946-32959 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T201 33023-33044 http://purl.obolibrary.org/obo/GO_0032606 denotes type I IFN production
T202 33177-33192 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T203 33347-33375 http://purl.obolibrary.org/obo/GO_0042326 denotes inhibits the phosphorylation
T204 33360-33375 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T205 33380-33391 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T206 33563-33586 http://purl.obolibrary.org/obo/GO_0034343 denotes type III IFN production
T207 34028-34050 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T208 34035-34050 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T209 34162-34175 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T210 34176-34194 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T211 34176-34185 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T212 34220-34251 http://purl.obolibrary.org/obo/GO_0043687 denotes posttranslational modifications
T213 34268-34283 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T214 34301-34314 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T215 34332-34343 http://purl.obolibrary.org/obo/GO_0016925 denotes SUMOylation
T216 34473-34486 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T217 34487-34505 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T218 34487-34496 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T219 34514-34529 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T220 34588-34604 http://purl.obolibrary.org/obo/GO_0016579 denotes deubiquitination
T221 34625-34636 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T222 34645-34661 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T223 34670-34685 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinases
T224 34687-34691 http://purl.obolibrary.org/obo/GO_0004843 denotes DUBs
T225 34718-34728 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T226 34757-34766 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T227 34784-34788 http://purl.obolibrary.org/obo/GO_0004843 denotes DUBs
T228 34824-34834 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T229 34838-34851 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T230 34852-34870 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T231 34852-34861 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T232 34922-34926 http://purl.obolibrary.org/obo/GO_0004843 denotes DUBs
T233 35081-35091 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinase
T234 35230-35244 http://purl.obolibrary.org/obo/GO_0016579 denotes deubiquitinate
T235 35295-35313 http://purl.obolibrary.org/obo/GO_0051607 denotes antiviral response
T236 35345-35348 http://purl.obolibrary.org/obo/GO_0004843 denotes DUB
T237 35372-35387 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T238 35488-35491 http://purl.obolibrary.org/obo/GO_0004843 denotes DUB
T239 35577-35600 http://purl.obolibrary.org/obo/GO_0101005 denotes deubiquitinase activity
T240 35577-35600 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinase activity
T241 35741-35763 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T242 35748-35763 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T243 35922-35925 http://purl.obolibrary.org/obo/GO_0004843 denotes DUB
T244 35939-35980 http://purl.obolibrary.org/obo/GO_0032480 denotes negatively regulate type I IFN production
T245 35950-35980 http://purl.obolibrary.org/obo/GO_0032479 denotes regulate type I IFN production
T246 35959-35980 http://purl.obolibrary.org/obo/GO_0032606 denotes type I IFN production
T247 36125-36144 http://purl.obolibrary.org/obo/GO_0048018 denotes signaling molecules
T248 36125-36134 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T249 36436-36439 http://purl.obolibrary.org/obo/GO_0004843 denotes DUB
T250 36603-36619 http://purl.obolibrary.org/obo/GO_0016579 denotes deubiquitination
T251 36755-36769 http://purl.obolibrary.org/obo/GO_0016579 denotes deubiquitinate
T252 36804-36815 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T253 36850-36859 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T254 37025-37034 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T255 37025-37034 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T256 37047-37061 http://purl.obolibrary.org/obo/GO_0042783 denotes immune evasion
T257 37183-37200 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T258 37183-37192 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T259 37217-37220 http://purl.obolibrary.org/obo/GO_0004843 denotes DUB
T260 37299-37315 http://purl.obolibrary.org/obo/GO_0016579 denotes deubiquitination
T261 37451-37455 http://purl.obolibrary.org/obo/GO_0004843 denotes DUBs
T262 37486-37498 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T263 37614-37618 http://purl.obolibrary.org/obo/GO_0004843 denotes DUBs
T264 37669-37672 http://purl.obolibrary.org/obo/GO_0004843 denotes DUB
T265 37993-38006 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T266 38007-38016 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T267 38078-38089 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T268 38213-38226 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T269 38272-38281 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T270 38354-38365 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T271 38373-38394 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factors
T272 38373-38386 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T273 38427-38445 http://purl.obolibrary.org/obo/GO_0051607 denotes antiviral response
T274 38765-38786 http://purl.obolibrary.org/obo/GO_0032606 denotes type I IFN production
T275 39041-39045 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T276 39128-39151 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune responses
T277 39219-39228 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T278 39260-39277 http://purl.obolibrary.org/obo/GO_0008233 denotes protease activity
T279 39345-39354 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T280 39383-39387 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T281 39559-39568 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T282 39663-39677 http://purl.obolibrary.org/obo/GO_0042783 denotes immune evasion
T283 39723-39736 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T284 39792-39811 http://purl.obolibrary.org/obo/GO_0051607 denotes antiviral responses
T285 40024-40041 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T286 40024-40033 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T287 40282-40299 http://purl.obolibrary.org/obo/GO_0051169 denotes nuclear transport
T288 40290-40299 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T289 40329-40344 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T290 40468-40477 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T291 40552-40561 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T292 40849-40864 http://purl.obolibrary.org/obo/GO_0039703 denotes RNA replication
T293 41109-41122 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T294 41287-41312 http://purl.obolibrary.org/obo/GO_0004521 denotes endoribonuclease activity
T295 41330-41341 http://purl.obolibrary.org/obo/GO_0036260 denotes RNA capping
T296 41330-41341 http://purl.obolibrary.org/obo/GO_0009452 denotes RNA capping
T297 41441-41452 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T298 41663-41680 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T299 41663-41680 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T300 41881-41894 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T301 41885-41894 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T302 42227-42243 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T303 42543-42552 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T304 42945-42969 http://purl.obolibrary.org/obo/GO_0034343 denotes type III IFNs production
T305 43100-43114 http://purl.obolibrary.org/obo/GO_0019076 denotes viral shedding
T306 43236-43251 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T307 43345-43368 http://purl.obolibrary.org/obo/GO_0044405 denotes recognition by the host
T308 43623-43634 http://purl.obolibrary.org/obo/GO_0032259 denotes Methylation
T309 43844-43857 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T310 44124-44139 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T311 44140-44150 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T312 44522-44543 http://purl.obolibrary.org/obo/GO_0032606 denotes type I IFN production
T313 44610-44624 http://purl.obolibrary.org/obo/GO_0042783 denotes immune evasion
T314 44671-44685 http://purl.obolibrary.org/obo/GO_0007165 denotes signal pathway
T315 44920-44938 http://purl.obolibrary.org/obo/GO_0051607 denotes antiviral response
T316 44950-44967 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T317 44950-44967 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T318 45355-45373 http://purl.obolibrary.org/obo/GO_0051607 denotes antiviral response
T319 45445-45467 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T320 45452-45467 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T321 45557-45575 http://purl.obolibrary.org/obo/GO_0051607 denotes antiviral response
T322 45755-45770 http://purl.obolibrary.org/obo/GO_0006401 denotes RNA degradation
T323 45759-45770 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T324 45899-45908 http://purl.obolibrary.org/obo/GO_0023052 denotes Signaling
T325 46114-46137 http://purl.obolibrary.org/obo/GO_0043066 denotes inhibition of apoptosis
T326 46128-46137 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T327 46128-46137 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T328 46358-46367 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T329 46358-46367 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T330 46403-46420 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T331 46403-46420 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T332 46564-46593 http://purl.obolibrary.org/obo/GO_0042327 denotes activates the phosphorylation
T333 46578-46593 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T334 46724-46733 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T335 46904-46926 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T336 46911-46926 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T337 47232-47241 http://purl.obolibrary.org/obo/GO_0097194 denotes Apoptosis
T338 47232-47241 http://purl.obolibrary.org/obo/GO_0006915 denotes Apoptosis
T339 47242-47257 http://purl.obolibrary.org/obo/GO_0016032 denotes Viral infection
T340 47272-47287 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T341 47321-47342 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokines’ production
T342 47409-47426 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T343 47409-47426 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T344 47612-47621 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T345 47612-47621 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T346 47784-47816 http://purl.obolibrary.org/obo/GO_0140374 denotes antiviral innate immune response
T347 47794-47816 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T348 47801-47816 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T349 47888-47897 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T350 47888-47897 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T351 47923-47940 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T352 47923-47940 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T353 48060-48069 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T354 48060-48069 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T355 48146-48155 http://purl.obolibrary.org/obo/GO_0097194 denotes Apoptosis
T356 48146-48155 http://purl.obolibrary.org/obo/GO_0006915 denotes Apoptosis
T357 48366-48375 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T358 48366-48375 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T359 48480-48511 http://purl.obolibrary.org/obo/GO_0030264 denotes apoptotic nuclear fragmentation
T360 48567-48576 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T361 48567-48576 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T362 48683-48692 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T363 48683-48692 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T364 48763-48772 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T365 48763-48772 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T366 49077-49094 http://purl.obolibrary.org/obo/GO_0006412 denotes protein synthesis
T367 49085-49094 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T368 49411-49430 http://purl.obolibrary.org/obo/GO_0006412 denotes protein translation
T369 49503-49518 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T370 49542-49557 http://purl.obolibrary.org/obo/GO_0006457 denotes protein folding
T371 49562-49573 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T372 49600-49609 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T373 49600-49609 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T374 49693-49711 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T375 49693-49702 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T376 49721-49730 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T377 49721-49730 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T378 49732-49741 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T379 49732-49741 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T380 49782-49820 http://purl.obolibrary.org/obo/GO_0002218 denotes activation, and innate immune response
T381 49798-49820 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T382 49805-49820 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T383 50014-50023 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T384 50014-50023 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T385 50126-50137 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channel
T386 50480-50489 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T387 50480-50489 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T388 50493-50502 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T389 50493-50502 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T390 50535-50544 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T391 50535-50544 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T392 50612-50621 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T393 50612-50621 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T394 50636-50645 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T395 50636-50645 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T396 50662-50680 http://purl.obolibrary.org/obo/GO_0034976 denotes ER stress response
T397 50701-50719 http://purl.obolibrary.org/obo/GO_0034976 denotes ER stress response
T398 50731-50741 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T399 50807-50824 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T400 50807-50816 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T401 51241-51260 http://purl.obolibrary.org/obo/GO_0048018 denotes signaling molecules
T402 51241-51250 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T403 51336-51354 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T404 51336-51345 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T405 51581-51602 http://purl.obolibrary.org/obo/GO_0032606 denotes type I IFN production
T406 51722-51743 http://purl.obolibrary.org/obo/GO_0032606 denotes type I IFN production
T407 51881-51890 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T408 52117-52126 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T409 52117-52126 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T410 52128-52137 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T411 52128-52137 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T412 52172-52195 http://purl.obolibrary.org/obo/GO_0019048 denotes virus-host interactions
T413 52305-52318 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T414 53850-53862 http://purl.obolibrary.org/obo/GO_0006370 denotes mRNA capping
T415 53913-53927 http://purl.obolibrary.org/obo/GO_0042783 denotes immune evasion
T416 53933-53942 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T417 53989-54004 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T418 54281-54285 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T419 54322-54326 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T420 54354-54365 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T421 54413-54428 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T422 54469-54490 http://purl.obolibrary.org/obo/GO_0032606 denotes type I IFN production
T423 54544-54565 http://purl.obolibrary.org/obo/GO_0032606 denotes type I IFN production
T424 55056-55071 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T425 55113-55122 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T426 55113-55122 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T427 55152-55169 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T428 55152-55169 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T429 55171-55184 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T430 55213-55220 http://purl.obolibrary.org/obo/GO_0051320 denotes S-phase
T431 55224-55234 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T432 55270-55279 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T433 55281-55296 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T434 55309-55330 http://purl.obolibrary.org/obo/GO_0051701 denotes interaction with host
T435 55363-55378 http://purl.obolibrary.org/obo/GO_0019068 denotes virion assembly
T436 55383-55396 http://purl.obolibrary.org/obo/GO_0046755 denotes virus budding
T437 55389-55396 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T438 55441-55452 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T439 55446-55452 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T440 55468-55475 http://purl.obolibrary.org/obo/GO_0051320 denotes S-phase
T441 55553-55560 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T442 55656-55663 http://purl.obolibrary.org/obo/GO_0051320 denotes S-phase
T443 55678-55695 http://purl.obolibrary.org/obo/GO_0006900 denotes vesicle formation
T444 55686-55695 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T445 55794-55805 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T446 55829-55844 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T447 55849-55860 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T448 56019-56036 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T449 56019-56036 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T450 56072-56086 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinase
T451 56088-56091 http://purl.obolibrary.org/obo/GO_0004843 denotes DUB
T452 56098-56113 http://purl.obolibrary.org/obo/GO_0016579 denotes deubiquitinates
T453 56166-56175 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T454 56275-56298 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune responses
T455 56577-56594 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T456 56577-56594 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T457 56649-56666 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T458 56649-56666 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T459 56706-56717 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T460 56760-56787 http://purl.obolibrary.org/obo/GO_0008859 denotes 5′ exoribonuclease activity
T461 56763-56787 http://purl.obolibrary.org/obo/GO_0004532 denotes exoribonuclease activity
T462 56814-56829 http://purl.obolibrary.org/obo/GO_0006298 denotes mismatch repair
T463 56844-56857 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T464 56848-56857 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T465 57041-57052 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-67 Sentence denotes Porcine Epidemic Diarrhea Virus and the Host Innate Immune Response
T2 69-77 Sentence denotes Abstract
T3 78-220 Sentence denotes Porcine epidemic diarrhea virus (PEDV), a swine enteropathogenic coronavirus (CoV), is the causative agent of porcine epidemic diarrhea (PED).
T4 221-381 Sentence denotes PED causes lethal watery diarrhea in piglets, which has led to substantial economic losses in many countries and is a great threat to the global swine industry.
T5 382-587 Sentence denotes Interferons (IFNs) are major cytokines involved in host innate immune defense, which induce the expression of a broad range of antiviral effectors that help host to control and antagonize viral infections.
T6 588-753 Sentence denotes PEDV infection does not elicit a robust IFN response, and some of the mechanisms used by the virus to counteract the host innate immune response have been unraveled.
T7 754-831 Sentence denotes PEDV evades the host innate immune response by two main strategies including:
T8 832-975 Sentence denotes 1) encoding IFN antagonists to disrupt innate immune pathway, and 2) hiding its viral RNA to avoid the exposure of viral RNA to immune sensors.
T9 976-1188 Sentence denotes This review highlights the immune evasion mechanisms employed by PEDV, which provides insights for the better understanding of PEDV-host interactions and developing effective vaccines and antivirals against CoVs.
T10 1190-1192 Sentence denotes 1.
T11 1193-1205 Sentence denotes Introduction
T12 1206-1532 Sentence denotes Porcine epidemic diarrhea virus (PEDV) is the etiological agent of porcine epidemic diarrhea (PED) that causes an acute and highly contagious enteric disease of swine characterized by vomiting, diarrhea, dehydration, and anorexia in pigs of all ages, especially resulting in severe diarrhea and high mortality rate in piglets.
T13 1533-1622 Sentence denotes In serious cases, outbreak of PED even leads to a mortality rate of 100% in pigs [1,2,3].
T14 1623-1698 Sentence denotes The causative agent of PED was first described in the 1970s in England [4].
T15 1699-1787 Sentence denotes In 1976, an unrecognized enteric disease was reported in several European countries [5].
T16 1788-1853 Sentence denotes The viral diarrhea was collectively designated “PED” in 1982 [6].
T17 1854-1984 Sentence denotes Endemic PED had been described in both developed and developing countries, but with a low impact on the swine industry until 2010.
T18 1985-2197 Sentence denotes In 2010, outbreaks of PED caused by highly pathogenic variant PEDV strains occurred in China, and this was immediately reported in other Asian counties, causing up to 100% mortality in suckling piglets [1,7,8,9].
T19 2198-2327 Sentence denotes In April 2013, PEDV entered the United States (US) for the first time and the virulent strains spread rapidly across the US [10].
T20 2328-2461 Sentence denotes Apart from almost 100% mortality rate in suckling piglets, PEDV infection also damaged the growth performance of finishing pigs [11].
T21 2462-2615 Sentence denotes The highly pathogenic strains of PEDV spread worldwide, resulting in serious problems to the swine industry and substantial economic losses [7,10,12,13].
T22 2616-2848 Sentence denotes Vaccination used to be the main strategy to prevent and control the rate of PEDV infection [14], however, the current available PEDV vaccines cannot provide complete protection for the pigs affected by the highly pathogenic strains.
T23 2849-3013 Sentence denotes The optimal vaccines should induce efficient maternal antibodies in sows that could be transmitted to the offspring and protect neonatal suckling piglets from PEDV.
T24 3014-3110 Sentence denotes The vaccination method is critically associated with the antibodies’ induction by PEDV vaccines.
T25 3111-3202 Sentence denotes Oral vaccination with attenuated PEDV seems to be more efficacious than injectable vaccine.
T26 3203-3435 Sentence denotes Oral immunization of PEDV-seronegative pregnant sows with attenuated PEDV leads to lower mortality rate of piglets and higher amounts of IgA transferred from the sows to the offspring than that in the intramuscularly injected group.
T27 3436-3543 Sentence denotes However, the duration of virus shedding after challenge was not reduced compared to the control group [15].
T28 3544-3703 Sentence denotes The immunization dose of the virus for sows and the challenge dose of the virus for piglets significantly affected the protection against virus challenge [16].
T29 3704-4006 Sentence denotes Moreover, epidemiological studies have demonstrated that the prevalent strains causing previous PED outbreaks in China in 2010 and the recent outbreaks in North America and Asia all belong to the genogroup II (GII) PEDV and the S gene of GIIb PEDV contains typical insertion and deletion mutations [2].
T30 4007-4087 Sentence denotes Therefore, new PEDV vaccines should be developed based on these variant strains.
T31 4088-4223 Sentence denotes The biological characteristics, pathogenicity and immune protective effects of GIIb PEDV strains should be studied as soon as possible.
T32 4224-4357 Sentence denotes An inactivated vaccine based on genotype IIb strain AJ1102 developed by Wuhan Keqian company was approved for clinical trial in 2014.
T33 4358-4541 Sentence denotes In addition, the lactic acid bacteria (LAB) that have the ability to interact with the intestinal cells can be used as a potential vector for improving delivery of oral vaccines [17].
T34 4542-4730 Sentence denotes Developing the transgenic plants expressing antigenic proteins as edible vaccines to induce efficient mucosal immune responses might be a prominent strategy to prevent PEDV infection [18].
T35 4731-4848 Sentence denotes Choosing appropriate and effective adjuvants for PEDV vaccines to enhance adaptive immune response is also important.
T36 4849-5026 Sentence denotes In addition, the construction of recombinant PEDV with deletion or mutation of the immune antagonistic regions or sites is a potential strategy to develop PEDV vaccines as well.
T37 5027-5169 Sentence denotes The produced modified antigens will induce an increased and earlier immune response in pigs, compared with the antigens from wildtype viruses.
T38 5170-5527 Sentence denotes Therefore, the modification of viral antigens, the optimization of immunization methods, screening effective adjuvants, and exploiting a new generation of vaccines are promising directions for the control of PED.PEDV is classified as a coronavirus (CoV), due to its similar electron microscopic appearance and polypeptide structure to other CoVs [19,20,21].
T39 5528-5707 Sentence denotes CoVs (subfamily Coronavirinae, family Coronaviridae, order Nidovirales) are a large family of viruses that have broad host ranges and have caused global public health issues [22].
T40 5708-5931 Sentence denotes The currently known CoVs are divided into four genera, which include Alphacoronavirus (α-CoV), Betacoronavirus (β-CoV), Gammacoronavirus (γ-CoV) and Deltacoronavirus (δ-CoV), according to the genome phylogeny and serotypes.
T41 5932-6075 Sentence denotes CoVs give rise to a wide spectrum of diseases in humans and animals, but generally fall into two classes, with respiratory or enteric tropisms.
T42 6076-6367 Sentence denotes Moreover, the β-CoV genus consists of a lot of important CoVs that result in serious respiratory illnesses in humans, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and the latest 2019 novel coronavirus (SARS-CoV2).
T43 6368-6466 Sentence denotes SARS-CoV resulted in an outbreak of severe respiratory disease through China in 2002–2003 [23,24].
T44 6467-6656 Sentence denotes MERS-CoV was first identified in Saudi Arabia in 2012 and is associated with severe pneumonia and acute respiratory distress syndrome (ARDS) that results in a high mortality (~35%) [25,26].
T45 6657-6829 Sentence denotes SARS-CoV2 was identified in Wuhan, China in December 2019, which leads to similar symptoms in humans as SARS-CoV, but it is more infectious to humans than SARS-CoV [27,28].
T46 6830-7085 Sentence denotes Furthermore, α-CoV genus includes porcine respiratory coronavirus (PRCV) and various enteric CoVs that lead to viral diarrhea in pigs, such as PEDV, transmissible gastroenteritis virus (TGEV), and HKU2-like porcine enteric alphacoronavirus (PEAV) [29,30].
T47 7086-7236 Sentence denotes PRCV infects the upper respiratory epithelial cells and alveolar macrophages, but the clinical manifestations caused by PRCV are not significant [31].
T48 7237-7399 Sentence denotes The swine enteric CoVs cause severe diarrhea, vomiting, and mortality in piglets, having contributed to enormous economic losses to the global swine industry [6].
T49 7400-7465 Sentence denotes PEDV is the main causative pathogen of viral diarrhea in piglets.
T50 7466-7561 Sentence denotes Over the years, significant work has been done to investigate PEDV pathogenesis and prevention.
T51 7562-7680 Sentence denotes Aminopeptidase N protein (APN, also known as CD13) is identified as a functional receptor of PEDV and TGEV [32,33,34].
T52 7681-7801 Sentence denotes APN, a 150 KD type II transmembrane glycoprotein, is mainly expressed on the apical membrane of mature enterocytes [35].
T53 7802-7904 Sentence denotes APN binds to the 477-629 amino-acid region in the C-terminal region of PEDV spike 1 (S1) protein [34].
T54 7905-7963 Sentence denotes Apart from APN, PEDV is able to bind to sialic acids [36].
T55 7964-8050 Sentence denotes It remains unknown whether PEDV uses sugar coreceptors during viral infection [34,36].
T56 8051-8164 Sentence denotes PEDV infects multiple cell lines from different species including bat and primate (human and non-human) in vitro.
T57 8165-8416 Sentence denotes The ability of PEDV to infect the cells of different species indicates that the virus utilizes the evolutionarily conserved cell components as receptors, thereby enhancing the potential for cross-species and potentially, zoonotic transmission [37,38].
T58 8417-8652 Sentence denotes The highly pathogenic variant strains of PEDV were identified in 2010 and caused a high morbidity of up to 100% in piglets, and since then, these strains become dominant, leading to most of the acute outbreaks of PED worldwide [1,7,8].
T59 8653-8771 Sentence denotes The high virulence of these strains is critically associated with the immune evasion mechanisms employed by the virus.
T60 8772-8901 Sentence denotes PEDV has evolved different strategies to delicately manipulate and damage the host innate immune system for their multiplication.
T61 8902-9099 Sentence denotes Clarification of these mechanisms is critical for understanding the host range, tropisms, pathogenesis, and for developing effective vaccines and antiviral drugs to curb the spread of PEDV in pigs.
T62 9100-9214 Sentence denotes In this review, we provide an overview of different mechanisms used by PEDV to evade host innate immune responses.
T63 9216-9218 Sentence denotes 2.
T64 9219-9244 Sentence denotes Genomic Structure of PEDV
T65 9245-9309 Sentence denotes PEDV is an enveloped, positive-sense, single-stranded RNA virus.
T66 9310-9377 Sentence denotes The PEDV genome constitution represents a standard CoV arrangement.
T67 9378-9601 Sentence denotes The viral genome is approximately 28 kb in length, containing a 5′ terminal cap, a 3′ poly (A) tail, as well as seven open reading frames (ORFs), including the ORF1a, ORF1b, S, ORF3, E, M, and N genes (Figure 1) [39,40,41].
T68 9602-9778 Sentence denotes The N terminal ORF1a and ORF1b encode two large replicase polyprotein precursors (pp1a and pp1ab), which are subsequently processed into 16 nonstructural proteins (nsp1 to 16).
T69 9779-9878 Sentence denotes ORF1a encodes pp1a which is cleaved by viral proteases into 11 nonstructural proteins (nsp1-nsp11).
T70 9879-10021 Sentence denotes The ORF1b generates five additional nonstructural proteins (nsp12–16) that are proteolytically cleaved by the viral proteases from pp1ab [42].
T71 10022-10168 Sentence denotes Nsp3 contains two papain-like protease domains (PLP1 and PLP2 or PLpro) that cleave the nsp1–4 region of the replicase polyprotein at three sites.
T72 10169-10291 Sentence denotes Nsp5, a chymotrypsin-like enzyme also known as 3C-like protease, cleaves the polyprotein at remaining cleavage sites [43].
T73 10292-10547 Sentence denotes The C terminus of viral genome contains five ORFs, encoding four structure proteins (spike protein (S), small envelope glycoprotein (E), membrane glycoprotein (M), and nucleocapsid protein (N)), as well as a hypothetical accessory protein ORF3 [44,45,46].
T74 10548-10746 Sentence denotes The 16 nsps, together with the N protein, and several host proteins, form a large replication and transcription complex (RTC) that engages in the minus-strand RNA synthesis, using viral genomic RNA.
T75 10747-10863 Sentence denotes These nsps play important roles in virion structure modification and the replication and transcription of PEDV [47].
T76 10865-10867 Sentence denotes 3.
T77 10868-10905 Sentence denotes Biological Functions of PEDV Proteins
T78 10906-11036 Sentence denotes The viral proteins of PEDV perform different biological functions during viral entry, replication cycle and propagation (Table 1).
T79 11037-11277 Sentence denotes PEDV S protein, a type I membrane glycoprotein protein located on the envelope of the virus, consists of an N-terminal signal peptide, a large extracellular region, a single transmembrane domain, as well as a short cytoplasmic tail [48,49].
T80 11278-11335 Sentence denotes The ectodomain of S protein comprises S1 and S2 subunits.
T81 11336-11468 Sentence denotes The N-terminal S1 region, containing N- and C-terminal domains (S1-NTD and S1-CTD), is mainly responsible for receptor binding [50].
T82 11469-11611 Sentence denotes The C-terminal membrane-anchored S2 region is mainly involved in triggering the fusion of the viral envelope with host cell membranes [48,49].
T83 11612-11723 Sentence denotes The interaction of the CoV S protein with its host cell surface receptor is a key determinant for host tropism.
T84 11724-11877 Sentence denotes The S1-CTD of most known members of α-CoV genus, including PEDV, interacts with aminopeptidase N (APN) to entry into the target cell [32,36,51,52,53,54].
T85 11878-11979 Sentence denotes In addition, S protein contains the epitopes that are the major targets of the neutralizing antibody.
T86 11980-12088 Sentence denotes N protein is the most abundant viral protein during the early phase of infection in CoV-infected cells [55].
T87 12089-12342 Sentence denotes Similar to the N proteins of other CoVs, the PEDV N protein has multiple functions, such as acting as a structural protein that forms nucleocapsid with viral genomic RNA, playing important roles in viral replication, transcription, and assembly [56,57].
T88 12343-12529 Sentence denotes The expression of the N protein in intestinal epithelial cells extends the S-phase of cell cycle, causes endoplasmic reticulum (ER) stress, and upregulates interleukin-8 expression [44].
T89 12530-12717 Sentence denotes Moreover, the N proteins of several α-CoVs and β-CoVs, including PEDV, PDCoV, SARS-CoV, and mouse hepatitis virus (MHV), have been identified as innate immunity antagonists [58,59,60,61].
T90 12718-12791 Sentence denotes However, the involved antagonistic mechanisms are particularly different.
T91 12792-12983 Sentence denotes PEDV M protein participates in virion assembly and virus budding through collaboration with other viral proteins, and engages in the induction of neutralizing antibodies against PEDV [62,63].
T92 12984-13039 Sentence denotes PEDV M protein is distributed throughout the cytoplasm.
T93 13040-13154 Sentence denotes It induces the cell growth retardation in intestinal epithelial cells (IEC) and arrests the cells in S-phase [64].
T94 13155-13267 Sentence denotes In addition, PEDV M protein is identified as an interferon (IFN) antagonist with an unrecognized mechanism [65].
T95 13268-13337 Sentence denotes PEDV E protein is important for the virus packaging and budding [66].
T96 13338-13454 Sentence denotes It is predominantly localized in the ER, having no effect on cell growth, cell cycle and cyclin A expression in IEC.
T97 13455-13640 Sentence denotes However, it causes ER stress and activates the nuclear factor-κB (NF-κB) pathway which is responsible for the up-regulation of IL-8 and the anti-apoptotic protein Bcl-2 expression [67].
T98 13641-13773 Sentence denotes ORF3 has been predicted to possess multiple transmembrane domains [68], while it is predominantly distributed in the cytoplasm [69].
T99 13774-13886 Sentence denotes ORF3 also detains cells at S-phase, facilitating vesicle formation, and thus promoting PEDV multiplication [69].
T100 13887-14016 Sentence denotes A recent study suggests that ORF3 interacts with S protein during PEDV assembly and consequently benefits viral replication [70].
T101 14017-14401 Sentence denotes CoV nsps play multiple roles in the synthesis or processing of viral RNA, or in virus-host interactions aiming to create an optimal environment for virus replication, such as facilitating viral entry, viral gene expression, RNA synthesis, and virion release. nsp1 is a N-terminal cleavage product of ORF1a polyprotein [71], a 9-kDa protein, that exists only in α-CoVs and β-CoVs [72].
T102 14402-14506 Sentence denotes The nsp1 of α-CoVs is not very similar to β-CoVs nsp1 with regard to sequence homology and size [73,74].
T103 14507-14645 Sentence denotes Based on the sequence alignment analysis of the genomes of different CoVs, the viral nsp1 can be regarded as a genus-specific marker [75].
T104 14646-14728 Sentence denotes Moreover, β-CoVs nsp1 has been widely reported to inhibit host protein expression.
T105 14729-14801 Sentence denotes However, the biological functions of α-CoVs nsp1 remain largely unknown.
T106 14802-14951 Sentence denotes Despite the lack of overall sequence similarity, the nsp1 of different CoVs shares a similar function to interfere with host protein expression [76].
T107 14952-15045 Sentence denotes These studies suggest the importance of nsp1 in the life cycle of different lineages of CoVs.
T108 15046-15144 Sentence denotes It is shown that TGEV nsp1 inhibits host gene expression and is critical for viral virulence [77].
T109 15145-15267 Sentence denotes PEDV nsp1 induces the degradation of CBP and NF-κB to abate IFN response [78], but the detailed mechanisms remain unclear.
T110 15268-15359 Sentence denotes The sizes and amino acid sequence identity of nsp 2 are variable among different CoVs [76].
T111 15360-15426 Sentence denotes Nsp2 of MHV and SARS-CoV are involved in viral RNA synthesis [79].
T112 15427-15535 Sentence denotes PEDV nsp2 has unknown functions in replication, and may implicate the virus-host interactions and virulence.
T113 15536-15736 Sentence denotes Nsp3 is the largest nsp protein, containing two papain-like protease (PLP1 and PLP2) domains, of which PEDV PLP2 acts as a viral deubiquitinase (DUB), to negatively regulate type I IFN signaling [80].
T114 15737-15851 Sentence denotes CoVs PLPs domains exhibit multiple functions, serving as a viral protease, DUB, as well as an IFN antagonist [81].
T115 15852-16003 Sentence denotes CoVs, like other positive-stranded RNA viruses, induce membranous rearrangements of varying morphologies that are essential for RTCs anchoring [82,83].
T116 16004-16253 Sentence denotes The CoV-induced replicative structures consist of double-membrane vesicles (DMVs) and convoluted membranes (CMs), which form a large reticulovesicular network that are critical for viral replication and transcription [84,85,86,87,88,89,90,91,92,93].
T117 16254-16420 Sentence denotes Among the CoV nsps, nsp3, nsp4, and nsp6 include the hydrophobic transmembrane domains engaging in anchoring the viral RNA synthesis components to the membranes [94].
T118 16421-16511 Sentence denotes For MERS-CoV and SARS-CoV, co-expression of nsp3 and nsp4 is required to induce DMVs [95].
T119 16512-16616 Sentence denotes SARS-CoV nsp6 has membrane proliferation ability as well, which also contributes to DMVs formation [96].
T120 16617-16684 Sentence denotes The structure and functions of α-CoV nsp3 are largely unknown [97].
T121 16685-16945 Sentence denotes Nsp4 is also a marker for CoV-induced membrane structures; some results indicate that the nsp4–10 of pp1a act as a large complex through multidomain structure or scaffold during viral RNA replication progress, before its cleavage into individual products [98].
T122 16946-16994 Sentence denotes CoVs nsp5 encodes a 3C-like proteinase (3CLpro).
T123 16995-17113 Sentence denotes The polyproteins pp1a and pp1ab are processed into individual elements of replicase by 3C-like protease and PLPs [99].
T124 17114-17227 Sentence denotes Moreover, PEDV nsp5 plays a crucial role in virus replication and also blocks host innate immune responses [100].
T125 17228-17439 Sentence denotes Crystallographic or nuclear magnetic resonance structures have shown that nsp3, nsp5, nsp7, nsp8, nsp9, and nsp10 have the PLprob and the ADP-ribose 1′′-phosphatase (ADRP) activity [101,102,103,104,105,106,107].
T126 17440-17561 Sentence denotes The crystal structure of SARS-CoV nsp9 suggests that nsp9 is dimeric and it is able to bind to single-stranded RNA [108].
T127 17562-17707 Sentence denotes The crystal structure of SARS CoV nsp10 protein suggests that nsp10 is a zinc-finger protein, which is existent exclusively in CoVs so far [107].
T128 17708-17815 Sentence denotes Moreover, nsp7–10 have RNA binding activity and nsp12 encodes a single RNA-dependent RNA polymerase (RdRp).
T129 17816-17982 Sentence denotes The biochemical characterization and crystallization of SARS CoV nsp7 and nsp8 manifests that eight copies of nsp8 and eight copies of nsp7 form a supercomplex [106].
T130 17983-18102 Sentence denotes The complex is supportive for nucleic acid binding and may be associated with the processivity of viral RdRp [102,106].
T131 18103-18285 Sentence denotes Recently, structural studies have described that the SARS-CoV nsp12 polymerase binds to the nsp7 and nsp8 complex [109] that may increase the polymerase activity of nsp12 RdRp [110].
T132 18286-18386 Sentence denotes CoV nsp13, a NTPase/helicase, is also determined to play essential roles in viral replication [111].
T133 18387-18515 Sentence denotes CoV nsp14 is a multifunctional protein with 3′-5′ exoribonuclease activity and N-7-methyltransferase [MTase] activity [112,113].
T134 18516-18589 Sentence denotes Nsp14 catalyzes the N7-methylation of Gppp-RNA to form a cap-0 structure.
T135 18590-18703 Sentence denotes CoV nsp15 encodes an endoribonuclease (EndoU), performing functions through a hexamer in many CoVs [114,115,116].
T136 18704-18790 Sentence denotes The endoribonuclease activity of nsp15 is not essential for CoV replication [117,118].
T137 18791-19044 Sentence denotes For CoVs, the 5′ end of the viral genomic RNA and subgenomic mRNA (sgmRNA) is supposed to have cap structures: an N-7 methylated guanosine nucleoside (m7GpppN) (cap 0) and a methyl group at the 2′-O-ribose position (cap 1) of the first nucleotide [119].
T138 19045-19253 Sentence denotes These cap structures enhance the initiation of translation of viral proteins, protect viral mRNAs against cellular 5′-3′-exoribonuclease and limit the recognition of viral RNA by host innate system [120,121].
T139 19254-19346 Sentence denotes Nsp13 is proposed to catalyze the first step of the 5′-capping reaction of viral RNAs [122].
T140 19347-19514 Sentence denotes The methylation of the two sites in the 5′ cap are catalyzed by three nsps; nsp14 (the N-7-MTase), nsp16 (the 2′-O-methyltransferase), and nsp10 [112,123,124,125,126].
T141 19515-19698 Sentence denotes In addition, the 3′-5′ exoribonuclease activity of nsp14 is involved in a replicative mismatch repair system during RNA synthesis, which improves the replication fidelity of CoV [42].
T142 19699-19948 Sentence denotes Although these nsps have been demonstrated to play essential roles in viral replication, transcription and/or post-translational polyprotein processing [127], the nsp12–16 of PEDV and other CoVs are poorly characterized to date, except for SARS-CoV.
T143 19950-19952 Sentence denotes 4.
T144 19953-19990 Sentence denotes Innate Immunity during PEDV Infection
T145 19991-20227 Sentence denotes Host cells generally defend against virus infection by mounting an innate antiviral immune response to prevent the spread of the infection and aid in initiating an adaptive immune response which eventually removes the viruses from host.
T146 20228-20445 Sentence denotes Therefore, the first barrier to restrain viral infections is the host innate immune system, which is related to multiple proteins and mechanisms, including IFNs, inflammatory cytokine, apoptosis, autophagy, and so on.
T147 20447-20451 Sentence denotes 4.1.
T148 20452-20477 Sentence denotes Overview of IFN Responses
T149 20478-20810 Sentence denotes The activation of type I IFN responses is composed of three stages: (1) recognition of pathogen-associated molecular pattern (PAMP) by PRRs; (2) secretion of type I IFNs through paracrine or autocrine pathways; and (3) expression of numerous antiviral IFN-stimulated genes (ISGs) which bring the host into the antiviral state [136].
T150 20811-21289 Sentence denotes At least three important PRRs have been identified in recognition of viral nucleic acids, including retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) (detection of viral RNA in the cytoplasm) [137], the membrane-bound Toll-like receptors (TLRs) (recognition of viral RNA or DNA in the endosome) [138], as well as a structurally unrelated group of viral DNA sensors (e.g., cGAS (cyclic GMP-AMP synthase) and IFI16) localized in the host cytoplasm and/or nucleus [139].
T151 21290-21422 Sentence denotes In the cytosol, the formation of specific secondary structure of viral RNA is closely related to viral RNA delivery and replication.
T152 21423-21622 Sentence denotes These molecular signatures are detected by RLRs including RIG-I (also known as DDX58), melanoma differentiation-associated gene 5 (MDA5), and laboratory of genetics and physiology-2 (LGP2) [140,141].
T153 21623-21820 Sentence denotes PRRs recognize PAMPs, inducing an intracellular signaling cascade, thus leading to the activation of transcription factors such as IRFs and NF-κB, which in turn induce the production of IFNs [142].
T154 21821-21997 Sentence denotes Both RIG-I and MDA5 have two N-terminal CARD domains to interact with the CARD domains of the downstream adaptor proteins, and a DEAD/H-box RNA helicase domain for RNA binding.
T155 21998-22287 Sentence denotes However, LGP2 does not have the N-terminalCARD domains, and the involved functions remain unclear [143,144,145]. dsRNA, as a specific secondary structure of viral RNA, can be sensed by RIG-I/MDA5 to induce IFN-α/β production through the cascade activation of the RLR pathway [146,147,148].
T156 22288-22485 Sentence denotes Activated RIG-I/MDA5 forms homo-oligomers and recruits the adaptor mitochondrial antiviral signaling (MAVS) to induce the formation of signaling complex of MAVS with other proteins on mitochondria.
T157 22486-22701 Sentence denotes TNF receptor-associated factor 6 (TRAF6) associates with TNFR1-associated death domain protein (TRADD), tripartite motif 14 (TRIM14), and pyruvate carboxylase (PC), resulting in the activation of IκB kinases (IKKs).
T158 22702-22834 Sentence denotes IKKs (IKKα, IKKβ and IKKγ) phosphorylate NF-κB inhibitor (IκB), leading to the ubiquitination of IκB and its subsequent degradation.
T159 22835-22953 Sentence denotes NF-κB is then activated and translocated into the nucleus to turn on the expression of proinflammatory and type I IFN.
T160 22954-23147 Sentence denotes MAVS also recruits and activates TBK1/IKKε by TRAFs that are pre-associated with TBK1/IKKε, via direct interaction between the SDD domain of TBK1/IKKε and the coiled-coil domain of TRAFs [149].
T161 23148-23302 Sentence denotes Activated TBK1/IKKε phosphorylates IFN regulatory factors (IRF3/IRF7), that further dimerize and import into the nucleus to promote type I IFN production.
T162 23303-23446 Sentence denotes On the other hand, MAVS interacts with MITA (also known as STING), that is located in mitochondria and the endoplasmic reticulum (ER) membrane.
T163 23447-23557 Sentence denotes MITA interacts with the TRAP complex, which may be involved in recruiting TBK1 and IKKε to phosphorylate IRF3.
T164 23558-23658 Sentence denotes Ubiquitination and deubiquitination are decisive in the regulation of RLR pathways activation [150].
T165 23659-23795 Sentence denotes Upon binding to viral dsRNA, RIG-I and MDA5 undergo conformational changes and release the N-terminal tandem CARD domains [151,152,153].
T166 23796-23932 Sentence denotes The CARD domains of RIG-I are modified by lysine 63 (K63) polyubiquitin chains through the ubiquitin ligases TRIM25, RNF135, and RIPLET.
T167 23933-23998 Sentence denotes This modification is crucial for RIG-I to recruit MAVS [154,155].
T168 23999-24202 Sentence denotes In addition to the ubiquitination of RLRs, the polyubiquitylation of TRAF3 and TRAF6 also play an important role in the regulation of innate immune signaling by activation of TBK1 and IKKs, respectively.
T169 24203-24373 Sentence denotes The K63 polyubiquitin chains can be removed by DUBs such as the tumor suppressor protein CYLD, DUBA and A20, providing a mechanism to downregulate immune responses [156].
T170 24374-24470 Sentence denotes Ubiquitination and deubiquitination are in a dynamic equilibrium to maintain immune homeostasis.
T171 24471-24590 Sentence denotes Type I IFNs are secreted by secretory cells and peripheral cells through self-secretion or paracrine secretion manners.
T172 24591-24829 Sentence denotes Extracellular type I IFNs bind to a heterodimeric complex composed of subunits of IFN-α receptors 1 (IFNAR1) and 2 (IFNAR2) located on the cell surface, which activates the tyrosine kinase 2 (TYK2)/Janus kinase 1 (JAK1) signal transducer.
T173 24830-25042 Sentence denotes TYK2/JAK1 subsequently induces the phosphorylation of transcription factors STAT1 and STAT2, which dimerize and in turn recruit IFN-regulatory factor 9 (IRF9), to form STAT1-STAT2-IRF9 trimerized complex (ISGF3).
T174 25043-25198 Sentence denotes This complex then translocates to the nucleus, where it binds to the IFN-stimulated response elements (ISRE motif; conserved sequence is TTTCNNTTTC) [157].
T175 25199-25359 Sentence denotes The binding of ISGF3 to ISRE finally triggers expression of IFN-stimulated genes (ISGs) that directly or indirectly exert antiviral effects in host cells [157].
T176 25360-25423 Sentence denotes Three types of IFNs (types I, II and III) have been identified.
T177 25424-25474 Sentence denotes Type I and type II IFNs have been widely reported.
T178 25475-25507 Sentence denotes Type II IFNs only contain IFN-γ.
T179 25508-25667 Sentence denotes IFN-γ is produced by natural killer (NK) cells and activated CD4+ and CD8+ T cells in response to the cytokines such as interleukin-12 (IL-12) and IL-18 [158].
T180 25668-25752 Sentence denotes IFN-γ binds to the type II IFN receptor composed of two subunits, IFNGR1 and IFNGR2.
T181 25753-25818 Sentence denotes IFNGR1 and IFNGR2 induce the formation of STAT1-STAT1 homodimers.
T182 25819-26000 Sentence denotes STAT1-STAT1 homodimers translocate to the nucleus and bind to the promoter of the IFN-γ-activation site (GAS) elements, to initiate the transcription of IFN-γ-regulated genes [159].
T183 26001-26133 Sentence denotes Type III IFNs have been explored in recent years, to unravel the underlying mechanisms that manipulate host innate immune responses.
T184 26134-26259 Sentence denotes Type III IFNs in humans contains IFN-λ1 (interleukin 29 [IL-29]), IFN-λ2 (IL-28A), IFN-λ3 (IL-28B), and IFN-λ4 [160,161,162].
T185 26260-26366 Sentence denotes Their expression profiles, signaling pathways, and gene expression programs resemble those of type I IFNs.
T186 26367-26519 Sentence denotes The production of type I and III IFNs are both initiated through the recognition of PAMPs or damage associated molecular patterns (DAMPs) by PRRs [163].
T187 26520-26764 Sentence denotes Despite the fact that the same transcriptional factors are required for the activation of promoters of type I and III IFNs, the NF-κB pathway is a pivotal regulator in IFN-λ production, whereas the IRFs pathway dominates type I IFNs expression.
T188 26765-26864 Sentence denotes The promoter of IFN-λ1 includes more NF-κB binding sites compared with in the IFN-β promoter [164].
T189 26865-26988 Sentence denotes The signal transduction of type III IFNs depends on the IFN-λ-specific receptor, IL-28Ra chain and IL-10R2 chain [161,165].
T190 26989-27219 Sentence denotes Synthetic IFN-λ binds to IL-28Rα and induces a conformational change within the receptor subunits, that triggers the activation of the receptor-associated tyrosine kinases (TYK2 and JAK1), which then phosphorylate STAT1 and STAT2.
T191 27220-27444 Sentence denotes STAT1 and STAT2 are heterodimerized and interact with IRF9 to form the ISGF3 transcription complex that binds to ISRE in the promoters of ISGs, to induce the expression of hundreds of proteins with antiviral functions [166].
T192 27446-27450 Sentence denotes 4.2.
T193 27451-27484 Sentence denotes Immune Evasion Mechanisms of PEDV
T194 27485-27604 Sentence denotes Induction of IFN-α/β is the most rapid and effective mechanism for hosts to initiate antiviral innate immune responses.
T195 27605-27661 Sentence denotes SARS-CoV, MHV and many other CoVs are sensitive to IFNs.
T196 27662-27818 Sentence denotes A great number of viral dsRNAs intermediates are generated during CoVs infection that contribute to IFN production, but these CoVs remain highly pathogenic.
T197 27819-27985 Sentence denotes As a matter of fact, CoVs have developed a set of elaborate mechanisms to evade or inhibit the host antiviral innate immune response during virus evolution [134,167].
T198 27986-28346 Sentence denotes The evasive strategies utilized by PEDV are classified into four major types: (1) inhibition of RLRs-mediated IFN production pathways, (2) inhibition of the activation of transcription factors responsible for IFN induction, (3) disruption of the signal cascades induced by IFN, and (4) hiding its viral RNA to avoid the exposure of viral RNA to immune sensors.
T199 28347-28538 Sentence denotes In the past decade, accumulating evidence demonstrates that PEDV N protein, nsp1, PLP2, nsp5, nsp15, and nsp16 antagonize type I IFN or type III IFNs production [58,65,78,80,100,132,135,168].
T200 28539-28644 Sentence denotes This explains why only weak IFNs’ and cytokines’ expression is detected in PEDV-infected cells [169,170].
T201 28646-28652 Sentence denotes 4.2.1.
T202 28653-28667 Sentence denotes PEDV N Protein
T203 28668-28841 Sentence denotes N protein, as an abundantly produced structural protein within CoV-infected cells, has multiple functions, including virus replication, transcription, and assembly [56,134].
T204 28842-28996 Sentence denotes PEDV N protein has been identified as an IFN antagonist that blocks the expression of IFN-β and ISGs by suppression of the IRF3 and NF-κB activities [58].
T205 28997-29194 Sentence denotes PEDV N protein inhibits the activation of the IFN-β promoter induced by TBK1 and its upstream RIG-I, MDA-5, VISA, and TRAF3, while not affecting the activation of the IFN-β promoter driven by IRF3.
T206 29195-29385 Sentence denotes Further experiments confirm that N directly interacts with TBK1 to obstruct the association between TBK1 and IRF3, which inhibits TBK1-induced IRF3 phosphorylation and IFN-β production [58].
T207 29386-29482 Sentence denotes Moreover, the effect of PEDV N protein on type III IFN production has also been evaluated [168].
T208 29483-29725 Sentence denotes N protein inhibits polyinosinic-polycytidylic acid (poly(I:C))-induced IFN-λ3 production by blocking the nuclear translocation of NF-κB, but does not antagonize the type I or type II IFN expression induced by poly(I:C) in IPEC-J2 cells [168].
T209 29726-29864 Sentence denotes Recent studies show that SARS-CoV N protein inhibits type I IFN production through suppressing TRIM25-mediated RIG-I ubiquitination [171].
T210 29865-29948 Sentence denotes The MERS-CoV N protein also blocks IFN production by interacting with TRIM25 [171].
T211 29949-30181 Sentence denotes In addition, both MHV and SARS-CoV N proteins perturb the function of cellular protein activator of protein kinase R (PACT), which can bind to RIG-I and MDA5 to activate IFN production, and thus antagonize type-I IFN signaling [61].
T212 30182-30292 Sentence denotes These results indicate the important function of the CoVs N protein in modulating host innate immune response.
T213 30293-30362 Sentence denotes Whether PEDV N protein targets TRIM25 or PACT should be investigated.
T214 30363-30573 Sentence denotes Although several studies have been performed to understand the pathogenicity of PEDV, there remains limited information about the interaction between viral proteins and host cell factors during viral infection.
T215 30574-30643 Sentence denotes CoV N protein is a vital viral protein involved in virus replication.
T216 30644-30839 Sentence denotes Current researches have indicated that N protein interacts with many host proteins, such as hCypA [172], proteasome subunit p42 [173], Smad3 [174], hnRNP-A1 [175], and the chemokine CXCL16 [176].
T217 30840-30916 Sentence denotes In the host cells, a large number of host proteins reveal various functions.
T218 30917-30996 Sentence denotes However, for the virus, the genome only encodes several limited viral proteins.
T219 30997-31109 Sentence denotes Therefore, these viral proteins have to be multifunctional, which is pivotal to virus replication and existence.
T220 31111-31117 Sentence denotes 4.2.2.
T221 31118-31127 Sentence denotes PEDV nsp1
T222 31128-31288 Sentence denotes PEDV nsp1 is the N-terminal cleavage product from polyproteins pp1a and pp1a/b processed by nsp3 and nsp5 [177] and is about 110 amino acids in length [74,178].
T223 31289-31436 Sentence denotes Nsp1 of many α-CoV and β-CoV exhibits both functional conservation and mechanistic diversity in suppressing host gene expression and IFN signaling.
T224 31437-31596 Sentence denotes For SARS-CoV, nsp1 triggers the decay and cleavage of host mRNA and inhibits host protein translation, subsequently inhibiting type I IFN production [179,180].
T225 31597-31734 Sentence denotes SARS-CoV nsp1 also blocks the expression of IFN-inducible genes, by restraining the signal transduction during virus infection [181,182].
T226 31735-31825 Sentence denotes The TGEV nsp1 considerably suppresses host protein expression during viral infection [77].
T227 31826-31951 Sentence denotes Structural studies show that the core structure of PEDV nsp1 is highly similar to those of SARS-CoV nsp1 and TGEV nsp1 [183].
T228 31952-32180 Sentence denotes PEDV nsp1 inhibits host gene expression and three motifs (amino acids 67 to 71, 78 to 85, and 103 to 110) form a stable functional region for inhibition of host protein synthesis, differing considerably from SARS-CoV nsp1 [183].
T229 32181-32298 Sentence denotes PEDV nsp1 has been identified as an IFN antagonist, which constrains poly (I:C)-induced IFN-β promoter activity [65].
T230 32299-32458 Sentence denotes Nsp1 significantly inhibits the activation of IFN-β promoter triggered by IRF3, whereas it does not inhibit IRF3 phosphorylation and its nuclear translocation.
T231 32459-32613 Sentence denotes Nsp1 interrupts the association of IRF3 with CREB-binding protein (CBP), by promoting CBP degradation in the nucleus via the proteasome-dependent pathway.
T232 32614-32754 Sentence denotes CBP/p300, the transcription co-activator cAMP responsive element binding protein (CREB), forms a complex with the activated IRF3 in nucleus.
T233 32755-32994 Sentence denotes The IRF3-CBP/p300 complex binds to the positive regulatory domain (PRD) regions of the IFN-β promoter, to assemble the enhanceosome with NF-κB and other factors, which ultimately turn on the transcription of type I IFN genes [184,185,186].
T234 32995-33060 Sentence denotes Therefore, PEDV nsp1 blocks type I IFN production in the nucleus.
T235 33061-33193 Sentence denotes Activated NF-κB induces the production of type I IFNs and proinflammatory cytokines and is important for inhibiting viral infection.
T236 33194-33343 Sentence denotes PEDV nsp1 has been shown to interfere with the NF-κB activity [78] and is the most potent suppressor of proinflammatory cytokines at early infection.
T237 33344-33538 Sentence denotes It inhibits the phosphorylation and degradation of IκBα, and blocks p65 nuclear translocation, leading to the suppression of both IFN and the early production of pro-inflammatory cytokines [78].
T238 33539-33697 Sentence denotes Moreover, PEDV inhibits type III IFN production and nsp1, nsp3, nsp5, nsp8, nsp14, nsp15, nsp16, ORF3, E, M, and N are identified as type III IFN antagonists.
T239 33698-33764 Sentence denotes Among these antagonists, nsp1 is the most potent suppressor [130].
T240 33765-33905 Sentence denotes PEDV nsp1 blocks the nuclear translocation of IRF1 and decreases the amounts of peroxisomes and then suppresses IRF1-mediated type III IFNs.
T241 33906-33988 Sentence denotes The conserved residues of PEDV nsp1 protein are crucial for IFN suppression [130].
T242 33989-34134 Sentence denotes Multiple effects of nsp1 on modulating innate immune response during PEDV infection suggest the vital role of nsp1 in the PEDV replication cycle.
T243 34136-34142 Sentence denotes 4.2.3.
T244 34143-34147 Sentence denotes PLP2
T245 34148-34506 Sentence denotes The antiviral innate immune signaling pathways are regulated by several posttranslational modifications (PTMs), such as phosphorylation, ubiquitination, glycosylation, NEDDylation and SUMOylation [187], of which ubiquitination is a critical modification to modulate the stability and activity of PRRs and other components of innate immune signaling pathways.
T246 34507-34662 Sentence denotes During viral infection, a reciprocatory action (occurrence of ubiquitination and deubiquitination) helps maintain the homeostasis of host immune responses.
T247 34663-34773 Sentence denotes Hence, deubiquitinases (DUBs) are indispensable in the regulation of virus-induced type I IFN signaling [188].
T248 34774-34885 Sentence denotes Many host DUBs have been reported engaging in the regulation of innate immune signaling pathways [189,190,191].
T249 34886-35031 Sentence denotes In recent years, a variety of viral DUBs have been discovered to target key components of type I IFN pathway during various RNA virus infections.
T250 35032-35275 Sentence denotes For example, foot-and-mouth disease virus leader proteinase (FMDV Lbpro) [192], and porcine reproductive and respiratory syndrome virus nsp2 (PRRSV nsp2) possess ubiquitin-deconjugating activity to deubiquitinate key host components [193,194].
T251 35276-35388 Sentence denotes To counteract host antiviral response, CoVs likely take advantage of DUB activity to break host innate immunity.
T252 35389-35536 Sentence denotes Indeed, the PLPs of mouse hepatitis virus A59 (MHV-A59) [195], SARS [196], and human CoV NL63 have DUB activity and antagonize IFN induction [197].
T253 35537-35665 Sentence denotes PEDV PLP2 has been reported as having a deubiquitinase activity as well, and it can be co-immunoprecipitated by RIG-I and STING.
T254 35666-35835 Sentence denotes As mentioned above, FMDV Lbpro, MHV PLP2 and SARS PLPs all counteract host innate immune response through blocking the ubiquitination of the components of RLRs pathways.
T255 35836-35981 Sentence denotes Similarly, PEDV PLP2 removes the ubiquitinated conjugates from RIG-I and STING by its DUB activity, to negatively regulate type I IFN production.
T256 35982-36145 Sentence denotes PEDV PLP2 probably interacts with RIG-I and STING, which prevents the activation of RIG-I and STING by hindering the recruitment of downstream signaling molecules.
T257 36146-36266 Sentence denotes As expected, the interference with the ubiquitination of RIG-I and STING by PLP2 clearly benefits PEDV replication [80].
T258 36267-36327 Sentence denotes PEDV nsp3 contains two core domains of PLPs (PLPl and PLP2).
T259 36328-36431 Sentence denotes It is determined that PEDV PLP2, but not PLP1, inhibits the IFN-β promoter activation in HEK293T cells.
T260 36432-36503 Sentence denotes The DUB activity of PLP2 is highly dependent on its catalytic activity.
T261 36504-36685 Sentence denotes Three catalytically inactive mutants of PEDV PLP2 (C1729A, H1888A and D1901A) are defective in the deubiquitination of its targets and fail to impair virus-induced IFN-β production.
T262 36686-36866 Sentence denotes SARS-CoV PLP2 interacts with MDM2 (mouse double minute 2 homolog) to deubiquitinate and stabilize MDM2, approving the degradation of p53 and the suppression of IFN signaling [198].
T263 36867-36936 Sentence denotes PEDV infection degrades p53 by upregulation of MDM2 expression [198].
T264 36937-37062 Sentence denotes PEDV PLP2 may be responsible for targeting the p53 pathway and inhibiting p53-dependent apoptosis, leading to immune evasion.
T265 37063-37236 Sentence denotes A recent study determined that TGEV PL1 inhibits the IFN-β expression and interferes with the RIG-1- and STING-mediated signaling pathway through a viral DUB activity [195].
T266 37237-37352 Sentence denotes It suggests that different viral proteins are involved in the deubiquitination of host proteins for different CoVs.
T267 37353-37507 Sentence denotes However, these studies offer a probability to design a common therapeutic against different viral DUBs to reduce the replication and pathogenesis of CoVs.
T268 37508-37682 Sentence denotes Therefore, further studies are required to understand more about the substrate specificity of these viral DUBs and clarify the precise functions of CoV protease/DUB activity.
T269 37684-37690 Sentence denotes 4.2.4.
T270 37691-37700 Sentence denotes PEDV nsp5
T271 37701-37808 Sentence denotes Notably, 3Cpro is a critical IFN antagonistic protein identified in multiple different families of viruses.
T272 37809-38090 Sentence denotes The 3Cpro of picornaviruses, including FMDV [199], hepatitis A virus (HAV) [200], enteroviruses (EV71, EV-D68) and coxsackieviruses (CVB3, CV-A16, CV-A6) [201,202,203,204], antagonize innate immune signaling by targeting the critical components of the IFN pathways for proteolysis.
T273 38091-38243 Sentence denotes A newly emerged picornavirus, Seneca Valley virus (SVV), has also evolved an effective mechanism to escape host antiviral innate immune using its 3Cpro.
T274 38244-38456 Sentence denotes Moreover, 3Cpro cleaves the signaling components (MAVS, TRIF, and TANK) of type I IFN pathway and induces the degradation of the transcription factors IRF3 and IRF7 to constrain host antiviral response [205,206].
T275 38457-38549 Sentence denotes CoV nsp5 is called 3C-like protease (3CLpro), that resembles the 3Cpro of other RNA viruses.
T276 38550-38675 Sentence denotes For CoV, the polyprotein precursors (pp1a and pp1b) are mainly processed to generate mature nonstructural proteins by 3CLpro.
T277 38676-38863 Sentence denotes To date, the 3CLpro of CoVs, including PEDV and PDCoV, have been confirmed to antagonize type I IFN production by the cleavage of NF-κB essential modulator (NEMO) and STAT2 [100,207,208].
T278 38864-38946 Sentence denotes NEMO is essential for RNA virus-induced activation of NF-κB, IRF3, and IRF7 [209].
T279 38947-39057 Sentence denotes NEMO is required for MAVS-induced IKKα/β activation and is also crucial for the activation of TBK1/IKKε [149].
T280 39058-39152 Sentence denotes To establish successful infections, PEDV targets NEMO to subvert host innate immune responses.
T281 39153-39284 Sentence denotes PEDV nsp5 significantly inhibits Sendai virus (SeV)-induced IFN-β synthesis and the process depends on its protease activity [100].
T282 39285-39388 Sentence denotes Further experiments show that PEDV nsp5 inhibits RIG-I/MDA5 signaling and targets the upstream of TBK1.
T283 39389-39474 Sentence denotes The cleavage of NEMO by nsp5 is identified as responsible for this inhibitive effect.
T284 39475-39569 Sentence denotes The PEDV nsp5-mediated cleavage of NEMO efficiently blocks NEMO-mediated downstream signaling.
T285 39570-39644 Sentence denotes The cleavage site within NEMO that is grasped by nsp5 has been determined.
T286 39645-39812 Sentence denotes Of these reported immune evasion strategies employed by CoVs, the cleavage of innate immune adaptors is a particularly effective manner to disrupt antiviral responses.
T287 39813-39883 Sentence denotes Nsp5 is essential for the life cycle of PEDV and other CoVs [210,211].
T288 39884-39962 Sentence denotes It is a potential target for the development of anti-coronaviral therapeutics.
T289 39963-40135 Sentence denotes Although PEDV nsp5 does not target STAT2 mediated type Ⅰ IFN signaling pathway, PEDV nsp7 has been reported to inhibit the STAT1 and STAT2 induced activation of ISRE [212].
T290 40136-40300 Sentence denotes Nsp7 competes with Karyopherin α (KPNA1), which is an adaptor mediating nuclear translocation of ISGF3, in combination with STAT1, to block ISGF3 nuclear transport.
T291 40301-40394 Sentence denotes However, the expression and phosphorylation of STAT1 and STAT2 are not affected by PEDV nsp7.
T292 40395-40484 Sentence denotes In fact, PEDV infection degrades STAT1, leading to the inhibition of IFN signaling [170].
T293 40485-40562 Sentence denotes Therefore, other PEDV encoded proteins likely target IFNs mediated signaling.
T294 40564-40570 Sentence denotes 4.2.5.
T295 40571-40603 Sentence denotes Evasion of Viral RNA Recognition
T296 40604-40745 Sentence denotes CoVs belong to RNA viruses, which produce several RNA species, such as dsRNA intermediates and RNA with a 5′-triphosphate during replication.
T297 40746-40881 Sentence denotes These RNA intermediates are potent stimulators of PRRs and are associated with the organelles of viral RNA replication, DMVs [213,214].
T298 40882-41043 Sentence denotes DMVs formed from membranous rearrangements seem to sequester the replication intermediates using membrane-bound vesicles or invaginations to keep away from PRRs.
T299 41044-41161 Sentence denotes Therefore, the form of DMVs may be a strategy for PEDV to escape innate immune recognition in the cytosol (Figure 2).
T300 41162-41245 Sentence denotes However, whether DMVs alone are sufficient to shield RNA from PRRs remains unknown.
T301 41246-41463 Sentence denotes Besides, the replication organelles, the endoribonuclease activity and viral 5′ end RNA capping/protection mechanisms are also the critical ways of avoiding RNA recognition or protecting it from degradation [132,135].
T302 41464-41477 Sentence denotes 1) PEDV nsp15
T303 41478-41586 Sentence denotes CoV nsp15 has EndoU catalytic activity that was initially thought to play a vital role in virus replication.
T304 41587-41723 Sentence denotes However, the catalytic-defective EndoU of MHV shows only a subtle defect in viral replication compared to WT virus in fibroblasts [215].
T305 41724-41804 Sentence denotes Similar results are found for the nsp15 mutants of SARS-CoV and HCoV-229E [216].
T306 41805-41895 Sentence denotes These findings suggest that the EndoU activity of nsp15 is not required for RNA synthesis.
T307 41896-41987 Sentence denotes Recently, nsp15 has been demonstrated to act as a new IFN antagonist of CoVs [117,118,217].
T308 41988-42147 Sentence denotes Recent reports indicate that CoVs’ EndoU activity is essential for prevention of RNA recognition by MDA5, protein kinase R (PKR), and OAS/RNAse L system [118].
T309 42148-42244 Sentence denotes PKR and OAS/RNAse L recognize and destroy foreign RNA in the cytosol to defend viral infections.
T310 42245-42393 Sentence denotes To counteract the function of PKR and OAS/RNAse L, the virus hides or modifies its viral RNA, to avoid the exposure of viral RNA to these molecules.
T311 42394-42463 Sentence denotes In all CoVs, the EndoU catalytic domain in nsp15 is highly conserved.
T312 42464-42559 Sentence denotes PEDV EndoU activity has been indicated as having an antagonistic effect on IFN signaling [135].
T313 42560-42734 Sentence denotes The EndoU activity of PEDV nsp15 not only inhibits the type I IFN response in porcine macrophages, but also antagonizes the type III IFN response in porcine epithelial cells.
T314 42735-42883 Sentence denotes The replication of EndoU-mutant PEDV (icPEDV-EnUmt) is considerably impaired in porcine epithelial cells compared to the wild type PEDV (icPEDV-wt).
T315 42884-43039 Sentence denotes The icPEDV-EnUmt clearly induces early and robust type I and type III IFNs production, as well as ISGs’ expression compared with that induced by icPEDV-wt.
T316 43040-43129 Sentence denotes The EndoU-deficient PEDV infected animals also show reduced viral shedding and mortality.
T317 43130-43269 Sentence denotes These results indicate that the EndoU activity of PEDV nsp15 plays a vital role in evading host antiviral innate immunity (Figure 2) [135].
T318 43270-43283 Sentence denotes 2) PEDV nsp16
T319 43284-43335 Sentence denotes CoV nsp16 is a 2′-O-methyltransferase (2′-O-MTase).
T320 43336-43458 Sentence denotes To evade recognition by the host immune sensors, many CoVs encode methyltransferases involved in the capping of viral RNA.
T321 43459-43622 Sentence denotes This modification makes the viral RNA indistinguishable with host cell mRNA, which is important to avoid the recognition of viral RNA by MDA5 (Figure 2) [121,218].
T322 43623-43783 Sentence denotes Methylation of the two sites in the 5′ cap is catalyzed by three nsps, including nsp14 (the N-7-MTase), nsp16 (the 2′-O-MTase), and nsp10 [112,123,124,125,126].
T323 43784-43916 Sentence denotes For example, SARS-CoV nsp16 acts as a 2′-O-MTase to prevent innate immune recognition and promote viral proliferation [113,121,123].
T324 43917-43997 Sentence denotes PEDV nsp14 and nsp16 have been identified as the viral IFN antagonists [65,132].
T325 43998-44168 Sentence denotes The overexpression of nsp14 or nsp16 remarkably inhibits IFN-β production, but nsp16 appears to play a more important role in innate immunity regulation than nsp14 [132].
T326 44169-44294 Sentence denotes Nsp16 is a highly conserved methyltransferase which contains an invariant KDKE motif within the methyltransferase core [219].
T327 44295-44347 Sentence denotes This KDKE motif is required to mediate its activity.
T328 44348-44456 Sentence denotes Notably, the mutation of any of the KDKE active sit has been shown to abolish the 2′-O-MTase activity [123].
T329 44457-44625 Sentence denotes PEDV nsp16 KDKE motif plays a critical role in the inhibition of type I IFN production, suggesting the important role of the 2′-O-MTase in PEDV-mediated immune evasion.
T330 44626-44831 Sentence denotes PEDV nsp16 negatively regulates RLR-mediated signal pathway activation, and inhibits the expression of the IFN-stimulated IFIT family members (IFIT1, IFIT2, IFIT3), which in turn promotes PEDV replication.
T331 44832-44974 Sentence denotes Taken together, these results demonstrate that PEDV nsp16 negatively regulates cellular antiviral response to promote viral replication [132].
T332 44975-45154 Sentence denotes Screening inhibitors targeting the 2′-O-MTase of nsp16 might be a prominent strategy to inhibit CoV infections and develop antivirals for treatment of the diseases caused by CoVs.
T333 45155-45245 Sentence denotes Additionally, CoVs nsp14 also includes the 3′-to-5′ exoribonuclease (ExoN) activity [113].
T334 45246-45380 Sentence denotes A mutation of TGEV nsp14 ExoN generates lower levels of dsRNA than wildtype TGEV and thus triggers a reduced antiviral response [220].
T335 45381-45496 Sentence denotes Nsp14 ExoN activity is also critical for the resistance of host innate immune response in MHV-infected cells [221].
T336 45497-45638 Sentence denotes The role of nsp ExoN activity of PEDV in counteracting host antiviral response should be investigated to uncover more functions of PEDV nsps.
T337 45639-45819 Sentence denotes These data suggest that PEDV has evolved multiple evasive mechanisms to circumvent viral RNA recognition or prevent RNA degradation to establish a successful infection in the host.
T338 45821-45827 Sentence denotes 4.2.6.
T339 45828-45908 Sentence denotes PEDV Inhibits Heat Shock Protein 27 Expression to Impair Innate Immune Signaling
T340 45909-46148 Sentence denotes Heat shock protein 27 (HSP27) belongs to the small heat shock proteins family, which has been identified as a multifunctional protein involved in cytoskeletal stability, proinflammatory processes, and the inhibition of apoptosis [222,223].
T341 46149-46247 Sentence denotes Several HSPs have been reported to be implicated in PEDV infection in vitro and in vivo [224,225].
T342 46248-46431 Sentence denotes Indeed, the infection of many viruses up-regulates HSP27 expression by different mechanisms to delay cellular apoptosis, then supplies sufficient time for viral replication [226,227].
T343 46432-46557 Sentence denotes However, PEDV infection significantly induces the decreased expression of HSP27 in Vero cells [225] and MARC-145 cells [228].
T344 46558-46669 Sentence denotes HSP27 activates the phosphorylation of NF-κB, and thus promotes the mRNA expression of IFN-β in MARC-145 cells.
T345 46670-46803 Sentence denotes As HSP27 is an upstream regulator of antiviral immune signaling, overexpression of HSP27 significantly inhibits the PEDV replication.
T346 46804-46933 Sentence denotes PEDV has developed a strategy via mediating the suppression of HSP27 production to escape from host innate immune response [228].
T347 46934-47022 Sentence denotes HSP70, the most conserved HSP, is also important for the multiplication of several CoVs.
T348 47023-47132 Sentence denotes The recruitment of HSP70 is thought to be a viral survival strategy for several viruses in their hosts [229].
T349 47133-47211 Sentence denotes The relationship between HSP70 and PEDV should be exploited further in future.
T350 47213-47217 Sentence denotes 4.3.
T351 47218-47241 Sentence denotes Modulation of Apoptosis
T352 47242-47343 Sentence denotes Viral infection triggers host immune response to induce IFNs’ and inflammatory cytokines’ production.
T353 47344-47449 Sentence denotes Released IFNs elicit the expression of numerous ISGs which limit viral replication in the infected cells.
T354 47450-47582 Sentence denotes However, the release of excessive amounts of IFNs and inflammatory cytokines will lead to autoimmune and auto-inflammatory diseases.
T355 47583-47670 Sentence denotes The concomitant uncontrolled apoptosis is also one outcome that is harmful to the host.
T356 47671-47823 Sentence denotes To maintain the reaction in a proper balance, hosts have evolved a series of effective mechanisms to control the antiviral innate immune response [230].
T357 47824-47941 Sentence denotes In contrast, viruses often break this balance, causing improper apoptosis reaction, which benefits viral replication.
T358 47942-48046 Sentence denotes PEDV infects various host cells including Vero, PK-15 and Marc-145 and cause obvious cytopathic effects.
T359 48047-48145 Sentence denotes PEDV-induced apoptosis of the infected cell has been demonstrated both in vitro and in vivo [231].
T360 48146-48268 Sentence denotes Apoptosis is induced through the activation of apoptotic caspases, including caspase-2, -3, -6, -7, -8, -9, and -10 [232].
T361 48269-48512 Sentence denotes PEDV infection results in obvious caspase-3 and caspase-8 activation, as well as the cleavage of apoptosis-inducing factor mitochondria-associated 1 (AIFM1) and poly ADP-ribose polymerase (PARP), which leads to apoptotic nuclear fragmentation.
T362 48513-48693 Sentence denotes PEDV spike protein S1 significantly elicits host cell apoptosis, while the nsp1–16 and other structural proteins (M, N, E, S2, and ORF3) have none or few effects on cell apoptosis.
T363 48694-48795 Sentence denotes Therefore, S1 protein is probably the critical protein mediating the apoptosis induced by PEDV [128].
T364 48797-48801 Sentence denotes 4.4.
T365 48802-48811 Sentence denotes ER Stress
T366 48812-48959 Sentence denotes The multiple stages of CoV replication cycle are closely associated with cellular membrane compartments, especially the endoplasmic reticulum (ER).
T367 48960-49071 Sentence denotes The shape and functions of ER can be influenced by different physiological states and environmental conditions.
T368 49072-49218 Sentence denotes When protein synthesis amounts surpass the folding capacity, the accumulation of a large amount of unfolded proteins in the ER leads to ER stress.
T369 49219-49350 Sentence denotes Consequently, cells manifest a corresponding biological reaction that is widely known as the unfolded protein response (UPR) [233].
T370 49351-49558 Sentence denotes Once the UPR is induced, it alleviates the problems by host protein translation inhibition (by the transducer PKR-like ER protein kinase (PERK)-induced phosphorylation of eIF2a), stimulating protein folding.
T371 49559-49634 Sentence denotes If homeostasis cannot be re-established, apoptosis eventually is triggered.
T372 49635-49827 Sentence denotes Indeed, the activation of UPR regulates a wide variety of signaling pathways, such as apoptosis, autophagy, mitogen-activated protein (MAP) kinase activation, and innate immune response [234].
T373 49828-49906 Sentence denotes Furthermore, α-CoV and β-CoV may induce ER stress in the infected cells [235].
T374 49907-50037 Sentence denotes PEDV ORF3, as the only accessory protein encoded by PEDV, is thought to be related to virus production and virulence of PEDV [68].
T375 50038-50162 Sentence denotes A series of studies suggest that ORF3 plays multiple roles, in addition to acting as an ion channel during PEDV replication.
T376 50163-50307 Sentence denotes Recent studies show that PEDV ORF3 consists of four transmembrane domains (TMDs) and localizes in the cytoplasm in the aggregation manner [236].
T377 50308-50503 Sentence denotes ORF3 is a transmembrane protein, and the confocal microscopy analysis indicates that the aggregated ORF3 localizes in the ER to induce the ER stress associated with either apoptosis or autophagy.
T378 50504-50622 Sentence denotes However, PEDV ORF3 induces the autophagy via driving conversion of LC3-I to LC3-II, but not influencing the apoptosis.
T379 50623-50681 Sentence denotes ORF3-induced autophagy is dependent on ER stress response.
T380 50682-50825 Sentence denotes PEDV ORF3 triggers ER stress response via the up-regulation of GRP78 protein expression and the activation of the PERK-eIF2α signaling pathway.
T381 50826-50958 Sentence denotes Moreover, ORF3 protein is identified as an IFN antagonist to block IFN response by an unknown mechanism in PEDV-infected cells [65].
T382 50959-51014 Sentence denotes The functions of PEDV ORF3 should be further exploited.
T383 51016-51018 Sentence denotes 5.
T384 51019-51030 Sentence denotes Conclusions
T385 51031-51177 Sentence denotes PEDV has caused epidemic and endemic infections in pig populations in many countries and has become a major economic threat to the swine industry.
T386 51178-51386 Sentence denotes Previous studies have identified viral factors that target key signaling molecules in the RLRs’ pathways, as well as viral factors that target the downstream signaling pathways responsible for ISGs induction.
T387 51387-51502 Sentence denotes Of the 23 PEDV-encoded proteins, at least 10 viral proteins have been identified as type I IFN antagonists [65,78].
T388 51503-51653 Sentence denotes The mechanisms utilized by PEDV nsp1, PLP2, nsp5, and N protein to antagonize type I IFN production have been clarified (Figure 3, [58,65,78,80,129]).
T389 51654-51767 Sentence denotes However, the specific mechanisms of other viral proteins to inhibit type I IFN production remain largely unknown.
T390 51768-51848 Sentence denotes At present, 11 PEDV proteins have been identified as type III IFNs’ antagonists.
T391 51849-52034 Sentence denotes The suppression of type III IFN signaling by N protein, nsp1, as well as nsp15, has been reported, while the mechanisms utilized by these viral proteins need to be further investigated.
T392 52035-52225 Sentence denotes In addition, the CoVs replication cycle may induce the changes of ER stress, cell apoptosis, autophagy pathways, which contain intricate virus-host interactions and cross-talk relationships.
T393 52226-52328 Sentence denotes Thus, more researches for PEDV are needed to truly reflect viral evasions from innate immune defenses.
T394 52329-52413 Sentence denotes The findings of PEDV-host interactions will help prevent and control PEDV spreading.
T395 52415-52430 Sentence denotes Acknowledgments
T396 52431-52492 Sentence denotes We are thankful to everybody who participated in the studies.
T397 52494-52514 Sentence denotes Author Contributions
T398 52515-52605 Sentence denotes The manuscript was prepared by S.L., J.Y., Z.Z., and H.Z., and reviewed by the co-authors.
T399 52606-52682 Sentence denotes All authors have read and agreed to the published version of the manuscript.
T400 52684-52691 Sentence denotes Funding
T401 52692-52974 Sentence denotes This work was supported by grants from the National Key R&D Program of China (2018YFD0500103 and 2017YFE0204100), the Key Technologies R&D Program of Gansu Province (19ZDNA001) and the Chinese Academy of Agricultural Science and Technology Innovation Project (CAAS-ASTIP-2020-LVRI).
T402 52976-52997 Sentence denotes Conflicts of Interest
T403 52998-53042 Sentence denotes The authors declare no conflict of interest.
T404 53044-53113 Sentence denotes Figure 1 Porcine epidemic diarrhea virus (PEDV) genome constitution.
T405 53114-53225 Sentence denotes The viral genome is composed of seven open reading frames (ORFs) and the 5′ and 3′ untranslated regions (UTRs).
T406 53226-53353 Sentence denotes The ORFs encode four structure proteins (S, E, M and N), a hypothetical accessory protein (ORF3), as well as 16 nsps (nsp1–16).
T407 53354-53418 Sentence denotes Nsp3 contains two papain-like proteases domains (PLP1 and PLP2).
T408 53419-53431 Sentence denotes Definitions:
T409 53432-53699 Sentence denotes 3CLpro, 3C-like protease (nsp5); RdRp, RNA-dependent RNA polymerase (nsp12); HEL, 5′-to-3′ Helicase (nsp13); ExoN, 3′-to-5′ exoribonuclease (nsp14); N7-MTase, N7-methyl transferase (nsp14); EndoU, endoribonuclease (nsp15); 2′-O-MTase, 2′-O-methyl transferase (nsp16).
T410 53700-53774 Sentence denotes Figure 2 The model of PEDV to avoid viral RNA recognition by RNA sensors.
T411 53775-53928 Sentence denotes The immunosuppressive effect of PEDV nsp16 and nsp15 suggests that PEDV 5’ mRNA capping and viral EndoU activity are important for innate immune evasion.
T412 53929-54067 Sentence denotes The formation of double-membrane vesicles (DMVs) induced by viral infection is also an important strategy for hiding of RNA intermediates.
T413 54068-54134 Sentence denotes Figure 3 The action model of PEDV interferons (IFNs) antagonists.
T414 54135-54448 Sentence denotes For type I IFN, PEDV PLP2 removes ubiquitinated conjugates from RIG-I; PEDV nsp5 induces cleavage of NEMO; PEDV N protein directly interacts with TBK1 to obstruct the association between TBK1 and IRF3; PEDV nsp1 causes degradation of CBP and IκBα, as well as inhibition of IκBα phosphorylation and p65 activation.
T415 54449-54566 Sentence denotes PEDV nsp16 inhibits type I IFN production and nsp10 enhances the inhibitory effect of nsp16 on type I IFN production.
T416 54567-54733 Sentence denotes For type III IFN, PEDV N protein blocks the nuclear translocation of NF-κB; PEDV nsp1 blocks the nuclear translocation of IRF1 and reduces the amounts of peroxisomes.
T417 54734-54818 Sentence denotes PEDV nsp15 inhibits the type I IFN and type III IFN responses by unknown mechanisms.
T418 54819-54900 Sentence denotes PEDV nsp7 interacts with STAT1 and STAT2 to block nuclear translocation of ISGF3.
T419 54901-54947 Sentence denotes Table 1 The functions of PEDV viral proteins.
T420 54948-55008 Sentence denotes PEDV Proteins The Biological Processes Involved References
T421 55009-55148 Sentence denotes S (S1 and S2) receptor binding and subsequent membrane fusion; replication cycle and propagation; cell apoptosis induction [48,49,50,128]
T422 55149-55359 Sentence denotes N viral replication, transcription, and assembly; extension of S-phase of cell cycle; endoplasmic reticulum (ER) stress formation; innate immunity antagonist; interaction with host protein NPM1 [44,56,57,129]
T423 55360-55529 Sentence denotes M virion assembly and virus budding; induction of PEDV neutralizing antibodies; cell growth retardation in S-phase; IFN antagonist with unknown mechanism [62,63,64,65]
T424 55530-55627 Sentence denotes E virus packaging and budding; stimulation of ER stress and activation of NF-κB pathway [66,67]
T425 55628-55732 Sentence denotes ORF3 detention of cells at S-phase; facilitating vesicle formation; promoting PEDV replication [69,70]
T426 55733-55959 Sentence denotes nsp1 type I IFNs and type III IFN antagonists; inducing the degradation of CBP; suppression of phosphorylation and degradation of IκBα, as well as p65 nuclear translocation; blocking nuclear translocation of IRF1 [65,78,130]
T427 55960-55973 Sentence denotes nsp2 Unknown
T428 55974-56187 Sentence denotes nsp3,4,6 nsp3, 4, and 6 are all involved in viral replication process; nsp3 also acts as a viral deubiquitinase (DUB) that deubiquitinates RIG-I and STING and negatively regulates type I IFN signaling [80,94,99]
T429 56188-56352 Sentence denotes nsp5 3CLpro; processing replicase polyprotein during virus replication; blocking host innate immune responses by cleavage of NF-κB essential modulator (NEMO) [99]
T430 56353-56552 Sentence denotes nsp7–10 Nsp7 is an IFN antagonist; nsp8 inhibits type III IFN response; nsp9 is involved in nucleic acid binding; nsp10 enhances the inhibitory effect of nsp16 on IFN-β production. [65,131,132,133]
T431 56553-56601 Sentence denotes nsp12 encoding a RdRp; viral replication [134]
T432 56602-56673 Sentence denotes nsp13 a NTPase/helicase that is essential for viral replication [111]
T433 56674-56898 Sentence denotes nsp14 N-7-MTase; catalyzing N7-methylation of Gppp-RNA to form a cap-0 structure; 3′-5′ exoribonuclease activity involves in a replicative mismatch repair system during RNA synthesis; IFN antagonist [42,65,112,113,119,133]
T434 56899-57007 Sentence denotes nsp15 EndoU; IFN antagonist; inhibition of the type I IFN and the type III IFN responses [114,115,116,135]
T435 57008-57109 Sentence denotes nsp16 2′-O-MTase that catalyzes methylation of the 5’ cap; IFN antagonist [112,123,124,125,126,132]

2_test

Id Subject Object Predicate Lexical cue
32403318-22261231-82827216 1615-1616 22261231 denotes 1
32403318-27261169-82827217 1617-1618 27261169 denotes 2
32403318-6245603-82827218 1619-1620 6245603 denotes 3
32403318-888300-82827219 1695-1696 888300 denotes 4
32403318-103154-82827220 1784-1785 103154 denotes 5
32403318-83132-82827221 1850-1851 83132 denotes 6
32403318-22261231-82827222 2188-2189 22261231 denotes 1
32403318-22840964-82827223 2190-2191 22840964 denotes 7
32403318-23797760-82827224 2192-2193 23797760 denotes 8
32403318-25694517-82827225 2194-2195 25694517 denotes 9
32403318-23963154-82827226 2323-2325 23963154 denotes 10
32403318-25768287-82827227 2457-2459 25768287 denotes 11
32403318-22840964-82827228 2603-2604 22840964 denotes 7
32403318-23963154-82827229 2605-2607 23963154 denotes 10
32403318-22923806-82827230 2608-2610 22923806 denotes 12
32403318-24292967-82827231 2611-2613 24292967 denotes 13
32403318-28947336-82827232 2708-2710 28947336 denotes 14
32403318-16730762-82827233 3539-3541 16730762 denotes 15
32403318-26273575-82827234 3699-3701 26273575 denotes 16
32403318-27261169-82827235 4003-4004 27261169 denotes 2
32403318-29178509-82827236 4537-4539 29178509 denotes 17
32403318-12922142-82827237 4726-4728 12922142 denotes 18
32403318-2853174-82827238 5517-5519 2853174 denotes 19
32403318-3140695-82827239 5520-5522 3140695 denotes 20
32403318-8560773-82827240 5523-5525 8560773 denotes 21
32403318-12690091-82827241 6459-6461 12690091 denotes 23
32403318-12723282-82827242 6462-6464 12723282 denotes 24
32403318-23075143-82827243 6649-6651 23075143 denotes 25
32403318-31668197-82827244 6652-6654 31668197 denotes 26
32403318-31953166-82827245 6822-6824 31953166 denotes 27
32403318-29102111-82827246 7078-7080 29102111 denotes 29
32403318-22278237-82827247 7081-7083 22278237 denotes 30
32403318-22152290-82827248 7232-7234 22152290 denotes 31
32403318-83132-82827249 7396-7397 83132 denotes 6
32403318-17467767-82827250 7670-7672 17467767 denotes 32
32403318-20074871-82827251 7673-7675 20074871 denotes 33
32403318-26907329-82827252 7676-7678 26907329 denotes 34
32403318-18603472-82827253 7797-7799 18603472 denotes 35
32403318-26907329-82827254 7900-7902 26907329 denotes 34
32403318-25787280-82827255 7959-7961 25787280 denotes 36
32403318-26907329-82827256 8043-8045 26907329 denotes 34
32403318-25787280-82827257 8046-8048 25787280 denotes 36
32403318-23486053-82827258 8409-8411 23486053 denotes 37
32403318-23486063-82827259 8412-8414 23486063 denotes 38
32403318-22261231-82827260 8645-8646 22261231 denotes 1
32403318-22840964-82827261 8647-8648 22840964 denotes 7
32403318-23797760-82827262 8649-8650 23797760 denotes 8
32403318-8209771-82827263 9591-9593 8209771 denotes 39
32403318-22270324-82827264 9594-9596 22270324 denotes 40
32403318-26743534-82827265 9597-9599 26743534 denotes 41
32403318-24269475-82827266 10017-10019 24269475 denotes 42
32403318-27712628-82827267 10287-10289 27712628 denotes 43
32403318-23562137-82827268 10537-10539 23562137 denotes 44
32403318-21613395-82827269 10540-10542 21613395 denotes 45
32403318-23936367-82827270 10543-10545 23936367 denotes 46
32403318-18451981-82827271 10859-10861 18451981 denotes 47
32403318-27578435-82827272 11270-11272 27578435 denotes 48
32403318-27712627-82827273 11273-11275 27712627 denotes 49
32403318-26855426-82827274 11464-11466 26855426 denotes 50
32403318-27578435-82827275 11604-11606 27578435 denotes 48
32403318-27712627-82827276 11607-11609 27712627 denotes 49
32403318-17467767-82827277 11858-11860 17467767 denotes 32
32403318-25787280-82827278 11861-11863 25787280 denotes 36
32403318-8970993-82827279 11864-11866 8970993 denotes 51
32403318-1350661-82827280 11867-11869 1350661 denotes 52
32403318-8764078-82827281 11870-11872 8764078 denotes 53
32403318-1350662-82827282 11873-11875 1350662 denotes 54
32403318-23389550-82827283 12084-12086 23389550 denotes 55
32403318-16971454-82827284 12335-12337 16971454 denotes 56
32403318-16338414-82827285 12338-12340 16338414 denotes 57
32403318-23562137-82827286 12525-12527 23562137 denotes 44
32403318-24872591-82827287 12704-12706 24872591 denotes 58
32403318-20976535-82827288 12707-12709 20976535 denotes 59
32403318-17182678-82827289 12710-12712 17182678 denotes 60
32403318-28591694-82827290 12713-12715 28591694 denotes 61
32403318-1645905-82827291 12976-12978 1645905 denotes 62
32403318-9658133-82827292 12979-12981 9658133 denotes 63
32403318-26435150-82827293 13150-13152 26435150 denotes 64
32403318-26773386-82827294 13263-13265 26773386 denotes 65
32403318-15609507-82827295 13333-13335 15609507 denotes 66
32403318-23332027-82827296 13636-13638 23332027 denotes 67
32403318-22245155-82827297 13708-13710 22245155 denotes 68
32403318-26531166-82827298 13769-13771 26531166 denotes 69
32403318-26531166-82827299 13882-13884 26531166 denotes 69
32403318-15609509-82827300 14336-14338 15609509 denotes 71
32403318-21994708-82827301 14397-14399 21994708 denotes 72
32403318-17207625-82827302 14499-14501 17207625 denotes 73
32403318-23269811-82827303 14502-14504 23269811 denotes 74
32403318-12927536-82827304 14641-14643 12927536 denotes 75
32403318-25432065-82827305 14947-14949 25432065 denotes 76
32403318-31350335-82827306 15140-15142 31350335 denotes 77
32403318-28715653-82827307 15219-15221 28715653 denotes 78
32403318-25432065-82827308 15355-15357 25432065 denotes 76
32403318-16227261-82827309 15422-15424 16227261 denotes 79
32403318-23596270-82827310 15732-15734 23596270 denotes 80
32403318-20181693-82827311 15847-15849 20181693 denotes 81
32403318-18414501-82827312 15996-15998 18414501 denotes 82
32403318-15609503-82827313 15999-16001 15609503 denotes 83
32403318-18798692-82827314 16222-16224 18798692 denotes 84
32403318-11907209-82827315 16225-16227 11907209 denotes 85
32403318-16731931-82827316 16231-16233 16731931 denotes 87
32403318-15030705-82827317 16234-16236 15030705 denotes 88
32403318-20088951-82827318 16237-16239 20088951 denotes 89
32403318-19844604-82827319 16240-16242 19844604 denotes 90
32403318-27218226-82827320 16246-16248 27218226 denotes 92
32403318-20542253-82827321 16249-16251 20542253 denotes 93
32403318-16928755-82827322 16416-16418 16928755 denotes 94
32403318-20668092-82827323 16680-16682 20668092 denotes 97
32403318-16341254-82827324 16941-16943 16341254 denotes 98
32403318-19430490-82827325 17109-17111 19430490 denotes 99
32403318-26656704-82827326 17222-17225 26656704 denotes 100
32403318-12093723-82827327 17410-17413 12093723 denotes 101
32403318-16188992-82827328 17414-17417 16188992 denotes 102
32403318-16581910-82827329 17418-17421 16581910 denotes 103
32403318-16271890-82827330 17422-17425 16271890 denotes 104
32403318-14962394-82827331 17426-17429 14962394 denotes 105
32403318-16228002-82827332 17430-17433 16228002 denotes 106
32403318-16873246-82827333 17434-17437 16873246 denotes 107
32403318-15007178-82827334 17556-17559 15007178 denotes 108
32403318-16873246-82827335 17702-17705 16873246 denotes 107
32403318-16228002-82827336 17977-17980 16228002 denotes 106
32403318-16188992-82827337 18093-18096 16188992 denotes 102
32403318-16228002-82827338 18097-18100 16228002 denotes 106
32403318-31138817-82827339 18218-18221 31138817 denotes 109
32403318-25197083-82827340 18280-18283 25197083 denotes 110
32403318-16979681-82827341 18381-18384 16979681 denotes 111
32403318-19208801-82827342 18506-18509 19208801 denotes 112
32403318-16549795-82827343 18510-18513 16549795 denotes 113
32403318-19023218-82827344 18690-18693 19023218 denotes 114
32403318-16873248-82827345 18694-18697 16873248 denotes 115
32403318-16216269-82827346 18698-18701 16216269 denotes 116
32403318-28158275-82827347 18781-18784 28158275 denotes 117
32403318-28484023-82827348 18785-18788 28484023 denotes 118
32403318-21217758-82827349 19248-19251 21217758 denotes 121
32403318-15140959-82827350 19341-19344 15140959 denotes 122
32403318-19208801-82827351 19493-19496 19208801 denotes 112
32403318-18417574-82827352 19497-19500 18417574 denotes 123
32403318-22022266-82827353 19501-19504 22022266 denotes 124
32403318-26159422-82827354 19505-19508 26159422 denotes 125
32403318-25074927-82827355 19509-19512 25074927 denotes 126
32403318-24269475-82827356 19694-19696 24269475 denotes 42
32403318-12917450-82827357 19852-19855 12917450 denotes 127
32403318-19120477-82827358 20805-20808 19120477 denotes 136
32403318-25594890-82827359 21015-21018 25594890 denotes 137
32403318-19076341-82827360 21118-21121 19076341 denotes 138
32403318-25795286-82827361 21284-21287 25795286 denotes 139
32403318-19604485-82827362 21613-21616 19604485 denotes 140
32403318-15208624-82827363 21617-21620 15208624 denotes 141
32403318-23947345-82827364 21815-21818 23947345 denotes 142
32403318-24551857-82827365 22097-22100 24551857 denotes 143
32403318-20080593-82827366 22101-22104 20080593 denotes 144
32403318-16210631-82827367 22105-22108 16210631 denotes 145
32403318-28458619-82827368 22274-22277 28458619 denotes 146
32403318-20144765-82827369 22278-22281 20144765 denotes 147
32403318-27212682-82827370 22282-22285 27212682 denotes 148
32403318-29125880-82827371 23142-23145 29125880 denotes 149
32403318-19325622-82827372 23653-23656 19325622 denotes 150
32403318-22000019-82827373 23782-23785 22000019 denotes 151
32403318-21947008-82827374 23786-23789 21947008 denotes 152
32403318-22000018-82827375 23790-23793 22000018 denotes 153
32403318-22705106-82827376 23989-23992 22705106 denotes 154
32403318-20403326-82827377 23993-23996 20403326 denotes 155
32403318-18535581-82827378 24368-24371 18535581 denotes 156
32403318-22520844-82827379 25193-25196 22520844 denotes 157
32403318-22520844-82827380 25354-25357 22520844 denotes 157
32403318-9638361-82827381 25662-25665 9638361 denotes 158
32403318-29117564-82827382 25995-25998 29117564 denotes 159
32403318-24751921-82827383 26246-26249 24751921 denotes 160
32403318-12483210-82827384 26250-26253 12483210 denotes 161
32403318-23291588-82827385 26254-26257 23291588 denotes 162
32403318-19686699-82827386 26514-26517 19686699 denotes 163
32403318-19570999-82827387 26859-26862 19570999 denotes 164
32403318-12483210-82827388 26979-26982 12483210 denotes 161
32403318-12469119-82827389 26983-26986 12469119 denotes 165
32403318-31771761-82827390 27439-27442 31771761 denotes 166
32403318-28643204-82827391 27976-27979 28643204 denotes 134
32403318-24908561-82827392 27980-27983 24908561 denotes 167
32403318-24872591-82827393 28509-28511 24872591 denotes 58
32403318-26773386-82827394 28512-28514 26773386 denotes 65
32403318-28715653-82827395 28515-28517 28715653 denotes 78
32403318-23596270-82827396 28518-28520 23596270 denotes 80
32403318-26656704-82827397 28521-28524 26656704 denotes 100
32403318-30849413-82827398 28525-28528 30849413 denotes 132
32403318-30728254-82827399 28529-28532 30728254 denotes 135
32403318-26283628-82827400 28635-28638 26283628 denotes 169
32403318-27384656-82827401 28639-28642 27384656 denotes 170
32403318-16971454-82827402 28833-28835 16971454 denotes 56
32403318-28643204-82827403 28836-28839 28643204 denotes 134
32403318-24872591-82827404 28992-28994 24872591 denotes 58
32403318-24872591-82827405 29381-29383 24872591 denotes 58
32403318-28591694-82827406 30177-30179 28591694 denotes 61
32403318-15358143-82827407 30743-30746 15358143 denotes 172
32403318-20478047-82827408 30773-30776 20478047 denotes 173
32403318-18055455-82827409 30786-30789 18055455 denotes 174
32403318-10603321-82827410 30802-30805 10603321 denotes 175
32403318-20960183-82827411 30834-30837 20960183 denotes 176
32403318-17251282-82827412 31235-31238 17251282 denotes 177
32403318-23269811-82827413 31280-31282 23269811 denotes 74
32403318-17202208-82827414 31283-31286 17202208 denotes 178
32403318-18305050-82827415 31587-31590 18305050 denotes 179
32403318-22174690-82827416 31591-31594 22174690 denotes 180
32403318-16912115-82827417 31725-31728 16912115 denotes 181
32403318-17715225-82827418 31729-31732 17715225 denotes 182
32403318-31350335-82827419 31821-31823 31350335 denotes 77
32403318-29237834-82827420 31946-31949 29237834 denotes 183
32403318-29237834-82827421 32175-32178 29237834 denotes 183
32403318-26773386-82827422 32294-32296 26773386 denotes 65
32403318-17483521-82827423 32981-32984 17483521 denotes 184
32403318-9566918-82827424 32985-32988 9566918 denotes 185
32403318-17574024-82827425 32989-32992 17574024 denotes 186
32403318-28715653-82827426 33257-33259 28715653 denotes 78
32403318-28715653-82827427 33534-33536 28715653 denotes 78
32403318-28885059-82827428 34345-34348 28885059 denotes 187
32403318-27012466-82827429 34768-34771 27012466 denotes 188
32403318-21119682-82827430 34872-34875 21119682 denotes 189
32403318-25070846-82827431 34876-34879 25070846 denotes 190
32403318-25972356-82827432 34880-34883 25972356 denotes 191
32403318-21307201-82827433 35106-35109 21307201 denotes 192
32403318-22072774-82827434 35266-35269 22072774 denotes 193
32403318-20504922-82827435 35270-35273 20504922 denotes 194
32403318-18957937-82827436 35446-35449 18957937 denotes 195
32403318-24622840-82827437 35458-35461 24622840 denotes 196
32403318-16104827-82827438 35531-35534 16104827 denotes 197
32403318-23596270-82827439 36262-36264 23596270 denotes 80
32403318-25505178-82827440 36861-36864 25505178 denotes 198
32403318-25505178-82827441 36931-36934 25505178 denotes 198
32403318-18957937-82827442 37231-37234 18957937 denotes 195
32403318-22718831-82827443 37854-37857 22718831 denotes 199
32403318-24920812-82827444 37885-37888 24920812 denotes 200
32403318-24942571-82827445 37964-37967 24942571 denotes 201
32403318-21697485-82827446 37968-37971 21697485 denotes 202
32403318-21436888-82827447 37972-37975 21436888 denotes 203
32403318-28424289-82827448 37976-37979 28424289 denotes 204
32403318-28566380-82827449 38447-38450 28566380 denotes 205
32403318-29427864-82827450 38451-38454 29427864 denotes 206
32403318-26656704-82827451 38850-38853 26656704 denotes 100
32403318-27984784-82827452 38854-38857 27984784 denotes 207
32403318-17468758-82827453 38941-38944 17468758 denotes 209
32403318-29125880-82827454 39052-39055 29125880 denotes 149
32403318-26656704-82827455 39279-39282 26656704 denotes 100
32403318-27173881-82827456 39874-39877 27173881 denotes 210
32403318-27128350-82827457 39878-39881 27128350 denotes 211
32403318-27384656-82827458 40479-40482 27384656 denotes 170
32403318-25054883-82827459 40872-40875 25054883 denotes 213
32403318-20825348-82827460 40876-40879 20825348 denotes 214
32403318-30849413-82827461 41454-41457 30849413 denotes 132
32403318-30728254-82827462 41458-41461 30728254 denotes 135
32403318-17898055-82827463 41718-41721 17898055 denotes 215
32403318-21422822-82827464 41799-41802 21422822 denotes 216
32403318-28158275-82827465 41974-41977 28158275 denotes 117
32403318-28484023-82827466 41978-41981 28484023 denotes 118
32403318-29307596-82827467 41982-41985 29307596 denotes 217
32403318-28484023-82827468 42142-42145 28484023 denotes 118
32403318-30728254-82827469 42554-42557 30728254 denotes 135
32403318-30728254-82827470 43264-43267 30728254 denotes 135
32403318-21217758-82827471 43613-43616 21217758 denotes 121
32403318-25278144-82827472 43617-43620 25278144 denotes 218
32403318-19208801-82827473 43762-43765 19208801 denotes 112
32403318-18417574-82827474 43766-43769 18417574 denotes 123
32403318-22022266-82827475 43770-43773 22022266 denotes 124
32403318-26159422-82827476 43774-43777 26159422 denotes 125
32403318-25074927-82827477 43778-43781 25074927 denotes 126
32403318-16549795-82827478 43903-43906 16549795 denotes 113
32403318-21217758-82827479 43907-43910 21217758 denotes 121
32403318-18417574-82827480 43911-43914 18417574 denotes 123
32403318-26773386-82827481 43989-43991 26773386 denotes 65
32403318-30849413-82827482 43992-43995 30849413 denotes 132
32403318-30849413-82827483 44163-44166 30849413 denotes 132
32403318-12032088-82827484 44289-44292 12032088 denotes 219
32403318-18417574-82827485 44451-44454 18417574 denotes 123
32403318-30849413-82827486 44969-44972 30849413 denotes 132
32403318-16549795-82827487 45240-45243 16549795 denotes 113
32403318-27009949-82827488 45375-45378 27009949 denotes 220
32403318-18007587-82827489 46139-46142 18007587 denotes 222
32403318-22564335-82827490 46143-46146 22564335 denotes 223
32403318-27916855-82827491 46238-46241 27916855 denotes 224
32403318-25604190-82827492 46242-46245 25604190 denotes 225
32403318-24465692-82827493 46422-46425 24465692 denotes 226
32403318-18604870-82827494 46426-46429 18604870 denotes 227
32403318-25604190-82827495 46527-46530 25604190 denotes 225
32403318-28622863-82827496 46552-46555 28622863 denotes 228
32403318-28622863-82827497 46928-46931 28622863 denotes 228
32403318-28690332-82827498 47818-47821 28690332 denotes 230
32403318-17082813-82827499 48263-48266 17082813 denotes 232
32403318-30404647-82827500 48790-48793 30404647 denotes 128
32403318-17565364-82827501 49345-49348 17565364 denotes 233
32403318-24987391-82827502 49822-49825 24987391 denotes 234
32403318-27384577-82827503 49901-49904 27384577 denotes 235
32403318-22245155-82827504 50033-50035 22245155 denotes 68
32403318-31383304-82827505 50302-50305 31383304 denotes 236
32403318-26773386-82827506 50954-50956 26773386 denotes 65
32403318-26773386-82827507 51495-51497 26773386 denotes 65
32403318-28715653-82827508 51498-51500 28715653 denotes 78
32403318-24872591-82827509 51635-51637 24872591 denotes 58
32403318-26773386-82827510 51638-51640 26773386 denotes 65
32403318-28715653-82827511 51641-51643 28715653 denotes 78
32403318-23596270-82827512 51644-51646 23596270 denotes 80
32403318-28045037-82827513 51647-51650 28045037 denotes 129

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
1 0-31 Species denotes Porcine Epidemic Diarrhea Virus Tax:28295
19 628-631 Gene denotes IFN Gene:3439
20 844-847 Gene denotes IFN Gene:3439
21 78-109 Species denotes Porcine epidemic diarrhea virus Tax:28295
22 111-115 Species denotes PEDV Tax:28295
23 120-125 Species denotes swine Tax:9823
24 143-154 Species denotes coronavirus Tax:11118
25 156-159 Species denotes CoV Tax:11118
26 366-371 Species denotes swine Tax:9823
27 588-592 Species denotes PEDV Tax:28295
28 754-758 Species denotes PEDV Tax:28295
29 1041-1045 Species denotes PEDV Tax:28295
30 1103-1107 Species denotes PEDV Tax:28295
31 1183-1187 Species denotes CoVs Tax:11118
32 205-213 Disease denotes diarrhea MESH:D003967
33 246-254 Disease denotes diarrhea MESH:D003967
34 570-586 Disease denotes viral infections MESH:D001102
35 593-602 Disease denotes infection MESH:D007239
141 1206-1237 Species denotes Porcine epidemic diarrhea virus Tax:28295
142 1239-1243 Species denotes PEDV Tax:28295
143 1367-1372 Species denotes swine Tax:9823
144 1439-1443 Species denotes pigs Tax:9823
145 1609-1613 Species denotes pigs Tax:9823
146 1958-1963 Species denotes swine Tax:9823
147 2047-2051 Species denotes PEDV Tax:28295
148 2213-2217 Species denotes PEDV Tax:28295
149 2387-2391 Species denotes PEDV Tax:28295
150 2451-2455 Species denotes pigs Tax:9823
151 2495-2499 Species denotes PEDV Tax:28295
152 2555-2560 Species denotes swine Tax:9823
153 2692-2696 Species denotes PEDV Tax:28295
154 2744-2748 Species denotes PEDV Tax:28295
155 2801-2805 Species denotes pigs Tax:9823
156 3008-3012 Species denotes PEDV Tax:28295
157 3096-3100 Species denotes PEDV Tax:28295
158 3144-3148 Species denotes PEDV Tax:28295
159 3224-3228 Species denotes PEDV Tax:28295
160 3272-3276 Species denotes PEDV Tax:28295
161 3919-3923 Species denotes PEDV Tax:28295
162 3947-3951 Species denotes PEDV Tax:28295
163 4022-4026 Species denotes PEDV Tax:28295
164 4172-4176 Species denotes PEDV Tax:28295
165 4710-4714 Species denotes PEDV Tax:28295
166 4780-4784 Species denotes PEDV Tax:28295
167 4894-4898 Species denotes PEDV Tax:28295
168 5004-5008 Species denotes PEDV Tax:28295
169 5114-5118 Species denotes pigs Tax:9823
170 5382-5386 Species denotes PEDV Tax:28295
171 5406-5417 Species denotes coronavirus Tax:11118
172 5419-5422 Species denotes CoV Tax:11118
173 5511-5515 Species denotes CoVs Tax:11118
174 5528-5532 Species denotes CoVs Tax:11118
175 5566-5579 Species denotes Coronaviridae Tax:11118
176 5728-5732 Species denotes CoVs Tax:11118
177 5797-5800 Species denotes CoV Tax:11118
178 5803-5818 Species denotes Betacoronavirus Tax:694002
179 5820-5825 Species denotes β-CoV Tax:694002
180 5848-5851 Species denotes CoV Tax:11118
181 5877-5880 Species denotes CoV Tax:11118
182 5932-5936 Species denotes CoVs Tax:11118
183 5981-5987 Species denotes humans Tax:9606
184 6090-6095 Species denotes β-CoV Tax:694002
185 6133-6137 Species denotes CoVs Tax:11118
186 6186-6192 Species denotes humans Tax:9606
187 6202-6247 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
188 6249-6257 Species denotes SARS-CoV Tax:694009
189 6260-6315 Species denotes Middle East respiratory syndrome coronavirus (MERS-CoV) Tax:1335626
190 6332-6354 Species denotes 2019 novel coronavirus Tax:2697049
191 6356-6365 Species denotes SARS-CoV2 Tax:2697049
192 6368-6376 Species denotes SARS-CoV Tax:694009
193 6467-6475 Species denotes MERS-CoV Tax:1335626
194 6657-6666 Species denotes SARS-CoV2 Tax:2697049
195 6751-6757 Species denotes humans Tax:9606
196 6761-6769 Species denotes SARS-CoV Tax:694009
197 6800-6806 Species denotes humans Tax:9606
198 6812-6820 Species denotes SARS-CoV Tax:694009
199 6845-6848 Species denotes CoV Tax:11118
200 6864-6895 Species denotes porcine respiratory coronavirus Tax:11146
201 6923-6927 Species denotes CoVs Tax:11118
202 6959-6963 Species denotes pigs Tax:9823
203 6973-6977 Species denotes PEDV Tax:28295
204 6979-7014 Species denotes transmissible gastroenteritis virus Tax:11149
205 7016-7020 Species denotes TGEV Tax:11149
206 7037-7069 Species denotes porcine enteric alphacoronavirus Tax:2018513
207 7241-7246 Species denotes swine Tax:9823
208 7255-7259 Species denotes CoVs Tax:11118
209 7380-7385 Species denotes swine Tax:9823
210 1348-1355 Species denotes enteric Tax:28293
211 1724-1731 Species denotes enteric Tax:28293
212 6058-6065 Species denotes enteric Tax:28293
213 6786-6796 Species denotes infectious Tax:11120
214 6915-6922 Species denotes enteric Tax:28293
215 7247-7254 Species denotes enteric Tax:28293
216 6897-6901 Species denotes PRCV Tax:11146
217 7071-7075 Species denotes PEAV Tax:2018513
218 7086-7090 Species denotes PRCV Tax:11146
219 7206-7210 Species denotes PRCV Tax:11146
220 4375-4386 Chemical denotes lactic acid MESH:D019344
221 1290-1298 Disease denotes diarrhea MESH:D003967
222 1390-1398 Disease denotes vomiting MESH:D014839
223 1400-1408 Disease denotes diarrhea MESH:D003967
224 1410-1421 Disease denotes dehydration MESH:D003681
225 1427-1435 Disease denotes anorexia MESH:D000855
226 1488-1496 Disease denotes diarrhea MESH:D003967
227 1506-1515 Disease denotes mortality MESH:D003643
228 1583-1592 Disease denotes mortality MESH:D003643
229 1792-1806 Disease denotes viral diarrhea
230 2157-2166 Disease denotes mortality MESH:D003643
231 2351-2360 Disease denotes mortality MESH:D003643
232 2392-2401 Disease denotes infection MESH:D007239
233 2697-2706 Disease denotes infection MESH:D007239
234 3292-3301 Disease denotes mortality MESH:D003643
235 4715-4724 Disease denotes infection MESH:D007239
236 6161-6182 Disease denotes respiratory illnesses MESH:D012140
237 6411-6430 Disease denotes respiratory disease MESH:D012140
238 6551-6560 Disease denotes pneumonia MESH:D011014
239 6565-6600 Disease denotes acute respiratory distress syndrome MESH:D012128
240 6602-6606 Disease denotes ARDS MESH:D012128
241 6631-6640 Disease denotes mortality MESH:D003643
242 6941-6955 Disease denotes viral diarrhea
243 7273-7281 Disease denotes diarrhea MESH:D003967
244 7283-7291 Disease denotes vomiting MESH:D014839
245 7297-7306 Disease denotes mortality MESH:D003643
270 7562-7578 Gene denotes Aminopeptidase N Gene:290
271 7588-7591 Gene denotes APN Gene:290
272 7681-7684 Gene denotes APN Gene:290
273 7802-7805 Gene denotes APN Gene:290
274 7916-7919 Gene denotes APN Gene:290
275 7400-7404 Species denotes PEDV Tax:28295
276 7528-7532 Species denotes PEDV Tax:28295
277 7655-7659 Species denotes PEDV Tax:28295
278 7664-7668 Species denotes TGEV Tax:11149
279 7921-7925 Species denotes PEDV Tax:28295
280 7991-7995 Species denotes PEDV Tax:28295
281 8051-8055 Species denotes PEDV Tax:28295
282 8134-8139 Species denotes human Tax:9606
283 8148-8153 Species denotes human Tax:9606
284 8180-8184 Species denotes PEDV Tax:28295
285 8458-8462 Species denotes PEDV Tax:28295
286 8772-8776 Species denotes PEDV Tax:28295
287 9086-9090 Species denotes PEDV Tax:28295
288 9094-9098 Species denotes pigs Tax:9823
289 9171-9175 Species denotes PEDV Tax:28295
290 7945-7957 Chemical denotes sialic acids MESH:D012794
291 7439-7453 Disease denotes viral diarrhea
292 8026-8041 Disease denotes viral infection MESH:D001102
293 8386-8394 Disease denotes zoonotic MESH:D015047
308 9555-9559 Gene denotes ORF3 Gene:136991
309 9684-9688 Gene denotes pp1a Gene:5499
310 9766-9770 Gene denotes nsp1 Gene:10045
311 9793-9797 Gene denotes pp1a Gene:5499
312 9866-9870 Gene denotes nsp1 Gene:10045
313 10070-10074 Gene denotes PLP1 Gene:5354
314 10079-10083 Gene denotes PLP2 Gene:5355
315 10110-10114 Gene denotes nsp1 Gene:10045
316 10169-10173 Gene denotes Nsp5 Gene:92521
317 10531-10535 Gene denotes ORF3 Gene:136991
318 9245-9249 Species denotes PEDV Tax:28295
319 9314-9318 Species denotes PEDV Tax:28295
320 9361-9364 Species denotes CoV Tax:11118
321 10853-10857 Species denotes PEDV Tax:28295
323 10892-10896 Species denotes PEDV Tax:28295
359 11804-11820 Gene denotes aminopeptidase N Gene:290
360 11822-11825 Gene denotes APN Gene:290
361 12499-12512 Gene denotes interleukin-8 Gene:3576
362 13215-13218 Gene denotes IFN Gene:3439
363 13427-13435 Gene denotes cyclin A Gene:890
364 13521-13526 Gene denotes NF-κB Gene:4790
365 13582-13586 Gene denotes IL-8 Gene:3576
366 13618-13623 Gene denotes Bcl-2 Gene:596
367 13641-13645 Gene denotes ORF3 Gene:136991
368 13774-13778 Gene denotes ORF3 Gene:136991
369 13916-13920 Gene denotes ORF3 Gene:136991
370 10928-10932 Species denotes PEDV Tax:28295
371 11037-11041 Species denotes PEDV Tax:28295
372 11635-11638 Species denotes CoV Tax:11118
373 11762-11765 Species denotes CoV Tax:11118
374 11783-11787 Species denotes PEDV Tax:28295
375 12124-12128 Species denotes CoVs Tax:11118
376 12568-12572 Species denotes CoVs Tax:11118
377 12579-12583 Species denotes CoVs Tax:11118
378 12595-12599 Species denotes PEDV Tax:28295
379 12608-12616 Species denotes SARS-CoV Tax:694009
380 12622-12643 Species denotes mouse hepatitis virus Tax:11138
381 12792-12796 Species denotes PEDV Tax:28295
382 12970-12974 Species denotes PEDV Tax:28295
383 12984-12988 Species denotes PEDV Tax:28295
384 13168-13172 Species denotes PEDV Tax:28295
385 13268-13272 Species denotes PEDV Tax:28295
386 13861-13865 Species denotes PEDV Tax:28295
387 13953-13957 Species denotes PEDV Tax:28295
388 12645-12648 Species denotes MHV Tax:11138
389 12051-12060 Disease denotes infection MESH:D007239
390 12064-12076 Disease denotes CoV-infected MESH:D018352
391 12475-12481 Disease denotes stress MESH:D000079225
392 13067-13078 Disease denotes retardation MESH:D008607
393 13477-13483 Disease denotes stress MESH:D000079225
429 14276-14280 Gene denotes nsp1 Gene:10045
430 14406-14410 Gene denotes nsp1 Gene:10045
431 14451-14455 Gene denotes nsp1 Gene:10045
432 14592-14596 Gene denotes nsp1 Gene:10045
433 14663-14667 Gene denotes nsp1 Gene:10045
434 14773-14777 Gene denotes nsp1 Gene:10045
435 14855-14859 Gene denotes nsp1 Gene:10045
436 14992-14996 Gene denotes nsp1 Gene:10045
437 15068-15072 Gene denotes nsp1 Gene:10045
438 15150-15154 Gene denotes nsp1 Gene:10045
439 15182-15185 Gene denotes CBP Gene:1387
440 15190-15195 Gene denotes NF-κB Gene:4790
441 15205-15208 Gene denotes IFN Gene:3439
442 15606-15610 Gene denotes PLP1 Gene:5354
443 15615-15619 Gene denotes PLP2 Gene:5355
444 15644-15648 Gene denotes PLP2 Gene:5355
445 15831-15834 Gene denotes IFN Gene:3439
446 14017-14020 Species denotes CoV Tax:11118
447 14380-14384 Species denotes CoVs Tax:11118
448 14391-14395 Species denotes CoVs Tax:11118
449 14416-14420 Species denotes CoVs Tax:11118
450 14446-14450 Species denotes CoVs Tax:11118
451 14576-14580 Species denotes CoVs Tax:11118
452 14658-14662 Species denotes CoVs Tax:11118
453 14768-14772 Species denotes CoVs Tax:11118
454 14873-14877 Species denotes CoVs Tax:11118
455 15040-15044 Species denotes CoVs Tax:11118
456 15063-15067 Species denotes TGEV Tax:11149
457 15145-15149 Species denotes PEDV Tax:28295
458 15349-15353 Species denotes CoVs Tax:11118
459 15376-15384 Species denotes SARS-CoV Tax:694009
460 15427-15431 Species denotes PEDV Tax:28295
461 15639-15643 Species denotes PEDV Tax:28295
462 15737-15741 Species denotes CoVs Tax:11118
463 15368-15371 Species denotes MHV Tax:11138
500 16786-16790 Gene denotes pp1a Gene:5499
501 16951-16955 Gene denotes nsp5 Gene:92521
502 17012-17016 Gene denotes pp1a Gene:5499
503 17129-17133 Gene denotes nsp5 Gene:92521
504 17308-17312 Gene denotes nsp5 Gene:92521
505 18306-18314 Gene denotes helicase Gene:164045
506 18629-18634 Gene denotes EndoU Gene:8909
507 15852-15856 Species denotes CoVs Tax:11118
508 16008-16011 Species denotes CoV Tax:11118
509 16264-16267 Species denotes CoV Tax:11118
510 16425-16433 Species denotes MERS-CoV Tax:1335626
511 16438-16446 Species denotes SARS-CoV Tax:694009
512 16512-16520 Species denotes SARS-CoV Tax:694009
513 16650-16653 Species denotes CoV Tax:11118
514 16711-16714 Species denotes CoV Tax:11118
515 16946-16950 Species denotes CoVs Tax:11118
516 17124-17128 Species denotes PEDV Tax:28295
517 17465-17473 Species denotes SARS-CoV Tax:694009
518 17587-17595 Species denotes SARS CoV Tax:694009
519 17689-17693 Species denotes CoVs Tax:11118
520 17872-17880 Species denotes SARS CoV Tax:694009
521 18156-18164 Species denotes SARS-CoV Tax:694009
522 18286-18289 Species denotes CoV Tax:11118
523 18387-18390 Species denotes CoV Tax:11118
524 18590-18593 Species denotes CoV Tax:11118
525 18684-18688 Species denotes CoVs Tax:11118
526 18764-18767 Species denotes CoV Tax:11118
527 18795-18799 Species denotes CoVs Tax:11118
528 19689-19692 Species denotes CoV Tax:11118
529 19874-19878 Species denotes PEDV Tax:28295
530 19889-19893 Species denotes CoVs Tax:11118
531 19939-19947 Species denotes SARS-CoV Tax:694009
532 16596-16600 Chemical denotes DMVs
533 18920-18940 Chemical denotes guanosine nucleoside
534 18942-18949 Chemical denotes m7GpppN
535 18990-18996 Chemical denotes ribose MESH:D012266
538 19976-19980 Species denotes PEDV Tax:28295
539 19981-19990 Disease denotes Infection MESH:D007239
544 20134-20137 Gene denotes aid Gene:57379
545 20027-20042 Disease denotes virus infection MESH:D001102
546 20120-20129 Disease denotes infection MESH:D007239
547 20269-20285 Disease denotes viral infections MESH:D001102
549 20464-20467 Gene denotes IFN Gene:3439
603 21200-21223 Gene denotes cyclic GMP-AMP synthase Gene:115004
604 21229-21234 Gene denotes IFI16 Gene:3428
605 21481-21486 Gene denotes RIG-I Gene:23586
606 21502-21507 Gene denotes DDX58 Gene:23586
607 21510-21552 Gene denotes melanoma differentiation-associated gene 5 Gene:64135
608 21554-21558 Gene denotes MDA5 Gene:64135
609 21606-21610 Gene denotes LGP2 Gene:79132
610 21763-21768 Gene denotes NF-κB Gene:4790
611 21826-21831 Gene denotes RIG-I Gene:23586
612 21836-21840 Gene denotes MDA5 Gene:64135
613 22007-22011 Gene denotes LGP2 Gene:79132
614 22183-22188 Gene denotes RIG-I Gene:23586
615 22189-22193 Gene denotes MDA5 Gene:64135
616 22204-22211 Gene denotes IFN-α/β Gene:3440
617 22298-22303 Gene denotes RIG-I Gene:23586
618 22304-22308 Gene denotes MDA5 Gene:64135
619 22390-22394 Gene denotes MAVS Gene:57506
620 22444-22448 Gene denotes MAVS Gene:57506
621 22486-22518 Gene denotes TNF receptor-associated factor 6 Gene:222344
622 22520-22525 Gene denotes TRAF6 Gene:222344
623 22543-22580 Gene denotes TNFR1-associated death domain protein Gene:8717
624 22582-22587 Gene denotes TRADD Gene:8717
625 22611-22617 Gene denotes TRIM14 Gene:9830
626 22624-22644 Gene denotes pyruvate carboxylase Gene:5091
627 22708-22712 Gene denotes IKKα Gene:1147
628 22714-22718 Gene denotes IKKβ Gene:1147
629 22723-22727 Gene denotes IKKγ Gene:8517
630 22743-22748 Gene denotes NF-κB Gene:4790
631 22835-22840 Gene denotes NF-κB Gene:4790
632 22987-22991 Gene denotes TBK1 Gene:29110
633 22992-22996 Gene denotes IKKε Gene:9641
634 23035-23039 Gene denotes TBK1 Gene:29110
635 23040-23044 Gene denotes IKKε Gene:9641
636 23095-23099 Gene denotes TBK1 Gene:29110
637 23100-23104 Gene denotes IKKε Gene:9641
638 23158-23162 Gene denotes TBK1 Gene:29110
639 23163-23167 Gene denotes IKKε Gene:9641
640 23183-23186 Gene denotes IFN Gene:3439
641 23207-23211 Gene denotes IRF3 Gene:3661
642 23212-23216 Gene denotes IRF7 Gene:3665
643 23322-23326 Gene denotes MAVS Gene:57506
644 23342-23346 Gene denotes MITA Gene:340061
645 23362-23367 Gene denotes STING Gene:340061
646 23447-23451 Gene denotes MITA Gene:340061
647 23521-23525 Gene denotes TBK1 Gene:29110
648 23530-23534 Gene denotes IKKε Gene:9641
649 23552-23556 Gene denotes IRF3 Gene:3661
650 22954-22958 Gene denotes MAVS Gene:57506
651 20943-20948 Gene denotes RIG-I Gene:23586
652 23287-23290 Gene denotes IFN Gene:3439
653 22949-22952 Gene denotes IFN Gene:3439
654 20730-20733 Gene denotes IFN Gene:3439
655 21965-21973 Gene denotes helicase Gene:164045
672 23688-23693 Gene denotes RIG-I Gene:23586
673 23698-23702 Gene denotes MDA5 Gene:64135
674 23816-23821 Gene denotes RIG-I Gene:23586
675 23905-23911 Gene denotes TRIM25 Gene:7706
676 23913-23919 Gene denotes RNF135 Gene:84282
677 23925-23931 Gene denotes RIPLET Gene:84282
678 23966-23971 Gene denotes RIG-I Gene:23586
679 23983-23987 Gene denotes MAVS Gene:57506
680 24068-24073 Gene denotes TRAF3 Gene:7187
681 24078-24083 Gene denotes TRAF6 Gene:222344
682 24174-24178 Gene denotes TBK1 Gene:29110
683 24292-24296 Gene denotes CYLD Gene:1540
684 24298-24302 Gene denotes DUBA Gene:55593
685 24307-24310 Gene denotes A20 Gene:28935
686 23838-23844 Chemical denotes lysine MESH:D008239
687 24267-24272 Disease denotes tumor MESH:D009369
706 24692-24698 Gene denotes IFNAR1 Gene:3454
707 24707-24713 Gene denotes IFNAR2 Gene:3455
708 24764-24781 Gene denotes tyrosine kinase 2 Gene:7297
709 24783-24787 Gene denotes TYK2 Gene:7297
710 24789-24803 Gene denotes Janus kinase 1 Gene:3716
711 24805-24809 Gene denotes JAK1 Gene:3716
712 24830-24834 Gene denotes TYK2 Gene:7297
713 24835-24839 Gene denotes JAK1 Gene:3716
714 24906-24911 Gene denotes STAT1 Gene:6772
715 24916-24921 Gene denotes STAT2 Gene:6773
716 24983-24987 Gene denotes IRF9 Gene:10379
717 24998-25003 Gene denotes STAT1 Gene:6772
718 25004-25009 Gene denotes STAT2 Gene:6773
719 25010-25014 Gene denotes IRF9 Gene:10379
720 25035-25040 Gene denotes ISGF3 Gene:10379
721 25112-25115 Gene denotes IFN Gene:3439
722 25214-25219 Gene denotes ISGF3 Gene:10379
723 25259-25262 Gene denotes IFN Gene:3439
740 25501-25506 Gene denotes IFN-γ Gene:3458
741 25508-25513 Gene denotes IFN-γ Gene:3458
742 25569-25572 Gene denotes CD4 Gene:920
743 25578-25581 Gene denotes CD8 Gene:925
744 25655-25660 Gene denotes IL-18 Gene:3606
745 25668-25673 Gene denotes IFN-γ Gene:3458
746 25734-25740 Gene denotes IFNGR1 Gene:3459
747 25745-25751 Gene denotes IFNGR2 Gene:3460
748 25753-25759 Gene denotes IFNGR1 Gene:3459
749 25764-25770 Gene denotes IFNGR2 Gene:3460
750 25795-25800 Gene denotes STAT1 Gene:6772
751 25801-25806 Gene denotes STAT1 Gene:6772
752 25819-25824 Gene denotes STAT1 Gene:6772
753 25825-25830 Gene denotes STAT1 Gene:6772
754 25901-25906 Gene denotes IFN-γ Gene:3458
755 25972-25977 Gene denotes IFN-γ Gene:3458
770 26167-26173 Gene denotes IFN-λ1 Gene:282618
771 26175-26189 Gene denotes interleukin 29 Gene:282618
772 26191-26196 Gene denotes IL-29 Gene:282618
773 26200-26206 Gene denotes IFN-λ2 Gene:282616
774 26208-26214 Gene denotes IL-28A Gene:282616
775 26217-26223 Gene denotes IFN-λ3 Gene:282617
776 26225-26231 Gene denotes IL-28B Gene:282617
777 26238-26244 Gene denotes IFN-λ4 Gene:282617
778 26648-26653 Gene denotes NF-κB Gene:4790
779 26781-26787 Gene denotes IFN-λ1 Gene:282618
780 26802-26807 Gene denotes NF-κB Gene:4790
781 26843-26848 Gene denotes IFN-β Gene:3439
782 26688-26691 Gene denotes IFN Gene:3439
783 26151-26157 Species denotes humans Tax:9606
796 26946-26953 Gene denotes IL-28Ra Gene:163702
797 26964-26971 Gene denotes IL-10R2 Gene:3588
798 27014-27021 Gene denotes IL-28Rα Gene:163702
799 27162-27166 Gene denotes TYK2 Gene:7297
800 27171-27175 Gene denotes JAK1 Gene:3716
801 27203-27208 Gene denotes STAT1 Gene:6772
802 27213-27218 Gene denotes STAT2 Gene:6773
803 27220-27225 Gene denotes STAT1 Gene:6772
804 27230-27235 Gene denotes STAT2 Gene:6773
805 27274-27278 Gene denotes IRF9 Gene:10379
806 27291-27296 Gene denotes ISGF3 Gene:10379
807 26999-27002 Gene denotes IFN Gene:3439
809 27480-27484 Species denotes PEDV Tax:28295
827 27498-27505 Gene denotes IFN-α/β Gene:3440
828 27762-27765 Gene denotes IFN Gene:3439
829 28195-28198 Gene denotes IFN Gene:3439
830 28259-28262 Gene denotes IFN Gene:3439
831 28423-28427 Gene denotes nsp1 Gene:10045
832 28429-28433 Gene denotes PLP2 Gene:5355
833 28435-28439 Gene denotes nsp5 Gene:92521
834 27605-27613 Species denotes SARS-CoV Tax:694009
835 27634-27638 Species denotes CoVs Tax:11118
836 27788-27792 Species denotes CoVs Tax:11118
837 27840-27844 Species denotes CoVs Tax:11118
838 28021-28025 Species denotes PEDV Tax:28295
839 28407-28411 Species denotes PEDV Tax:28295
840 27615-27618 Species denotes MHV Tax:11138
841 28096-28099 Gene denotes IFN Gene:3439
842 27728-27742 Disease denotes CoVs infection MESH:D018352
843 28614-28627 Disease denotes PEDV-infected MESH:D007239
845 28648-28651 Gene denotes 2.1 Gene:6700
875 28883-28886 Gene denotes IFN Gene:3439
876 28928-28933 Gene denotes IFN-β Gene:3439
877 28965-28969 Gene denotes IRF3 Gene:3661
878 28974-28979 Gene denotes NF-κB Gene:4790
879 29043-29048 Gene denotes IFN-β Gene:3439
880 29069-29073 Gene denotes TBK1 Gene:29110
881 29091-29096 Gene denotes RIG-I Gene:23586
882 29098-29103 Gene denotes MDA-5 Gene:64135
883 29105-29109 Gene denotes VISA Gene:57506
884 29115-29120 Gene denotes TRAF3 Gene:7187
885 29164-29169 Gene denotes IFN-β Gene:3439
886 29189-29193 Gene denotes IRF3 Gene:3661
887 29254-29258 Gene denotes TBK1 Gene:29110
888 29295-29299 Gene denotes TBK1 Gene:29110
889 29304-29308 Gene denotes IRF3 Gene:3661
890 29325-29329 Gene denotes TBK1 Gene:29110
891 29338-29342 Gene denotes IRF3 Gene:3661
892 29363-29368 Gene denotes IFN-β Gene:3439
893 29554-29560 Gene denotes IFN-λ3 Gene:282617
894 29613-29618 Gene denotes NF-κB Gene:4790
895 28842-28846 Species denotes PEDV Tax:28295
896 28997-29001 Species denotes PEDV Tax:28295
897 29410-29414 Species denotes PEDV Tax:28295
898 29666-29669 Gene denotes IFN Gene:3439
899 29502-29533 Chemical denotes polyinosinic-polycytidylic acid MESH:D011070
900 29535-29544 Chemical denotes poly(I:C) MESH:D011070
901 29692-29701 Chemical denotes poly(I:C) MESH:D011070
902 28731-28743 Disease denotes CoV-infected MESH:D018352
903 29705-29712 CellLine denotes IPEC-J2 CVCL:2246
921 29821-29827 Gene denotes TRIM25 Gene:7706
922 29837-29842 Gene denotes RIG-I Gene:23586
923 29900-29903 Gene denotes IFN Gene:3439
924 29935-29941 Gene denotes TRIM25 Gene:7706
925 30049-30065 Gene denotes protein kinase R Gene:5610
926 30067-30071 Gene denotes PACT Gene:8575
927 30092-30097 Gene denotes RIG-I Gene:23586
928 30102-30106 Gene denotes MDA5 Gene:64135
929 30119-30122 Gene denotes IFN Gene:3439
930 30324-30330 Gene denotes TRIM25 Gene:7706
931 30334-30338 Gene denotes PACT Gene:8575
932 30162-30165 Gene denotes IFN Gene:3439
933 29751-29759 Species denotes SARS-CoV Tax:694009
934 29869-29877 Species denotes MERS-CoV Tax:1335626
935 30235-30239 Species denotes CoVs Tax:11118
936 29967-29970 Species denotes MHV Tax:11138
937 29975-30002 Disease denotes SARS-CoV N proteins perturb MESH:C000657245
946 30736-30741 Gene denotes hCypA Gene:5478
947 30749-30771 Gene denotes proteasome subunit p42 Gene:5706
948 30779-30784 Gene denotes Smad3 Gene:4088
949 30792-30800 Gene denotes hnRNP-A1 Gene:3178
950 30826-30832 Gene denotes CXCL16 Gene:58191
951 30443-30447 Species denotes PEDV Tax:28295
952 30574-30577 Species denotes CoV Tax:11118
953 30557-30572 Disease denotes viral infection MESH:D001102
984 31133-31137 Gene denotes nsp1 Gene:10045
985 31229-31233 Gene denotes nsp5 Gene:92521
986 31289-31293 Gene denotes Nsp1 Gene:10045
987 31422-31425 Gene denotes IFN Gene:3439
988 31451-31455 Gene denotes nsp1 Gene:10045
989 31606-31610 Gene denotes nsp1 Gene:10045
990 31744-31748 Gene denotes nsp1 Gene:10045
991 31882-31886 Gene denotes nsp1 Gene:10045
992 31926-31930 Gene denotes nsp1 Gene:10045
993 31940-31944 Gene denotes nsp1 Gene:10045
994 31957-31961 Gene denotes nsp1 Gene:10045
995 32169-32173 Gene denotes nsp1 Gene:10045
996 31641-31644 Gene denotes IFN Gene:3439
997 31128-31132 Species denotes PEDV Tax:28295
998 31304-31307 Species denotes CoV Tax:11118
999 31312-31317 Species denotes β-CoV Tax:694002
1000 31441-31449 Species denotes SARS-CoV Tax:694009
1001 31597-31605 Species denotes SARS-CoV Tax:694009
1002 31739-31743 Species denotes TGEV Tax:11149
1003 31877-31881 Species denotes PEDV Tax:28295
1004 31917-31925 Species denotes SARS-CoV Tax:694009
1005 31935-31939 Species denotes TGEV Tax:11149
1006 31952-31956 Species denotes PEDV Tax:28295
1007 32160-32168 Species denotes SARS-CoV Tax:694009
1008 31708-31723 Disease denotes virus infection MESH:D001102
1009 31804-31819 Disease denotes viral infection MESH:D001102
1064 32186-32190 Gene denotes nsp1 Gene:10045
1065 32217-32220 Gene denotes IFN Gene:3439
1066 32269-32274 Gene denotes IFN-β Gene:3439
1067 32299-32303 Gene denotes Nsp1 Gene:10045
1068 32345-32350 Gene denotes IFN-β Gene:3439
1069 32373-32377 Gene denotes IRF3 Gene:3661
1070 32407-32411 Gene denotes IRF3 Gene:3661
1071 32459-32463 Gene denotes Nsp1 Gene:10045
1072 32494-32498 Gene denotes IRF3 Gene:3661
1073 32504-32524 Gene denotes CREB-binding protein Gene:1387
1074 32526-32529 Gene denotes CBP Gene:1387
1075 32545-32548 Gene denotes CBP Gene:1387
1076 32614-32618 Gene denotes CBP/ Gene:1387
1077 32618-32622 Gene denotes p300 Gene:2033
1078 32696-32700 Gene denotes CREB Gene:1385
1079 32738-32742 Gene denotes IRF3 Gene:3661
1080 32759-32763 Gene denotes IRF3 Gene:3661
1081 32764-32768 Gene denotes CBP/ Gene:1387
1082 32768-32772 Gene denotes p300 Gene:2033
1083 32842-32847 Gene denotes IFN-β Gene:3439
1084 32892-32897 Gene denotes NF-κB Gene:4790
1085 33011-33015 Gene denotes nsp1 Gene:10045
1086 33071-33076 Gene denotes NF-κB Gene:4790
1087 33199-33203 Gene denotes nsp1 Gene:10045
1088 33241-33246 Gene denotes NF-κB Gene:4790
1089 33395-33399 Gene denotes IκBα Gene:4792
1090 33412-33415 Gene denotes p65 Gene:5970
1091 33474-33477 Gene denotes IFN Gene:3439
1092 33572-33575 Gene denotes IFN Gene:3439
1093 33591-33595 Gene denotes nsp1 Gene:10045
1094 33603-33607 Gene denotes nsp5 Gene:92521
1095 33636-33640 Gene denotes ORF3 Gene:136991
1096 33723-33727 Gene denotes nsp1 Gene:10045
1097 33770-33774 Gene denotes nsp1 Gene:10045
1098 33811-33815 Gene denotes IRF1 Gene:3659
1099 33877-33881 Gene denotes IRF1 Gene:3659
1100 33937-33941 Gene denotes nsp1 Gene:10045
1101 33966-33969 Gene denotes IFN Gene:3439
1102 34009-34013 Gene denotes nsp1 Gene:10045
1103 34099-34103 Gene denotes nsp1 Gene:10045
1104 32181-32185 Species denotes PEDV Tax:28295
1105 33006-33010 Species denotes PEDV Tax:28295
1106 33194-33198 Species denotes PEDV Tax:28295
1107 33549-33553 Species denotes PEDV Tax:28295
1108 33765-33769 Species denotes PEDV Tax:28295
1109 33932-33936 Species denotes PEDV Tax:28295
1110 34058-34062 Species denotes PEDV Tax:28295
1111 34111-34115 Species denotes PEDV Tax:28295
1112 32970-32973 Gene denotes IFN Gene:3439
1113 32250-32260 Chemical denotes poly (I:C) MESH:D011070
1114 32655-32659 Chemical denotes cAMP
1115 33177-33192 Disease denotes viral infection MESH:D001102
1116 33333-33342 Disease denotes infection MESH:D007239
1117 34063-34072 Disease denotes infection MESH:D007239
1167 35516-35519 Gene denotes IFN Gene:3439
1168 35542-35546 Gene denotes PLP2 Gene:5355
1169 35649-35654 Gene denotes RIG-I Gene:23586
1170 35659-35664 Gene denotes STING Gene:340061
1171 35702-35706 Gene denotes PLP2 Gene:5355
1172 35852-35856 Gene denotes PLP2 Gene:5355
1173 35899-35904 Gene denotes RIG-I Gene:23586
1174 35909-35914 Gene denotes STING Gene:340061
1175 35987-35991 Gene denotes PLP2 Gene:5355
1176 36016-36021 Gene denotes RIG-I Gene:23586
1177 36066-36071 Gene denotes RIG-I Gene:23586
1178 36076-36081 Gene denotes STING Gene:340061
1179 36203-36208 Gene denotes RIG-I Gene:23586
1180 36213-36218 Gene denotes STING Gene:340061
1181 36222-36226 Gene denotes PLP2 Gene:5355
1182 36312-36316 Gene denotes PLPl Gene:56936
1183 36321-36325 Gene denotes PLP2 Gene:5355
1184 36355-36359 Gene denotes PLP2 Gene:5355
1185 36369-36373 Gene denotes PLP1 Gene:5354
1186 36388-36393 Gene denotes IFN-β Gene:3439
1187 36452-36456 Gene denotes PLP2 Gene:5355
1188 36549-36553 Gene denotes PLP2 Gene:5355
1189 36668-36673 Gene denotes IFN-β Gene:3439
1190 36026-36031 Gene denotes STING Gene:340061
1191 35093-35097 Species denotes FMDV Tax:12110
1192 35116-35167 Species denotes porcine reproductive and respiratory syndrome virus Tax:28344
1193 35174-35179 Species denotes PRRSV Tax:28344
1194 35315-35319 Species denotes CoVs Tax:11118
1195 35409-35430 Species denotes mouse hepatitis virus Tax:11138
1196 35468-35473 Species denotes human Tax:9606
1197 35474-35477 Species denotes CoV Tax:11118
1198 35537-35541 Species denotes PEDV Tax:28295
1199 35686-35690 Species denotes FMDV Tax:12110
1200 35847-35851 Species denotes PEDV Tax:28295
1201 35982-35986 Species denotes PEDV Tax:28295
1202 36244-36248 Species denotes PEDV Tax:28295
1203 36267-36271 Species denotes PEDV Tax:28295
1204 36350-36354 Species denotes PEDV Tax:28295
1205 36544-36548 Species denotes PEDV Tax:28295
1206 35478-35482 Species denotes NL63 Tax:277944
1207 35436-35439 Species denotes MHV Tax:11138
1208 35698-35701 Species denotes MHV Tax:11138
1209 34514-34529 Disease denotes viral infection MESH:D001102
1210 35014-35030 Disease denotes virus infections MESH:D001102
1211 35045-35080 Disease denotes foot-and-mouth disease virus leader MESH:D005536
1212 36417-36424 CellLine denotes HEK293T CVCL:0063
1213 36555-36561 Mutation denotes C1729A c.1729C>A
1214 36563-36569 Mutation denotes H1888A p.H1888A
1215 36574-36580 Mutation denotes D1901A p.D1901A
1238 36695-36699 Gene denotes PLP2 Gene:18824
1239 36715-36719 Gene denotes MDM2 Gene:17246
1240 36721-36750 Gene denotes mouse double minute 2 homolog Gene:17246
1241 36784-36788 Gene denotes MDM2 Gene:17246
1242 36819-36822 Gene denotes p53 Gene:22060
1243 36846-36849 Gene denotes IFN Gene:3439
1244 36891-36894 Gene denotes p53 Gene:7157
1245 36914-36918 Gene denotes MDM2 Gene:4193
1246 36942-36946 Gene denotes PLP2 Gene:5355
1247 36984-36987 Gene denotes p53 Gene:7157
1248 37011-37014 Gene denotes p53 Gene:7157
1249 37116-37121 Gene denotes IFN-β Gene:3439
1250 37157-37162 Gene denotes RIG-1 Gene:5920
1251 36686-36694 Species denotes SARS-CoV Tax:694009
1252 36867-36871 Species denotes PEDV Tax:28295
1253 36937-36941 Species denotes PEDV Tax:28295
1254 37094-37098 Species denotes TGEV Tax:11149
1255 37347-37351 Species denotes CoVs Tax:11118
1256 37502-37506 Species denotes CoVs Tax:11118
1257 37656-37659 Species denotes CoV Tax:11118
1258 37168-37173 Gene denotes STING Gene:340061
1259 36872-36881 Disease denotes infection MESH:D007239
1261 37691-37695 Species denotes PEDV Tax:28295
1277 37730-37733 Gene denotes IFN Gene:3439
1278 38061-38064 Gene denotes IFN Gene:3439
1279 38294-38298 Gene denotes MAVS Gene:57506
1280 38300-38304 Gene denotes TRIF Gene:148022
1281 38395-38399 Gene denotes IRF3 Gene:3661
1282 38404-38408 Gene denotes IRF7 Gene:3665
1283 37848-37852 Species denotes FMDV Tax:12110
1284 37906-37910 Species denotes EV71 Tax:39054
1285 37912-37918 Species denotes EV-D68 Tax:42789
1286 37942-37946 Species denotes CVB3 Tax:12072
1287 37948-37954 Species denotes CV-A16 Tax:31704
1288 37956-37961 Species denotes CV-A6 Tax:86107
1289 38121-38140 Species denotes Seneca Valley virus Tax:390157
1290 37879-37882 Species denotes HAV Tax:12092
1291 38142-38145 Species denotes SVV Tax:390157
1353 38461-38465 Gene denotes nsp5 Gene:92521
1354 38587-38591 Gene denotes pp1a Gene:5499
1355 38806-38831 Gene denotes NF-κB essential modulator Gene:8517
1356 38833-38837 Gene denotes NEMO Gene:8517
1357 38843-38848 Gene denotes STAT2 Gene:6773
1358 38864-38868 Gene denotes NEMO Gene:8517
1359 38918-38923 Gene denotes NF-κB Gene:4790
1360 38925-38929 Gene denotes IRF3 Gene:3661
1361 38935-38939 Gene denotes IRF7 Gene:3665
1362 38947-38951 Gene denotes NEMO Gene:8517
1363 38968-38972 Gene denotes MAVS Gene:57506
1364 39041-39045 Gene denotes TBK1 Gene:29110
1365 39046-39050 Gene denotes IKKε Gene:9641
1366 39158-39162 Gene denotes nsp5 Gene:92521
1367 39213-39218 Gene denotes IFN-β Gene:3439
1368 39320-39324 Gene denotes nsp5 Gene:92521
1369 39334-39339 Gene denotes RIG-I Gene:23586
1370 39340-39344 Gene denotes MDA5 Gene:64135
1371 39383-39387 Gene denotes TBK1 Gene:29110
1372 39405-39409 Gene denotes NEMO Gene:8517
1373 39413-39417 Gene denotes nsp5 Gene:92521
1374 39484-39488 Gene denotes nsp5 Gene:92521
1375 39510-39514 Gene denotes NEMO Gene:8517
1376 39534-39538 Gene denotes NEMO Gene:8517
1377 39595-39599 Gene denotes NEMO Gene:8517
1378 39619-39623 Gene denotes nsp5 Gene:92521
1379 39813-39817 Gene denotes Nsp5 Gene:92521
1380 39977-39981 Gene denotes nsp5 Gene:92521
1381 39998-40003 Gene denotes STAT2 Gene:6773
1382 40086-40091 Gene denotes STAT1 Gene:6772
1383 40096-40101 Gene denotes STAT2 Gene:6773
1384 40170-40175 Gene denotes KPNA1 Gene:3836
1385 40233-40238 Gene denotes ISGF3 Gene:10379
1386 40260-40265 Gene denotes STAT1 Gene:6772
1387 40276-40281 Gene denotes ISGF3 Gene:10379
1388 40348-40353 Gene denotes STAT1 Gene:6772
1389 40358-40363 Gene denotes STAT2 Gene:6773
1390 40428-40433 Gene denotes STAT1 Gene:6772
1391 40464-40467 Gene denotes IFN Gene:3439
1392 38457-38460 Species denotes CoV Tax:11118
1393 38554-38557 Species denotes CoV Tax:11118
1394 38699-38703 Species denotes CoVs Tax:11118
1395 38715-38719 Species denotes PEDV Tax:28295
1396 39094-39098 Species denotes PEDV Tax:28295
1397 39153-39157 Species denotes PEDV Tax:28295
1398 39186-39198 Species denotes Sendai virus Tax:11191
1399 39315-39319 Species denotes PEDV Tax:28295
1400 39479-39483 Species denotes PEDV Tax:28295
1401 39701-39705 Species denotes CoVs Tax:11118
1402 39853-39857 Species denotes PEDV Tax:28295
1403 39868-39872 Species denotes CoVs Tax:11118
1404 39972-39976 Species denotes PEDV Tax:28295
1405 40043-40047 Species denotes PEDV Tax:28295
1406 40384-40388 Species denotes PEDV Tax:28295
1407 40404-40408 Species denotes PEDV Tax:28295
1408 40502-40506 Species denotes PEDV Tax:28295
1409 39200-39203 Species denotes SeV Tax:11191
1410 39937-39948 Species denotes coronaviral Tax:11118
1411 39107-39111 Gene denotes NEMO Gene:8517
1412 39082-39092 Disease denotes infections MESH:D007239
1413 40409-40418 Disease denotes infection MESH:D007239
1418 40604-40608 Species denotes CoVs Tax:11118
1419 41094-41098 Species denotes PEDV Tax:28295
1420 40710-40725 Chemical denotes 5′-triphosphate
1421 41067-41071 Chemical denotes DMVs
1423 41467-41471 Species denotes PEDV Tax:28295
1458 41492-41497 Gene denotes EndoU Gene:8909
1459 41837-41842 Gene denotes EndoU Gene:8909
1460 41950-41953 Gene denotes IFN Gene:3439
1461 42023-42028 Gene denotes EndoU Gene:8909
1462 42088-42092 Gene denotes MDA5 Gene:64135
1463 42094-42110 Gene denotes protein kinase R Gene:5610
1464 42469-42474 Gene denotes EndoU Gene:8909
1465 42539-42542 Gene denotes IFN Gene:3439
1466 42564-42569 Gene denotes EndoU Gene:8909
1467 42754-42759 Gene denotes EndoU Gene:8909
1468 43162-43167 Gene denotes EndoU Gene:8909
1469 41620-41625 Gene denotes EndoU Gene:8909
1470 41478-41481 Species denotes CoV Tax:11118
1471 41775-41783 Species denotes SARS-CoV Tax:694009
1472 41788-41797 Species denotes HCoV-229E Tax:11137
1473 41968-41972 Species denotes CoVs Tax:11118
1474 42017-42021 Species denotes CoVs Tax:11118
1475 42401-42405 Species denotes CoVs Tax:11118
1476 42464-42468 Species denotes PEDV Tax:28295
1477 42582-42586 Species denotes PEDV Tax:28295
1478 42767-42771 Species denotes PEDV Tax:28295
1479 42866-42870 Species denotes PEDV Tax:28295
1480 43180-43184 Species denotes PEDV Tax:28295
1481 42638-42645 Species denotes porcine Tax:2018513
1482 42709-42716 Species denotes porcine Tax:2018513
1483 42815-42822 Species denotes porcine Tax:2018513
1484 41629-41632 Species denotes MHV Tax:11138
1485 42411-42416 Gene denotes EndoU Gene:8909
1486 42122-42125 Disease denotes OAS MESH:C537769
1487 42156-42159 Disease denotes OAS MESH:C537769
1488 42227-42243 Disease denotes viral infections MESH:D001102
1489 42283-42286 Disease denotes OAS MESH:C537769
1490 43044-43073 Disease denotes EndoU-deficient PEDV infected MESH:D007239
1491 43119-43128 Disease denotes mortality MESH:D003643
1493 43273-43277 Species denotes PEDV Tax:28295
1520 43596-43600 Gene denotes MDA5 Gene:64135
1521 43972-43975 Gene denotes IFN Gene:3439
1522 44055-44060 Gene denotes IFN-β Gene:3439
1523 44733-44736 Gene denotes IFN Gene:3439
1524 44769-44774 Gene denotes IFIT1 Gene:3434
1525 44776-44781 Gene denotes IFIT2 Gene:3433
1526 44783-44788 Gene denotes IFIT3 Gene:3437
1527 43284-43287 Species denotes CoV Tax:11118
1528 43390-43394 Species denotes CoVs Tax:11118
1529 43797-43805 Species denotes SARS-CoV Tax:694009
1530 43917-43921 Species denotes PEDV Tax:28295
1531 44457-44461 Species denotes PEDV Tax:28295
1532 44596-44600 Species denotes PEDV Tax:28295
1533 44626-44630 Species denotes PEDV Tax:28295
1534 44814-44818 Species denotes PEDV Tax:28295
1535 44879-44883 Species denotes PEDV Tax:28295
1536 45149-45153 Species denotes CoVs Tax:11118
1537 45169-45173 Species denotes CoVs Tax:11118
1538 45260-45264 Species denotes TGEV Tax:11149
1539 45322-45326 Species denotes TGEV Tax:11149
1540 45530-45534 Species denotes PEDV Tax:28295
1541 45628-45632 Species denotes PEDV Tax:28295
1542 45663-45667 Species denotes PEDV Tax:28295
1543 45071-45085 Disease denotes CoV infections MESH:D018352
1544 45471-45483 Disease denotes MHV-infected MESH:D007239
1545 45797-45806 Disease denotes infection MESH:D007239
1547 45828-45832 Species denotes PEDV Tax:28295
1571 45932-45937 Gene denotes HSP27 Gene:3315
1572 46299-46304 Gene denotes HSP27 Gene:3315
1573 46506-46511 Gene denotes HSP27 Gene:3315
1574 46558-46563 Gene denotes HSP27 Gene:3315
1575 46597-46602 Gene denotes NF-κB Gene:4790
1576 46645-46650 Gene denotes IFN-β Gene:3439
1577 46673-46678 Gene denotes HSP27 Gene:3315
1578 46753-46758 Gene denotes HSP27 Gene:3315
1579 46867-46872 Gene denotes HSP27 Gene:3315
1580 46934-46939 Gene denotes HSP70 Gene:3308
1581 47042-47047 Gene denotes HSP70 Gene:3308
1582 47158-47163 Gene denotes HSP70 Gene:3308
1583 46201-46205 Species denotes PEDV Tax:28295
1584 46441-46445 Species denotes PEDV Tax:28295
1585 46786-46790 Species denotes PEDV Tax:28295
1586 46804-46808 Species denotes PEDV Tax:28295
1587 47017-47021 Species denotes CoVs Tax:11118
1588 47168-47172 Species denotes PEDV Tax:28295
1589 46206-46215 Disease denotes infection MESH:D007239
1590 46260-46269 Disease denotes infection MESH:D007239
1591 46446-46455 Disease denotes infection MESH:D007239
1592 46536-46544 CellLine denotes MARC-145 CVCL:4540
1593 46654-46662 CellLine denotes MARC-145 CVCL:4540
1596 47242-47257 Disease denotes Viral infection MESH:D001102
1597 47434-47442 Disease denotes infected MESH:D007239
1612 48303-48312 Gene denotes caspase-3 Gene:836
1613 48317-48326 Gene denotes caspase-8 Gene:841
1614 48366-48417 Gene denotes apoptosis-inducing factor mitochondria-associated 1 Gene:9131
1615 48419-48424 Gene denotes AIFM1 Gene:9131
1616 48430-48456 Gene denotes poly ADP-ribose polymerase Gene:142
1617 48458-48462 Gene denotes PARP Gene:142
1618 48644-48648 Gene denotes ORF3 Gene:136991
1619 47942-47946 Species denotes PEDV Tax:28295
1620 48047-48051 Species denotes PEDV Tax:28295
1621 48269-48273 Species denotes PEDV Tax:28295
1622 48513-48517 Species denotes PEDV Tax:28295
1623 48784-48788 Species denotes PEDV Tax:28295
1624 48077-48085 Disease denotes infected MESH:D007239
1625 48274-48283 Disease denotes infection MESH:D007239
1627 48805-48811 Disease denotes Stress MESH:D000079225
1632 49489-49493 Gene denotes PERK Gene:9451
1633 49522-49527 Gene denotes eIF2a Gene:1965
1634 48835-48838 Species denotes CoV Tax:11118
1635 49211-49217 Disease denotes stress MESH:D000079225
1670 49912-49916 Gene denotes ORF3 Gene:136991
1671 50071-50075 Gene denotes ORF3 Gene:136991
1672 50193-50197 Gene denotes ORF3 Gene:136991
1673 50308-50312 Gene denotes ORF3 Gene:136991
1674 50408-50412 Gene denotes ORF3 Gene:136991
1675 50518-50522 Gene denotes ORF3 Gene:136991
1676 50623-50627 Gene denotes ORF3 Gene:136991
1677 50687-50691 Gene denotes ORF3 Gene:136991
1678 50745-50750 Gene denotes GRP78 Gene:3309
1679 50796-50800 Gene denotes PERK Gene:9451
1680 50801-50806 Gene denotes eIF2α Gene:83939
1681 50836-50840 Gene denotes ORF3 Gene:136991
1682 50869-50872 Gene denotes IFN Gene:3439
1683 50893-50896 Gene denotes IFN Gene:3439
1684 50981-50985 Gene denotes ORF3 Gene:136991
1685 50571-50574 Gene denotes LC3 Gene:84557
1686 50580-50583 Gene denotes LC3 Gene:84557
1687 49843-49846 Species denotes CoV Tax:11118
1688 49851-49856 Species denotes β-CoV Tax:694002
1689 49907-49911 Species denotes PEDV Tax:28295
1690 49959-49963 Species denotes PEDV Tax:28295
1691 50027-50031 Species denotes PEDV Tax:28295
1692 50145-50149 Species denotes PEDV Tax:28295
1693 50188-50192 Species denotes PEDV Tax:28295
1694 50513-50517 Species denotes PEDV Tax:28295
1695 50682-50686 Species denotes PEDV Tax:28295
1696 50976-50980 Species denotes PEDV Tax:28295
1697 49871-49877 Disease denotes stress MESH:D000079225
1698 49885-49893 Disease denotes infected MESH:D007239
1699 50238-50242 Disease denotes TMDs
1700 50450-50456 Disease denotes stress MESH:D000079225
1701 50665-50671 Disease denotes stress MESH:D000079225
1702 50704-50710 Disease denotes stress MESH:D000079225
1703 50933-50946 Disease denotes PEDV-infected MESH:D007239
1721 51535-51539 Gene denotes nsp1 Gene:10045
1722 51541-51545 Gene denotes PLP2 Gene:5355
1723 51547-51551 Gene denotes nsp5 Gene:92521
1724 51905-51909 Gene denotes nsp1 Gene:10045
1725 51031-51035 Species denotes PEDV Tax:28295
1726 51082-51085 Species denotes pig Tax:9823
1727 51162-51167 Species denotes swine Tax:9823
1728 51397-51401 Species denotes PEDV Tax:28295
1729 51530-51534 Species denotes PEDV Tax:28295
1730 51783-51787 Species denotes PEDV Tax:28295
1731 52052-52056 Species denotes CoVs Tax:11118
1732 52252-52256 Species denotes PEDV Tax:28295
1733 52345-52349 Species denotes PEDV Tax:28295
1734 52398-52402 Species denotes PEDV Tax:28295
1735 51371-51375 Chemical denotes ISGs
1736 51068-51078 Disease denotes infections MESH:D007239
1737 52104-52110 Disease denotes stress MESH:D000079225
2448 53317-53321 Gene denotes ORF3 Gene:136991
2449 53344-53348 Gene denotes nsp1 Gene:10045
2450 53403-53407 Gene denotes PLP1 Gene:5354
2451 53412-53416 Gene denotes PLP2 Gene:5355
2452 53458-53462 Gene denotes nsp5 Gene:92521
2453 53622-53627 Gene denotes EndoU Gene:8909
2454 53054-53085 Species denotes Porcine epidemic diarrhea virus Tax:28295
2455 53087-53091 Species denotes PEDV Tax:28295
2461 53873-53878 Gene denotes EndoU Gene:8909
2462 53723-53727 Species denotes PEDV Tax:28295
2463 53807-53811 Species denotes PEDV Tax:28295
2464 53842-53846 Species denotes PEDV Tax:28295
2465 53989-54004 Disease denotes viral infection MESH:D001102
2494 54156-54160 Gene denotes PLP2 Gene:5355
2495 54199-54204 Gene denotes RIG-I Gene:23586
2496 54211-54215 Gene denotes nsp5 Gene:92521
2497 54236-54240 Gene denotes NEMO Gene:8517
2498 54281-54285 Gene denotes TBK1 Gene:29110
2499 54322-54326 Gene denotes TBK1 Gene:29110
2500 54331-54335 Gene denotes IRF3 Gene:3661
2501 54342-54346 Gene denotes nsp1 Gene:10045
2502 54369-54372 Gene denotes CBP Gene:1387
2503 54377-54381 Gene denotes IκBα Gene:4792
2504 54408-54412 Gene denotes IκBα Gene:4792
2505 54433-54436 Gene denotes p65 Gene:5970
2506 54636-54641 Gene denotes NF-κB Gene:4790
2507 54648-54652 Gene denotes nsp1 Gene:10045
2508 54689-54693 Gene denotes IRF1 Gene:3659
2509 54844-54849 Gene denotes STAT1 Gene:6772
2510 54854-54859 Gene denotes STAT2 Gene:6773
2511 54894-54899 Gene denotes ISGF3 Gene:10379
2512 54098-54102 Species denotes PEDV Tax:28295
2513 54151-54155 Species denotes PEDV Tax:28295
2514 54206-54210 Species denotes PEDV Tax:28295
2515 54242-54246 Species denotes PEDV Tax:28295
2516 54337-54341 Species denotes PEDV Tax:28295
2517 54449-54453 Species denotes PEDV Tax:28295
2518 54643-54647 Species denotes PEDV Tax:28295
2519 54734-54738 Species denotes PEDV Tax:28295
2520 54819-54823 Species denotes PEDV Tax:28295
2521 54580-54583 Gene denotes IFN Gene:3439
2552 55339-55343 Gene denotes NPM1 Gene:4869
2553 55477-55480 Gene denotes IFN Gene:3439
2554 55605-55610 Gene denotes NF-κB Gene:4790
2555 55628-55632 Gene denotes ORF3 Gene:136991
2556 55764-55767 Gene denotes IFN Gene:3439
2557 55809-55812 Gene denotes CBP Gene:1387
2558 55864-55868 Gene denotes IκBα Gene:4792
2559 55881-55884 Gene denotes p65 Gene:5970
2560 55942-55946 Gene denotes IRF1 Gene:3659
2561 56114-56119 Gene denotes RIG-I Gene:23586
2562 56124-56129 Gene denotes STING Gene:340061
2563 56188-56192 Gene denotes nsp5 Gene:92521
2564 56314-56339 Gene denotes NF-κB essential modulator Gene:8517
2565 56341-56345 Gene denotes NEMO Gene:8517
2566 56373-56376 Gene denotes IFN Gene:3439
2567 56412-56415 Gene denotes IFN Gene:3439
2568 56517-56522 Gene denotes IFN-β Gene:3439
2569 56618-56626 Gene denotes helicase Gene:164045
2570 56859-56862 Gene denotes IFN Gene:3439
2571 56906-56911 Gene denotes EndoU Gene:8909
2572 56913-56916 Gene denotes IFN Gene:3439
2573 57068-57071 Gene denotes IFN Gene:3439
2574 55733-55737 Gene denotes nsp1 Gene:10045
2575 54948-54952 Species denotes PEDV Tax:28295
2576 55707-55711 Species denotes PEDV Tax:28295
2577 55411-55415 Species denotes PEDV Tax:28295
2578 56162-56165 Gene denotes IFN Gene:3439
2579 55263-55269 Disease denotes stress MESH:D000079225
2580 55446-55464 Disease denotes growth retardation MESH:D006130
2581 55580-55586 Disease denotes stress MESH:D000079225
2583 54927-54931 Species denotes PEDV Tax:28295