PMC:7279430 / 5356-6245 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"261","span":{"begin":61,"end":69},"obj":"Species"},{"id":"262","span":{"begin":109,"end":131},"obj":"Species"},{"id":"263","span":{"begin":156,"end":164},"obj":"Species"},{"id":"264","span":{"begin":366,"end":374},"obj":"Species"},{"id":"265","span":{"begin":423,"end":427},"obj":"Species"},{"id":"266","span":{"begin":563,"end":568},"obj":"Species"},{"id":"267","span":{"begin":579,"end":587},"obj":"Species"},{"id":"268","span":{"begin":631,"end":639},"obj":"Species"},{"id":"269","span":{"begin":758,"end":762},"obj":"Species"},{"id":"270","span":{"begin":40,"end":49},"obj":"Species"},{"id":"271","span":{"begin":405,"end":414},"obj":"Species"},{"id":"272","span":{"begin":717,"end":726},"obj":"Species"},{"id":"273","span":{"begin":8,"end":21},"obj":"Chemical"},{"id":"274","span":{"begin":184,"end":197},"obj":"Chemical"},{"id":"275","span":{"begin":208,"end":219},"obj":"Chemical"},{"id":"276","span":{"begin":230,"end":241},"obj":"Chemical"},{"id":"277","span":{"begin":251,"end":262},"obj":"Chemical"},{"id":"278","span":{"begin":276,"end":287},"obj":"Chemical"},{"id":"279","span":{"begin":298,"end":306},"obj":"Chemical"},{"id":"280","span":{"begin":318,"end":326},"obj":"Chemical"},{"id":"281","span":{"begin":339,"end":350},"obj":"Chemical"},{"id":"282","span":{"begin":656,"end":669},"obj":"Chemical"},{"id":"283","span":{"begin":671,"end":682},"obj":"Chemical"},{"id":"284","span":{"begin":688,"end":699},"obj":"Chemical"},{"id":"285","span":{"begin":822,"end":833},"obj":"Chemical"},{"id":"286","span":{"begin":835,"end":846},"obj":"Chemical"},{"id":"287","span":{"begin":852,"end":860},"obj":"Chemical"}],"attributes":[{"id":"A261","pred":"tao:has_database_id","subj":"261","obj":"Tax:164405"},{"id":"A262","pred":"tao:has_database_id","subj":"262","obj":"Tax:164405"},{"id":"A263","pred":"tao:has_database_id","subj":"263","obj":"Tax:164405"},{"id":"A264","pred":"tao:has_database_id","subj":"264","obj":"Tax:164405"},{"id":"A265","pred":"tao:has_database_id","subj":"265","obj":"Tax:114727"},{"id":"A266","pred":"tao:has_database_id","subj":"266","obj":"Tax:129772"},{"id":"A267","pred":"tao:has_database_id","subj":"267","obj":"Tax:164405"},{"id":"A268","pred":"tao:has_database_id","subj":"268","obj":"Tax:164405"},{"id":"A269","pred":"tao:has_database_id","subj":"269","obj":"Tax:114727"},{"id":"A270","pred":"tao:has_database_id","subj":"270","obj":"Tax:11520"},{"id":"A271","pred":"tao:has_database_id","subj":"271","obj":"Tax:11520"},{"id":"A272","pred":"tao:has_database_id","subj":"272","obj":"Tax:11520"},{"id":"A273","pred":"tao:has_database_id","subj":"273","obj":"MESH:D009822"},{"id":"A274","pred":"tao:has_database_id","subj":"274","obj":"MESH:C034019"},{"id":"A275","pred":"tao:has_database_id","subj":"275","obj":"MESH:C018669"},{"id":"A276","pred":"tao:has_database_id","subj":"276","obj":"MESH:C018669"},{"id":"A277","pred":"tao:has_database_id","subj":"277","obj":"MESH:D000077591"},{"id":"A278","pred":"tao:has_database_id","subj":"278","obj":"MESH:C027009"},{"id":"A279","pred":"tao:has_database_id","subj":"279","obj":"MESH:C007210"},{"id":"A280","pred":"tao:has_database_id","subj":"280","obj":"MESH:C005451"},{"id":"A281","pred":"tao:has_database_id","subj":"281","obj":"MESH:C016775"},{"id":"A282","pred":"tao:has_database_id","subj":"282","obj":"MESH:C034019"},{"id":"A283","pred":"tao:has_database_id","subj":"283","obj":"MESH:C027009"},{"id":"A284","pred":"tao:has_database_id","subj":"284","obj":"MESH:C016775"},{"id":"A285","pred":"tao:has_database_id","subj":"285","obj":"MESH:C018669"},{"id":"A286","pred":"tao:has_database_id","subj":"286","obj":"MESH:C018669"},{"id":"A287","pred":"tao:has_database_id","subj":"287","obj":"MESH:C007210"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Another essential oil with notable anti-influenza effects is tea tree, which is extracted from the leaves of Melaleuca alternifolia (Myrtaceae). Commercial tea tree oil is composed of terpinen-4-ol (30–48%), γ-terpinene (10–28%), α-terpinene (5–13%), 1,8-cineole (up to 15%), terpinolene (1.5–5%), p-cymene (0.5–12%), α-pinene (1–6%), and α-terpineol (1.5–8%) [30]. Tea tree oil showed 100% inhibition of influenza type A (H1N1) virus at 0.01% concentration and a median inhibitory concentration (IC50) of 6 μg/mL [31,32]. In addition, 30 min exposure of type A (H11N9) virus to tea tree oil vapor caused 100% inhibition [33]. The tea tree oil components, terpinen-4-ol, terpinolene, and α-terpineol, have shown anti-influenza virus activity against type A (H1N1), with IC50 values of 25, 12, and 250 μg/mL, respectively. α-Terpinene, γ-terpinene, and p-cymene were inactive, however [31]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T49","span":{"begin":40,"end":49},"obj":"Disease"},{"id":"T50","span":{"begin":405,"end":414},"obj":"Disease"},{"id":"T51","span":{"begin":717,"end":726},"obj":"Disease"}],"attributes":[{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"}],"text":"Another essential oil with notable anti-influenza effects is tea tree, which is extracted from the leaves of Melaleuca alternifolia (Myrtaceae). Commercial tea tree oil is composed of terpinen-4-ol (30–48%), γ-terpinene (10–28%), α-terpinene (5–13%), 1,8-cineole (up to 15%), terpinolene (1.5–5%), p-cymene (0.5–12%), α-pinene (1–6%), and α-terpineol (1.5–8%) [30]. Tea tree oil showed 100% inhibition of influenza type A (H1N1) virus at 0.01% concentration and a median inhibitory concentration (IC50) of 6 μg/mL [31,32]. In addition, 30 min exposure of type A (H11N9) virus to tea tree oil vapor caused 100% inhibition [33]. The tea tree oil components, terpinen-4-ol, terpinolene, and α-terpineol, have shown anti-influenza virus activity against type A (H1N1), with IC50 values of 25, 12, and 250 μg/mL, respectively. α-Terpinene, γ-terpinene, and p-cymene were inactive, however [31]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T38","span":{"begin":202,"end":204},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T39","span":{"begin":420,"end":421},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T40","span":{"begin":429,"end":434},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T41","span":{"begin":462,"end":463},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T42","span":{"begin":560,"end":561},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T43","span":{"begin":570,"end":575},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T44","span":{"begin":727,"end":732},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T45","span":{"begin":733,"end":741},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T46","span":{"begin":755,"end":756},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Another essential oil with notable anti-influenza effects is tea tree, which is extracted from the leaves of Melaleuca alternifolia (Myrtaceae). Commercial tea tree oil is composed of terpinen-4-ol (30–48%), γ-terpinene (10–28%), α-terpinene (5–13%), 1,8-cineole (up to 15%), terpinolene (1.5–5%), p-cymene (0.5–12%), α-pinene (1–6%), and α-terpineol (1.5–8%) [30]. Tea tree oil showed 100% inhibition of influenza type A (H1N1) virus at 0.01% concentration and a median inhibitory concentration (IC50) of 6 μg/mL [31,32]. In addition, 30 min exposure of type A (H11N9) virus to tea tree oil vapor caused 100% inhibition [33]. The tea tree oil components, terpinen-4-ol, terpinolene, and α-terpineol, have shown anti-influenza virus activity against type A (H1N1), with IC50 values of 25, 12, and 250 μg/mL, respectively. α-Terpinene, γ-terpinene, and p-cymene were inactive, however [31]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T67","span":{"begin":8,"end":21},"obj":"Chemical"},{"id":"T68","span":{"begin":156,"end":168},"obj":"Chemical"},{"id":"T69","span":{"begin":251,"end":262},"obj":"Chemical"},{"id":"T70","span":{"begin":255,"end":262},"obj":"Chemical"},{"id":"T71","span":{"begin":276,"end":287},"obj":"Chemical"},{"id":"T72","span":{"begin":298,"end":306},"obj":"Chemical"},{"id":"T73","span":{"begin":320,"end":326},"obj":"Chemical"},{"id":"T74","span":{"begin":341,"end":350},"obj":"Chemical"},{"id":"T75","span":{"begin":579,"end":591},"obj":"Chemical"},{"id":"T76","span":{"begin":631,"end":643},"obj":"Chemical"},{"id":"T77","span":{"begin":671,"end":682},"obj":"Chemical"},{"id":"T78","span":{"begin":690,"end":699},"obj":"Chemical"},{"id":"T79","span":{"begin":852,"end":860},"obj":"Chemical"}],"attributes":[{"id":"A67","pred":"chebi_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/CHEBI_83630"},{"id":"A68","pred":"chebi_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/CHEBI_83629"},{"id":"A69","pred":"chebi_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/CHEBI_27961"},{"id":"A70","pred":"chebi_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/CHEBI_23243"},{"id":"A71","pred":"chebi_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/CHEBI_9457"},{"id":"A72","pred":"chebi_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/CHEBI_28768"},{"id":"A73","pred":"chebi_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/CHEBI_17187"},{"id":"A74","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_26876"},{"id":"A75","pred":"chebi_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/CHEBI_83629"},{"id":"A76","pred":"chebi_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/CHEBI_83629"},{"id":"A77","pred":"chebi_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/CHEBI_9457"},{"id":"A78","pred":"chebi_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/CHEBI_26876"},{"id":"A79","pred":"chebi_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/CHEBI_28768"}],"text":"Another essential oil with notable anti-influenza effects is tea tree, which is extracted from the leaves of Melaleuca alternifolia (Myrtaceae). Commercial tea tree oil is composed of terpinen-4-ol (30–48%), γ-terpinene (10–28%), α-terpinene (5–13%), 1,8-cineole (up to 15%), terpinolene (1.5–5%), p-cymene (0.5–12%), α-pinene (1–6%), and α-terpineol (1.5–8%) [30]. Tea tree oil showed 100% inhibition of influenza type A (H1N1) virus at 0.01% concentration and a median inhibitory concentration (IC50) of 6 μg/mL [31,32]. In addition, 30 min exposure of type A (H11N9) virus to tea tree oil vapor caused 100% inhibition [33]. The tea tree oil components, terpinen-4-ol, terpinolene, and α-terpineol, have shown anti-influenza virus activity against type A (H1N1), with IC50 values of 25, 12, and 250 μg/mL, respectively. α-Terpinene, γ-terpinene, and p-cymene were inactive, however [31]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T37","span":{"begin":0,"end":144},"obj":"Sentence"},{"id":"T38","span":{"begin":145,"end":365},"obj":"Sentence"},{"id":"T39","span":{"begin":366,"end":522},"obj":"Sentence"},{"id":"T40","span":{"begin":523,"end":626},"obj":"Sentence"},{"id":"T41","span":{"begin":627,"end":889},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Another essential oil with notable anti-influenza effects is tea tree, which is extracted from the leaves of Melaleuca alternifolia (Myrtaceae). Commercial tea tree oil is composed of terpinen-4-ol (30–48%), γ-terpinene (10–28%), α-terpinene (5–13%), 1,8-cineole (up to 15%), terpinolene (1.5–5%), p-cymene (0.5–12%), α-pinene (1–6%), and α-terpineol (1.5–8%) [30]. Tea tree oil showed 100% inhibition of influenza type A (H1N1) virus at 0.01% concentration and a median inhibitory concentration (IC50) of 6 μg/mL [31,32]. In addition, 30 min exposure of type A (H11N9) virus to tea tree oil vapor caused 100% inhibition [33]. The tea tree oil components, terpinen-4-ol, terpinolene, and α-terpineol, have shown anti-influenza virus activity against type A (H1N1), with IC50 values of 25, 12, and 250 μg/mL, respectively. α-Terpinene, γ-terpinene, and p-cymene were inactive, however [31]."}

{"project":"2_test","denotations":[{"id":"32408699-16243420-52981847","span":{"begin":361,"end":363},"obj":"16243420"},{"id":"32408699-19843207-52981848","span":{"begin":515,"end":517},"obj":"19843207"},{"id":"32408699-21095205-52981849","span":{"begin":518,"end":520},"obj":"21095205"},{"id":"32408699-19843207-52981850","span":{"begin":885,"end":887},"obj":"19843207"},{"id":"T84306","span":{"begin":361,"end":363},"obj":"16243420"},{"id":"T22380","span":{"begin":515,"end":517},"obj":"19843207"},{"id":"T23801","span":{"begin":518,"end":520},"obj":"21095205"},{"id":"T90152","span":{"begin":885,"end":887},"obj":"19843207"}],"text":"Another essential oil with notable anti-influenza effects is tea tree, which is extracted from the leaves of Melaleuca alternifolia (Myrtaceae). Commercial tea tree oil is composed of terpinen-4-ol (30–48%), γ-terpinene (10–28%), α-terpinene (5–13%), 1,8-cineole (up to 15%), terpinolene (1.5–5%), p-cymene (0.5–12%), α-pinene (1–6%), and α-terpineol (1.5–8%) [30]. Tea tree oil showed 100% inhibition of influenza type A (H1N1) virus at 0.01% concentration and a median inhibitory concentration (IC50) of 6 μg/mL [31,32]. In addition, 30 min exposure of type A (H11N9) virus to tea tree oil vapor caused 100% inhibition [33]. The tea tree oil components, terpinen-4-ol, terpinolene, and α-terpineol, have shown anti-influenza virus activity against type A (H1N1), with IC50 values of 25, 12, and 250 μg/mL, respectively. α-Terpinene, γ-terpinene, and p-cymene were inactive, however [31]."}