PMC:7278709 / 99754-100718 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":871,"end":882},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"text":"The present paper possibly still stands as the first reported attempt to establish means of making use of sequence motifs that could be recognized between strains, albeit that the order and to some extent precise nature of the amino acid residues appears less important, or perhaps more subtle, than has been considered in previous papers in this series [4,5], which is why it required the development of the predictive technique (SABR-P). This will be advanced in future work, but the present method already helps to make quick comparisons between SARS-CoV-2 sequences and to consider the effects of viral mutations. However, it was surprising that a very simple approach was so useful, and it can easily be reproduced in a very few lines of computer program. The important consequence of the present study, however, is that there are already a variety of inhibitors of sialic acid binding that may serve as anti-viral agents, and this will be examined elsewhere."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T1280","span":{"begin":549,"end":559},"obj":"SP_7"},{"id":"T1281","span":{"begin":601,"end":606},"obj":"NCBITaxon:10239"},{"id":"T1282","span":{"begin":857,"end":867},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T1283","span":{"begin":871,"end":882},"obj":"CHEBI:26667;CHEBI:26667"},{"id":"T1284","span":{"begin":914,"end":919},"obj":"NCBITaxon:10239"}],"text":"The present paper possibly still stands as the first reported attempt to establish means of making use of sequence motifs that could be recognized between strains, albeit that the order and to some extent precise nature of the amino acid residues appears less important, or perhaps more subtle, than has been considered in previous papers in this series [4,5], which is why it required the development of the predictive technique (SABR-P). This will be advanced in future work, but the present method already helps to make quick comparisons between SARS-CoV-2 sequences and to consider the effects of viral mutations. However, it was surprising that a very simple approach was so useful, and it can easily be reproduced in a very few lines of computer program. The important consequence of the present study, however, is that there are already a variety of inhibitors of sialic acid binding that may serve as anti-viral agents, and this will be examined elsewhere."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":227,"end":237},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma82739"}],"text":"The present paper possibly still stands as the first reported attempt to establish means of making use of sequence motifs that could be recognized between strains, albeit that the order and to some extent precise nature of the amino acid residues appears less important, or perhaps more subtle, than has been considered in previous papers in this series [4,5], which is why it required the development of the predictive technique (SABR-P). This will be advanced in future work, but the present method already helps to make quick comparisons between SARS-CoV-2 sequences and to consider the effects of viral mutations. However, it was surprising that a very simple approach was so useful, and it can easily be reproduced in a very few lines of computer program. The important consequence of the present study, however, is that there are already a variety of inhibitors of sialic acid binding that may serve as anti-viral agents, and this will be examined elsewhere."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T191","span":{"begin":549,"end":557},"obj":"Disease"}],"attributes":[{"id":"A191","pred":"mondo_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"The present paper possibly still stands as the first reported attempt to establish means of making use of sequence motifs that could be recognized between strains, albeit that the order and to some extent precise nature of the amino acid residues appears less important, or perhaps more subtle, than has been considered in previous papers in this series [4,5], which is why it required the development of the predictive technique (SABR-P). This will be advanced in future work, but the present method already helps to make quick comparisons between SARS-CoV-2 sequences and to consider the effects of viral mutations. However, it was surprising that a very simple approach was so useful, and it can easily be reproduced in a very few lines of computer program. The important consequence of the present study, however, is that there are already a variety of inhibitors of sialic acid binding that may serve as anti-viral agents, and this will be examined elsewhere."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":227,"end":246},"obj":"http://purl.obolibrary.org/obo/CHEBI_33708"},{"id":"T2","span":{"begin":227,"end":246},"obj":"http://purl.obolibrary.org/obo/PR_000036907"},{"id":"T3","span":{"begin":300,"end":303},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T4","span":{"begin":650,"end":651},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T5","span":{"begin":723,"end":724},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T6","span":{"begin":844,"end":845},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The present paper possibly still stands as the first reported attempt to establish means of making use of sequence motifs that could be recognized between strains, albeit that the order and to some extent precise nature of the amino acid residues appears less important, or perhaps more subtle, than has been considered in previous papers in this series [4,5], which is why it required the development of the predictive technique (SABR-P). This will be advanced in future work, but the present method already helps to make quick comparisons between SARS-CoV-2 sequences and to consider the effects of viral mutations. However, it was surprising that a very simple approach was so useful, and it can easily be reproduced in a very few lines of computer program. The important consequence of the present study, however, is that there are already a variety of inhibitors of sialic acid binding that may serve as anti-viral agents, and this will be examined elsewhere."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T12869","span":{"begin":227,"end":237},"obj":"Chemical"},{"id":"T81890","span":{"begin":227,"end":232},"obj":"Chemical"},{"id":"T73138","span":{"begin":233,"end":237},"obj":"Chemical"},{"id":"T20402","span":{"begin":857,"end":867},"obj":"Chemical"},{"id":"T16800","span":{"begin":871,"end":882},"obj":"Chemical"},{"id":"T38416","span":{"begin":878,"end":882},"obj":"Chemical"},{"id":"T69539","span":{"begin":909,"end":926},"obj":"Chemical"}],"attributes":[{"id":"A64171","pred":"chebi_id","subj":"T12869","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A95840","pred":"chebi_id","subj":"T81890","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A77247","pred":"chebi_id","subj":"T73138","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A44242","pred":"chebi_id","subj":"T20402","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A20140","pred":"chebi_id","subj":"T16800","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A28787","pred":"chebi_id","subj":"T38416","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A68919","pred":"chebi_id","subj":"T69539","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"}],"text":"The present paper possibly still stands as the first reported attempt to establish means of making use of sequence motifs that could be recognized between strains, albeit that the order and to some extent precise nature of the amino acid residues appears less important, or perhaps more subtle, than has been considered in previous papers in this series [4,5], which is why it required the development of the predictive technique (SABR-P). This will be advanced in future work, but the present method already helps to make quick comparisons between SARS-CoV-2 sequences and to consider the effects of viral mutations. However, it was surprising that a very simple approach was so useful, and it can easily be reproduced in a very few lines of computer program. The important consequence of the present study, however, is that there are already a variety of inhibitors of sialic acid binding that may serve as anti-viral agents, and this will be examined elsewhere."}

{"project":"LitCovid-sentences","denotations":[{"id":"T571","span":{"begin":0,"end":439},"obj":"Sentence"},{"id":"T572","span":{"begin":440,"end":617},"obj":"Sentence"},{"id":"T573","span":{"begin":618,"end":760},"obj":"Sentence"},{"id":"T574","span":{"begin":761,"end":964},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The present paper possibly still stands as the first reported attempt to establish means of making use of sequence motifs that could be recognized between strains, albeit that the order and to some extent precise nature of the amino acid residues appears less important, or perhaps more subtle, than has been considered in previous papers in this series [4,5], which is why it required the development of the predictive technique (SABR-P). This will be advanced in future work, but the present method already helps to make quick comparisons between SARS-CoV-2 sequences and to consider the effects of viral mutations. However, it was surprising that a very simple approach was so useful, and it can easily be reproduced in a very few lines of computer program. The important consequence of the present study, however, is that there are already a variety of inhibitors of sialic acid binding that may serve as anti-viral agents, and this will be examined elsewhere."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1848","span":{"begin":549,"end":559},"obj":"Species"},{"id":"1849","span":{"begin":871,"end":882},"obj":"Chemical"}],"attributes":[{"id":"A1848","pred":"tao:has_database_id","subj":"1848","obj":"Tax:2697049"},{"id":"A1849","pred":"tao:has_database_id","subj":"1849","obj":"MESH:D019158"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The present paper possibly still stands as the first reported attempt to establish means of making use of sequence motifs that could be recognized between strains, albeit that the order and to some extent precise nature of the amino acid residues appears less important, or perhaps more subtle, than has been considered in previous papers in this series [4,5], which is why it required the development of the predictive technique (SABR-P). This will be advanced in future work, but the present method already helps to make quick comparisons between SARS-CoV-2 sequences and to consider the effects of viral mutations. However, it was surprising that a very simple approach was so useful, and it can easily be reproduced in a very few lines of computer program. The important consequence of the present study, however, is that there are already a variety of inhibitors of sialic acid binding that may serve as anti-viral agents, and this will be examined elsewhere."}