PMC:7278709 / 52387-53822
Annnotations
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It is nonetheless the binding of the appropriate glycans containing sialic acid that may still be important for SARS-CoV and SARS-CoV-2 infection in vivo, as it is for other viruses [16]. The fact that other viruses, including other coronaviruses, require that function, followed by any demonstration that SARS-CoV and SARS-CoV-2 still possess that function, would suggest that it could still be a target for pharmaceutical drug development, at least as a preventative. This argument is not unique in its general form. For example, Fantani and colleagues believe that the SARS-CoV-2 also uses sialic acids linked to host cell surface gangliosides to somehow facilitate host cell entry and so could represent a therepeutic target 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