| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-127 |
Sentence |
denotes |
A large number of COVID-19 interventional clinical trials were registered soon after the pandemic onset: a descriptive analysis |
| T2 |
128-138 |
Sentence |
denotes |
Background |
| T3 |
139-311 |
Sentence |
denotes |
There is a pressing need for evidence-based interventions to address the devastating clinical and public health effects of the Coronavirus disease 2019 (COVID-19) pandemic. |
| T4 |
312-389 |
Sentence |
denotes |
The number of registered trials related to COVID-19 is increasing by the day. |
| T5 |
390-400 |
Sentence |
denotes |
Objectives |
| T6 |
401-497 |
Sentence |
denotes |
To describe the characteristics of the currently registered clinical trials related to COVID-19. |
| T7 |
498-505 |
Sentence |
denotes |
Methods |
| T8 |
506-628 |
Sentence |
denotes |
We searched the World Health Organization (WHO)’s International Clinical Trials Registry Platform (ICTRP) on May 15, 2020. |
| T9 |
629-679 |
Sentence |
denotes |
We included any entry that is related to COVID-19. |
| T10 |
680-901 |
Sentence |
denotes |
We abstracted then descriptively analyzed the following characteristics of the registered trials: study design, status, phase, primary endpoints, experimental interventions, and geographic location among other qualifiers. |
| T11 |
902-909 |
Sentence |
denotes |
Results |
| T12 |
910-957 |
Sentence |
denotes |
We identified 1,308 eligible registered trials. |
| T13 |
958-1112 |
Sentence |
denotes |
The majority of trials were initially registered with ClinicalTrials.gov (n= 703; 53.7%) and the Chinese Clinical Trial Registry (ChiCTR) (n= 291; 22.2%). |
| T14 |
1113-1232 |
Sentence |
denotes |
The number of participants to be enrolled across these trials was 734,657, with a median of 110 participants per trial. |
| T15 |
1233-1380 |
Sentence |
denotes |
The most-commonly studied intervention category was pharmacologic (n=763; 58.3%), with antiparasitic medications being the most common subcategory. |
| T16 |
1381-1505 |
Sentence |
denotes |
While over half of trials were already recruiting, we identified published peer-reviewed results for only 8 of those trials. |
| T17 |
1506-1516 |
Sentence |
denotes |
Conclusion |
| T18 |
1517-1611 |
Sentence |
denotes |
There is a relatively large number of registered trials but very few results published so far. |
| T19 |
1612-1807 |
Sentence |
denotes |
While our findings suggest an appropriate initial response by the research community, the real challenge will be to get these trials completed, published, and translated into practice and policy. |