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PMC:7278327 / 8309-10442 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T65 200-208 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T66 240-247 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T67 578-581 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T68 955-959 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T69 1655-1662 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T70 1715-1722 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T71 1884-1894 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T72 2072-2084 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T73 2120-2127 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
289 234-239 Gene denotes spike Gene:43740568
290 981-986 Gene denotes nAChR Gene:1137
291 1959-1964 Gene denotes nAChR Gene:1137
292 2114-2119 Gene denotes spike Gene:43740568
293 1709-1714 Gene denotes spike Gene:43740568
294 223-233 Species denotes SARS-CoV-2 Tax:2697049
295 556-566 Species denotes SARS-CoV-2 Tax:2697049
296 662-667 Species denotes human Tax:9606
297 767-772 Species denotes human Tax:9606
298 904-914 Species denotes SARS-CoV-2 Tax:2697049
299 940-945 Species denotes human Tax:9606
300 1077-1082 Species denotes human Tax:9606
301 1179-1187 Species denotes SARS-CoV Tax:694009
302 1193-1223 Species denotes canine respiratory coronavirus Tax:215681
303 1271-1277 Species denotes canine Tax:9615
304 1390-1394 Species denotes dogs Tax:9615
305 1645-1654 Species denotes mammalian Tax:9606
306 1698-1708 Species denotes SARS-CoV-2 Tax:2697049
307 2103-2113 Species denotes SARS-CoV-2 Tax:2697049
308 149-153 Species denotes RABV Tax:11292
309 718-722 Species denotes RABV Tax:11292
310 789-793 Species denotes RABV Tax:11292
311 1225-1230 Species denotes CRCoV Tax:215681
312 1410-1415 Species denotes CRCoV Tax:215681
313 1475-1479 Species denotes RABV Tax:11292
314 2060-2064 Species denotes RABV Tax:11292
315 1553-1558 Gene denotes nAChR Gene:1137
316 348-356 Disease denotes COVID 19 MESH:C000657245
317 1289-1308 Disease denotes respiratory disease MESH:D012140

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T68 223-231 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 348-356 Disease denotes COVID 19 http://purl.obolibrary.org/obo/MONDO_0100096
T70 556-564 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T71 668-674 Disease denotes rabies http://purl.obolibrary.org/obo/MONDO_0019173
T72 904-912 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T73 1168-1178 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T74 1179-1187 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 1278-1288 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T76 1289-1308 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T77 1698-1706 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T78 2103-2111 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T105 24-27 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T106 38-39 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T107 56-57 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T108 125-126 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T109 270-271 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T110 578-581 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T111 578-581 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T112 662-667 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T113 757-763 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T114 767-772 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T115 940-945 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T116 955-965 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines
T117 1077-1082 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T118 1159-1160 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T119 1240-1241 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T120 1318-1320 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T121 1423-1424 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T33 200-208 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T34 240-247 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T35 1655-1662 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T36 1715-1722 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T37 1884-1894 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T38 1884-1889 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T39 1890-1894 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T40 2072-2084 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T41 2120-2127 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T32 981-986 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T33 1553-1558 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR
T34 1959-1964 http://purl.obolibrary.org/obo/GO_0022848 denotes nAChR

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T41 0-357 Sentence denotes Our critical discussion has presented a hypothesis with a potentially high degree of biomedical feasibility, indicating that a novel non-replicating RABV vaccine engineered to contain chimeric capsid proteins with discrete SARS-CoV-2 spike protein domains may represent a highly efficacious preventive measure against neurological comorbidities of COVID 19.
T42 358-443 Sentence denotes This hypothesis is based on critical evaluation of the current biomedical literature.
T43 444-588 Sentence denotes Currently, however, there are no vaccines in development that are designed to specifically target or neutralize SARS-CoV-2 entry into CNS areas.
T44 589-794 Sentence denotes The accepted standard of clinical care employs passive immunization with human rabies immune globulin (HRIG) in conjunction with RABV vaccine administration to prevent animal-to-human transmission of RABV.
T45 795-1099 Sentence denotes Positive results obtained from in vitro studies designed to evaluate potential inhibitory effects of HRIG on SARS-CoV-2 entry and replication in human neuronal cell lines expressing the nAChR may provide putative proof of principle of our testable hypothesis and justify subsequent human clinical trials.
T46 1100-1322 Sentence denotes Recent studies in the veterinary literature have described a highly infectious SARS-CoV-like canine respiratory coronavirus (CRCoV) that is a major causative agent in the canine infectious respiratory disease complex [36].
T47 1323-1575 Sentence denotes We speculate that the absence of observed neurological sequelae in dogs afflicted with CRCoV may be a functional consequence of widespread prophylactic RABV vaccination that potentially engenders cross-reacting IgGs against viral nAChR-binding domains.
T48 1576-1845 Sentence denotes Finally, conformational matching and stereo-selective recognition of mammalian protein domains by discrete regions of the SARS-CoV-2 spike protein may have been acquired via evolutionary selection of randomly obtained genomic sequences by multiple recombination events.
T49 1846-2133 Sentence denotes Evolutionary conservation of multiple amino acid domains within the primary sequences of variant subtypes of the nAChR, which appears to be evolutionarily ancient, may underlie the observed functional targeting by RABV capsid glycoprotein and putatively by SARS-CoV-2 spike protein [37].